Search Result
Results for "
Synthetic peptide
" in MedChemExpress (MCE) Product Catalog:
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P1701
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Opioid Receptor
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Cardiovascular Disease
Neurological Disease
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Morphiceptin is a potent and specific agonist for morphine (μ) receptors. Morphiceptin, as a synthetic peptide, is the amide of a fragment of the milk protein β-casein. Morphiceptin has morphinelike activities and is highly specific for morphine (μ) receptors but not for enkephalin (⸹) receptors .
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- HY-P1626
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Opioid Receptor
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Neurological Disease
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Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .
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- HY-P0290
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GRGDSP
5 Publications Verification
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Integrin
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Cancer
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GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.
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-
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- HY-P1000
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-
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- HY-P1344A
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DAPK
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Cancer
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DAPK Substrate Peptide TFA is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM .
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- HY-P1459
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Bacterial
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Infection
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Sphistin Synthetic Peptide (12-38, Fitc in N-Terminal-Fluorescently Labeled Peptide) is a truncated fragments of Sphistin Synthetic Peptide that shows potent antimicrobial activity.
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- HY-P10462
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Synthetic anti-inflammatory peptide 15
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HDAC
NF-κB
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Inflammation/Immunology
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SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .
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- HY-P10082
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Caspase
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Others
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Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
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- HY-P10685
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[Tyr5,12,Lys7]-Polyphemusin II
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HIV
CMV
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Infection
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T-22 (polyphemusin II with [Tyr5,12,Lys7]) is a new synthetic peptide that fights HIV, with an EC50 of 0.008 μg/mL and a CC50 of 54 μg/mL. T22 promotes plant height, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, and it can resist CMV .
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- HY-P1344
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DAPK
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Cancer
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DAPK Substrate Peptide is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM .
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- HY-P5884
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PKC
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Others
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PKCθ pseudosubstrate peptide inhibitor, myristoylated is a synthetic peptide that can be used to study the mechanism of action of PKCθ .
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- HY-P5884A
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PKC
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Others
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PKCθ pseudosubstrate peptide inhibitor, myristoylated TFA is a synthetic peptide that can be used to study the mechanism of action of PKCθ .
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- HY-15664
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- HY-P2641
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MMP
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Cancer
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Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .
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- HY-137199
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- HY-P1595
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PKA
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Metabolic Disease
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CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.
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- HY-P0141
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Akt
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Others
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Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or
MAPK1 .
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- HY-P5463
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Bacterial
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Others
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C18G is a biological active peptide. (C18G is a synthetic α-helical peptide derived from human platelet factor IV. This peptide was found to be antibacterial and is active against Salmonella.)
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- HY-P0141A
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Akt
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Others
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Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .
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- HY-P5385
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Angiotensin Receptor
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Others
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Renin substrate, angiotensinogen (1-14), rat is a biological active peptide. (This peptide is derived from rat angiotensinogen amino acid residues 1-14. It is a synthetic renin substrate.)
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- HY-P4514
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Proteasome
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Others
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Z-Gly-Gly-Arg-βNA is the synthetic peptide substrate of trypsin-like activities of the proteasome .
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- HY-P1155
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rGHRH(1-29)NH2
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GHSR
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Cancer
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GRF (1-29) amide (rat) is a synthetic peptide which can stimulate the growth hormone (GH) secretion.
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- HY-P3590
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HCV
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Others
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PQDVKFP is a synthetic peptide, recognizing antigenic domains within the hepatitis C virus (HCV) core protein .
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- HY-P2496
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Endothelin Receptor
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Cardiovascular Disease
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Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB .
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- HY-114426
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-
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- HY-P1595A
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PKA
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Metabolic Disease
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CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a PKA substrate .
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- HY-156560
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Cathepsin
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Infection
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Z-LVG is an irreversible cysteine proteinase inhibitor. Z-LVG is a tripeptide derivative from cystatin C which can inhibit viral replication. Z-LVG can be used for virus diseases research .
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- HY-P1034
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DAPTA
2 Publications Verification
D-Ala-peptide T-amide; Adaptavir
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CCR
HIV
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Infection
Endocrinology
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DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.
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- HY-114426A
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-
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- HY-P3944
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CaMK
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Neurological Disease
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Calmodulin Dependent Protein Kinase Substrate is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide substrate for protein kinases .
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- HY-P0181
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Tau Protein
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Neurological Disease
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Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.
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- HY-P5998
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Myosin
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Cancer
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Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate .
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- HY-P3943
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CaMK
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Neurological Disease
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Calmodulin Dependent Protein Kinase Substrate Analog is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases .
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- HY-P3523
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Integrin
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Others
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KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser .
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- HY-149988
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MDM-2/p53
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Cancer
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UNP-6457 is a potent active MDM2-p53 interaction inhibitor with an IC50 values of 8.9 nM .
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- HY-P2207
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Biochemical Assay Reagents
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Others
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Sinapultide is a 21-amino-acid peptide that mimics the action of human surfactant protein-B (SP-B). Sinapultide can be used for synthetic phospholipids surfactants improvement .
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- HY-W142064
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Antibiotic
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Others
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Fmoc-L-photo-proline is a photo-crosslinking amino acid which can be incorporated into synthetic peptides using solid-phase Fmoc chemistry. Fmoc-L-photo-proline can synthesis of cyclic peptidomimetic antibiotic and be used for preparation of diverse peptide-based photoaffinity probes research .
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- HY-P5483
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Bacterial
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Others
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Retro-indolicidin is a biological active peptide. (Reverse peptide of indolicidin (Rev4) is a 13-amino acid residue peptide based on the sequence of indolicidin. Indolicidin, a member of the cathelicidin protein family, is a 13-amino acid residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. The synthetic peptide Rev4 has been shown to possess strong antimicrobial as well as protease inhibitory activities in vitro.)
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- HY-P10285
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D-(KLAKLAK)2
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Mitochondrial Metabolism
PARP
Caspase
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Cancer
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d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects .
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- HY-P5444
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Bacterial
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Others
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Drosocin is a biological active peptide. (Drosocin is a 19-mer cationic antimicrobial peptide from Drosophila melanogaster. In Drosophila native drosocin carries a disaccharide moiety attached to a threonine residue in mid-chain position. This synthetic drosocin peptide of identical amino acid sequence without the disaccharide has an activity several times lower than the native compound.)
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- HY-P2207A
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Biochemical Assay Reagents
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Others
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Sinapultide TFA is a 21-amino-acid peptide that mimics the action of human surfactant protein-B (SP-B). Sinapultide TFA can be used for synthetic phospholipids surfactants improvement .
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- HY-W003592A
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Drug intermediate
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Others
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L-Orinithine lactam (hydrochloride) is a synthetic intermediate. L-Orinithine lactam (hydrochloride) can be used in the synthesis of dipeptidyl peptidase 4 (DPP-4) inhibitors, as well as signaling peptides .
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- HY-18678A
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PT-141 Acetate
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Melanocortin Receptor
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Endocrinology
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Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction .
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- HY-P0202
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-
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- HY-P0202A
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Endothelin Receptor
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Cardiovascular Disease
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Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB .
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- HY-139201B
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CaSR
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Neurological Disease
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Poly-D-lysine hydrobromide (MW 84000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .
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- HY-P4896
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Integrin
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Cancer
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FITC-Ahx Gly Arg Gly Asp Ser Pro is a GRGDSP (HY-P0290) coupled to FITC. GRGDSP is an integrin inhibitor that can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis .
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- HY-P4042
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hepatitis B peptide 4980
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HBV
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Infection
Inflammation/Immunology
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Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization .
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- HY-P4106
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Amino Acid Derivatives
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Neurological Disease
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Tat-GluR23Y, scrambled is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD) .
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- HY-P4106A
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Amino Acid Derivatives
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Neurological Disease
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Tat-GluR23Y, scrambled TFA is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD) .
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- HY-P0139
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Gap 27
5 Publications Verification
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Gap Junction Protein
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Cardiovascular Disease
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Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .
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- HY-139201
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CaSR
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Neurological Disease
Cancer
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Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .
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- HY-139201A
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CaSR
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Neurological Disease
Cancer
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Poly-D-lysine hydrobromide (MW 70000-150000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .
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- HY-105088
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MSI 78 free base
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Bacterial
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Infection
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Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections .
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- HY-19529
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- HY-P5486
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Bacterial
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Others
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Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)
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- HY-P3904
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Biochemical Assay Reagents
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Others
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P34cdc2 Kinase Substrate Peptide is a synthetic peptide substrates for P34 cdc2 kinase, with a Km of 74 μM for the purified human enzyme. P34cdc2 Kinase Substrate Peptide can be used in a rapid assay of P34 cdc2 phosphorylation in vitro. P34 cdc2, a protein serinehhreonine kinase, is a cell division cycle-regulated protein kinase .
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- HY-P10529
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Trk Receptor
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Infection
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Ganglioside GM1-binding peptides p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of GM1 ganglioside. The dynamic transformation of Ganglioside GM1-binding peptides p3 may play an important role in the function of GM1 as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptides p3 can be used to study the interaction between GM1 and its ligands .
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- HY-P1714
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FE 203799
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GLP Receptor
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Metabolic Disease
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Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .
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- HY-105077A
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INN 00835 diTFA
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5-HT Receptor
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Neurological Disease
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Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action . Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF) . Nemifitide diTFA can cross the blood-brain barrier .
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- HY-P1714A
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FE 203799 TFA
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GLP Receptor
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Metabolic Disease
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Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .
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- HY-138143
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Chromozym-TH
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Fluorescent Dye
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Others
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N-(p-Tosyl)-GPR-pNA acetate (Chromozym-TH) is a chromogenic substrate targeting the synthetic peptides Hirunorm IV and Hirunorm V and can be used to detect the dissociation constants (KI) of both peptides. Hirunorm IV and Hirunorm V are reversible inhibitors of amidolytic thrombin activity. By varying the peptide concentration at a fixed concentration of the chromogenic substrate N-(p-Tosyl)-GPR-pNA acetate, the dissociation constants determined were 0.134 nM (Hirunorm IV) and 0.245 nM (Hirunorm V) .
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- HY-P0222
-
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PKA
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Others
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PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .
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- HY-P1930A
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Integrin
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Inflammation/Immunology
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Risuteganib hydrochloride is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retina .
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- HY-P1930
-
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Integrin
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Inflammation/Immunology
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Risuteganib is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. Risuteganib is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retina .
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- HY-P35433
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T-1249
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HIV
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Inflammation/Immunology
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Tifuvirtide (T-1249) is a peptide human immunodeficiency virus type-1 (HIV-1) fusion inhibitor. Tifuvirtide is a synthetically designed hybrid retroviral envelope polypeptide. Tifuvirtide has antiretroviral activity. Tifuvirtide can be used for the research of HIV infection .
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- HY-P0222A
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PKA
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Others
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PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .
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- HY-P1949
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CXCR
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Cardiovascular Disease
Cancer
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Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice .
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- HY-P3601
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FGF basic (1-24)
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Bacterial
HBV
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Infection
Inflammation/Immunology
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Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) is a synthetic peptide, shows anti-bacterial and anti-HBV activities. Brain Derived Basic Fibroblast Growth Factor (1-24) can be used in infection disease and immune disease research .
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- HY-P1949A
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CXCR
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Cardiovascular Disease
Cancer
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Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice .
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- HY-126810
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Fungal
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Infection
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NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections .
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- HY-P3496
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Pyroptosis
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Inflammation/Immunology
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Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .
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- HY-126810A
-
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Fungal
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Infection
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NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
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- HY-P1978
-
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Bacterial
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Infection
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CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of CysHHC10 against E. coli, P. aeruginosa, S. aureus and S. epidermidis are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively .
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- HY-109127A
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BCX7353 dihydrochloride
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Kallikrein
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Others
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Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .
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- HY-P5309
-
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Biochemical Assay Reagents
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Inflammation/Immunology
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(Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
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- HY-P1978A
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Bacterial
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Infection
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CysHHC10 TFA is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of CysHHC10 TFA against E. coli, P. aeruginosa, S. aureus and S. epidermidis are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively .
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- HY-P2834
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PGA
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Biochemical Assay Reagents
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Infection
Cancer
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Penicillin amidase (EC 3.5.1.11) (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics .
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- HY-P5203
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EntK1
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Bacterial
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Infection
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Enterocin K1 (EntK1) is a bacteriocin. Enterocin K1 is a ribosomal synthetic peptide. Enterocin K1 specifically targets Enterococcus faecalis via the Eep protein on the bacterial membrane. Enterocin K1 displays a potent antibacterial activity against VRE. Enterocin K1 can be used for related studies of VRE infections .
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- HY-161401
-
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Protease Activated Receptor (PAR)
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Cardiovascular Disease
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PAR4 antagonist 2 (Compound 31) is a protease activated receptor 4 (PAR4) antagonist, with IC50 values of 95 nM and 367 nM for human PAR4 and mouse PAR4. PAR4 antagonist 2 is active against PAR4 activation by the native protease thrombin cleavage but not the synthetic PAR4 agonist peptide AYPGKF .
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- HY-162832
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Amyloid-β
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Neurological Disease
|
Amyloid-β-IN-1 (compound 13) is a synthetic peptide containing the hydrophobic C-terminal region "VVIA-NH2" and its reverse sequence "AIVV-NH2" of Aβ42, which is an Aβ inhibitor. Amyloid-β-IN-1 can inhibit Aβ aggregation and has neuroprotective effects .
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- HY-P4038
-
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HCV Protease
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Infection
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Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .
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- HY-P5038
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c(GRGDSP)
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Integrin
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Cancer
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Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells .
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- HY-P2651
-
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Fluorescent Dye
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Others
|
Dansyl-D-Ala-Gly-Phe(pNO2)-Gly is a synthetic peptide substrate. As a substrate of NEP, Dansyl-D-Ala-Gly-Phe(pNO2)-Gly can be specifically recognized and cleaved by the enzyme, thereby releasing the fluorophore dansyl, which can be quantitatively detected. Therefore, it is often used to determine the activity of NEP .
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- HY-P10574
-
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Checkpoint Kinase (Chk)
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Cancer
|
Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. Phosphorylated CHKtide is used in the assays of cell cycle checkpoint kinases 1 and 2 (CHK1/CHK2) and salt-inducible kinases (SIKs) .
|
-
- HY-15582
-
|
Microtubule/Tubulin
ADC Cytotoxin
|
Cancer
|
Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids .
|
-
- HY-127090
-
MDP
|
p38 MAPK
NOD-like Receptor (NLR)
|
Inflammation/Immunology
Cancer
|
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist .
|
-
- HY-P1640
-
|
Complement System
|
Inflammation/Immunology
|
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca 2+ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC50 of 9.5, 2.0 and 0.8 nM, respectively .
|
-
- HY-W927376
-
|
Fluorescent Dye
|
Others
|
Boc-Val-Arg-AMC is a synthetic peptide compound. As a specific fluorescent substrate, Boc-Val-Arg-AMC can be specifically cleaved by specific enzymes, especially thrombin, to release a fluorescent molecule AMC (7-amino-4-methylcoumarin), which can be used to monitor thrombin activity. Boc-Val-Arg-AMC can be used to detect thrombin activity in plasma samples .
|
-
- HY-P3560
-
TV 4710
|
Apoptosis
|
Inflammation/Immunology
|
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .
|
-
- HY-109127R
-
|
Ser/Thr Protease
|
Others
|
Berotralstat (Standard) is the analytical standard of Berotralstat. This product is intended for research and analytical applications. Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .
|
-
- HY-126402
-
|
Integrin
|
Cancer
|
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1. It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.
|
-
- HY-P1556
-
|
PKG
|
Cardiovascular Disease
|
Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
|
-
- HY-P1556A
-
|
PKG
|
Metabolic Disease
|
Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
|
-
- HY-P10329
-
|
Fungal
|
Infection
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
|
-
- HY-P2380
-
TFRGAP
|
Protease Activated Receptor (PAR)
|
Inflammation/Immunology
|
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.
|
-
- HY-P1821
-
MHP4-14
|
PKC
|
Neurological Disease
|
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
|
-
- HY-P1821A
-
MHP4-14 TFA
|
PKC
|
Neurological Disease
|
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
|
-
- HY-W814315
-
CH5424802 analog; RO5424802 analog; RG7853 analog
|
Others
|
Cancer
|
Alectinib analog (CH5424802 analog) is a selective ALK inhibitor with activity in blocking resistance gating mutations. The synthetic optimization of alectinib analog allows it to be combined with specific peptides to improve the ability to target cancer cells. Alectinib analog exhibits low micromolar IC50 values in antiproliferation and shows good cytotoxic effects. The inhibitory activity of alectinib analog is closely related to its stability and release of active ingredients. Alectinib analog demonstrated the ability to inhibit vascular septal length or width in an in vivo zebrafish model .
|
-
- HY-P0064
-
Palmitoyl Tetrapeptide-7
|
Interleukin Related
|
Inflammation/Immunology
|
Palmitoyl Tetrapeptide-3 (Palmitoyl Tetrapeptide-7) is a synthetic peptide corresponding to amino acids 341-344 of the human immunoglobulin heavy chain, with the ability to stimulate phagocytosis. Palmitoyl tetrapeptide-3 reduces interleukin-6 (IL-6) secretion in keratinocytes and inhibits the UVB radiation-exposure inflammatory response of skin. Palmitoyl tetrapeptide-3 It also has anti-inflammatory and anti-aging effects, reducing skin wrinkles by promoting the production of elastic fibers in the papillary dermis .
|
-
- HY-P3375
-
IBI-362; LY-3305677; OXM-3
|
GCGR
GLP Receptor
|
Metabolic Disease
|
Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) .
|
-
- HY-P3375A
-
IBI-362 TFA; LY-3305677 TFA; OXM-3 TFA
|
GCGR
GLP Receptor
|
Metabolic Disease
|
Mazdutide (IBI-362; LY-3305677) TFA is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide TFA binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide TFA is used in studies of obesity and type 2 diabetes (T2D) .
|
-
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P3744
-
|
Peptides
|
Others
|
pp60v-src Autophosphorylation site is a synthetic peptide. pp60v-src Autophosphorylation site can be used for various biochemical studies .
|
-
- HY-P1459
-
|
Bacterial
|
Infection
|
Sphistin Synthetic Peptide (12-38, Fitc in N-Terminal-Fluorescently Labeled Peptide) is a truncated fragments of Sphistin Synthetic Peptide that shows potent antimicrobial activity.
|
-
- HY-P4063
-
|
Peptides
|
Metabolic Disease
|
Pegylated synthetic human c-peptide retains bioactivity comparable to that of natural (i.e. non-polyethylene glycolated) C-peptides and has a prolonged circulating residence time in plasma for use in diabetic peripheral neuropathy studies .
|
-
- HY-P10462
-
Synthetic anti-inflammatory peptide 15
|
HDAC
NF-κB
|
Inflammation/Immunology
|
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .
|
-
- HY-P10143
-
|
Peptides
|
Others
|
MMP-2/MMP-9 Substrate, a synthetic colorimetric substrate, is a peptide .
|
-
- HY-P3521
-
|
Peptides
|
Cancer
|
RGDT is a synthetic peptide. RGDT can be used in the research of cancer .
|
-
- HY-P10082
-
|
Caspase
|
Others
|
Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
|
-
- HY-115379
-
|
Peptides
|
Cancer
|
Latromotide is a synthetic peptide with antineoplastic activity. It consists of 10 amino acids corresponding to amino acid residues 66-75 of the human kinesin-like protein KIF20A. Latromotide has a sequence of H-Lys-Val-Tyr-Leu-Arg-Val-Arg-Pro Leu-Leu-OH .
|
-
- HY-P3489
-
|
Peptides
|
Endocrinology
|
β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release .
|
-
- HY-P3602
-
|
Peptides
|
Cancer
|
C3 Peptide P16, is a 16 amino acid synthetic peptide derived from human C3d, a fragment generated in trypsin-cleaved C3. C3 Peptide P16 enhances in vitro phosphorylation of pp105 and pp100, a cellular component presenting in the human B lymphoma cells .
|
-
- HY-P10685
-
[Tyr5,12,Lys7]-Polyphemusin II
|
HIV
CMV
|
Infection
|
T-22 (polyphemusin II with [Tyr5,12,Lys7]) is a new synthetic peptide that fights HIV, with an EC50 of 0.008 μg/mL and a CC50 of 54 μg/mL. T22 promotes plant height, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, and it can resist CMV .
|
-
- HY-P1701
-
|
Opioid Receptor
|
Cardiovascular Disease
Neurological Disease
|
Morphiceptin is a potent and specific agonist for morphine (μ) receptors. Morphiceptin, as a synthetic peptide, is the amide of a fragment of the milk protein β-casein. Morphiceptin has morphinelike activities and is highly specific for morphine (μ) receptors but not for enkephalin (⸹) receptors .
|
-
- HY-P4371A
-
|
Peptides
|
Others
|
Hel 13-5 TFA is a monomeric synthetic peptide based on the N-terminal fragment of human SP-B. Hel 13-5 TFA is mainly α-helical and consists of 13 hydrophobic amino acid residues and 5 hydrophilic amino acid residues. Hel 13-5 TFA can be combined with phospholipids for the development of a model system for pulmonary surfactant .
|
-
- HY-P3541
-
MBP8298
|
Peptides
|
Neurological Disease
Inflammation/Immunology
|
Dirucotide (MBP8298) is a synthetic peptide that consists of 17 amino acids linked in a sequence identical to that of a portion of human myelin basic protein. Dirucotide can be used for the research in autoimmune disorder of the central nervous system, such as Multiple sclerosis (MS) .
|
-
- HY-P3630
-
|
Peptides
|
Others
|
Stick Insect Hypertrehalosaemic Factor II is a synthetic peptide. Stick Insect Hypertrehalosaemic Factor II has the same FAB spectra, reversed-phase high-performance liquid chromatographic behavior, and biological behavior as the natural material. Stick Insect Hypertrehalosaemic Factor II can be used for the research of hypertrehalosaemic effect .
|
-
- HY-P10525
-
|
Peptides
|
Neurological Disease
|
MBP Ac1-9 (4Y) is a synthetic peptide derived from a fragment of myelin basic protein (MBP) that has undergone specific chemical modifications. MBP Ac1-9 (4Y) is able to form a complex with the MHC class II molecule I-Au and activate specific T cell receptor (TCR), thus playing a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). MBP Ac1-9 (4Y) can be used to study autoimmune diseases, especially those involving the central nervous system, such as multiple sclerosis .
|
-
- HY-P1662
-
-
- HY-P3464
-
-
- HY-P1626
-
|
Opioid Receptor
|
Neurological Disease
|
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .
|
-
- HY-P3592
-
-
- HY-P0290
-
GRGDSP
5 Publications Verification
|
Integrin
|
Cancer
|
GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.
|
-
- HY-P1344
-
|
DAPK
|
Cancer
|
DAPK Substrate Peptide is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM .
|
-
- HY-P1000
-
-
- HY-P1344A
-
|
DAPK
|
Cancer
|
DAPK Substrate Peptide TFA is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM .
|
-
- HY-P5884
-
|
PKC
|
Others
|
PKCθ pseudosubstrate peptide inhibitor, myristoylated is a synthetic peptide that can be used to study the mechanism of action of PKCθ .
|
-
- HY-P10156
-
Cell-penetrating peptide MAP17
|
Peptides
|
Others
|
MAP17 (Cell-penetrating peptide MAP17) is a synthetic secondary amphipathic cell-penetrating peptides, with sequence of QLALQLALQALQAALQLA .
|
-
- HY-P5884A
-
|
PKC
|
Others
|
PKCθ pseudosubstrate peptide inhibitor, myristoylated TFA is a synthetic peptide that can be used to study the mechanism of action of PKCθ .
|
-
- HY-15664
-
-
- HY-P1027
-
|
Peptides
|
Others
|
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
|
-
- HY-P3942
-
|
Peptides
|
Others
|
SDP116 is a synthetic Stachel-derived peptide of GPR116 Stachel peptide. SDP116 has ADGRF5 agonist effect .
|
-
- HY-P2641
-
|
MMP
|
Cancer
|
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .
|
-
- HY-137199
-
-
- HY-P1595
-
|
PKA
|
Metabolic Disease
|
CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.
|
-
- HY-P0141
-
|
Akt
|
Others
|
Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or
MAPK1 .
|
-
- HY-P5463
-
|
Bacterial
|
Others
|
C18G is a biological active peptide. (C18G is a synthetic α-helical peptide derived from human platelet factor IV. This peptide was found to be antibacterial and is active against Salmonella.)
|
-
- HY-P0141A
-
|
Akt
|
Others
|
Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .
|
-
- HY-P5385
-
|
Angiotensin Receptor
|
Others
|
Renin substrate, angiotensinogen (1-14), rat is a biological active peptide. (This peptide is derived from rat angiotensinogen amino acid residues 1-14. It is a synthetic renin substrate.)
|
-
- HY-P0267
-
|
Peptides
|
Neurological Disease
|
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.
|
-
- HY-P3614
-
|
Peptides
|
Others
|
[Ala3,11,18, Nle7] Endothelin-1, human is a synthetic peptide.
|
-
- HY-P4514
-
|
Proteasome
|
Others
|
Z-Gly-Gly-Arg-βNA is the synthetic peptide substrate of trypsin-like activities of the proteasome .
|
-
- HY-P10064
-
|
Peptides
|
Others
|
Akt Substrate (Akt/SKG substrate) is a 7 amino acid synthetic peptide suitable as a substrate for Akt .
|
-
- HY-P2171
-
|
Peptides
|
Inflammation/Immunology
|
CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .
|
-
- HY-P1155
-
rGHRH(1-29)NH2
|
GHSR
|
Cancer
|
GRF (1-29) amide (rat) is a synthetic peptide which can stimulate the growth hormone (GH) secretion.
|
-
- HY-P3590
-
|
HCV
|
Others
|
PQDVKFP is a synthetic peptide, recognizing antigenic domains within the hepatitis C virus (HCV) core protein .
|
-
- HY-P4336
-
|
Peptides
|
Others
|
Dansyl-Ala-Arg is a synthetic peptide. Dansyl-Ala-Arg can be used for various biochemical studies .
|
-
- HY-P2496
-
|
Endothelin Receptor
|
Cardiovascular Disease
|
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB .
|
-
- HY-P0312
-
|
Peptides
|
Cancer
|
c-Myc Peptide (TFA) is a synthetic peptide corresponding to the C-terminal amino acids (410-419) of human c-myc protein, and participates in regulation of growth-related gene transcription.
|
-
- HY-P2171A
-
|
Peptides
|
Inflammation/Immunology
|
CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .
|
-
- HY-U00372
-
|
Peptides
|
Neurological Disease
|
2: PN: US20040072744 SEQID: 2 claimed protein is a synthetic peptide, used for the research of Down's syndrome and schizophrenia.
|
-
- HY-P5466
-
|
Peptides
|
Others
|
S6(229-239) is a biological active peptide. (This is a synthetic peptide substrate for S6 kinase shown to be phosphorylated by protein kinase c with phosphorylation site identified at Ser235)
|
- HY-P1595A
-
|
PKA
|
Metabolic Disease
|
CREBtide TFA is a CREB (cAMP response element binding protein)-like peptide. CREBtide TFA a synthetic 13 amino acid peptide, has been reported as a PKA substrate .
|
- HY-P1034
-
DAPTA
2 Publications Verification
D-Ala-peptide T-amide; Adaptavir
|
CCR
HIV
|
Infection
Endocrinology
|
DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.
|
- HY-P3944
-
|
CaMK
|
Neurological Disease
|
Calmodulin Dependent Protein Kinase Substrate is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide substrate for protein kinases .
|
- HY-P0181
-
|
Tau Protein
|
Neurological Disease
|
Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.
|
- HY-P0182
-
|
Peptides
|
Others
|
NH2-QGGYTMHQDQEGDTDAGLK-COOH is a synthetic peptide chain with an amine group attached to lysine and an carboxyl group attached to glutamine.
|
- HY-105042A
-
Selanc diacetate; TP-7 diacetate
|
Peptides
|
Neurological Disease
|
Selank (Selanc) acetate is a synthetic peptide derived from tuftsin. Selank acetate has anxiolytic activity, and is a nootropic, neuropsychotropic, antidepressant, and antistress compound .
|
- HY-P5998
-
|
Myosin
|
Cancer
|
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate .
|
- HY-P3943
-
|
CaMK
|
Neurological Disease
|
Calmodulin Dependent Protein Kinase Substrate Analog is a Ca 2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases .
|
- HY-P0248F
-
|
Peptides
|
Others
|
Kemptide, 5-FAM labeled is a biological active peptide. (Kemptide is a phosphate acceptor peptide that serves as a synthetic substrate for PKA (Km = 16 μM). The corresponding fluorescent and biotinylated peptides are also proven to be good substrates for PKA. 5-FAM labeled HY-P0248)
|
- HY-P1781
-
|
Peptides
|
Cancer
|
Peptide C105Y, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles .
|
- HY-P3523
-
|
Integrin
|
Others
|
KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser .
|
- HY-P5281
-
- HY-P1781A
-
|
Peptides
|
Cancer
|
Peptide C105Y TFA, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles .
|
- HY-P10181
-
|
Peptides
|
Others
|
Acetyl angiotensinogen (1-14), human is a synthetic peptide and N-terminal acetylated form of Angiotensinogen (1-14), human (HY-P1486) .
|
- HY-P2686
-
|
Peptides
|
Others
|
Acetyl angiotensinogen (1-14), porcine is a synthetic peptide and N-terminal acetylated form of Angiotensinogen (1-14) porcine (HY-P4774) .
|
- HY-P2207
-
|
Biochemical Assay Reagents
|
Others
|
Sinapultide is a 21-amino-acid peptide that mimics the action of human surfactant protein-B (SP-B). Sinapultide can be used for synthetic phospholipids surfactants improvement .
|
- HY-167847
-
|
Peptides
|
Neurological Disease
|
IRI-514 is a synthetic peptide analogue of Thymopentin (HY-N7122). IRI-514 plays a role in modulating behavioral and neuroendocrine responses to stress .
|
- HY-P5483
-
|
Bacterial
|
Others
|
Retro-indolicidin is a biological active peptide. (Reverse peptide of indolicidin (Rev4) is a 13-amino acid residue peptide based on the sequence of indolicidin. Indolicidin, a member of the cathelicidin protein family, is a 13-amino acid residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. The synthetic peptide Rev4 has been shown to possess strong antimicrobial as well as protease inhibitory activities in vitro.)
|
- HY-P10285
-
D-(KLAKLAK)2
|
Mitochondrial Metabolism
PARP
Caspase
|
Cancer
|
d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects .
|
- HY-P5444
-
|
Bacterial
|
Others
|
Drosocin is a biological active peptide. (Drosocin is a 19-mer cationic antimicrobial peptide from Drosophila melanogaster. In Drosophila native drosocin carries a disaccharide moiety attached to a threonine residue in mid-chain position. This synthetic drosocin peptide of identical amino acid sequence without the disaccharide has an activity several times lower than the native compound.)
|
- HY-P2207A
-
|
Biochemical Assay Reagents
|
Others
|
Sinapultide TFA is a 21-amino-acid peptide that mimics the action of human surfactant protein-B (SP-B). Sinapultide TFA can be used for synthetic phospholipids surfactants improvement .
|
- HY-18678A
-
PT-141 Acetate
|
Melanocortin Receptor
|
Endocrinology
|
Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction .
|
- HY-P0060A
-
Tetracosactrin acetate; ACTH(1–24) acetate
|
Peptides
|
Endocrinology
|
Tetracosactide acetate is a synthetic peptide stimulating the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .
|
- HY-P3837
-
XP-2
|
Peptides
|
Metabolic Disease
|
Xenopsin-Related Peptide 2 (XP-2) is an avian counterpart to amphibian Xenopsin (HY-P0253). Xenopsin-Related Peptide 2 displays abilities to release histamine from isolated rat mast cells and is as effective as synthetic Bradykinin (HY-P0206) .
|
- HY-P0202
-
- HY-P2372
-
|
Peptides
|
Others
|
P60v-src(137-157) is a synthetic peptide that inhibits the tyrosine kinase activity of p60 v-src (IC50: 7.5 μM) .
|
- HY-P0202A
-
|
Endothelin Receptor
|
Cardiovascular Disease
|
Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB .
|
- HY-P4896
-
|
Integrin
|
Cancer
|
FITC-Ahx Gly Arg Gly Asp Ser Pro is a GRGDSP (HY-P0290) coupled to FITC. GRGDSP is an integrin inhibitor that can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis .
|
- HY-P4042
-
hepatitis B peptide 4980
|
HBV
|
Infection
Inflammation/Immunology
|
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization .
|
- HY-P4106
-
|
Amino Acid Derivatives
|
Neurological Disease
|
Tat-GluR23Y, scrambled is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD) .
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- HY-P4106A
-
|
Amino Acid Derivatives
|
Neurological Disease
|
Tat-GluR23Y, scrambled TFA is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD) .
|
- HY-P10520
-
|
Peptides
|
Others
|
RWmix is a synthetic cell-penetrating peptide. The secondary amphiphilic nature of RWmix promotes cellular uptake, mainly due to the alternating arrangement of arginine and tryptophan. The presence of tryptophan enhances the anchoring of the peptide to the cell membrane, thereby improving its ability to penetrate the cell membrane. RWmix can be used for gene therapy and siRNA delivery research .
|
- HY-P0139
-
Gap 27
5 Publications Verification
|
Gap Junction Protein
|
Cardiovascular Disease
|
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .
|
- HY-105088
-
MSI 78 free base
|
Bacterial
|
Infection
|
Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections .
|
- HY-P10551
-
|
Peptides
|
Cardiovascular Disease
|
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). Apo A-I mimetic 5A peptide can promote the efflux of cholesterol from cells and help reduce the accumulation of cholesterol in cells. Apo A-I mimetic 5A peptide also shows anti-inflammatory activity and can reduce inflammatory markers in blood and tissues. Apo A-I mimetic 5A peptide can be used in the study of cardiovascular diseases .
|
- HY-P4011
-
|
Peptides
|
Neurological Disease
|
[1,6-Aminosuberic acid]-arginine-Vasotocin is a synthetic peptide analogue to neurohypophyseaI hormones. [1,6-Aminosuberic acid]-arginine-Vasotocin has excitatory effect on the periodically oxcillating neuron (PON) of A. fulica .
|
- HY-P4727
-
DSIP-isoD
|
Peptides
|
Others
|
(β-Asp5)-Delta-Sleep Inducing Peptide (DSIP-isoD) is a synthetic polypeptide that can be partially hydrolyzed by NaOH or SDS. (β-Asp5)-Delta-Sleep Inducing Peptide can be used to study the catalytic activity of mitochondrial protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) .
|
- HY-P5486
-
|
Bacterial
|
Others
|
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)
|
- HY-P3904
-
|
Biochemical Assay Reagents
|
Others
|
P34cdc2 Kinase Substrate Peptide is a synthetic peptide substrates for P34 cdc2 kinase, with a Km of 74 μM for the purified human enzyme. P34cdc2 Kinase Substrate Peptide can be used in a rapid assay of P34 cdc2 phosphorylation in vitro. P34 cdc2, a protein serinehhreonine kinase, is a cell division cycle-regulated protein kinase .
|
- HY-P10529
-
|
Trk Receptor
|
Infection
|
Ganglioside GM1-binding peptides p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of GM1 ganglioside. The dynamic transformation of Ganglioside GM1-binding peptides p3 may play an important role in the function of GM1 as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptides p3 can be used to study the interaction between GM1 and its ligands .
|
- HY-P1714
-
FE 203799
|
GLP Receptor
|
Metabolic Disease
|
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .
|
- HY-105077A
-
INN 00835 diTFA
|
5-HT Receptor
|
Neurological Disease
|
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action . Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF) . Nemifitide diTFA can cross the blood-brain barrier .
|
- HY-12523
-
|
Peptides
|
Others
|
Peptide M is a synthetic amino acid (18 amino acids in length which correspond to the amino acid positions 303-322 of bovine S-antigen: DTNLASSTIIKEGIDKTV), is capable of inducing experimental autoimmune uveitis in monkeys and Hartley guinea pigs as well as Lewis rats .
|
- HY-P1714A
-
FE 203799 TFA
|
GLP Receptor
|
Metabolic Disease
|
Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .
|
- HY-P3912
-
|
Peptides
|
Infection
|
Endotoxin inhibitor a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor inhibits the febrile response to LPS with very low toxicity and lethality .
|
- HY-P0222
-
|
PKA
|
Others
|
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .
|
- HY-P1930A
-
|
Integrin
|
Inflammation/Immunology
|
Risuteganib hydrochloride is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retina .
|
- HY-P1930
-
|
Integrin
|
Inflammation/Immunology
|
Risuteganib is a synthetic RGD (arginyl-glycyl-aspartic acid)-class peptide. Risuteganib is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retina .
|
- HY-P35433
-
T-1249
|
HIV
|
Inflammation/Immunology
|
Tifuvirtide (T-1249) is a peptide human immunodeficiency virus type-1 (HIV-1) fusion inhibitor. Tifuvirtide is a synthetically designed hybrid retroviral envelope polypeptide. Tifuvirtide has antiretroviral activity. Tifuvirtide can be used for the research of HIV infection .
|
- HY-P3912A
-
|
Peptides
|
Infection
|
Endotoxin inhibitor TFA is a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor TFA inhibits the febrile response to LPS with very low toxicity and lethality .
|
- HY-P0222A
-
|
PKA
|
Others
|
PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .
|
- HY-P1949
-
|
CXCR
|
Cardiovascular Disease
Cancer
|
Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice .
|
- HY-P3601
-
FGF basic (1-24)
|
Bacterial
HBV
|
Infection
Inflammation/Immunology
|
Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) is a synthetic peptide, shows anti-bacterial and anti-HBV activities. Brain Derived Basic Fibroblast Growth Factor (1-24) can be used in infection disease and immune disease research .
|
- HY-P10279
-
Human atrial natriuretic factor (102–126)
|
Peptides
|
Cardiovascular Disease
Others
|
Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival .
|
- HY-P1949A
-
|
CXCR
|
Cardiovascular Disease
Cancer
|
Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice .
|
- HY-P3496
-
|
Pyroptosis
|
Inflammation/Immunology
|
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .
|
- HY-P3713
-
|
Peptides
|
Cancer
|
Presenilin 1 (349-361) is an active petide, and synthetic peptides representing amino acids 349–361 can be phosphorylated by glycogen synthase kinase-3β(GSK3β) in vitro. Presenilin 1 (349-361) can be used for the research of various diseases .
|
- HY-P3051
-
|
Peptides
|
Inflammation/Immunology
|
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions .
|
- HY-126810A
-
|
Fungal
|
Infection
|
NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
|
- HY-P1978
-
|
Bacterial
|
Infection
|
CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of CysHHC10 against E. coli, P. aeruginosa, S. aureus and S. epidermidis are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively .
|
- HY-P4371
-
|
Peptides
|
Others
|
Hel 13-5 is a monomeric synthetic peptide based on the N-terminal segment of human SP-B. Hel 13-5 mainly is a-helical and consists of 13 hydrophobic and 5 hydrophilic amino acid residues. Hel 13-5 can be used in combination with phospholipids for developing pulmonary surfactant model systems .
|
- HY-P5309
-
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
(Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
|
- HY-P1978A
-
|
Bacterial
|
Infection
|
CysHHC10 TFA is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of CysHHC10 TFA against E. coli, P. aeruginosa, S. aureus and S. epidermidis are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively .
|
- HY-P5203
-
EntK1
|
Bacterial
|
Infection
|
Enterocin K1 (EntK1) is a bacteriocin. Enterocin K1 is a ribosomal synthetic peptide. Enterocin K1 specifically targets Enterococcus faecalis via the Eep protein on the bacterial membrane. Enterocin K1 displays a potent antibacterial activity against VRE. Enterocin K1 can be used for related studies of VRE infections .
|
- HY-P5309A
-
|
Peptides
|
Inflammation/Immunology
|
(Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide (TFA) (GN5) is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
|
- HY-P4038
-
|
HCV Protease
|
Infection
|
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .
|
- HY-P5038
-
c(GRGDSP)
|
Integrin
|
Cancer
|
Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells .
|
- HY-P2651
-
|
Fluorescent Dye
|
Others
|
Dansyl-D-Ala-Gly-Phe(pNO2)-Gly is a synthetic peptide substrate. As a substrate of NEP, Dansyl-D-Ala-Gly-Phe(pNO2)-Gly can be specifically recognized and cleaved by the enzyme, thereby releasing the fluorophore dansyl, which can be quantitatively detected. Therefore, it is often used to determine the activity of NEP .
|
- HY-P10503
-
|
Peptides
|
Cardiovascular Disease
Others
Inflammation/Immunology
|
S2-16 is a synthetic peptide from the S2 region of cardiac myosin. S2-16 is a cryptic epitope that induces myocarditis in Lewis rats. A cryptic epitope is an epitope that is not recognized by antibodies or T cells after the animal is immunized with the intact antigen. S2-16 can be used to study the mechanism of autoimmune myocarditis .
|
- HY-P10574
-
|
Checkpoint Kinase (Chk)
|
Cancer
|
Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. Phosphorylated CHKtide is used in the assays of cell cycle checkpoint kinases 1 and 2 (CHK1/CHK2) and salt-inducible kinases (SIKs) .
|
- HY-P3827
-
|
Peptides
|
Inflammation/Immunology
|
Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is a13-mer synthetic peptide containing seven amino acids homologous to SV40 T antigen. Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly is capable of inducing nuclear transport .
|
- HY-P3386
-
Cpne7-DP
|
Peptides
|
Metabolic Disease
|
Selcopintide (Cpne7-DP) consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin .
|
- HY-148195
-
|
Peptides
|
Neurological Disease
|
NNZ 2591 is a synthetic analogue of a small peptide of cyclic glycine proline (cGP). NNZ 2591 shows orally active and cross the blood-brain barrier. NNZ 2591 shows neuroprotective after ischemic brain injury. NNZ 2591 improves motor function in a rat model of Parkinson's disease. NNZ 2591 has the potential for the research of ischemic brain injury and angelman syndrome .
|
- HY-P3386A
-
Cpne7-DP acetate
|
Peptides
|
Metabolic Disease
|
Selcopintide (Cpne7-DP) acetate consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide acetate highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide acetate promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin .
|
- HY-P1640
-
|
Complement System
|
Inflammation/Immunology
|
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca 2+ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC50 of 9.5, 2.0 and 0.8 nM, respectively .
|
- HY-P3560
-
TV 4710
|
Apoptosis
|
Inflammation/Immunology
|
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .
|
- HY-P1556
-
|
PKG
|
Cardiovascular Disease
|
Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
|
- HY-P1556A
-
|
PKG
|
Metabolic Disease
|
Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .
|
- HY-P10329
-
|
Fungal
|
Infection
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
|
- HY-P2380
-
TFRGAP
|
Protease Activated Receptor (PAR)
|
Inflammation/Immunology
|
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.
|
- HY-P1821
-
MHP4-14
|
PKC
|
Neurological Disease
|
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca 2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .
|
- HY-P0064
-
Palmitoyl Tetrapeptide-7
|
Interleukin Related
|
Inflammation/Immunology
|
Palmitoyl Tetrapeptide-3 (Palmitoyl Tetrapeptide-7) is a synthetic peptide corresponding to amino acids 341-344 of the human immunoglobulin heavy chain, with the ability to stimulate phagocytosis. Palmitoyl tetrapeptide-3 reduces interleukin-6 (IL-6) secretion in keratinocytes and inhibits the UVB radiation-exposure inflammatory response of skin. Palmitoyl tetrapeptide-3 It also has anti-inflammatory and anti-aging effects, reducing skin wrinkles by promoting the production of elastic fibers in the papillary dermis .
|
- HY-P10490
-
|
Peptides
|
Others
Cancer
|
(D-His(Bzl)6)-LHRH (1-7) free acid is a synthetic peptide compound that is a derivative of luteinizing hormone-releasing hormone (LHRH). (D-His(Bzl)6)-LHRH (1-7) free acid enhances its stability and biological activity by introducing unnatural amino acid residues at specific positions of the LHRH molecule. This modification can improve the drug's performance in the body half-life, reducing the rate at which it is rapidly metabolized and cleared, thereby enhancing its efficacy in inhibiting cell proliferation .
|
- HY-P3375
-
IBI-362; LY-3305677; OXM-3
|
GCGR
GLP Receptor
|
Metabolic Disease
|
Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) .
|
- HY-P3375A
-
IBI-362 TFA; LY-3305677 TFA; OXM-3 TFA
|
GCGR
GLP Receptor
|
Metabolic Disease
|
Mazdutide (IBI-362; LY-3305677) TFA is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide TFA binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide TFA is used in studies of obesity and type 2 diabetes (T2D) .
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