TLR7 - toll like receptor 7 Gene

Homo sapiens

Also known as IMD74; SLEB17; TLR7-like

Gene ID: 51284 | Gene type: protein coding

About TLR7

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,867,072-12,890,361 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 3.3), appendix (RPKM 3.0) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign Microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA Oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020]

TLR7 Products(2)

mRNA	Protein	Name
NG_001066.3
NM_016562.4	NP_057646.1	toll-like receptor 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	16111635	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33432245	GOA
enables single-stranded RNA binding	IMP IMP: Inferred from mutant phenotype	35477763	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in I-kappaB phosphorylation	IDA IDA: Inferred from direct assay	19740627	GOA
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	35477763	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in defense response to virus	IEP IEP: Inferred from expression pattern	32634389	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	16188996	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	35477763	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	12032557	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	16188996	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in response to cGMP	IMP IMP: Inferred from mutant phenotype	35477763	GOA
involved in toll-like receptor 7 signaling pathway	IDA IDA: Inferred from direct assay	12032557	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19740627	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19740627	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR7 Protein Structure

LRR_8

LRR_1

LRR_8

LRR_1

TIR

0
200
400
600
800
1049 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 7

toll-like receptor 7-like

Related Diseases

Diseases

Alias

Micronodular Basal Cell Carcinoma

Skin Micronodular Basal Cell Carcinoma

Basal Cell Carcinoma, Micronodular

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ehf
Ebola Fever	Ebola
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Actinic Keratosis

Solar Keratosis	Actinic Keratosis
Senile Hyperkeratosis	Sk - Solar Keratosis
Keratosis, Actinic	Seborrheic Keratosis
Ak - [Actinic Keratosis]	Sk - [Solar Keratosis]

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Parasitic Protozoa Infectious Disease

Protozoan Infections	Mastigophora Infectious Disease
Sarcomastigophora Infectious Disease

Systemic Lupus Erythematosus 17

SLEB17

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Encephalopathy With Basal Ganglia Calcification	Aicardi-Goutières Syndrome
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Pre-Malignant Neoplasm

Common Wart

Verruca Vulgaris	Viral Warts Nos
Filiform Warts	Digitate Warts

Autoimmune Disease Of Skin And Connective Tissue

Immune-Complex Glomerulonephritis

Immune Complex Glomerulonephritis

Skin Carcinoma

Skin Cancer	Carcinoma Of Skin
Ca - Skin Cancer	Cancer Of Skin
Malignant Neoplasm Of Skin	Melanoma And Non-Melanoma Skin Cancer
Skin Cancers	Cancer, Skin

Anaerobic Pneumonia

Pneumonia Due To Anaerobes

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Autoimmune Disease Of Exocrine System

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Immunodeficiency 74, Covid19-Related, X-Linked

Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection	IMD74
Tlr7 Deficiency

Severe Covid-19

Respiratory Failure

Acute Respiratory Failure	Chronic Respiratory Failure
Respiratory Insufficiency	Acute-On-Chronic Respiratory Failure
Acute And Chronic Respiratory Failure	Respiratory Insufficiency/Failure
Chronic Respiratory Disease	Respiratory Disease
Pulmonary Valve Insufficiency	Chronic Disease Of Respiratory System
Respiration Disorders	Respiratory Tract Diseases
Lung Failure Nos	Pulmonary Failure
Arf - [Acute Respiratory Failure]	Acute Respiratory Insufficiency
Acute Pulmonary Insufficiency	Acute Respiration Failure
Chronic Respiration Failure

Primary Bacterial Infectious Disease

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lyme Disease

Lyme Borreliosis	Lyme Neuroborreliosis
Borreliosis	Borrelia Burgdorferi Infection
Neuroborreliosis	Bannwarth Syndrome
Bannworth'S Syndrome	Neurological Lyme Disease
B. Burgdorferi Infection	Borreliosis, Lyme
Infection By Borrelia Burgdorferi	Infection Due To Borrelia Burgdorferi Sensu Lato
Lym	Borrelia Infections

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma	Multicentric Basal Cell Carcinoma
Superficial Multicentric Basal-Cell Carcinoma

Herpangina

Vesicular Pharyngitis

Bronchiolitis

Genital Herpes

Herpes Genitalis	Genital Herpes Simplex
Venereal Herpes	Virus-Genital Herpes

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

Integumentary System Disease

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Chronic Adenitis	Acute Adenitis
Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

T Cell Deficiency

T Cell Immunodeficiency	T Lymphocyte Deficiency
T Lymphocyte Immunodeficiency	T-Lymphocyte Deficiency

Borst-Jadassohn Intraepidermal Carcinoma

Intraepidermal Epithelioma Of Jadassohn

Bowen'S Disease, Clonal

Autoimmune Disease Of Musculoskeletal System

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Mouth Disease

Mouth Diseases

Mouth Disorders

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Chromoblastomycosis

Chromomycosis	Mossy Foot Disease
Verrucous Dermatitis	Fonseca Disease
Pedroso Disease	Drechslera Hawaiiensis
Drechslera Infection

Coronavirus Infectious Disease

Subcutaneous Mycosis

Subcutaneous Fungal Disease

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

X-Linked Immunodeficiency 74

Immunodeficiency 74, Covid-19-Related, X-Linked	Imd74
Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection	Tlr7 Deficiency
X-Linked Immunodeficiency 74,Covid-19-Related

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Viral Infectious Disease

Arbovirus Infections	Viral Disease
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Anogenital Venereal Wart

Genital Warts	Condylomata Acuminata
Anogenital Warts	Condyloma Acuminatum
Anogenital Human Papilloma Virus Infectious Disease	Genital Wart Virus Infectious Disease
Venereal Wart	Venereal Warts
Verrucae Anogenitales	Verrucae Genitales

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0180	Imiquimod	Agonist	99.96%	Yes
HY-B1370	Hydroxychloroquine sulfate	Inhibitor	99.99%	Yes
HY-B0180A	Imiquimod hydrochloride	Agonist	99.77%	Yes
HY-B0180B	Imiquimod maleate	Agonist	99.25%	Yes
HY-B1370B	(R)-Hydroxychloroquine	Inhibitor	/	Unkown
HY-B1370A	(S)-Hydroxychloroquine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-134581	Enpatoran	Inhibitor	99.77%	Phase 2
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.33%	Phase 2
HY-108472	Loxoribine	Agonist	99.64%	Phase 2
HY-118250	GSK2245035	Agonist	99.85%	Phase 2
HY-111269	AZD8848	Agonist	99.14%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-100176	PF-4878691	Agonist	99.89%	Phase 2
HY-13655A	Isatoribine	Agonist	/	Phase 2
HY-109104	Telratolimod	Agonist	98.98%	Phase 1
HY-111786	LHC-165	Agonist	≥98.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (61)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0201	Atractylenolide I	Antagonist	99.94%	Unkown
HY-124603	AT791	Inhibitor	98.77%	Unkown
HY-128799	CL097	Agonist	99.89%	Unkown
HY-103697A	Gardiquimod diTFA	Agonist	≥99.0%	Unkown
HY-139323	TLR7/8-IN-1	Inhibitor	99.92%	Unkown
HY-103697	Gardiquimod	Agonist	99.91%	Unkown
HY-103698	TLR7/8 agonist 1	Agonist	97.33%	Unkown
HY-12756A	E6446 dihydrochloride	Antagonist	99.96%	Unkown
HY-135905	CL264	Inhibitor	98.63%	Unkown
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	Unkown
HY-110120	DSR-6434	Agonist	99.55%	Unkown
HY-150736	ODN 20844	Inhibitor	/	Unkown
HY-117602	TLR7 agonist 3	Agonist	99.90%	Unkown
HY-131945	CU-115	Antagonist	99.55%	Unkown
HY-139017	TLR7/8 agonist 4	Agonist	99.04%	Unkown
HY-115400	1V209	Agonist	99.67%	Unkown
HY-10018	Toll-like receptor modulator	Modulator	99.36%	Unkown
HY-160229	ssRNA40 sodium	Activator	93.25%	Unkown
HY-12756	E6446	Antagonist	≥98.0%	Unkown
HY-153071	TLR7 agonist 6	Agonist	98.08%	Unkown
HY-13740S	Resiquimod-d5	Agonist	99.84%	Unkown
HY-111358	TLR7 agonist 1	Agonist	98.95%	Unkown
HY-110207	SM-324405	Agonist	98.52%	Unkown
HY-128799A	CL097 hydrochloride	Agonist	99.51%	Unkown
HY-150158	TMX-201		≥95.0%	Unkown
HY-111582	BBIQ	Agonist	99.85%	Unkown
HY-157793	SMU-L11	Agonist	99.64%	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-145961	TLR7 agonist 4	Agonist	98.87%	Unkown
HY-160227A	ORN 06 sodium	Activator	90.78%	Unkown
HY-159102	PVP-037.2	Agonist	/	Unkown
HY-158694A	TLR7 agonist 20 hydrochloride	Agonist	99.86%	Unkown
HY-138139A	AXC-715 hydrochloride	Agonist	/	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-153543	TLR7/8 agonist 8	Agonist	/	Unkown
HY-156174	E104	Inhibitor	/	Unkown
HY-139575	Guretolimod	Agonist	/	Unkown
HY-141454	TLR8 agonist 2	Agonist	/	Unkown
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	Unkown
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	Unkown
HY-147215	UC-1V150	Agonist	/	Unkown
HY-B1370R	Hydroxychloroquine sulfate (Standard)	Inhibitor	/	Unkown
HY-121496	3M-011	Agonist	/	Unkown
HY-153070	TLR7 agonist 5	Agonist	/	Unkown
HY-168157	TLR7 agonist 26	Agonist	/	Unkown
HY-168159	TLR7 agonist 27	Agonist	/	Unkown
HY-153544	TLR7/8 agonist 9	Inhibitor	/	Unkown
HY-158694	TLR7 agonist 20	Agonist	/	Unkown
HY-152726	TLR7 agonist 9	Agonist	/	Unkown
HY-162725	TLR7 agonist 24	Agonist	/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-162845	TLR7/8 agonist 11	Agonist	/	Unkown
HY-156175	TLR7 agonist 14	Agonist	/	Unkown
HY-153072	TLR7 agonist 7	Agonist	/	Unkown
HY-169017	MTT5	Agonist	/	Unkown
HY-169057	BI1543673	Inhibitor	/	Unkown
HY-163398	TLR7-IN-1	Inhibitor	/	Unkown
HY-160227	ORN 06	Activator	/	Unkown
HY-153073	TLR7 agonist 8	Agonist	/	Unkown
HY-162115	TLR7 agonist 17	Agonist	/	Unkown
HY-111582G	BBIQ (GMP)	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TLR7	MGD	MGI:2176882
Bos taurus	TLR7	VGNC	VGNC:52836
Rattus norvegicus	TLR7	RGD	RGD:1563357
Canis familiaris	TLR7	VGNC	VGNC:54607
Macaca mulatta	TLR7	VGNC	VGNC:78390