1. Gene
  2. BCL2L2 - BCL2 like 2 Gene

BCL2L2 - BCL2 like 2 Gene

Homo sapiens

Also known as BCLW; BCL-W; PPP1R51; BCL2-L-2

Gene ID: 599 | Gene type: protein coding

About BCL2L2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,306,833-23,311,751 (from NCBI)

This gene has 10 transcripts (splice variants), 61 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 35.0), fat (RPKM 31.5) and 25 other tissues.

Summary

This gene encodes a member of the Bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell Apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

BCL2L2 Products(2)

mRNA Protein Name
NM_004050.5 NP_004041.2 bcl-2-like protein 2
NM_001199839.2 NP_001186768.2 bcl-2-like protein 2

BCL2L2 Protein Structure

BH4

BH4: Bcl-2 homology region 4 (7 - 31)

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (46 - 144)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 2

apoptosis regulator BCL-W

protein phosphatase 1, regulatory subunit 51

BCL2L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BCL2L2 Q92843 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
BCL2L2 Q92843 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1
Y2H Array
32296183
Intra
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1
Validated Y2H
32296183
Intra
BCL2L2 Q92843 RTL10 Homo sapiens Q7L3V2
Anti Tag CoIP
23055042
Intra
BCL2L2 Q92843 MGST2 Homo sapiens Q99735
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 MGST2 Homo sapiens Q99735
Validated Y2H
32296183
Intra
BCL2L2 Q92843 MGST2 Homo sapiens Q99735
Y2H Array
32296183
Intra
BCL2L2 Q92843 TEX11 Homo sapiens Q8IYF3-3
Y2H
27107012
Intra
BCL2L2 Q92843 TEX11 Homo sapiens Q8IYF3-3
BFG-2H
27107012
Intra
BCL2L2 Q92843 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
BCL2L2 Q92843 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra
BCL2L2 Q92843 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 GPR151 Homo sapiens Q8TDV0
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 GPR151 Homo sapiens Q8TDV0
Y2H Array
32296183
Intra
BCL2L2 Q92843 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
BCL2L2 Q92843 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
BCL2L2 Q92843 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra
BCL2L2 Q92843 BNIP5 Homo sapiens P0C671
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 BNIP5 Homo sapiens P0C671
Y2H Array
32296183
Intra
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2
Y2H Array
32296183
Intra
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2
Validated Y2H
32296183
Intra
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
BCL2L2 Q92843 SLC39A6 Homo sapiens Q13433-2
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 SLC39A6 Homo sapiens Q13433-2
Y2H Array
32296183
Intra
BCL2L2 Q92843 C10orf67 Homo sapiens Q8IYJ2-2
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 C10orf67 Homo sapiens Q8IYJ2-2
Y2H Array
32296183
Intra
BCL2L2 Q92843 SLC35E3 Homo sapiens Q7Z769
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 SLC35E3 Homo sapiens Q7Z769
Y2H Array
32296183
Intra
BCL2L2 Q92843 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2
Validated Y2H
32296183
Intra
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2
Y2H Array
32296183
Intra
BCL2L2 Q92843 BHLHA9 Homo sapiens Q7RTU4
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 BHLHA9 Homo sapiens Q7RTU4
Y2H Array
32296183
Intra
BCL2L2 Q92843 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
BCL2L2 Q92843 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra
BCL2L2 Q92843 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08
Validated Y2H
32296183
Intra
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 APOC4 Homo sapiens P55056
Y2H Array
32296183
Intra
BCL2L2 Q92843 APOC4 Homo sapiens P55056
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 ATP5PF Homo sapiens P18859
Y2H Array
32296183
Intra
BCL2L2 Q92843 ATP5PF Homo sapiens P18859
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 LRP10 Homo sapiens Q7Z4F1
Y2H Array
32296183
Intra
BCL2L2 Q92843 LRP10 Homo sapiens Q7Z4F1
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
BCL2L2 Q92843 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9
Y2H Array
32296183
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9
Y2H Prey Pooling
25416956
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9
Validated Y2H
25416956
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9
Validated Y2H
32296183
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9
Y2H Array
25416956
Intra
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 G0S2 Homo sapiens P27469
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 G0S2 Homo sapiens P27469
Y2H Array
32296183
Intra
BCL2L2 Q92843 BAX Homo sapiens Q07812
Anti Tag CoIP
17289999
Intra
BCL2L2 Q92843 BAX Homo sapiens Q07812
Anti Tag CoIP
21199865
Intra
BCL2L2 Q92843 BAX Homo sapiens Q07812
Anti Tag CoIP
33961781
Intra
BCL2L2 Q92843 BID Homo sapiens P55957
Anti Tag CoIP
33961781
Intra
BCL2L2 Q92843 BID Homo sapiens P55957
FPS
16697956
Intra
BCL2L2 Q92843 BAK1 Homo sapiens Q16611
Y2H Array
32296183
Intra
BCL2L2 Q92843 BAK1 Homo sapiens Q16611
Y2H Prey Pooling
25416956
Intra
BCL2L2 Q92843 BAK1 Homo sapiens Q16611
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 BAK1 Homo sapiens Q16611
Y2H Array
25416956
Intra
BCL2L2 Q92843 BBC3 Homo sapiens Q9BXH1
Anti Tag CoIP
28514442
Intra
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521
Anti Tag CoIP
33961781
Intra
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521
Y2H Array
32296183
Intra
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
BCL2L2 Q92843 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
BCL2L2 Q92843 BAD Homo sapiens Q92934
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 BAD Homo sapiens Q92934
Y2H Array
32296183
Intra
BCL2L2 Q92843 BAD Homo sapiens Q92934
ITC
22000515
Intra
BCL2L2 Q92843 BAD Homo sapiens Q92934
Validated Y2H
32296183
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323
Y2H
27107012
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323
Validated Y2H
27107012
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323
SLC
27107012
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323
BFG-2H
27107012
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7
Validated Y2H
32296183
Intra
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7
Y2H Array
32296183
Intra
BCL2L2 Q92843 ANKS6 Homo sapiens Q68DC2
Y2H Array
32296183
Intra
BCL2L2 Q92843 ANKS6 Homo sapiens Q68DC2
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Cross
BCL2L2 Q92843 Bmf Mus musculus Q91ZE9
FPS
16697956
Intra
BCL2L2 Q92843 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra
BCL2L2 Q92843 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
BCL2L2 Q92843 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0
BFG-2H
27107012
Intra
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
BCL2L2 Q92843 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
BCL2L2 Q92843 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCL2L2 Proteins

Cat. No. Product Name Accession Purity
HY-P7653 Bcl-2-like protein 2 Protein, Human (His) AAI13523.1 (A2-T172) ≥95%

Related Diseases

Diseases Alias
Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BCL2L2 RGD RGD:620717
Mus musculus BCL2L2 MGD MGI:108052
Bos taurus BCL2L2 VGNC VGNC:55105
Others BCL2L2 NCBI