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Results for "

PTP1B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (1) Aldose Reductase (2) Amylases (2) Amyloid-β (1) Antibiotic (7) Apoptosis (3) Autophagy (1) Bacterial (8) Beta-secretase (1) Dipeptidyl Peptidase (1) Endogenous Metabolite (2) Enterovirus (1) Fungal (7) Glycosidase (7) HIV (1) IKK (1) Insulin Receptor (1) Ligands for Target Protein for PROTAC (1) Lipoxygenase (1) Monoamine Oxidase (1) Parasite (8) Phosphatase (102) PPAR (2) PROTAC Linkers (1) PROTACs (3) PTEN (3) SHP2 (8) STAT (1) Tie (1) TMV (1) TNF Receptor (1)
By Research Areas:	Cancer (33) Cardiovascular Disease (2) Endocrinology (5) Infection (12) Inflammation/Immunology (8) Metabolic Disease (63) Neurological Disease (8)
Oligonucleotides:	Antisense Oligonucleotides (2)

113

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10704

PTP1B-IN-1 5 Publications Verification PTP1B inhibitor	Phosphatase	Metabolic Disease
PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of *PTP1B* with an IC₅₀ value of 1.6 mM. It is often used as the mother core for derivatives of analogues ^[1] .

HY-15133

PTP1B-IN-3	Phosphatase	Metabolic Disease Cancer
PTP1B-IN-3 is a potent and orally active *PTP1B* inhibitor with IC₅₀s of 120 nM for both *PTP1B* and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects ^[1] .

HY-15133A

PTP1B-IN-3 diammonium	Phosphatase	Metabolic Disease Cancer
PTP1B-IN-3 diammonium is a potent and orally active *PTP1B* inhibitor with IC₅₀s of 120 nM for both *PTP1B* and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects ^[1] .

HY-15756

PTP1B-IN-4	Phosphatase	Metabolic Disease
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase *PTP1B, with an IC₅₀* of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes ^[1] .

HY-153018

PTP1B-IN-22	Phosphatase	Metabolic Disease
PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes ^[1].

HY-161321

PTP1B-IN-24	Phosphatase Insulin Receptor Akt	Metabolic Disease
PTP1B-IN-24 (Compound 9) is a reversible *PTP1B* inhibitor with an IC₅₀ value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of *PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1* and AKT ^[1].

HY-144718

PTP1B-IN-17	Phosphatase	Metabolic Disease
PTP1B-IN-17 (Compound 45), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 30.2 μM. PTP1B-IN-17 can be used for the research of type 2 diabetes.

HY-144716

PTP1B-IN-19	Phosphatase	Metabolic Disease
PTP1B-IN-19 (Compound 43), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 23.3 μM. PTP1B-IN-19 can be used for the research of type 2 diabetes.

HY-144713

PTP1B-IN-16	Phosphatase	Metabolic Disease
PTP1B-IN-16 (Compound 46), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 12.6 μM. PTP1B-IN-16 can be used for the research of type 2 diabetes.

HY-162479

PTP1B-IN-26	Phosphatase Amyloid-β	Metabolic Disease
PTP1B-IN-26 (Compound 7a) is a derivative of phenylthiosemicarbazide‐phenoxy‐1,2,3‐triazole‐N‐phenylacetamide. PTP1B-IN-26 is an inhibitor of protein tyrosine phosphatase 1B (PTP-1B). PTP1B-IN-26 is a competitive inhibitor. PTP1B-IN-26 can be used to research in type 2 diabetes ^[1].

HY-108196

PTP1B-IN-15	Phosphatase	Endocrinology
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity ^[1].

HY-100462

PTP1B-IN-2 3 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 50 nM.

HY-139641

PTP1B-IN-14	Phosphatase	Others
PTP1B-IN-14 is a selective *PTP1B* inhibitor (IC₅₀ = 0.72 μM) targeting the allosteric site.

HY-139640

PTP1B-IN-13	Phosphatase	Others
PTP1B-IN-13 is a selective *PTP1B* inhibitor targeting the allosteric site with an IC₅₀ value of 1.59 μM.

HY-163463

PTP1B-IN-25	Phosphatase Fungal HIV Bacterial	Infection Metabolic Disease
PTP1B-IN-25 (Compound 19) is a *PTP1B* inhibitor with remarkable antiviral, antibacterial, and antidiabetic activities. PTP1B-IN-25 has IC₅₀ values of 0.37 μM, 8.6 μM, 3.7 μM, and 29 μM against *PTP1B, HIV, α-Glucosidase, and methicillin-resistant Staphylococcus aureus* (MRSA) respectively ^[1].

HY-144717

PTP1B-IN-18	Phosphatase	Metabolic Disease
PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research ^[1].

HY-171027

PTP1B/TC-PTP IN-1	Ligands for Target Protein for PROTAC	Cancer
PTP1B/TC-PTP IN-1 is a *PTP1B* and *TC-PTP* dual inhibitor. PTP1B/TC-PTP IN-1 can be used as a target protein ligand for the synthesis of DU-14 (PTP1B/TC-PTP PROTAC) (HY-164864) ^[1].

HY-170582

PTP1B-IN-29	Phosphatase	Metabolic Disease
PTP1B-IN-29 (Compound A2B5) is an inhibitor for phosphatase, that inhibits protein tyrosine phosphatase 1B (PTP1B), TCPTP and λPPase with IC₅₀s of 1.27 μM, 4.38 μM and 8.79 μM, respectively. PTP1B-IN-29 can be used in research of diabete and obesity ^[1].

HY-162480

PTP1B-IN-27	Glycosidase Phosphatase	Endocrinology
PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC₅₀=8.2 µM). PTP1B-IN-27 also inhibits α-Glucosidase (IC₅₀=120 µM) and shows competitive inhibition (K_i=118 µM) ^[1].

HY-N10649

PTP1B-IN-21	Phosphatase	Metabolic Disease
PTP1B-IN-21 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; *IC₅₀*=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC₅₀>100 μM), which is a key target for type 2 diabetes inhibition ^[1].

HY-N10648

PTP1B-IN-20	Phosphatase	Metabolic Disease
PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; *IC₅₀*=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC₅₀=78.0 μM), which is a key target for type 2 diabetes inhibition ^[1].

HY-149255

PTP1B/AKR1B1-IN-2	Phosphatase Aldose Reductase	Metabolic Disease
PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual *PTP1B/AKR1B1* inhibitor (IC₅₀s: 3.2 and 2.1 μM, K_is: 4.0 and 0.9μM). PTP1B/AKR1B1-IN-2 is an insulin-mimetic agent. PTP1B/AKR1B1-IN-2 improves glucose uptake in murine C2C12 myoblasts. PTP1B/AKR1B1-IN-2 can be used for research of Type 2 diabetes mellitus (T2DM) ^[1].

HY-149254

PTP1B/AKR1B1-IN-1	Phosphatase Aldose Reductase	Metabolic Disease
PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC₅₀s of 0.06 μM and 4.3 μM, respectively. PTP1B/AKR1B1-IN-1 also inhibits *TC-PTP* with an IC₅₀ value of 9 μM. PTP1B/AKR1B1-IN-1 serves as an insulin-mimetic agent in murine myoblasts, and reduces AKR1B1-dependent sorbitol accumulation. PTP1B/AKR1B1-IN-1 inhibits development of type 2 diabetes mellitus (T2DM) to control blood glucose levels ^[1].

HY-158381

*PROTAC PTP1B degrader 1*	PROTACs Phosphatase	Metabolic Disease
PROTAC PTP1B degrader 1 (compound 75) is a CRBN-based *PTP1B* PROTAC degrader, with DC₅₀ values of 0.2 μM (48 h) and 0.05 μM (72 h) (Red: PTP1B ligand Oleanolic acid (HY-N0156); Black: linker; Blue: CRBN ligand) ^[1].

HY-168185

*α-glucosidase/PTP1B-IN-1*	Glycosidase Phosphatase Amylases	Metabolic Disease
α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and *PTP1B* inhibitor with an IC₅₀ value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC₅₀ of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus ^[1].

HY-164864

*DU-14 (PTP1B/TC-PTP* PROTAC)**	PROTACs STAT	Cancer
DU-14 (PTP1B/TC-PTP PROTAC) is a potent and selective *PTP1B* and *TC-PTP* dual PROTAC degrader. DU-14 (PTP1B/TC-PTP PROTAC) has the IC₅₀ for *PTP1B* and *TC-PTP* phosphatase activity of 24.2 nM and 30.1 nM, respectively. DU-14 (PTP1B/TC-PTP PROTAC) enhances IFN-γ signaling, promotes T cell activation, and has anti-tumor activity. (Pink: PTP1B/TC-PTP inhibitor (HY-171027); Black: Linker (HY-W340290); Blue: E3 ligand (HY-112078)) ^[1].

HY-121515

DPM-1001	Phosphatase	Metabolic Disease
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property ^[1].

HY-162499

MY17	Phosphatase	Metabolic Disease
MY17 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC₅₀=0.41±0.05 μM). MY17 alleviates palmitic acid (PA) -induced insulin resistance by up-regulating the expression of phosphorylated insulin receptor substrate (IRS1) and protein kinase B (AKT). By binding with *PTP1B, MY17 can inhibit the activity of PTP1B*, thereby improving insulin signaling and having anti-diabetic activity. MY17 can be used in the study of type 2 diabetes ^[1].

HY-N1743

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)	Phosphatase	Metabolic Disease
1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes ^[1].

HY-N3267

Methyl pseudolarate B	Phosphatase	Metabolic Disease
Methyl pseudolarate B, a natural diterpenoid, is a protein tyrosine phosphatase 1B (PTP1B) (Phosphatase) inhibitor with an IC₅₀ value of 10.9 μM ^[1].

HY-N13199

3-O-Dihydro-p-coumaroyltohogenol	Phosphatase	Metabolic Disease
3-O-Dihydro-p-coumaroyltohogenol is a *PTP1B* inhibitor (IC₅₀=6.27 μM) with antidiabetic and antiobesity activities ^[1].

HY-N12354

Stevisaliosides D	Phosphatase	Metabolic Disease
Stevisaliosides D (Compound 5) can be isolated from Stevia serrata roots. Stevisaliosides D inhibits *PTP1B* (IC₅₀: 31.8 μM). Stevisalioside D can be used for antidiabetic research ^[1].

HY-125108

PHPS1 sodium 2 Publications Verification	SHP2 Phosphatase	Cardiovascular Disease Cancer
PHPS1 sodium is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively ^[1].

HY-112368

PHPS1 2 Publications Verification	SHP2 Phosphatase	Cardiovascular Disease Cancer
PHPS1 is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively ^[1].

HY-111469

CPT-157633 1 Publications Verification	Phosphatase	Metabolic Disease
CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a *PTP1B* inhibitor. CPT-157633 prevents binge drinking-induced glucose intolerance ^[1].

HY-N8200

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Inflammation/Immunology
Cassiaside B2 is a protein tyrosine phosphatase 1B *(PTP1B)* and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist ^[1] . ..

HY-N9326

Uralenol	Phosphatase	Metabolic Disease
Uralenol is a natural *PTP1B* inhibitor (IC₅₀=21. 5 μM) from Broussonetia papyrifera. PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor in many cellular and biochemical studies ^[1].

HY-168706

LXQ-87	Phosphatase	Metabolic Disease
LXQ-87 is an oral noncompetitive inhibitor of *PTP1B* with an IC₅₀ of 1.061 μM, showing hypoglycemic activity. LXQ-87 alleviates insulin resistance and promotes cellular glucose uptake, making it useful for research on type 2 diabetes ^[1].

HY-19383

Ertiprotafib PTP 112	Phosphatase IKK PPAR	Metabolic Disease
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC₅₀ of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC₅₀ of ~1 μM for PPARα/PPARβ.

HY-N12915

SHP2-IN-29	SHP2 Phosphatase	Metabolic Disease Cancer
SHP2-IN-29 (Compound 3) is a potent SHP2 inhibitor with an IC₅₀ value of 0.18 μM. SHP2-IN-29 also has inhibitory activity against *PTP1B* and TCPTP, with IC₅₀ values of 4.27 and 4.74 μM, respectively.

HY-12312

TCS 401 2 Publications Verification	Phosphatase	Metabolic Disease
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

HY-19779

JTT 551	Phosphatase	Metabolic Disease
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

HY-121515A

DPM-1001 trihydrochloride	Phosphatase	Metabolic Disease
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property ^[1].

HY-101964

SPI-112	SHP2 Phosphatase	Cancer
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC₅₀s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively ^[1] .

HY-141800

MurA-IN-1 1 Publications Verification	Phosphatase	Others
MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC₅₀ values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively ^[1]. (A family of human MAPK-specific protein tyrosine phosphatases)

HY-N7599

Chrysophanol triglucoside	Phosphatase Glycosidase	Metabolic Disease
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC₅₀s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research ^[1].

HY-W002314

2-Bromo-4'-hydroxyacetophenone	Phosphatase	Others
2-Bromo-4'-hydroxyacetophenone a *PTP1B* inhibitor, with a K_i of 42 μM ^[1].

HY-12312A

TCS 401 free base	Phosphatase	Metabolic Disease
TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

HY-N3734

Deoxyneocryptotanshinone	Beta-secretase Phosphatase	Neurological Disease
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity *BACE1* (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research ^[1] .

HY-N2111

Momordicoside A	Phosphatase	Metabolic Disease
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on protein tyrosine phosphatase (PTP1B) ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P1799

[pTyr5] EGFR (988-993)	Phosphatase	Others
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) ^[1].

HY-P1799A

[pTyr5] EGFR (988-993) (TFA)	Phosphatase	Others
[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P9970

Infliximab 10+ Cited Publications Avakine; CT-P13	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research ^[1] .

Cat. No.	Compare	Product Name	Species	Source

HY-P73685

	PTP1B Protein, Human (His) PTP-1B; PTPN1; Tyrosine-protein phosphatase non-receptor type 1	Human	E. coli
	PTP1B is an important tyrosine protein phosphatase that regulates the endoplasmic reticulum unfolded protein response by dephosphorylating EIF2AK3/PERK and inhibiting its kinase activity. It affects the signaling cascade induced by CKII and p60c-src, and may regulate the EFNA5-EPHA3 pathway, affecting cell reorganization. PTP1B Protein, Human (His) is the recombinant human-derived PTP1B protein, expressed by E. coli , with N-His labeled tag. The total length of PTP1B Protein, Human (His) is 320 a.a., with molecular weight of ~38.1 kDa.

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HY-P82031

	PTP1B Antibody (YA1776) PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B	WB, IHC-F, IHC-P, ICC/IF	Human
	PTP1B Antibody (YA1776) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1776), targeting PTP1B, with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). PTP1B Antibody (YA1776) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

HY-P81300

	*Phospho-PTP1B (Ser352) Antibody (YA1027)* PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B	WB, ICC/IF, IP	Human
	Phospho-PTP1B (Ser352) Antibody (YA1027) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1027), targeting Phospho-PTP1B (Ser352), with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Phospho-PTP1B (Ser352) Antibody (YA1027) can be used for WB, ICC/IF, IP experiment in human background.

HY-P81300A

	*Phospho-PTP1B (Ser378) Antibody (YA1028)* PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B	WB, IHC-P	Human
	Phospho-PTP1B (Ser378) Antibody (YA1028) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1028), targeting Phospho-PTP1B (Ser378), with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Phospho-PTP1B (Ser378) Antibody (YA1028) can be used for WB, IHC-P experiment in human background.

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HY-159694A

*IONIS PTP1BRx sodium* ISIS 404173 sodium		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity ^[1].

HY-159694

*IONIS PTP1BRx* ISIS 404173		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity ^[1].

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PTP1B

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