2. Gene
  3. KLK6 - kallikrein related peptidase 6 Gene

KLK6 - kallikrein related peptidase 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as hK6; Bssp; Klk7; SP59; PRSS9; PRSS18

Gene ID: 5653 | Gene type: protein coding

About KLK6

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,958,631-50,969,591 (from NCBI)

This gene has 7 transcripts (splice variants), 106 orthologues and 6 paralogues. Biased expression in esophagus (RPKM 23.8), brain (RPKM 23.7) and 4 other tissues.

Summary

This gene encodes a member of the Kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid Hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

KLK6 Products(5)

mRNA Protein Name
NM_001012964.3 NP_001012982.1 kallikrein-6 isoform A preproprotein
NM_001012965.3 NP_001012983.1 kallikrein-6 isoform B
NM_001319948.2 NP_001306877.1 kallikrein-6 isoform B
NM_001319949.2 NP_001306878.1 kallikrein-6 isoform B
NM_002774.4 NP_002765.1 kallikrein-6 isoform A preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12709365 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
16885167 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
16885167 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11668196 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
11668196 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK6 Protein Structure

Trypsin

Trypsin: Trypsin (23 - 237)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

kallikrein-6

neurosin

KLK6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KLK6 Q92876 NMU Homo sapiens P48645
Y2H Array
32814053
Intra
KLK6 Q92876 NMU Homo sapiens P48645
Validated Y2H
32814053
Intra
KLK6 Q92876 NMU Homo sapiens P48645
Y2H Pooling
32814053
Intra
KLK6 Q92876 ESRP1 Homo sapiens Q6NXG1
Validated Y2H
32814053
Intra
KLK6 Q92876 ESRP1 Homo sapiens Q6NXG1
Y2H Array
32814053
Intra
KLK6 Q92876 ESRP1 Homo sapiens Q6NXG1
Y2H Pooling
32814053
Intra
KLK6 Q92876 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Pooling
32814053
Intra
KLK6 Q92876 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32814053
Intra
KLK6 Q92876 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32814053
Intra
KLK6 Q92876 TWSG1 Homo sapiens Q9GZX9
Validated Y2H
32814053
Intra
KLK6 Q92876 TWSG1 Homo sapiens Q9GZX9
Y2H Array
32814053
Intra
KLK6 Q92876 TWSG1 Homo sapiens Q9GZX9
Y2H Pooling
32814053
Intra
KLK6 Q92876 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32814053
Intra
KLK6 Q92876 KRTAP19-5 Homo sapiens Q3LI72
Y2H Pooling
32814053
Intra
KLK6 Q92876 KRTAP19-5 Homo sapiens Q3LI72
Validated Y2H
32814053
Intra
KLK6 Q92876 LARP4B Homo sapiens Q92615
Validated Y2H
32814053
Intra
KLK6 Q92876 LARP4B Homo sapiens Q92615
Y2H Array
32814053
Intra
KLK6 Q92876 LARP4B Homo sapiens Q92615
Y2H Pooling
32814053
Intra
KLK6 Q92876 SDCCAG8 Homo sapiens Q86SQ7-2
Y2H Array
32814053
Intra
KLK6 Q92876 SDCCAG8 Homo sapiens Q86SQ7-2
Validated Y2H
32814053
Intra
KLK6 Q92876 SDCCAG8 Homo sapiens Q86SQ7-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 TPM3 Homo sapiens P06753-2
Validated Y2H
32814053
Intra
KLK6 Q92876 TPM3 Homo sapiens P06753-2
Y2H Array
32814053
Intra
KLK6 Q92876 TPM3 Homo sapiens P06753-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 MFSD10 Homo sapiens Q14728
Y2H Array
32814053
Intra
KLK6 Q92876 MFSD10 Homo sapiens Q14728
Y2H Pooling
32814053
Intra
KLK6 Q92876 MFSD10 Homo sapiens Q14728
Validated Y2H
32814053
Intra
KLK6 Q92876 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 SIAH1 Homo sapiens Q8IUQ4-2
Validated Y2H
32814053
Intra
KLK6 Q92876 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Array
32814053
Intra
KLK6 Q92876 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32814053
Intra
KLK6 Q92876 CARD9 Homo sapiens Q9H257-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 CARD9 Homo sapiens Q9H257-2
Y2H Array
32814053
Intra
KLK6 Q92876 EPB42 Homo sapiens P16452
Y2H Array
32814053
Intra
KLK6 Q92876 EPB42 Homo sapiens P16452
Validated Y2H
32814053
Intra
KLK6 Q92876 EPB42 Homo sapiens P16452
Y2H Pooling
32814053
Intra
KLK6 Q92876 UQCC1 Homo sapiens Q9NVA1
Y2H Pooling
32814053
Intra
KLK6 Q92876 UQCC1 Homo sapiens Q9NVA1
Validated Y2H
32814053
Intra
KLK6 Q92876 UQCC1 Homo sapiens Q9NVA1
Y2H Array
32814053
Intra
KLK6 Q92876 INVS Homo sapiens Q9Y283-3
Y2H Pooling
32814053
Intra
KLK6 Q92876 INVS Homo sapiens Q9Y283-3
Validated Y2H
32814053
Intra
KLK6 Q92876 INVS Homo sapiens Q9Y283-3
Y2H Array
32814053
Intra
KLK6 Q92876 ZNF444 Homo sapiens Q8N0Y2-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 ZNF444 Homo sapiens Q8N0Y2-2
Validated Y2H
32814053
Intra
KLK6 Q92876 ZNF444 Homo sapiens Q8N0Y2-2
Y2H Array
32814053
Intra
KLK6 Q92876 ASB13 Homo sapiens Q8WXK3-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 ASB13 Homo sapiens Q8WXK3-2
Validated Y2H
32814053
Intra
KLK6 Q92876 ASB13 Homo sapiens Q8WXK3-2
Y2H Array
32814053
Intra
KLK6 Q92876 WWOX Homo sapiens Q9NZC7-5
Y2H Pooling
32814053
Intra
KLK6 Q92876 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32814053
Intra
KLK6 Q92876 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32814053
Intra
KLK6 Q92876 RBFOX1 Homo sapiens Q9NWB1-5
Y2H Pooling
32814053
Intra
KLK6 Q92876 RBFOX1 Homo sapiens Q9NWB1-5
Validated Y2H
32814053
Intra
KLK6 Q92876 RBFOX1 Homo sapiens Q9NWB1-5
Y2H Array
32814053
Intra
KLK6 Q92876 ATP23 Homo sapiens Q9Y6H3
Validated Y2H
32814053
Intra
KLK6 Q92876 ATP23 Homo sapiens Q9Y6H3
Y2H Array
32814053
Intra
KLK6 Q92876 ATP23 Homo sapiens Q9Y6H3
Y2H Pooling
32814053
Intra
KLK6 Q92876 UNKL Homo sapiens Q9H9P5-5
Y2H Array
32814053
Intra
KLK6 Q92876 UNKL Homo sapiens Q9H9P5-5
Y2H Pooling
32814053
Intra
KLK6 Q92876 UNKL Homo sapiens Q9H9P5-5
Validated Y2H
32814053
Intra
KLK6 Q92876 SLC26A1 Homo sapiens Q9H2B4-2
Validated Y2H
32814053
Intra
KLK6 Q92876 SLC26A1 Homo sapiens Q9H2B4-2
Y2H Array
32814053
Intra
KLK6 Q92876 SLC26A1 Homo sapiens Q9H2B4-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 ALKBH8 Homo sapiens Q96BT7-2
Validated Y2H
32814053
Intra
KLK6 Q92876 ALKBH8 Homo sapiens Q96BT7-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 ALKBH8 Homo sapiens Q96BT7-2
Y2H Array
32814053
Intra
KLK6 Q92876 IL16 Homo sapiens Q14005-2
Validated Y2H
32814053
Intra
KLK6 Q92876 IL16 Homo sapiens Q14005-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 IL16 Homo sapiens Q14005-2
Y2H Array
32814053
Intra
KLK6 Q92876 HOXB1 Homo sapiens Q4VB01
Validated Y2H
32814053
Intra
KLK6 Q92876 HOXB1 Homo sapiens Q4VB01
Y2H Pooling
32814053
Intra
KLK6 Q92876 HOXB1 Homo sapiens Q4VB01
Y2H Array
32814053
Intra
KLK6 Q92876 FASTK Homo sapiens Q14296
Y2H Pooling
32814053
Intra
KLK6 Q92876 FASTK Homo sapiens Q14296
Validated Y2H
32814053
Intra
KLK6 Q92876 FASTK Homo sapiens Q14296
Y2H Array
32814053
Intra
KLK6 Q92876 ESRP1 Homo sapiens Q6NXG1-3
Y2H Pooling
32814053
Intra
KLK6 Q92876 ESRP1 Homo sapiens Q6NXG1-3
Validated Y2H
32814053
Intra
KLK6 Q92876 ESRP1 Homo sapiens Q6NXG1-3
Y2H Array
32814053
Intra
KLK6 Q92876 ARMCX4 Homo sapiens Q5H9R4-2
Validated Y2H
32814053
Intra
KLK6 Q92876 ARMCX4 Homo sapiens Q5H9R4-2
Y2H Array
32814053
Intra
KLK6 Q92876 ARMCX4 Homo sapiens Q5H9R4-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 TNIP3 Homo sapiens Q96KP6
Validated Y2H
32814053
Intra
KLK6 Q92876 TNIP3 Homo sapiens Q96KP6
Y2H Array
32814053
Intra
KLK6 Q92876 TNIP3 Homo sapiens Q96KP6
Y2H Pooling
32814053
Intra
KLK6 Q92876 COL9A1 Homo sapiens P20849
Y2H Pooling
32814053
Intra
KLK6 Q92876 COL9A1 Homo sapiens P20849
Validated Y2H
32814053
Intra
KLK6 Q92876 COL9A1 Homo sapiens P20849
Y2H Array
32814053
Intra
KLK6 Q92876 RGR Homo sapiens P47804-3
Validated Y2H
32814053
Intra
KLK6 Q92876 RGR Homo sapiens P47804-3
Y2H Array
32814053
Intra
KLK6 Q92876 RGR Homo sapiens P47804-3
Y2H Pooling
32814053
Intra
KLK6 Q92876 MLST8 Homo sapiens A0A0A0MR05
Validated Y2H
32814053
Intra
KLK6 Q92876 MLST8 Homo sapiens A0A0A0MR05
Y2H Array
32814053
Intra
KLK6 Q92876 MLST8 Homo sapiens A0A0A0MR05
Y2H Pooling
32814053
Intra
KLK6 Q92876 SCAPER Homo sapiens Q9BY12-3
Y2H Pooling
32814053
Intra
KLK6 Q92876 SCAPER Homo sapiens Q9BY12-3
Validated Y2H
32814053
Intra
KLK6 Q92876 SCAPER Homo sapiens Q9BY12-3
Y2H Array
32814053
Intra
KLK6 Q92876 TMPRSS6 Homo sapiens Q8IU80-2
Validated Y2H
32814053
Intra
KLK6 Q92876 TMPRSS6 Homo sapiens Q8IU80-2
Y2H Array
32814053
Intra
KLK6 Q92876 TMPRSS6 Homo sapiens Q8IU80-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 BET1 Homo sapiens O15155-2
Y2H Array
32814053
Intra
KLK6 Q92876 BET1 Homo sapiens O15155-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 BET1 Homo sapiens O15155-2
Validated Y2H
32814053
Intra
KLK6 Q92876 LOC57228 Homo sapiens O95332
Validated Y2H
32814053
Intra
KLK6 Q92876 LOC57228 Homo sapiens O95332
Y2H Array
32814053
Intra
KLK6 Q92876 LOC57228 Homo sapiens O95332
Y2H Pooling
32814053
Intra
KLK6 Q92876 PODXL2 Homo sapiens Q9NZ53-2
Y2H Array
32814053
Intra
KLK6 Q92876 PODXL2 Homo sapiens Q9NZ53-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 PODXL2 Homo sapiens Q9NZ53-2
Validated Y2H
32814053
Intra
KLK6 Q92876 DPY19L3 Homo sapiens Q6ZPD9-2
Validated Y2H
32814053
Intra
KLK6 Q92876 DPY19L3 Homo sapiens Q6ZPD9-2
Y2H Array
32814053
Intra
KLK6 Q92876 DPY19L3 Homo sapiens Q6ZPD9-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 STAC Homo sapiens Q99469
Y2H Array
32814053
Intra
KLK6 Q92876 STAC Homo sapiens Q99469
Validated Y2H
32814053
Intra
KLK6 Q92876 STAC Homo sapiens Q99469
Y2H Pooling
32814053
Intra
KLK6 Q92876 PRPF39 Homo sapiens Q86UA1
Y2H Array
32814053
Intra
KLK6 Q92876 PRPF39 Homo sapiens Q86UA1
Y2H Pooling
32814053
Intra
KLK6 Q92876 PRPF39 Homo sapiens Q86UA1
Validated Y2H
32814053
Intra
KLK6 Q92876 THADA Homo sapiens Q6YHU6
Validated Y2H
32814053
Intra
KLK6 Q92876 THADA Homo sapiens Q6YHU6
Y2H Array
32814053
Intra
KLK6 Q92876 THADA Homo sapiens Q6YHU6
Y2H Pooling
32814053
Intra
KLK6 Q92876 CDH16 Homo sapiens O75309
Y2H Array
32814053
Intra
KLK6 Q92876 CDH16 Homo sapiens O75309
Y2H Pooling
32814053
Intra
KLK6 Q92876 CDH16 Homo sapiens O75309
Validated Y2H
32814053
Intra
KLK6 Q92876 RBM4 Homo sapiens Q9BWF3
Y2H Pooling
32814053
Intra
KLK6 Q92876 RBM4 Homo sapiens Q9BWF3
Validated Y2H
32814053
Intra
KLK6 Q92876 RBM4 Homo sapiens Q9BWF3
Y2H Array
32814053
Intra
KLK6 Q92876 PRAM1 Homo sapiens Q96QH2
Y2H Array
32814053
Intra
KLK6 Q92876 PRAM1 Homo sapiens Q96QH2
Y2H Pooling
32814053
Intra
KLK6 Q92876 PRAM1 Homo sapiens Q96QH2
Validated Y2H
32814053
Intra
KLK6 Q92876 ACP2 Homo sapiens P11117
Validated Y2H
32814053
Intra
KLK6 Q92876 ACP2 Homo sapiens P11117
Y2H Array
32814053
Intra
KLK6 Q92876 ACP2 Homo sapiens P11117
Y2H Pooling
32814053
Intra
KLK6 Q92876 HK3 Homo sapiens P52790
Validated Y2H
32814053
Intra
KLK6 Q92876 HK3 Homo sapiens P52790
Y2H Array
32814053
Intra
KLK6 Q92876 HK3 Homo sapiens P52790
Y2H Pooling
32814053
Intra
KLK6 Q92876 MAPK11 Homo sapiens Q15759
Y2H Pooling
32814053
Intra
KLK6 Q92876 MAPK11 Homo sapiens Q15759
Validated Y2H
32814053
Intra
KLK6 Q92876 MAPK11 Homo sapiens Q15759
Y2H Array
32814053
Intra
KLK6 Q92876 CSNK2A1 Homo sapiens P68400
Y2H Pooling
32814053
Intra
KLK6 Q92876 CSNK2A1 Homo sapiens P68400
Validated Y2H
32814053
Intra
KLK6 Q92876 CSNK2A1 Homo sapiens P68400
Y2H Array
32814053
Intra
KLK6 Q92876 DYNLL1 Homo sapiens P63167
Y2H Array
32814053
Intra
KLK6 Q92876 DYNLL1 Homo sapiens P63167
Validated Y2H
32814053
Intra
KLK6 Q92876 DYNLL1 Homo sapiens P63167
Y2H Pooling
32814053
Intra
KLK6 Q92876 CFL2 Homo sapiens Q9Y281
Y2H Pooling
32814053
Intra
KLK6 Q92876 CFL2 Homo sapiens Q9Y281
Validated Y2H
32814053
Intra
KLK6 Q92876 CFL2 Homo sapiens Q9Y281
Y2H Array
32814053
Intra
KLK6 Q92876 SPRY4 Homo sapiens Q9C004
Y2H Array
32814053
Intra
KLK6 Q92876 SPRY4 Homo sapiens Q9C004
Validated Y2H
32814053
Intra
KLK6 Q92876 SPRY4 Homo sapiens Q9C004
Y2H Pooling
32814053
Intra
KLK6 Q92876 FAU Homo sapiens P62861
Validated Y2H
32814053
Intra
KLK6 Q92876 FAU Homo sapiens P62861
Y2H Array
32814053
Intra
KLK6 Q92876 FAU Homo sapiens P62861
Y2H Pooling
32814053
Intra
KLK6 Q92876 TSPAN2 Homo sapiens O60636
Y2H Array
32814053
Intra
KLK6 Q92876 TSPAN2 Homo sapiens O60636
Validated Y2H
32814053
Intra
KLK6 Q92876 TSPAN2 Homo sapiens O60636
Y2H Pooling
32814053
Intra
KLK6 Q92876 TLE6 Homo sapiens Q9H808
Validated Y2H
32814053
Intra
KLK6 Q92876 TLE6 Homo sapiens Q9H808
Y2H Array
32814053
Intra
KLK6 Q92876 TLE6 Homo sapiens Q9H808
Y2H Pooling
32814053
Intra
KLK6 Q92876 TCP10L Homo sapiens Q8TDR4
Y2H Array
32814053
Intra
KLK6 Q92876 TCP10L Homo sapiens Q8TDR4
Y2H Pooling
32814053
Intra
KLK6 Q92876 TCP10L Homo sapiens Q8TDR4
Validated Y2H
32814053
Intra
KLK6 Q92876 DCUN1D5 Homo sapiens Q9BTE7
Y2H Array
32814053
Intra
KLK6 Q92876 DCUN1D5 Homo sapiens Q9BTE7
Validated Y2H
32814053
Intra
KLK6 Q92876 DCUN1D5 Homo sapiens Q9BTE7
Y2H Pooling
32814053
Intra
KLK6 Q92876 EIF2B5 Homo sapiens Q13144
Y2H Pooling
32814053
Intra
KLK6 Q92876 EIF2B5 Homo sapiens Q13144
Validated Y2H
32814053
Intra
KLK6 Q92876 EIF2B5 Homo sapiens Q13144
Y2H Array
32814053
Intra
KLK6 Q92876 GADD45A Homo sapiens P24522
Y2H Pooling
32814053
Intra
KLK6 Q92876 GADD45A Homo sapiens P24522
Validated Y2H
32814053
Intra
KLK6 Q92876 GADD45A Homo sapiens P24522
Y2H Array
32814053
Intra
KLK6 Q92876 PTN Homo sapiens P21246
Y2H Array
32814053
Intra
KLK6 Q92876 PTN Homo sapiens P21246
Validated Y2H
32814053
Intra
KLK6 Q92876 PTN Homo sapiens P21246
Y2H Pooling
32814053
Intra
KLK6 Q92876 MAP3K5 Homo sapiens Q99683
Validated Y2H
32814053
Intra
KLK6 Q92876 MAP3K5 Homo sapiens Q99683
Y2H Pooling
32814053
Intra
KLK6 Q92876 MAP3K5 Homo sapiens Q99683
Y2H Array
32814053
Intra
KLK6 Q92876 XPO5 Homo sapiens Q9HAV4
Validated Y2H
32814053
Intra
KLK6 Q92876 XPO5 Homo sapiens Q9HAV4
Y2H Array
32814053
Intra
KLK6 Q92876 XPO5 Homo sapiens Q9HAV4
Y2H Pooling
32814053
Intra
KLK6 Q92876 PDCL Homo sapiens Q13371
Validated Y2H
32814053
Intra
KLK6 Q92876 PDCL Homo sapiens Q13371
Y2H Pooling
32814053
Intra
KLK6 Q92876 PDCL Homo sapiens Q13371
Y2H Array
32814053
Intra
KLK6 Q92876 INCA1 Homo sapiens Q0VD86
Validated Y2H
32814053
Intra
KLK6 Q92876 INCA1 Homo sapiens Q0VD86
Y2H Array
32814053
Intra
KLK6 Q92876 INCA1 Homo sapiens Q0VD86
Y2H Pooling
32814053
Intra
KLK6 Q92876 STX11 Homo sapiens O75558
Validated Y2H
32814053
Intra
KLK6 Q92876 STX11 Homo sapiens O75558
Y2H Array
32814053
Intra
KLK6 Q92876 STX11 Homo sapiens O75558
Y2H Pooling
32814053
Intra
KLK6 Q92876 KLHL20 Homo sapiens Q9Y2M5
Validated Y2H
32814053
Intra
KLK6 Q92876 KLHL20 Homo sapiens Q9Y2M5
Y2H Array
32814053
Intra
KLK6 Q92876 KLHL20 Homo sapiens Q9Y2M5
Y2H Pooling
32814053
Intra
KLK6 Q92876 FCGR2B Homo sapiens P31994
Validated Y2H
32814053
Intra
KLK6 Q92876 FCGR2B Homo sapiens P31994
Y2H Array
32814053
Intra
KLK6 Q92876 FCGR2B Homo sapiens P31994
Y2H Pooling
32814053
Intra
KLK6 Q92876 KRT81 Homo sapiens Q14533
Y2H Array
32814053
Intra
KLK6 Q92876 KRT81 Homo sapiens Q14533
Y2H Pooling
32814053
Intra
KLK6 Q92876 KRT81 Homo sapiens Q14533
Validated Y2H
32814053
Intra
KLK6 Q92876 SUFU Homo sapiens Q9UMX1
Y2H Pooling
32814053
Intra
KLK6 Q92876 SUFU Homo sapiens Q9UMX1
Validated Y2H
32814053
Intra
KLK6 Q92876 SUFU Homo sapiens Q9UMX1
Y2H Array
32814053
Intra
KLK6 Q92876 KRT19 Homo sapiens P08727
Validated Y2H
32814053
Intra
KLK6 Q92876 KRT19 Homo sapiens P08727
Y2H Array
32814053
Intra
KLK6 Q92876 KRT19 Homo sapiens P08727
Y2H Pooling
32814053
Intra
KLK6 Q92876 BEX2 Homo sapiens Q9BXY8
Validated Y2H
32814053
Intra
KLK6 Q92876 BEX2 Homo sapiens Q9BXY8
Y2H Array
32814053
Intra
KLK6 Q92876 BEX2 Homo sapiens Q9BXY8
Y2H Pooling
32814053
Intra
KLK6 Q92876 LOXL4 Homo sapiens Q96JB6
Y2H Pooling
32814053
Intra
KLK6 Q92876 LOXL4 Homo sapiens Q96JB6
Validated Y2H
32814053
Intra
KLK6 Q92876 LOXL4 Homo sapiens Q96JB6
Y2H Array
32814053
Intra
KLK6 Q92876 q96ej4_human Homo sapiens Q96EJ4
Validated Y2H
32814053
Intra
KLK6 Q92876 q96ej4_human Homo sapiens Q96EJ4
Y2H Pooling
32814053
Intra
KLK6 Q92876 q96ej4_human Homo sapiens Q96EJ4
Y2H Array
32814053
Intra
KLK6 Q92876 G2E3 Homo sapiens Q7L622
Validated Y2H
32814053
Intra
KLK6 Q92876 G2E3 Homo sapiens Q7L622
Y2H Pooling
32814053
Intra
KLK6 Q92876 G2E3 Homo sapiens Q7L622
Y2H Array
32814053
Intra
KLK6 Q92876 TENT5B Homo sapiens Q96A09
Y2H Pooling
32814053
Intra
KLK6 Q92876 TENT5B Homo sapiens Q96A09
Validated Y2H
32814053
Intra
KLK6 Q92876 TENT5B Homo sapiens Q96A09
Y2H Array
32814053
Intra
KLK6 Q92876 TNFAIP8L1 Homo sapiens Q8WVP5
Validated Y2H
32814053
Intra
KLK6 Q92876 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Array
32814053
Intra
KLK6 Q92876 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Pooling
32814053
Intra
KLK6 Q92876 APP Homo sapiens P05067
Protease Assay
12878203
Intra
KLK6 Q92876 DBH Homo sapiens P09172
Validated Y2H
32814053
Intra
KLK6 Q92876 DBH Homo sapiens P09172
Y2H Array
32814053
Intra
KLK6 Q92876 DBH Homo sapiens P09172
Y2H Pooling
32814053
Intra
KLK6 Q92876 GFOD1 Homo sapiens Q9NXC2
Y2H Pooling
32814053
Intra
KLK6 Q92876 GFOD1 Homo sapiens Q9NXC2
Validated Y2H
32814053
Intra
KLK6 Q92876 GFOD1 Homo sapiens Q9NXC2
Y2H Array
32814053
Intra
KLK6 Q92876 TOX Homo sapiens O94900
Validated Y2H
32814053
Intra
KLK6 Q92876 TOX Homo sapiens O94900
Y2H Array
32814053
Intra
KLK6 Q92876 TOX Homo sapiens O94900
Y2H Pooling
32814053
Intra
KLK6 Q92876 TUT7 Homo sapiens Q5VYS8-5
Y2H Pooling
32814053
Intra
KLK6 Q92876 TUT7 Homo sapiens Q5VYS8-5
Validated Y2H
32814053
Intra
KLK6 Q92876 TUT7 Homo sapiens Q5VYS8-5
Y2H Array
32814053
Intra
KLK6 Q92876 SEMA4G Homo sapiens Q9NTN9-3
Validated Y2H
32814053
Intra
KLK6 Q92876 SEMA4G Homo sapiens Q9NTN9-3
Y2H Array
32814053
Intra
KLK6 Q92876 SEMA4G Homo sapiens Q9NTN9-3
Y2H Pooling
32814053
Intra
KLK6 Q92876 GATA1 Homo sapiens P15976-2
Validated Y2H
32814053
Intra
KLK6 Q92876 GATA1 Homo sapiens P15976-2
Y2H Array
32814053
Intra
KLK6 Q92876 GATA1 Homo sapiens P15976-2
Y2H Pooling
32814053
Intra
KLK6 Q92876 BAIAP2 Homo sapiens Q9UQB8-6
Y2H Array
32814053
Intra
KLK6 Q92876 BAIAP2 Homo sapiens Q9UQB8-6
Y2H Pooling
32814053
Intra
KLK6 Q92876 BAIAP2 Homo sapiens Q9UQB8-6
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLK6 Proteins

Cat. No. Product Name Accession Purity
HY-P70887 Kallikrein-6 Protein, Human (HEK293, His) Q92876-1 (E17-K244) ≥95%

Related Diseases

Diseases Alias
Breast Cyst

Cyst Of The Breast

Breast Cysts
Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary
Postpoliomyelitis Syndrome

Postpolio Syndrome

Post-Polio Syndrome

Post Polio Syndrome

Polio Late Effects

Post-Polio Muscular Atrophy

Post-Polio Sequelae

Post-Poliomyelitic Syndrome

Postpolio Sequelae

Postpoliomyelitic Syndrome

Postpoliomyelitis Sequelae
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Netherton Syndrome

NETH

Ns

Netherton Disease

Comel-Netherton Syndrome

Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

Bamboo Hair Syndrome

Ichthyosis Linearis Circumflexa

Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

Ilc

Nts

N Syndrome
Peeling Skin Syndrome

Deciduous Skin

Familial Continuous Skin Peeling Syndrome

Idiopathic Deciduous Skin

Keratosis Exfoliativa Congenita

Pss

Peeling Skin Disease

Skin Peeling Syndrome

Familial Continuous Skin Peeling

Keratolysis Exfoliativa Congenita

Exfoliation Syndrome

Keratolysis Exfoliativa
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Psoriasis
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07384 KLK6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KLK6 VGNC VGNC:30680
Felis catus KLK6 VGNC VGNC:67966
Rattus norvegicus KLK6 RGD RGD:3419
Macaca mulatta KLK6 VGNC VGNC:74192
Mus musculus KLK6 MGD MGI:1343166
Canis familiaris KLK6 VGNC VGNC:54849
Others KLK6 NCBI