BRD4 - bromodomain containing 4 Gene

Homo sapiens

Also known as CAP; MCAP; HUNK1; HUNKI

Gene ID: 23476 | Gene type: protein coding

About BRD4

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,235,519-15,332,539 (from NCBI)

This gene has 13 transcripts (splice variants), 66 orthologues, 11 paralogues and is associated with 111 phenotypes. Ubiquitous expression in placenta (RPKM 10.8), testis (RPKM 9.2) and 25 other tissues.

Summary

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

BRD4 Products(11)

mRNA	Protein	Name
NM_001379292.1	NP_001366221.1	bromodomain-containing protein 4 isoform short
NM_001330384.2	NP_001317313.1	bromodomain-containing protein 4 isoform 3
XM_047438543.1	XP_047294499.1	bromodomain-containing protein 4 isoform X4
XM_047438541.1	XP_047294497.1	bromodomain-containing protein 4 isoform X2
XM_047438542.1	XP_047294498.1	bromodomain-containing protein 4 isoform X3
XR_007066712.1
NM_001379291.1	NP_001366220.1	bromodomain-containing protein 4 isoform long
XM_047438544.1	XP_047294500.1	bromodomain-containing protein 4 isoform X4
XM_047438540.1	XP_047294496.1	bromodomain-containing protein 4 isoform X1
NM_058243.3	NP_490597.1	bromodomain-containing protein 4 isoform long
NM_014299.3	NP_055114.1	bromodomain-containing protein 4 isoform short

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables P-TEFb complex binding	IDA IDA: Inferred from direct assay	17690245	GOA
enables RNA polymerase II C-terminal domain binding	IDA IDA: Inferred from direct assay	22509028	GOA
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IMP IMP: Inferred from mutant phenotype	22509028	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20871596	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	21555454	GOA
enables histone reader activity	IDA IDA: Inferred from direct assay	23086925	GOA
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	20871596	GOA
enables p53 binding	IDA IDA: Inferred from direct assay	23317504	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17023018	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	23086925	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	21555454	GOA
enables transcription coregulator activity	IMP IMP: Inferred from mutant phenotype	24360279	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	23728299	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	23728299	GOA
involved in negative regulation by host of viral transcription	IDA IDA: Inferred from direct assay	17690245	GOA
involved in negative regulation of DNA damage checkpoint	IMP IMP: Inferred from mutant phenotype	23728299	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21555454	GOA
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	10938129	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19103749	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23086925	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	19103749	GOA
acts upstream of or within positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18039861	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	19103749	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18039861	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome	IDA IDA: Inferred from direct assay	23728299	GOA
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	10938129	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20871596	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD4 Protein Structure

Bromodomain

0
300
600
900
1200
1362 a.a.

Protein Preferred Names

Protein Names

bromodomain-containing protein 4

chromosome-associated protein

mitotic chromosome-associated protein

BRD4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	BRD4	O60885	E2	Human papillomavirus	P03120	SLC	22761572
Cross	BRD4	O60885	E2	Human papillomavirus	P03120	Anti Tag CoIP	15109495
Cross	BRD4	O60885	E2	Human papillomavirus	P03120	Y2H	18305892
Intra	BRD4	O60885	TWIST1	Homo sapiens	Q15672	NMR	24525235
Intra	BRD4	O60885	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	BRD4	O60885	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Cross	BRD4	O60885	E2	Human papillomavirus	P04015	Affinity Chrom	17023018
Cross	BRD4	O60885	E2	Human papillomavirus	P04015	SLC	22761572
Cross	BRD4	O60885	E2	Human papillomavirus	P06790	SLC	22761572
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	Anti Bait CoIP	19103749
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	Pull Down	23686307
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	NMR	22645123
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	Anti Bait CoIP	23686307
Intra	BRD4	O60885	RELA	Homo sapiens	Q04206	X-Ray Diffraction	23686307
Intra	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Pull Down	24360279
Intra	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Anti Bait CoIP	24360279
Intra	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Anti Tag CoIP	24360279
Intra	BRD4	O60885	JMJD6	Homo sapiens	Q6NYC1	Y2H	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BRD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7846	BRD4 Protein, Human (His-Flag)	O60885-1 (E49-E460)	≥95%

BRD4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80976	BRD4 Antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Rhabdomyosarcoma

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies	Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome
Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Desmoplastic/Nodular Medulloblastoma	Medulloblastoma With Extensive Nodularity
Desmoplastic Medulloblastoma	Medulloblastoma, Somatic
Medulloblastoma, Desmoplastic	Brain Medulloblastoma
Cns Pnet	Infratentorial Primitive Neuroectodermal Tumor
Mben	Medulloblastoma Desmoplastic
Neuroectodermal Tumors, Primitive	Medulloblastomas
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Cornelia De Lange Syndrome 1

De Lange Syndrome	CDLS1
Cdl	Cdls
Typus Degenerativus Amstelodamensis	Brachmann-De Lange Syndrome
Bdls	Amstelodamensis Typus Degenerativus
Cornelia De Lange Syndrome, Type 1

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Ureteral Obstruction

Heterophyiasis

Heterophyes Infectious Disease

Nasal Cavity Cancer

Nasal Cavity Carcinoma	Malignant Neoplasm Of Nasal Cavities
Malignant Tumor Of The Nasal Cavity	Cancer Of Nasal Cavity
Carcinoma Of Nasal Cavity	Malignant Neoplasm Of Nasal Cavity
Neoplasm Of Nasal Cavity

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111916	ODM-207	Inhibitor	99.58%	Phase 2
HY-112090	ABBV-744	Inhibitor	99.97%	Phase 1

Pre-clinical Phase

Bioactive Molecules (122)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101838	dBET1	Inhibitor	99.24%	Unkown
HY-100972	ARV-771	Inhibitor	99.87%	Unkown
HY-136570	GSK778	Inhibitor	98.93%	Unkown
HY-12863	Pelabresib	Inhibitor	99.95%	Unkown
HY-122826	ZXH-3-26	Inhibitor	98.90%	Unkown
HY-136571	GSK046	Inhibitor	99.65%	Unkown
HY-14443	XMD8-92	Inhibitor	99.67%	Unkown
HY-100482	CPI-637	Inhibitor	99.94%	Unkown
HY-123941	FKBP12 PROTAC dTAG-7	Inhibitor	99.07%	Unkown
HY-114305	A1874	Inhibitor	99.70%	Unkown
HY-107443	I-BET762 carboxylic acid	Inhibitor	99.55%	Unkown
HY-19999A	PF-CBP1 hydrochloride	Inhibitor	99.99%	Unkown
HY-129937A	GNE-987	Inhibitor	99.91%	Unkown
HY-120028	GNE-207	Inhibitor	97.02%	Unkown
HY-101519	BETd-260	Inhibitor	99.59%	Unkown
HY-103632	PROTAC BRD9 Degrader-1	Inhibitor	/	Unkown
HY-123844	dBET57	Inhibitor	99.94%	Unkown
HY-141438	SIM1	Inhibitor	99.57%	Unkown
HY-110374	NVS-CECR2-1	Inhibitor	99.40%	Unkown
HY-101146	SF2523	Inhibitor	98.25%	Unkown
HY-133737	PROTAC BRD4 Degrader-5	Inhibitor	99.93%	Unkown
HY-125232	MS645		≥98.0%	Unkown
HY-126428	ZL0580	Modulator	99.26%	Unkown
HY-114204	GSK8814	Inhibitor	99.60%	Unkown
HY-112609	QCA570	Inhibitor	99.95%	Unkown
HY-112429	HJB97	Inhibitor	98.05%	Unkown
HY-120000	MS402	Inhibitor	99.62%	Unkown
HY-138563	GSK973	Inhibitor	99.97%	Unkown
HY-156828	MMH2	Degrader	98.03%	Unkown
HY-117491	BRD4 Inhibitor-10	Inhibitor	99.52%	Unkown
HY-111102	FL-411	Inhibitor	99.05%	Unkown
HY-129917	KB02-JQ1	Inhibitor	99.17%	Unkown
HY-136920	CBP/p300-IN-8	Inhibitor	99.94%	Unkown
HY-130622	LT052	Inhibitor	98.77%	Unkown
HY-133131	PROTAC BRD4 Degrader-1	Inhibitor	99.12%	Unkown
HY-114504	RVX-297	Inhibitor	95.00%	Unkown
HY-161515	BRD4/NAMPT-IN-1	Inhibitor	99.45%	Unkown
HY-107442	PROTAC BRD4-binding moiety 1		/	Unkown
HY-112610	CF53	Inhibitor	99.78%	Unkown
HY-148864	JQ1-TCO	Inhibitor	99.95%	Unkown
HY-156827	MMH1	Degrader	98.08%	Unkown
HY-111875	SNIPER(BRD)-1	Inhibitor	99.43%	Unkown
HY-101121	NI-42	Inhibitor	99.53%	Unkown
HY-111502	Y06036	Inhibitor	98.57%	Unkown
HY-160528	IBG3	Inhibitor	98.53%	Unkown
HY-147202	BRD4 Inhibitor-24	Inhibitor	99.27%	Unkown
HY-146208	BRD4 Inhibitor-20	Inhibitor	99.00%	Unkown
HY-112376	MZP-54	Inhibitor	98.16%	Unkown
HY-145260	BRD4/CK2-IN-1	Inhibitor	98.62%	Unkown
HY-131061	BET bromodomain inhibitor 1	Inhibitor	99.91%	Unkown
HY-114416	GS-626510	Inhibitor	99.80%	Unkown
HY-142520	I-BET567	Inhibitor	99.49%	Unkown
HY-139148	UMB298	Inhibitor	99.11%	Unkown
HY-158031	PLK1/BRD4-IN-5	Inhibitor	99.55%	Unkown
HY-129201	ZEN-2759	Inhibitor	99.51%	Unkown
HY-145264	OARV-771	Inhibitor	98.33%	Unkown
HY-136857	BRD4 degrader-3	Degrader	99.43%	Unkown
HY-103297	OXFBD02	Inhibitor	98.04%	Unkown
HY-148864A	(Z)-JQ1-TCO	Inhibitor	99.34%	Unkown
HY-160557	PLK1/BRD4-IN-2	Inhibitor	/	Unkown
HY-160558	PLK1/BRD4-IN-3	Inhibitor	99.66%	Unkown
HY-111503	Y06137	Inhibitor	99.90%	Unkown
HY-107425A	cis-MZ 1	Degrader	/	Unkown
HY-110215	XD14	Inhibitor	95.02%	Unkown
HY-114407	TD-428	Inhibitor	/	Unkown
HY-146999	YM458	Inhibitor	99.16%	Unkown
HY-161651	BRD4 ligand 6		/	Unkown
HY-135236	OXFBD04	Inhibitor	98.99%	Unkown
HY-111977	ZEN-3219	Inhibitor	99.75%	Unkown
HY-133136	PROTAC BRD4 Degrader-2	Inhibitor	/	Unkown
HY-146660	BRD4 Inhibitor-18	Inhibitor	/	Unkown
HY-126325	BY27	Inhibitor	/	Unkown
HY-102044	BET-IN-2	Inhibitor	/	Unkown
HY-149806	Bromodomain IN-2	Inhibitor	/	Unkown
HY-163413	BRD4-BD1-IN-3	Inhibitor	/	Unkown
HY-161368	BRD-SF2	Degrader	/	Unkown
HY-149098	SJ1461	Inhibitor	/	Unkown
HY-149100	PLK1-IN-6	Inhibitor	/	Unkown
HY-153945	BET-IN-15	Inhibitor	/	Unkown
HY-162240	SJH1-51B	Degrader	/	Unkown
HY-163282	NB512	Inhibitor	/	Unkown
HY-W265951	3-Methylcarbostyril	Inhibitor	/	Unkown
HY-143300	BRD4-BD1-IN-2	Inhibitor	/	Unkown
HY-111978	ZEN-3862	Inhibitor	98.86%	Unkown
HY-157460	BRD4 Inhibitor-29		/	Unkown
HY-143328	PROTAC BRD4 Degrader-17	Degrader	/	Unkown
HY-157290	HL403	Inhibitor	/	Unkown
HY-169170	PARP1/BRD4-IN-3	Inhibitor	/	Unkown
HY-143299	BRD4-BD1-IN-1	Inhibitor	/	Unkown
HY-155680	BET BD2-IN-1	Inhibitor	/	Unkown
HY-111979	ZEN-3411	Inhibitor	/	Unkown
HY-147374	Bromodomain inhibitor-9	Inhibitor	/	Unkown
HY-144338	PARP1/BRD4-IN-1	Inhibitor	/	Unkown
HY-139294	PROTAC BRD4 Degrader-15	Inhibitor	/	Unkown
HY-132128	BRD4 Inhibitor-12	Inhibitor	/	Unkown
HY-150613	PARP1/BRD4-IN-2	Inhibitor	/	Unkown
HY-147375	Bromodomain inhibitor-10	Inhibitor	/	Unkown
HY-150684	GXH-II-052	Inhibitor	/	Unkown
HY-153519	WWL0245	Inhibitor	/	Unkown
HY-152213	BET-IN-13	Inhibitor	/	Unkown
HY-130612	PROTAC BRD2/BRD4 degrader-1	Inhibitor	/	Unkown
HY-151972	BRD4 Inhibitor-25	Inhibitor	/	Unkown
HY-135558	PROTAC BRD4 Degrader-3	Inhibitor	/	Unkown
HY-158331	Gal-ARV-771	Degrader	/	Unkown
HY-131203	PROTAC BRD4 Degrader-6	Inhibitor	/	Unkown
HY-143235	BRD4 Inhibitor-15	Inhibitor	/	Unkown
HY-160662	BRD4-IN-5	Inhibitor	/	Unkown
HY-161650	PROTAC BRD4 Degrader-26	Degrader	/	Unkown
HY-104072	BRD4-IN-3	Inhibitor	/	Unkown
HY-168634	SJ46421	Inhibitor	/	Unkown
HY-129937	(S)-GNE-987	Inhibitor	/	Unkown
HY-136794	SB-284851-BT	Inhibitor	/	Unkown
HY-163638	BRD4 degrader-1	Degrader	/	Unkown
HY-150683	NC-III-49-1	Inhibitor	/	Unkown
HY-142705	BRD4 D1-IN-2	Inhibitor	/	Unkown
HY-163639	BRD4 degrader-2	Inhibitor	/	Unkown
HY-143471	WNY0824	Inhibitor	/	Unkown
HY-169358	L134	Inhibitor	/	Unkown
HY-100696	PNZ5	Inhibitor	/	Unkown
HY-136570A	GSK778 hydrochloride	Inhibitor	/	Unkown
HY-132130	BRD4 Inhibitor-13	Inhibitor	/	Unkown
HY-155222	TW9	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BRD4	VGNC	VGNC:38520
Macaca mulatta	BRD4	VGNC	VGNC:70301
Felis catus	BRD4	VGNC	VGNC:60168
Bos taurus	BRD4	VGNC	VGNC:26559
Rattus norvegicus	BRD4	RGD	RGD:1307282
Mus musculus	BRD4	MGD	MGI:1888520
Others	BRD4	NCBI

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