Tlr7 - toll-like receptor 7 Gene

Mus musculus

Gene ID: 170743 | Gene type: protein coding

About Tlr7

Chromosome X: 166,087,925-166,113,554 reverse strand.GRCm39:CM001013.3

This gene has 6 transcripts (splice variants), 197 orthologues, 23 paralogues and is associated with 14 phenotypes. Low expression observed in reference dataset.

Summary

Enables siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; response to virus; and Toll-like Receptor 7 signaling pathway. Acts upstream of or within positive regulation of interleukin-6 production and regulation of protein phosphorylation. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Tlr7 Products(5)

mRNA	Protein	Name
NM_001290757.1	NP_001277686.1	toll-like receptor 7 isoform a precursor
NM_001290756.1	NP_001277685.1	toll-like receptor 7 isoform a precursor
NM_001290755.1	NP_001277684.1	toll-like receptor 7 isoform a precursor
NM_001290758.1	NP_001277687.1	toll-like receptor 7 isoform b
NM_133211.4	NP_573474.1	toll-like receptor 7 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17452530	MGI
enables siRNA binding	IMP IMP: Inferred from mutant phenotype	15723075	MGI
enables single-stranded RNA binding	IMP IMP: Inferred from mutant phenotype	14976262	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	18802055	MGI
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	18802055	MGI
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	18802055	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	14976261	MGI
acts upstream of interleukin-6 production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of macrophage cytokine production	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	12032557	MGI
involved in positive regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	14976261	MGI
acts upstream of or within positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18802055	MGI
acts upstream of or within regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	24740015	MGI
involved in toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	14976261	MGI
involved in toll-like receptor 8 signaling pathway	IDA IDA: Inferred from direct assay	12032557	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in early phagosome	IDA IDA: Inferred from direct assay	18305481	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18305481	MGI
located in endosome	IDA IDA: Inferred from direct assay	18305481	MGI
located in lysosome	IDA IDA: Inferred from direct assay	18305481	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr7 Protein Structure

PRK15370

LRR_RI

PLN00113

LRR_RI

PCC

TIR

0
200
400
600
800
1050 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 7

Toll like receptor 7

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0180	Imiquimod	Agonist	99.96%	Unkown
HY-B1370	Hydroxychloroquine sulfate	Inhibitor	99.99%	Yes
HY-B0180A	Imiquimod hydrochloride	Agonist	99.77%	Yes
HY-B0180B	Imiquimod maleate	Agonist	99.25%	Yes
HY-B1370A	(S)-Hydroxychloroquine	Inhibitor	/	Unkown
HY-B1370B	(R)-Hydroxychloroquine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-134581	Enpatoran	Inhibitor	99.80%	Phase 2
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.33%	Phase 2
HY-108472	Loxoribine	Agonist	99.64%	Phase 2
HY-118250	GSK2245035	Agonist	99.85%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-100176	PF-4878691	Agonist	99.89%	Phase 2
HY-111269	AZD8848	Agonist	99.14%	Phase 2
HY-139575	Guretolimod	Agonist	/	Phase 2
HY-13655A	Isatoribine	Agonist	/	Phase 2
HY-109104	Telratolimod	Agonist	98.98%	Phase 1
HY-111786	LHC-165	Agonist	≥98.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (64)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0201	Atractylenolide I	Antagonist	99.94%	Unkown
HY-124603	AT791	Inhibitor	98.77%	Unkown
HY-128799	CL097	Agonist	99.90%	Unkown
HY-139323	TLR7/8-IN-1	Inhibitor	99.92%	Unkown
HY-103697	Gardiquimod	Agonist	99.91%	Unkown
HY-103698	TLR7/8 agonist 1	Agonist	97.33%	Unkown
HY-103697A	Gardiquimod diTFA	Agonist	≥99.0%	Unkown
HY-12756A	E6446 dihydrochloride	Antagonist	99.96%	Unkown
HY-160229	ssRNA40 sodium	Activator	93.25%	Unkown
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	Unkown
HY-135905	CL264	Inhibitor	98.63%	Unkown
HY-110120	DSR-6434	Agonist	99.55%	Unkown
HY-117602	TLR7 agonist 3	Agonist	99.90%	Unkown
HY-150736	ODN 20844	Inhibitor	/	Unkown
HY-12756	E6446	Antagonist	≥98.0%	Unkown
HY-131945	CU-115	Antagonist	99.55%	Unkown
HY-139017	TLR7/8 agonist 4	Agonist	99.04%	Unkown
HY-115400	1V209	Agonist	99.67%	Unkown
HY-110207	SM-324405	Agonist	98.52%	Unkown
HY-128799A	CL097 hydrochloride	Agonist	99.90%	Unkown
HY-111582	BBIQ	Agonist	99.85%	Unkown
HY-111358	TLR7 agonist 1	Agonist	98.19%	Unkown
HY-B1370R	Hydroxychloroquine (sulfate) (Standard)	Inhibitor	99.28%	Unkown
HY-153071	TLR7 agonist 6	Agonist	98.08%	Unkown
HY-156174	E104	Inhibitor	95.66%	Unkown
HY-157793	SMU-L11	Agonist	99.64%	Unkown
HY-159102	PVP-037.2	Agonist	99.18%	Unkown
HY-13740S	Resiquimod-d5	Agonist	99.84%	Unkown
HY-160227A	ORN 06 sodium	Activator	90.78%	Unkown
HY-150158	TMX-201		≥95.0%	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-145961	TLR7 agonist 4	Agonist	98.87%	Unkown
HY-158694A	TLR7 agonist 20 hydrochloride	Agonist	99.86%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-138139A	AXC-715 hydrochloride	Agonist	99.46%	Unkown
HY-153543	TLR7/8 agonist 8	Agonist	98.69%	Unkown
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	Unkown
HY-141454	TLR8 agonist 2	Agonist	/	Unkown
HY-147215	UC-1V150	Agonist	/	Unkown
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	Unkown
HY-121496	3M-011	Agonist	/	Unkown
HY-168157	TLR7 agonist 26	Agonist	/	Unkown
HY-169057	BI1543673	Inhibitor	/	Unkown
HY-168159	TLR7 agonist 27	Agonist	/	Unkown
HY-153544	TLR7/8 agonist 9	Inhibitor	/	Unkown
HY-152726	TLR7 agonist 9	Agonist	/	Unkown
HY-163398	TLR7-IN-1	Inhibitor	/	Unkown
HY-160227	ORN 06	Activator	/	Unkown
HY-162115	TLR7 agonist 17	Agonist	/	Unkown
HY-156175	TLR7 agonist 14	Agonist	/	Unkown
HY-169017	MTT5	Agonist	/	Unkown
HY-173070	TLR7 agonist 29	Agonist	/	Unkown
HY-153070	TLR7 agonist 5	Agonist	/	Unkown
HY-170899	TLR7 agonist 28	Agonist	/	Unkown
HY-158694	TLR7 agonist 20	Agonist	/	Unkown
HY-153073	TLR7 agonist 8	Agonist	/	Unkown
HY-162725	TLR7 agonist 24	Agonist	/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-162845	TLR7/8 agonist 11	Agonist	/	Unkown
HY-153072	TLR7 agonist 7	Agonist	/	Unkown
HY-159916	AYK004	Agonist	/	Unkown
HY-159914	AYK004-B1	Agonist	/	Unkown
HY-159919	UM-3006	Agonist	/	Unkown
HY-111582G	BBIQ (GMP)	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr7	NCBI	NCBI:51284

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