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Results for "

Aminopeptidases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (37) Amino Acid Derivatives (1) Antibiotic (9) Apoptosis (2) Bacterial (11) Biochemical Assay Reagents (5) Bradykinin Receptor (1) Dipeptidyl Peptidase (5) Endogenous Metabolite (2) Endothelin Receptor (1) Epoxide Hydrolase (1) Fluorescent Dye (3) GCGR (3) GLP Receptor (2) GnRH Receptor (1) Isotope-Labeled Compounds (1) Leukotriene Receptor (2) Lipase (1) MetAP (7) MMP (1) Neprilysin (2) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (1) Parasite (2) Phosphatase (1) Prolyl Endopeptidase (PREP) (1) Renin (1) Somatostatin Receptor (3)
By Research Areas:	Cancer (24) Cardiovascular Disease (9) Endocrinology (3) Infection (14) Inflammation/Immunology (8) Metabolic Disease (14) Neurological Disease (13)

By Targets:

Aminopeptidase (37)

Amino Acid Derivatives (1)

Antibiotic (9)

Apoptosis (2)

Bacterial (11)

Biochemical Assay Reagents (5)

Bradykinin Receptor (1)

Dipeptidyl Peptidase (5)

Endogenous Metabolite (2)

Endothelin Receptor (1)

Epoxide Hydrolase (1)

Fluorescent Dye (3)

GCGR (3)

GLP Receptor (2)

GnRH Receptor (1)

Isotope-Labeled Compounds (1)

Leukotriene Receptor (2)

Lipase (1)

MetAP (7)

MMP (1)

Neprilysin (2)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (1)

Parasite (2)

Phosphatase (1)

Prolyl Endopeptidase (PREP) (1)

Renin (1)

Somatostatin Receptor (3)

By Research Areas:

Cancer (24)

Cardiovascular Disease (9)

Endocrinology (3)

Infection (14)

Inflammation/Immunology (8)

Metabolic Disease (14)

Neurological Disease (13)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Aminopeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137528

H-Glu(4MβNA)-OH H-Glu(4MbetaNA)-OH; L-Glutamic acid γ-(4-methoxy-β-naphthylamide)	Others	Others
H-Glu(4MβNA)-OH is a substrate of aminopeptidases (APs) .

HY-120868

TP-004	MetAP	Metabolic Disease
TP-004 is a potent and reversible inhibitor of *methionine aminopeptidase* 2 (MetAP2), with an IC₅₀** of 6 nM .

HY-129298

Amastatin	Aminopeptidase	Others
Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC₅₀ of 0.54 μg/mL for AP-A .

HY-163714

IRAP-IN-1	Aminopeptidase	Metabolic Disease
IRAP-IN-1 (compound 3) is a potent and selective *insulin regulated aminopeptidase* (IRAP) inhibitor with an IC₅₀** value of 157 nM .

HY-117238

Ketomethylenebestatin	Aminopeptidase	Others
Ketomethylenebestatin is an aminopeptidase (AP) inhibitor and an analog of the natural aminopeptidase inhibitor Bestatin (HY-B0134) with IC₅₀ of 56 μM, 752 μM and 0.39 μM for AP-B, AP-M and Leu-AP, respectively .

HY-136614

H-Val-βNA L-Valine β-naphthylamide	Others	Others
H-Val-βNA (L-Valine β-naphthylamide) can be used as an aminopeptidase and a Valine arylamidase substrate .

HY-E70128

Leucyl aminopeptidase	Others	Others
Leucyl aminopeptidase is a metallopeptidase that cleave N-terminal residues from proteins and peptides. Leucyl aminopeptidase serves as transcriptional repressors to control pyrimidine, alginate and cholera toxin biosynthesis, as well as mediate site-specific recombination events in plasmids and phages .

HY-137928

H-Ala-4MβNA hydrochloride	Fluorescent Dye	Others
H-Ala-4MβNA hydrochloride is a specific fluorogenic substrate for aminopeptidase M .

HY-158410

PSA-IN-1	Others	Neurological Disease
PSA-IN-1 (compound 19) is a *puromycin sensitive aminopeptidase* (PSA) inhibitor with IC₅₀** at 7 nM. PSA-IN-1 has analgesic activity .

HY-D1534

H-L-Ile-Amc TFA	Biochemical Assay Reagents	Others
H-L-Ile-Amc (TFA) is an enzyme substrate, and can detect the yeasts and molds in the sample using aminopeptidase substrates .

HY-133125

ERAP1-IN-1 2 Publications Verification	Others	Inflammation/Immunology
ERAP1-IN-1 is an *endoplasmic reticulum aminopeptidase* 1 (ERAP1)** inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .

HY-168181

ERAP1-IN-2	Others	Others
ERAP1-IN-2 (compound 3f) is an inhibitor of ERAP1 (endoplasmic reticulum aminopeptidase 1). ERAP1-IN-2 has an IC₅₀ value of 1.72 μM against hERAP1 .

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dye	Others
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

HY-125422

Matlystatin A	Aminopeptidase	Cancer
Matlystatin A is a potent *aminopeptidase* inhibitor, with IC₅₀ values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. Matlystatin A can be utilized in cancer research .

HY-156960

JNJ-40929837	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 is a selective and orally active LTA₄H (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 effectively inhibits *aminopeptidase* activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .

HY-163727

MMV1557817	Parasite	Infection
MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites .

HY-156960A

JNJ-40929837 succinate	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 succinate is a selective and orally active LTA₄H (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits *aminopeptidase* activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research .

HY-136887

Arphamenine B hemisulfate	Others	Others
Arphamenine B (hemisulfate) is a Zn ²⁺-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B (hemisulfate) Arphamenine B (hemisulfate) is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B (hemisulfate) enhances the immune response and is used to characterize novel proteases .

HY-W717329

EC33	Aminopeptidase	Cardiovascular Disease
EC33 is a selective aminopeptidase A (APA) inhibitor. EC33 blocks the pressor response of exogenous Ang II. EC33 does not cross the blood-brain barrier. EC33 has the potential for salt-dependent model of hypertension research .

HY-115194

Amastatin hydrochloride	Aminopeptidase Bacterial	Infection
Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with K_i values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase .

HY-117702

RB 101	Prolyl Endopeptidase (PREP) Aminopeptidase	Metabolic Disease
RB 101 is an active mixed inhibitor against two enzymes which metabolize the enkephalins neutral endopeptidase and aminopeptidase N. RB 101 has rather long-lasting antinociceptive effects. RB 101 inhibits the in vivo [ ³H]DPN binding both under basal conditions and after swim stress in mice. RB 101 can be used to determine the precise in vivo localization of enkephalinergic pathways recruited by various stimuli .

HY-101932

TNP-470 1 Publications Verification AGM-1470	Aminopeptidase	Cardiovascular Disease Cancer
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

HY-151518

Aminopeptidase-IN-1	Aminopeptidase	Neurological Disease
Aminopeptidase-IN-1 (compound 16o) is a potent *insulin-regulated aminopeptidase* (IRAP) inhibitor with an K_i** value of 7.7 μM. Aminopeptidase-IN-1 can be used tor research cognitive and memory impairments .

HY-P2779

*Microsomal aminopeptidase, Microorganism*	Endogenous Metabolite	Metabolic Disease
Microsomal aminopeptidase, Microorganism is first reported from C. elegans. The Microsomal aminopeptidase, Microorganism is beneficial for the development of molecular vaccines against parasitic nematodes .

HY-P1044

Spinorphin LVV-hemorphin-4	Others	Neurological Disease
Spinorphin is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-108729

Tripeptidyl aminopeptidase Cerliponase alfa	Endogenous Metabolite	Neurological Disease
Tripeptidyl aminopeptidase (Cerliponase alfa) removes tripeptides from the free NH, terminus of longer peptides. Tripeptidyl aminopeptidase has the potential for the research of CLN2 disease .

HY-121483

Leucinal	Others	Others
Leucinal is a competitive inhibitor of brain aminopeptidase, inhibits brain soluble aminopeptidase activity (Ki = 22 microM), and can enhance the analgesia induced by leuprorelin, but has no effect on the analgesia induced by some other substances.

HY-13731

PPI-2458	MetAP	Inflammation/Immunology Cancer
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research .

HY-136542

H-β-Ala-AMC TFA	Others	Cancer
H-β-Ala-AMC TFA is a substrate for aminopeptidase.

HY-W027340

ARM1 1 Publications Verification 4BSA	Aminopeptidase Epoxide Hydrolase	Cancer
ARM1 (4BSA) is a potent *aminopeptidase* and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC₅₀ 7.61 µM and epoxide hydrolase inhibitory activity with an IC₅₀ 12.4 µM .

HY-133016A

(R)-M8891	MetAP	Others
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .

HY-P4205

Aminopeptidase N Ligand (CD13) NGR peptide	Aminopeptidase	Cancer
Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. Aminopeptidase N Ligand (CD13) NGR peptide is often used in cancer research .

HY-147401

Sitagliptin fenilalanil	Dipeptidyl Peptidase	Metabolic Disease
Sitagliptin fenilalanil is a *dipeptidyl aminopeptidase* 4 (DPP-4)** inhibitor .

HY-W015876

L-Leucinol (+)-Leucinol	Aminopeptidase	Others
L-Leucinol ((+)-Leucinol) is a competitive *aminopeptidase* inhibitor with K_i value of 17 μM .

HY-147401A

Sitagliptin fenilalanil hydrochloride	Dipeptidyl Peptidase	Metabolic Disease
Sitagliptin fenilalanil hydrochloride is a *dipeptidyl aminopeptidase* 4 (DPP-4)** inhibitor .

HY-16710

GPDA GPN; Glycylproline p-nitroanilide tosylate	Fluorescent Dye	Others
GPDA(Glycylproline p-nitroanilide tosylate) is the substarate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay.

HY-137901

L-Alanine 4-nitroanilide hydrochloride, 99% Ala-4-nitroanilide, 99%; H-Ala-pNA, 99%	Biochemical Assay Reagents	Others
L-Alanine 4-nitroanilide hydrochloride, 99% is a detection substrate for L-alanine aminopeptidase.

HY-W011911

L-Leucyl-4-nitroanilide	Biochemical Assay Reagents	Others
L-Leucyl-4-nitroanilide is a colorimetric substrate for leucine aminopeptidase assays.

HY-113952

Actinonin 5 Publications Verification (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-110259

HFI-142 1 Publications Verification	Aminopeptidase	Neurological Disease
HFI-142 is an *insulin-regulated aminopeptidase* (IRAP) inhibitor with a K_i** of 2.01 μM .

HY-P2842

*Aminopeptidase*	Others	Others Cancer
Aminopeptidase catalyzes the cleavage of amino acids from the amino terminus of protein or peptide substrates .

HY-118661

BDM14471	Aminopeptidase	Others
BDM14471 is a selective inhibitor of hydroxamate aminopeptidase M1 (PfAM1), with the IC₅₀ of 6 nM .

HY-B0134A

Bestatin hydrochloride 5+ Cited Publications Ubenimex hydrochloride	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin hydrochloride is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-B0134B

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin trifluoroacetate is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-P4549

H-D-Ala-D-Ala-D-Ala-D-Ala-OH	Aminopeptidase	Others
H-D-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate for D-aminopeptidase .

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-P2928

Aeromonas proteolytica aminopeptidase	Others	Others
Aeromonas proteolytica aminopeptidase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P3174

*Pyroglutamate aminopeptidase* I**	Others	Others
Pyroglutamate aminopeptidase I is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-137895

L-Arginine p-nitroanilide dihydrochloride, 98% H-Arg-pNA 2HCl, 98%	Biochemical Assay Reagents	Others
L-Arginine p-nitroanilide dihydrochloride, 98% (H-Arg-pNA 2HCl, 98%) is a chromogenic substrate for cathepsin H and aminopeptidases.

HY-133016

M8891	MetAP	Cardiovascular Disease Cancer
M8891 is an orally active, reversible and brain penetrant *Methionine Aminopeptidase-2 (MetAP-2)* inhibitor with an IC₅₀ of 54 nM and a K_i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC₅₀>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity .

Cat. No.	Product Name	Type

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dyes/Probes
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

HY-16710

GPDA GPN; Glycylproline p-nitroanilide tosylate	Chromogenic Substrates
GPDA(Glycylproline p-nitroanilide tosylate) is the substarate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay.

HY-137928

H-Ala-4MβNA hydrochloride	Fluorescent Dyes/Probes
H-Ala-4MβNA hydrochloride is a specific fluorogenic substrate for aminopeptidase M .

Cat. No.	Product Name	Target	Research Area

HY-P1044A

Spinorphin TFA LVV-hemorphin-4 TFA	Peptides	Neurological Disease
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-115431

Antho-rwamide I	Peptides	Neurological Disease
Antho-rwamide I is a neuropeptide that can be isolated from the sea anemone Anthopleura elegantissima. Antho-rwamide I is resistant to nonspecific aminopeptidases, which increases the stability of the peptide after neuronal release .

HY-137946

L-Leucine 4-methoxy-β-naphthylamide hydrochloride	Peptides	Others
L-Leucine 4-methoxy-β-naphthylamide hydrochloride is an aminopeptidase M and leucine aminopeptidase substrate .

HY-P4205

Aminopeptidase N Ligand (CD13) NGR peptide	Aminopeptidase	Cancer
Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. Aminopeptidase N Ligand (CD13) NGR peptide is often used in cancer research .

HY-P4549

H-D-Ala-D-Ala-D-Ala-D-Ala-OH	Aminopeptidase	Others
H-D-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate for D-aminopeptidase .

HY-P5607

Bombinin	Peptides	Infection
Bombinin is an antimicrobial peptide derived from frog Bombina variegata. Bombinin has a protective effect on aminopeptidase .

HY-P4584

TRH-βNA	Biochemical Assay Reagents	Others
TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity .

HY-P4658

H-Val-Ala-pNA	Peptides	Others
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .

HY-P4393

H-Leu-Trp-Met-Arg-OH	Aminopeptidase	Others
H-Leu-Trp-Met-Arg-OH is a tetrapeptide. H-Leu-Trp-Met-Arg-OH can be used as a substrate for *aminopeptidase*-mediated hydrolysis studies .

HY-P4553

H-Met-Pro-OH	Amino Acid Derivatives	Others
H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .

HY-P4461

Ala-Ala-Pro-pNA	Peptides	Others
Ala-Ala-Pro-pNA is a tripeptide, including chromophoric amino acids Pro-pNA. Ala-Ala-Pro-pNA is targeted by tripeptidyl aminopeptidase (SM-TAP) .

HY-P4227A

WRVYEKC(dnp)ALK tetraTFA	Peptides	Metabolic Disease
WRVYEKC(dnp)ALK tetraTFA contains tryptophan that can be liberated from the dinitrophenol (DNP) quencher by aminopeptidase activity. WRVYEKC(dnp)ALK tetraTFA can be used as a hydrolysis reaction decapeptide substrate .

HY-111173

Diprotin B	Dipeptidyl Peptidase	Others
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .

HY-P4528

Ala-Phe-Pro-βNA	Peptides	Others
Ala-Phe-Pro-βNA is the subsrate of prolyl tripeptidyl aminopeptidase, which is from Porphyromonas gingivalis. Ala-Phe-Pro-βNA binds to H-Ala-Ile-pyrrolidin-2-yl boronic acid for PTP39 and the E636A mutant with K_i values of 88.1 nM and 48.8 nM, respectivley .

HY-P2075

EMD 55068	Renin	Endocrinology
EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .

HY-P10472

Azaline B	GnRH Receptor	Endocrinology
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC₅₀ of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .

HY-P4757

N1-Glutathionyl-spermidine disulfide	Peptides	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-P10341

ZP3022	GCGR	Metabolic Disease
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-P4146

Survodutide BI 456906	GLP Receptor GCGR	Metabolic Disease
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC₅₀s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .

HY-P4146A

Survodutide TFA BI 456906 TFA	GLP Receptor GCGR	Metabolic Disease
Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC₅₀s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .

HY-103294

R892	Peptides	Others
R892 is a selective and efficient bradyK_inin B1 receptor antagonist with significant antagonistic activity. The pA2 values of R892 in human and rabbit B1 receptors are 8.8 and 8.6 respectively, indicating its strong anti-activity at these receptors. R892 exhibits selectivity with ID50 values of 2.8 nM and >600 nM for B1 and B2 receptors, respectively, and has no endogenous agonist activity. R892 is resistant to aminopeptidase and kininase II (ACE) degradation and exhibits metabolic stability .

HY-P2434

AP102	Somatostatin Receptor	Neurological Disease Metabolic Disease Cancer
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC₅₀: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .

HY-P5362

NODAGA-LM3	Somatostatin Receptor	Cancer
NODAGA-LM3 can be labeled by ⁶⁸Ga for PET imaging. ⁶⁸Ga-NODAGA-LM3 is a SSTR2 antagonist, and can be used for imaging of SSTR positive paragangliomas .

HY-P5362A

NODAGA-LM3 TFA	Somatostatin Receptor	Cancer
NODAGA-LM3 TFA can be labeled by ⁶⁸Ga for PET imaging. ⁶⁸Ga-NODAGA-LM3 TFA is a SSTR2 antagonist, and can be used for imaging of SSTR positive paragangliomas .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13731

PPI-2458	Classification of Application Fields Disease Research Fields Cancer	MetAP
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research .

HY-113952

Actinonin 5 Publications Verification (-)-Actinonin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-B0134A

Bestatin hydrochloride Maximum Cited Publications 7 Publications Verification Ubenimex hydrochloride	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Aminopeptidase Bacterial Antibiotic
Bestatin hydrochloride is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-114336

Enocyanin 1 Publications Verification	Anthocyans Flavonoids Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields Inflammation/Immunology	Phosphatase
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-B0134

Bestatin Maximum Cited Publications 7 Publications Verification Ubenimex	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Aminopeptidase Bacterial Antibiotic
Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-125422

Matlystatin A	Structural Classification Natural Products Microorganisms Source classification	Aminopeptidase
Matlystatin A is a potent *aminopeptidase* inhibitor, with IC₅₀ values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. Matlystatin A can be utilized in cancer research .

HY-108729

Tripeptidyl aminopeptidase Cerliponase alfa	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Tripeptidyl aminopeptidase (Cerliponase alfa) removes tripeptides from the free NH, terminus of longer peptides. Tripeptidyl aminopeptidase has the potential for the research of CLN2 disease .

HY-P2842

*Aminopeptidase*	Classification of Application Fields Disease Research Fields Cancer	Others
Aminopeptidase catalyzes the cleavage of amino acids from the amino terminus of protein or peptide substrates .

HY-B0134B

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Aminopeptidase Bacterial Antibiotic
Bestatin trifluoroacetate is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-116306

Probestin	Structural Classification Natural Products Microorganisms Source classification	Aminopeptidase
Probestin is a potent aminopeptidase N (APN) inhibitor produced by Streptomyces cyanogens MH663-2F6 .

HY-116126

Leuhistin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Aminopeptidase
Leuhistin is an AP-M (aminopeptidase-M) inhibitor. AP-M is an inactivating enzyme of bioactive peptides in cerebral membranes. Leuhistin can be produced by Bacillus laterosporus BMI156-14F1 .

HY-B0134R

Bestatin (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Aminopeptidase Bacterial Antibiotic
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-125564

Acetyltrialanine	Structural Classification Natural Products Microorganisms Source classification	Aminopeptidase
Acetyltrialanine is a peptide containing three amino acid residues in which the N-terminal amino acid is acetylated and used as a substrate for Nα-acetyl alanine aminopeptidase in order to study the activity and properties of the enzyme. Acetyltrialanine can be used in the study of protein degradation and N-terminal regulation .

HY-126564

Ebelactone A	Structural Classification Natural Products Microorganisms Source classification	Lipase MetAP
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis .

HY-121071

Ascamycin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Nucleoside Antimetabolite/Analog Antibiotic
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against *Xanthomonas* species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for *Xanthomonas citri, Xanthomonas oryzae* and *Mycobacterium phlei*, respectively .

HY-N9898

Sinocrassoside C1	Structural Classification Sinocrassula indica (Decne.) Berger Flavonoids Flavones Source classification Crassulaceae Plants Saccharides Monosaccharides	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

Cat. No.	Product Name	Chemical Structure

HY-B0134AS

Bestatin-d7 hydrochloride
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

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