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Results for "

hedgehog

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Hedgehog (54) Antibiotic (5) Apoptosis (7) Autophagy (7) Bacterial (3) Cytochrome P450 (4) Drug Metabolite (1) Endogenous Metabolite (8) Fungal (4) Gli (4) Glucocorticoid Receptor (2) HSP (1) Isotope-Labeled Compounds (2) Microtubule/Tubulin (2) Parasite (3) Phosphodiesterase (PDE) (1) PPAR (3) Smo (36)
By Research Areas:	Cancer (74) Endocrinology (2) Infection (10) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Screening Libraries

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Hedgehog

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111040

Hedgehog agonist 1	Hedgehog	Neurological Disease
Hh agonist 1 (compound 21k) is a potent Hedgehog (Hh) agonist, with an EC₅₀ 0.3 nM. Hh agonist 1 can be used for the research of stroke and other neurological disorders .

HY-100535

KAAD-Cyclopamine 1 Publications Verification Cyclopamine-KAAD	Smo	Cancer
KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist .

HY-153456

Hedgehog IN-2	Hedgehog	Cancer
Hedgehog IN-2 (Compound 20) is an inhibitor of *Hedgehog* pathway with an IC₅₀ value less than 0.003 μM in C3H10T1/2 cells .

HY-159511

Hedgehog IN-7	Hedgehog	Cancer
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of *Hedgehog, capable of reducing the expression of Hedgehog* genes and inhibiting *Hedgehog* signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the *Hedgehog* pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer .

HY-153730

Hedgehog IN-5	Hedgehog	Inflammation/Immunology
Hedgehog IN-5 is an orally active small molecule inhibitor of the *hedgehog* pathway. Hedgehog IN-5 can be used for the research of fibrotic disease .

HY-162372

Hedgehog IN-6	Hedgehog Smo	Cancer
Hedgehog IN-6 (Compound Q29) is a *Hedgehog* (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization .

HY-W838042

Hedgehog IN-8	Others	Others
Hedgehog IN-8 effectively inhibits hedgehog signaling and phosphodiesterase activity.

HY-153457

Hedgehog IN-3	Hedgehog	Cancer
Hedgehog IN-3 (compound 3) is a hedgehog pathway inhibitor (IC₅₀ = 0.01 µM). Hedgehog IN-3 can be used in cancer research .

HY-122814

Hedgehog IN-1	Hedgehog	Others Neurological Disease Cancer
Hedgehog IN-1 (Compound 7d) is an inhibitor for *Hedgehog* protein with IC₅₀ of 70 nM .

HY-120499

AZD8542	Hedgehog Smo	Cancer
AZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is a? Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment .

HY-161175

IMP-1575	Hedgehog	Cancer
IMP-1575 is the most potent Hedgehog acyltransferase (HHAT) inhibitor, with an IC₅₀ of 0.75 μM for inhibition of purified HHAT. IMP-1575 can be used for the research of cancer .

HY-145918

MRT-14	Smo	Cancer
MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling .

HY-100515

Robotnikinin 3 Publications Verification	Hedgehog	Inflammation/Immunology
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of *Sonic Hedgehog* (Shh)** signaling up stream of Smo .

HY-162274

Oxazepine	Hedgehog Antibiotic	Infection Cancer
Oxazepine (compound 4a) has antimicrobial viability via binding OMPA/ exo-1,3-beta-glucanase proteins. Oxazepine is a *hedgehog* signaling inhibitor with antitumor viability .

HY-15398C

3-epi-Vitamin D3 Epicholecalciferol	Hedgehog	Cancer
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC₅₀ of 39.2 μM measured in U87MG cells .

HY-156814

HPP-9	Hedgehog	Cancer
HPP-9 is a Proteolysis-Targeting Chimeras （PROTACs） based on *Hedgehog* Pathway Inhibitor-1 (HPI-1), with the pIC₅₀ of 6.71, that can degrade BET bromodomains. HPP-9 has antitumor activity ^[1[.

HY-117229

Sonidegib metabolite M48	Drug Metabolite	Cancer
Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer T_max (60 h) than Sonidegib .

HY-N0247

Saikosaponin B1	Smo	Cancer
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO .

HY-18287A

MRT-83 hydrochloride	Smo	Cancer
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease .

HY-N0247R

Saikosaponin B1 (Standard)	Smo	Cancer
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO .

HY-N0836

Jervine 2 Publications Verification 11-Ketocyclopamine	Hedgehog Smo	Inflammation/Immunology Cancer
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-122632

Ciliobrevin D 3 Publications Verification	Hedgehog	Cancer
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro .

HY-18366A

RU-SKI 43 hydrochloride 2 Publications Verification	Hedgehog	Cancer
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity .

HY-18366

RU-SKI 43	Hedgehog	Cancer
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity .

HY-N0836R

Jervine (Standard)	Hedgehog Smo	Inflammation/Immunology Cancer
Jervine (Standard) is the analytical standard of Jervine. This product is intended for research and analytical applications. Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-117903A

MRT-92	Smo Hedgehog	Cancer
MRT-92 is a Smoothened (Smo) antagonist (K_i=0.7 nM) with anticancer activity. MRT-92 inhibits *Hedgehog* signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC₅₀=0.4 nM). MRT-92 can be used in the study of cerebellar glioma .

HY-16475

TAK-441	Hedgehog	Cancer
TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC₅₀value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors .

HY-B0603

Fluticasone	Smo Glucocorticoid Receptor	Infection Inflammation/Immunology Endocrinology
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC₅₀ value of 99 nM. Fluticasone activates *Hedgehog* signaling and promotes the proliferation of primary neuronal stem or precursor cells .

HY-147670

TPB15	Hedgehog Smo Gli Apoptosis	Cancer
TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity .

HY-12317

GSA-10	Smo Hedgehog	Cancer
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development .

HY-143400

HSP70-IN-3	HSP Hedgehog	Cancer
HSP70-IN-3 is a potent HSP70 inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1 .

HY-B0603R

Fluticasone (Standard)	Smo Glucocorticoid Receptor	Infection Inflammation/Immunology Endocrinology
Fluticasone (Standard) is the analytical standard of Fluticasone. This product is intended for research and analytical applications. Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells .

HY-13901

GANT 61 Maximum Cited Publications 54 Publications Verification NSC 136476	Gli Autophagy	Cancer
GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.

HY-13307

JK184 2 Publications Verification	Hedgehog	Cancer
JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC₅₀ of 30 nM in mammalian cells.

HY-16587

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-16587A

Saridegib hydrochloride IPI 926 hydrochloride; Patidegib hydrochloride	Smo	Cancer
Saridegib hydrochloride is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-122590

Glabrescione B	Gli	Cancer
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells .

HY-17024

Cyclopamine 35+ Cited Publications 11-Deoxojervine	Hedgehog Smo Endogenous Metabolite	Cancer
Cyclopamine is a *Hedgehog* (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-18287

MRT-83	Smo	Cancer
MRT-83 is a potent antagonist of Smo, with an IC₅₀ in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.

HY-100790

Ciliobrevin A 2 Publications Verification HPI-4	Hedgehog	Cancer
Ciliobrevin A (HPI-4) is a *hedgehog* (Hh) signaling pathway inhibitor with median inhibitory concentration (IC₅₀) less than 10 μM .

HY-120664

BRD50837	Hedgehog	Cancer
BRD50837 is a potent inhibitor of *Sonic Hedgehog* (Shh), with the EC₅₀** of 0.09 μM. BRD50837 plays an important role in cancer research .

HY-17595S1

Mebendazole-d8	Isotope-Labeled Compounds Parasite Apoptosis	Infection Cancer
Mebendazole-d₈ is the deuterium labeled Mebendazole. Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor .

HY-123752

MS-0022	Hedgehog Smo	Cancer
MS-0022 is a Smoothened (SMO) antagonist. MS-0022 can inhibit the Hedgehog (Hh) signaling pathway. MS-0022 can be used in anti-tumor research .

HY-17024R

Cyclopamine (Standard)	Hedgehog Smo Endogenous Metabolite	Cancer
Cyclopamine (Standard) is the analytical standard of Cyclopamine. This product is intended for research and analytical applications. Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-148440

RL-0070933	Hedgehog Smo	Cancer
RL-0070933 is a potent smo cilial modulator with an EC₅₀ value of 0.02 µM. RL-0070933 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway .

HY-158059

DS-1-38	Hedgehog	Cancer
DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling. EYA1 is a haloacid dehalogenase phosphatase and transcription factor that regulates tumorigenesis and proliferation in SHH medulloblastoma (SHH-MB) .

HY-12848

SAG 20+ Cited Publications	Smo	Cancer
SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848B

SAG hydrochloride 20+ Cited Publications	Smo	Cancer
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848C

SAG dihydrochloride 20+ Cited Publications	Smo	Cancer
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-10440

Vismodegib 30+ Cited Publications GDC-0449	Hedgehog Autophagy	Cancer
Vismodegib (GDC-0449) is an orally active *hedgehog* pathway inhibitor with an IC₅₀ of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC₅₀ values of 3.0 μM and 1.4 μM, respectively .

Cat. No.	Product Name

HY-L020

Wnt/Hedgehog/Notch Compound Library

390 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 390 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

HY-L017

Stem Cell Signaling Compound Library

1,915 compounds

Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.

MCE owns a unique collection of 1,915 compounds that can be used for stem cell regulatory and signaling pathway research.

HY-L124

Anti-Prostate Cancer Compound Library

2,449 compounds

Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment.

MCE offers a unique collection of 2,449 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

HY-L039

Reprogramming Compound Library

2,254 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 2,254 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

HY-L038

Differentiation Inducing Compound Library

1,554 compounds

Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.

MCE Differentiation Inducing Compound Library contains a unique collection of 1,554 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0247

Saikosaponin B1	Structural Classification Classification of Application Fields Source classification Umbelliferae Plants Disease Research Fields Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Cancer	Smo
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO .

HY-N0836

Jervine 2 Publications Verification 11-Ketocyclopamine	Alkaloids Piperidine Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Hedgehog Smo
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-17024

Cyclopamine Maximum Cited Publications 39 Publications Verification 11-Deoxojervine	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Classification of Application Fields Source classification Pyridine Alkaloids Plants Endogenous metabolite Disease Research Fields Steroids Cancer	Hedgehog Smo Endogenous Metabolite
Cyclopamine is a *Hedgehog* (Hh) pathway antagonist with an IC₅₀ of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-12316

20(S)-Hydroxycholesterol 2 Publications Verification 20α-Hydroxycholesterol	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-113081

1-Methyladenosine 2 Publications Verification	Alkaloids Structural Classification Microorganisms Immune System Disorder Classification of Application Fields Source classification Disease markers Other Diseases Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite PPAR Hedgehog
1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates *Hedgehog* signaling pathway, driving liver tumorigenesis .

HY-17514

Itraconazole 10+ Cited Publications R51211	Microorganisms Source classification	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-N0247R

Saikosaponin B1 (Standard)	Structural Classification Source classification Umbelliferae Plants Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Smo
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO .

HY-N0836R

Jervine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Plants	Hedgehog Smo
Jervine (Standard) is the analytical standard of Jervine. This product is intended for research and analytical applications. Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-17024R

Cyclopamine (Standard)	Alkaloids Structural Classification Veratrum nigrum Linn. Liliaceae Source classification Pyridine Alkaloids Plants Endogenous metabolite Steroids	Hedgehog Smo Endogenous Metabolite
Cyclopamine (Standard) is the analytical standard of Cyclopamine. This product is intended for research and analytical applications. Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

HY-113081R

1-Methyladenosine (Standard)	Alkaloids Structural Classification Microorganisms Immune System Disorder Source classification Disease markers Endogenous metabolite Cancer	Endogenous Metabolite PPAR Hedgehog
1-Methyladenosine (Standard) is the analytical standard of 1-Methyladenosine. This product is intended for research and analytical applications. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates *Hedgehog* signaling pathway, driving liver tumorigenesis . In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells .

HY-12316R

20(S)-Hydroxycholesterol (Standard) 20α-Hydroxycholesterol (Standard)	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC₅₀ of 3 μM in a gene transcription reporter assay using NIH3T3 cells .

HY-N8270

Physalin H	Structural Classification Cardiacglycosides Source classification Solanum nigrum Linn. Plants Solanaceae Steroids	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-17514R

Itraconazole (Standard)	Microorganisms Source classification	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

Species:	Human (4) Mouse (2)
Tag:	His (2) Tag Free (4)
Source:	HEK293 (2) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P70467

	SHH Protein, Human Sonic hedgehog Protein; SHH; HHG-1	Human	E. coli
	SHH, Human, as a recombinant protein, is part of a small group of secreted proteins that are vital for development in both vertebrates and invertebrates. SHH, Human, produced in E.Coli, is a single, non-glycosylated polypeptide chain. SHH plays an important role in prostate cancer progression.

HY-P7407

	SHH Protein, Human (C24II) rHuSonic hedgehog, C24II; HHG1	Human	E. coli
	SHH Protein, Human (C24II) is a recombinant human sonic hedgehog variant. SHH Protein is a secreted signal transducer responsible not only for patterning of the anterior–posterior axis during early limb and neuronal development, but also for generating cell-type diversity at later developmental stages.

HY-P7408

	SHH Protein, Human (C24IVI) rHuSonic hedgehog, C24IVI; HHG1	Human	E. coli
	SHH Protein, Human (C24IVI) is a recombinant human sonic hedgehog variant. SHH Protein is a secreted signal transducer responsible not only for patterning of the anterior–posterior axis during early limb and neuronal development, but also for generating cell-type diversity at later developmental stages.

HY-P7409

	SHH Protein, Mouse (C25II) 2 Publications Verification rMuSonic hedgehog, C25II; Hhg1	Mouse	E. coli
	SHH Protein, Mouse (C25II) is a recombinant mouse sonic hedgehog variant.

HY-P73417

	SHH Protein, Human (HEK293, His) Sonic hedgehog Protein; SHH; HHG-1; ShhNC	Human	HEK293
	The SHH protein is cleaved into ShhN and ShhC fragments through autoproteolysis and cholesterol transferase activity. In the endoplasmic reticulum, ShhC is degraded, leaving behind lipidated ShhNp that is critical for developmental patterning. SHH Protein, Human (HEK293, His) is the recombinant human-derived SHH protein, expressed by HEK293 , with C-His labeled tag. The total length of SHH Protein, Human (HEK293, His) is 197 a.a., with molecular weight of ~24 kDa.

HY-P73418

	SHH Protein, Mouse (HEK293, His) 1 Publications Verification Sonic hedgehog Protein; SHH; HHG-1; ShhNC	Mouse	HEK293
	Sonic hedgehog (SHH) undergoes autoproteolysis in the endoplasmic reticulum to produce ShhN and ShhC.ShhN is covalently linked to cholesterol to form ShhNp, a morphogen critical for developmental patterning.SHH Protein, Mouse (HEK293, His) is the recombinant mouse-derived SHH protein, expressed by HEK293 , with C-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-17514S

Itraconazole-d5

Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].

HY-113081AS

1-Methyladenosine-d3 hydrochloride

1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis .

HY-17514S2

Itraconazole-d9

Itraconazole-d₉ is the deuterium labeled Itraconazole[1]. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor[2][3][4][5].