2. Gene
  3. Brd4 - bromodomain containing 4 Gene

Brd4 - bromodomain containing 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Brd5; MCAP; HUNK1; WI-11513

Gene ID: 57261 | Gene type: protein coding

About Brd4

Chromosome 17: 32,415,248-32,503,696 reverse strand.GRCm39:CM001010.3

This gene has 12 transcripts (splice variants), 66 orthologues, 11 paralogues and is associated with 41 phenotypes. Ubiquitous expression in thymus adult (RPKM 17.8), spleen adult (RPKM 13.4) and 28 other tissues.

Summary

This gene was temporarily named bromodomain-containing 5 (Brd5) and was renamed bromodomain-containing 4 (Brd4). [provided by RefSeq, Jul 2008]

Brd4 Products(3)

mRNA Protein Name
NM_198094.2 NP_932762.2 bromodomain-containing protein 4 isoform 2
NM_001286630.1 NP_001273559.1 bromodomain-containing protein 4 isoform 3
NM_020508.4 NP_065254.3 bromodomain-containing protein 4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
16109376 MGI
enables GTP-dependent protein kinase activity IDA
IDA: Inferred from direct assay
22509028 MGI
enables RNA polymerase II C-terminal domain binding IPI
IPI: Inferred from physical interaction
22509028 MGI
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
IDA: Inferred from direct assay
22509028 MGI
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
IMP: Inferred from mutant phenotype
22509028 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
23154982 MGI
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
29379197 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16109376 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chromosome segregation IMP
IMP: Inferred from mutant phenotype
16339075 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
11997514 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: Inferred from direct assay
16109376 MGI
involved in positive regulation of T-helper 17 cell lineage commitment IMP
IMP: Inferred from mutant phenotype
28262505 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
22509028 MGI
acts upstream of or within protein phosphorylation IPI
IPI: Inferred from physical interaction
16109376 MGI
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
16339075 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
10938129 MGI
part of cyclin/CDK positive transcription elongation factor complex IDA
IDA: Inferred from direct assay
23752591 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16109376 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10938129 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Brd4 Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (57 - 163)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (353 - 454)

BET

BET: pfam17035 (609 - 673)

PHA03247

PHA03247: cl33720 (791 - 1229)

TPH

TPH: cl38442 (1263 - 1306)

BRD4_CDT

BRD4_CDT: pfam17105 (1357 - 1399)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1400 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 4

bromodomain-containing 5

fsh-like protein

mitotic chromosome-associated protein

Brd4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Brd4 Q9ESU6 RELA Homo sapiens Q04206
Pull Down
19103749
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-111916 ODM-207 Inhibitor 99.58% Phase 2
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (121)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100972 ARV-771 Inhibitor 99.87% Unkown
HY-101838 dBET1 Inhibitor 99.24% Unkown
HY-136570 GSK778 Inhibitor 98.93% Unkown
HY-12863 Pelabresib Inhibitor 99.95% Unkown
HY-122826 ZXH-3-26 Inhibitor 98.90% Unkown
HY-136571 GSK046 Inhibitor 99.65% Unkown
HY-14443 XMD8-92 Inhibitor 99.67% Unkown
HY-123941 FKBP12 PROTAC dTAG-7 Inhibitor 99.07% Unkown
HY-100482 CPI-637 Inhibitor 99.94% Unkown
HY-114305 A1874 Inhibitor 99.70% Unkown
HY-107443 I-BET762 carboxylic acid Inhibitor 99.55% Unkown
HY-19999A PF-CBP1 hydrochloride Inhibitor 99.99% Unkown
HY-129937A GNE-987 Inhibitor 99.91% Unkown
HY-120028 GNE-207 Inhibitor 97.02% Unkown
HY-101519 BETd-260 Inhibitor 99.59% Unkown
HY-103632 PROTAC BRD9 Degrader-1 Inhibitor / Unkown
HY-123844 dBET57 Inhibitor 99.94% Unkown
HY-141438 SIM1 Inhibitor 99.57% Unkown
HY-133737 PROTAC BRD4 Degrader-5 Inhibitor 99.93% Unkown
HY-110374 NVS-CECR2-1 Inhibitor 99.40% Unkown
HY-125232 MS645 ≥98.0% Unkown
HY-101146 SF2523 Inhibitor 98.25% Unkown
HY-112429 HJB97 Inhibitor 98.05% Unkown
HY-120000 MS402 Inhibitor 99.62% Unkown
HY-126428 ZL0580 Modulator 99.26% Unkown
HY-138563 GSK973 Inhibitor 99.97% Unkown
HY-156828 MMH2 Degrader 98.03% Unkown
HY-114204 GSK8814 Inhibitor 99.60% Unkown
HY-112609 QCA570 Inhibitor 99.95% Unkown
HY-117491 BRD4 Inhibitor-10 Inhibitor 99.52% Unkown
HY-129917 KB02-JQ1 Inhibitor 99.17% Unkown
HY-111102 FL-411 Inhibitor 99.05% Unkown
HY-136920 CBP/p300-IN-8 Inhibitor 99.94% Unkown
HY-130622 LT052 Inhibitor 98.77% Unkown
HY-133131 PROTAC BRD4 Degrader-1 Inhibitor 99.12% Unkown
HY-114504 RVX-297 Inhibitor 95.00% Unkown
HY-161515 BRD4/NAMPT-IN-1 Inhibitor 99.45% Unkown
HY-107442 PROTAC BRD4-binding moiety 1 / Unkown
HY-112376 MZP-54 Inhibitor 98.16% Unkown
HY-112610 CF53 Inhibitor 99.78% Unkown
HY-148864 JQ1-TCO Inhibitor 99.95% Unkown
HY-156827 MMH1 Degrader 98.08% Unkown
HY-111875 SNIPER(BRD)-1 Inhibitor 99.43% Unkown
HY-114416 GS-626510 Inhibitor 99.80% Unkown
HY-101121 NI-42 Inhibitor 99.53% Unkown
HY-111502 Y06036 Inhibitor 98.57% Unkown
HY-160528 IBG3 Inhibitor 98.53% Unkown
HY-147202 BRD4 Inhibitor-24 Inhibitor 99.27% Unkown
HY-146208 BRD4 Inhibitor-20 Inhibitor 99.00% Unkown
HY-145260 BRD4/CK2-IN-1 Inhibitor 98.62% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% Unkown
HY-142520 I-BET567 Inhibitor 99.49% Unkown
HY-139148 UMB298 Inhibitor 99.11% Unkown
HY-158031 PLK1/BRD4-IN-5 Inhibitor 99.55% Unkown
HY-129201 ZEN-2759 Inhibitor 99.45% Unkown
HY-145264 OARV-771 Inhibitor 98.33% Unkown
HY-148864A (Z)-JQ1-TCO Inhibitor 99.34% Unkown
HY-160557 PLK1/BRD4-IN-2 Inhibitor / Unkown
HY-160558 PLK1/BRD4-IN-3 Inhibitor 99.66% Unkown
HY-136857 BRD4 degrader-3 Degrader / Unkown
HY-111503 Y06137 Inhibitor 99.90% Unkown
HY-103297 OXFBD02 Inhibitor 98.04% Unkown
HY-107425A cis-MZ 1 Degrader / Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-135236 OXFBD04 Inhibitor 98.99% Unkown
HY-114407 TD-428 Inhibitor / Unkown
HY-146999 YM458 Inhibitor 99.16% Unkown
HY-161651 BRD4 ligand 6 / Unkown
HY-111977 ZEN-3219 Inhibitor 99.75% Unkown
HY-133136 PROTAC BRD4 Degrader-2 Inhibitor / Unkown
HY-146660 BRD4 Inhibitor-18 Inhibitor / Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-102044 BET-IN-2 Inhibitor / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-163413 BRD4-BD1-IN-3 Inhibitor / Unkown
HY-161368 BRD-SF2 Degrader / Unkown
HY-149098 SJ1461 Inhibitor / Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown
HY-153945 BET-IN-15 Inhibitor / Unkown
HY-153519 WWL0245 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-162240 SJH1-51B Degrader / Unkown
HY-143300 BRD4-BD1-IN-2 Inhibitor / Unkown
HY-151972 BRD4 Inhibitor-25 Inhibitor / Unkown
HY-W265951 3-Methylcarbostyril Inhibitor / Unkown
HY-111978 ZEN-3862 Inhibitor 98.86% Unkown
HY-157460 BRD4 Inhibitor-29 / Unkown
HY-143328 PROTAC BRD4 Degrader-17 Degrader / Unkown
HY-157290 HL403 Inhibitor / Unkown
HY-169170 PARP1/BRD4-IN-3 Inhibitor / Unkown
HY-143299 BRD4-BD1-IN-1 Inhibitor / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-111979 ZEN-3411 Inhibitor / Unkown
HY-144338 PARP1/BRD4-IN-1 Inhibitor / Unkown
HY-139294 PROTAC BRD4 Degrader-15 Inhibitor / Unkown
HY-132128 BRD4 Inhibitor-12 Inhibitor / Unkown
HY-169358 L134 Inhibitor / Unkown
HY-150684 GXH-II-052 Inhibitor / Unkown
HY-150613 PARP1/BRD4-IN-2 Inhibitor / Unkown
HY-147375 Bromodomain inhibitor-10 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-130612 PROTAC BRD2/BRD4 degrader-1 Inhibitor / Unkown
HY-135558 PROTAC BRD4 Degrader-3 Inhibitor / Unkown
HY-158331 Gal-ARV-771 Degrader / Unkown
HY-131203 PROTAC BRD4 Degrader-6 Inhibitor / Unkown
HY-143235 BRD4 Inhibitor-15 Inhibitor / Unkown
HY-160662 BRD4-IN-5 Inhibitor / Unkown
HY-161650 PROTAC BRD4 Degrader-26 Degrader / Unkown
HY-104072 BRD4-IN-3 Inhibitor / Unkown
HY-168634 SJ46421 Inhibitor / Unkown
HY-129937 (S)-GNE-987 Inhibitor / Unkown
HY-136794 SB-284851-BT Inhibitor / Unkown
HY-163638 BRD4 degrader-1 Degrader / Unkown
HY-150683 NC-III-49-1 Inhibitor / Unkown
HY-142705 BRD4 D1-IN-2 Inhibitor / Unkown
HY-147374 Bromodomain inhibitor-9 Inhibitor / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-163639 BRD4 degrader-2 Inhibitor / Unkown
HY-100696 PNZ5 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown
HY-132130 BRD4 Inhibitor-13 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brd4 NCBI NCBI:23476