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Pathways Recommended:	Apoptosis

Results for "

Apoptosis. Nrf2.

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (33) Akt (1) Arenavirus (2) Autophagy (5) Bacterial (4) Bcl-2 Family (4) Calcium Channel (2) Caspase (7) COX (1) Cytochrome P450 (2) Drug Isomer (1) E1/E2/E3 Enzyme (1) EGFR (1) Endogenous Metabolite (13) Ferroptosis (7) Fungal (6) GABA Receptor (1) HDAC (1) HIV (4) Interleukin Related (3) Keap1-Nrf2 (33) Lactate Dehydrogenase (2) Mitochondrial Metabolism (2) MMP (1) mTOR (2) Necroptosis (1) NF-κB (9) NO Synthase (1) p38 MAPK (2) PARP (3) Reactive Oxygen Species (8) ROS Kinase (3) SARS-CoV (2) Sirtuin (1) TNF Receptor (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (8) Endocrinology (2) Infection (8) Inflammation/Immunology (21) Metabolic Disease (10) Neurological Disease (13)

By Targets:

Apoptosis (33)

Akt (1)

Arenavirus (2)

Autophagy (5)

Bacterial (4)

Bcl-2 Family (4)

Calcium Channel (2)

Caspase (7)

COX (1)

Cytochrome P450 (2)

Drug Isomer (1)

E1/E2/E3 Enzyme (1)

EGFR (1)

Endogenous Metabolite (13)

Ferroptosis (7)

Fungal (6)

GABA Receptor (1)

HDAC (1)

HIV (4)

Interleukin Related (3)

Keap1-Nrf2 (33)

Lactate Dehydrogenase (2)

Mitochondrial Metabolism (2)

MMP (1)

mTOR (2)

Necroptosis (1)

NF-κB (9)

NO Synthase (1)

p38 MAPK (2)

PARP (3)

Reactive Oxygen Species (8)

ROS Kinase (3)

SARS-CoV (2)

Sirtuin (1)

TNF Receptor (1)

By Research Areas:

Cancer (29)

Cardiovascular Disease (8)

Endocrinology (2)

Infection (8)

Inflammation/Immunology (21)

Metabolic Disease (10)

Neurological Disease (13)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: Apoptosis SNIPERs ASK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131592

Tricetin 1 Publications Verification	Apoptosis Keap1-Nrf2	Neurological Disease Inflammation/Immunology Cancer
Tricetin is a potent competitive inhibitor of the *Keap1-Nrf2* Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent *apoptosis* pathway .

HY-19543

Brusatol 25+ Cited Publications NSC 172924	Keap1-Nrf2 Apoptosis	Cancer
Brusatol (NSC?172924) is a unique inhibitor of the *Nrf2* pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular *apoptosis* .

HY-N0415

Trigonelline chloride 4 Publications Verification Trigonelline hydrochloride	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal	Infection Metabolic Disease Cancer
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent *Nrf2* inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0414

Trigonelline 4 Publications Verification Trigenolline	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal	Metabolic Disease Cancer
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent *Nrf2* inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0414R

Trigonelline (Standard)	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal	Metabolic Disease Cancer
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N1244

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Keap1-Nrf2 mTOR Apoptosis	Cancer
Sarmentosin is an activator of *Nrf2. Sarmentosin inhibits mTOR* signaling and induces autophagy-dependent *apoptosis* in human HCC cells .

HY-161992

Nrf2 activator-11	Keap1-Nrf2 Apoptosis	Neurological Disease Inflammation/Immunology
Nrf2 activator-11 (compound M11) is a *Nrf2* activator with blood-brain permeability. Nrf2 activator-11 has anti-oxidation, anti-inflammation, anti-ferroptosis and anti-apoptosis. Nrf2 activator-11 can be used to study cerebral  ischemia-reperfusion (CI/R) injury models .

HY-144099

Keap1-Nrf2-IN-4	E1/E2/E3 Enzyme Apoptosis	Cancer
Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC₅₀=2.55 µM). Keap1-Nrf2-IN-4 blocks the migration ability and induces *apoptosis* of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity .

HY-124834

Nrf2 activator-10	Keap1-Nrf2 Apoptosis	Cancer
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC₅₀ is 2.7 μM) and an activator for *Nrf2. Nrf2* activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H₂O₂-induced *apoptosis*.

HY-156081

Nrf2 activator-9	Keap1-Nrf2 Apoptosis	Metabolic Disease
Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis .

HY-N0415R

Trigonelline (chloride) (Standard)	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal	Infection Metabolic Disease Cancer
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N10313

Dehydrobruceine B	Bcl-2 Family Keap1-Nrf2 Apoptosis	Cancer
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce *apoptosis* via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses *Keap1-Nrf2* .

HY-B1971

Deltamethrin Decamethrin	Endogenous Metabolite Calcium Channel Caspase Apoptosis Bcl-2 Family NF-κB Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and *apoptosis* via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing *apoptosis*. Deltamethrin can be used extensively in pest control .

HY-N15190

Sesaminol	Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Sesaminol is an orally active activator for *Nrf2-ARE* pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and *apoptosis* in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease .

HY-130495

CDDO-TFEA CDDO-Trifluoethyl amide; RTA 404; TP-500	Keap1-Nrf2 Apoptosis	Cancer
CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an *Nrf2* activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models, including those mimicking multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC₅₀ values ranging from 85-170 nM.

HY-B1971R

Deltamethrin (Standard)	Endogenous Metabolite Calcium Channel Caspase Apoptosis Bcl-2 Family NF-κB Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Deltamethrin (Standard) is the analytical standard of Deltamethrin. This product is intended for research and analytical applications. Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control .

HY-113145

(Rac)-Salvianic acid A (Rac)-Danshensu; (Rac)-Tanshinol	Drug Isomer	Others
(Rac)-Salvianic acid A is the racemate of Salvianic acid A (HY-N1913). Salvianic acid A, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-77293

(E)-[6]-Dehydroparadol	Apoptosis Keap1-Nrf2	Cancer
(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent *Nrf2* activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells .

HY-N10431

Stigmane B	Keap1-Nrf2	Neurological Disease
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates *apoptosis* and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-N1970

5,7-Dihydroxychromone 1 Publications Verification	Keap1-Nrf2 Arenavirus Caspase PARP	Neurological Disease
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates *Nrf2/ARE* signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and *apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3* and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-W303895

Luteolin monohydrate Maximum Cited Publications 40 Publications Verification	Others	Others Cancer
Luteolin (monohydrate) is the monohydrate of Luteolin. Luteolin (Luteoline), a flavonoid, is also a potent Nrf2 inhibitor. Luteolin has anti-inflammatory and anticancer properties, induces apoptosis and cell cycle arrest in multiple human cancer cell lines, including non-small lung cancer cells, and inhibits cell metastasis and angiogenesis .

HY-N0162

Luteolin Maximum Cited Publications 40 Publications Verification Luteoline; Luteolol; Digitoflavone	Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Luteolin (Luteoline), a flavanoid compound, is a potent *Nrf2* inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of *apoptosis* and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .

HY-N0106

(Rac)-Salvianic acid A sodium 1 Publications Verification (Rac)-Danshensu sodium; (Rac)-Tanshinol sodium	Keap1-Nrf2 NF-κB Mitochondrial Metabolism Apoptosis	Infection Cardiovascular Disease Inflammation/Immunology
(Rac)-Salvianic acid A sodium is the racemic form of Salvianic acid A (HY-N1913). Salvianic acid A is an orally active phenolic compound that induces *Nrf2/HO-1* activation and inhibits the NF-κB pathway, and it also activates the mitochondrial antioxidant defense system (Mitochondrial Metabolism). Salvianic acid A exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties (Apoptosis), demonstrating potential for research into inflammation and cardiovascular diseases .

HY-B0854

Mancozeb	Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450	Infection Metabolic Disease Cancer
Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the *Keap1/Nrf2* signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells .

HY-N0394

L-Cystine 2 Publications Verification	Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2 Reactive Oxygen Species	Metabolic Disease Inflammation/Immunology Cancer
L-Cystine is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine elevates *Nrf2* protein expression and activates *Nrf2* transcription factor. L-cystine reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced *apoptosis*. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and kidney stones

HY-W009356

L-Cystine hydrochloride	Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2 Reactive Oxygen Species	Others
L-Cystine hydrochloride is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine hydrochloride elevates *Nrf2* protein expression and activates *Nrf2* transcription factor. L-Cystine hydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced *apoptosis*. L-Cystine hydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine hydrochloride is promising for research of cystinuria and kidney stones

HY-B0854R

Mancozeb (Standard)	Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450	Infection Metabolic Disease Cancer
Mancozeb (Standard) is the analytical standard of Mancozeb. This product is intended for research and analytical applications. Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the *Keap1/Nrf2* signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells.

HY-N0028

Forsythiaside A 2 Publications Verification	Others	Inflammation/Immunology
Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice. Forsythiaside A inhibits the interaction between KLRB1 and CLEC2D .

HY-116152

Cipepofol Ciprofol; HSK3486	GABA Receptor Sirtuin Keap1-Nrf2 Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABA_A receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte *apoptosis* .

HY-143243

Antioxidant agent-5	Apoptosis NF-κB Keap1-Nrf2 Reactive Oxygen Species	Cardiovascular Disease
Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced *apoptosis* and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating *Nrf2/HO-1* anti-oxidation pathway .

HY-N0028R

Forsythiaside A (Standard)	Others	Inflammation/Immunology
Forsythiaside A (Standard) is the analytical standard of Forsythiaside A. This product is intended for research and analytical applications. Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice .

HY-N0106R

(Rac)-Salvianic acid A (sodium) (Standard)	Keap1-Nrf2 NF-κB Mitochondrial Metabolism Apoptosis	Infection Cardiovascular Disease Inflammation/Immunology
(Rac)-Salvianic acid A (sodium) (Standard) is the analytical standard of (Rac)-Salvianic acid A (sodium). This product is intended for research and analytical applications. (Rac)-Salvianic acid A sodium is the racemic form of Salvianic acid A (HY-N1913). Salvianic acid A is an orally active phenolic compound that induces Nrf2/HO-1 activation and inhibits the NF-κB pathway, and it also activates the mitochondrial antioxidant defense system (Mitochondrial Metabolism). Salvianic acid A exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties (Apoptosis), demonstrating potential for research into inflammation and cardiovascular diseases .

HY-N1970R

5,7-Dihydroxychromone (Standard)	Keap1-Nrf2 Arenavirus Caspase PARP	Neurological Disease
5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone. This product is intended for research and analytical applications. 5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-N0162R

Luteolin (Standard) Maximum Cited Publications 40 Publications Verification Luteoline(Standard); Luteolol(Standard); Digitoflavone (Standard)	Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Luteolin (Standard) is the analytical standard of Luteolin. This product is intended for research and analytical applications. Luteolin (Luteoline), a flavanoid compound, is a potent *Nrf2* inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of *apoptosis* and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .

HY-14909

Bardoxolone 10+ Cited Publications CDDO; RTA 401	Keap1-Nrf2 Necroptosis	Metabolic Disease Cancer
Bardoxolone (RTA 401; CDDO) is a novel nuclear regulatory factor (NRf-2) activator. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis. Bardoxolone methyl enhances the antioxidant system, modulates inflammatory cytokines and inhibits apoptosis in rat kidney, demonstrating inhibition on APAP-induced acute kidney injury (AKI) and analgesic effect. Additionally, Bardoxolone methyl decreases Paclitaxel (PAC) (HY-B0015)-induced mitochondrial damage in neuronal cells. Bardoxolone methyl is promising for the research of chemotherapy-induced neuropathic pain and chronic kidney disease .

HY-N1913

Danshensu 1 Publications Verification Dan shen suan A; Salvianic acid A	Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Danshensu (Dan shen suan A), an orally active phenolic compound, can induce *Nrf2/HO-1* activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-N1913A

Danshensu sodium 1 Publications Verification Dan shen suan A sodium; Salvianic acid A sodium	Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce *Nrf2/HO-1* activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-145532

S-Allylmercaptocysteine	Apoptosis NF-κB Keap1-Nrf2	Inflammation/Immunology Cancer
S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the *apoptosis* of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation .

HY-W016412

Coenzyme Q0 2 Publications Verification CoQ0	Apoptosis Autophagy EGFR Akt mTOR Caspase Bcl-2 Family Reactive Oxygen Species PARP COX NO Synthase TNF Receptor Interleukin Related MMP NF-κB	Neurological Disease Inflammation/Immunology Cancer
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces *apoptosis* and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

HY-N0394R

L-Cystine (Standard)	Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2	Metabolic Disease Inflammation/Immunology Cancer
L-Cystine (Standard) is the analytical standard of L-Cystine. This product is intended for research and analytical applications. L-Cystine, the extracellular form of L-Cysteine (HY-Y0337), is a nutritionally dispensable semiessential sulfur-containing amino acid, occurring in proteins of plants and animals. L-Cystine induces Nrf2 protein elevation in a Keap1 (HY-P75897)-dependent manner and activates Nrf2 transcription factor. L-cystine can elicit cytoprotection by reducing ROS generation and protecting against oxidant- or doxorubicin-induced apoptosis. The reduced reabsorption of L-Cystine in renal tubules and its poor solubility in urine are the important causes of cystine precipitation and cystine crystal formation eventually leading to kidney stones. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and cystinosis

HY-N0568

Madecassoside Asiaticoside A	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase	Cardiovascular Disease Others Neurological Disease Inflammation/Immunology Endocrinology Cancer
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, *apoptosis* and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-N0568R

Madecassoside (Standard)	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase	Cardiovascular Disease Others Neurological Disease Inflammation/Immunology Endocrinology Cancer
Madecassoside (Standard) is the analytical standard of Madecassoside. This product is intended for research and analytical applications. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB , exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity[10]. Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-161783

HDAC6-IN-45	HDAC Keap1-Nrf2 Reactive Oxygen Species Apoptosis	Neurological Disease
HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC₅₀ of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H₂O₂-induced ROS production, inhibits *apoptosis* in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability .

HY-N2535

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced *apoptosis* through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-N2535R

Coniferaldehyde (Standard)	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

Cat. No.	Product Name	Type

HY-W016412

Coenzyme Q0

2 Publications Verification

CoQ0

Enzyme Substrates

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

Cat. No.	Product Name	Target	Research Area

HY-W009356

L-Cystine hydrochloride	Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2 Reactive Oxygen Species	Others
L-Cystine hydrochloride is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine hydrochloride elevates *Nrf2* protein expression and activates *Nrf2* transcription factor. L-Cystine hydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced *apoptosis*. L-Cystine hydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine hydrochloride is promising for research of cystinuria and kidney stones

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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