2. Gene
  3. TEAD4 - TEA domain transcription factor 4 Gene

TEAD4 - TEA domain transcription factor 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TEF3; RTEF1; TEF-3; EFTR-2; TEFR-1; TCF13L1; hRTEF-1B

Gene ID: 7004 | Gene type: protein coding

About TEAD4

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:2,959,397-3,040,676 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 4.8), placenta (RPKM 4.3) and 23 other tissues.

Summary

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

TEAD4 Products(3)

mRNA Protein Name
NM_003213.4 NP_003204.2 transcriptional enhancer factor TEF-3 isoform 1
NM_201441.3 NP_958849.1 transcriptional enhancer factor TEF-3 isoform 2
NM_201443.3 NP_958851.1 transcriptional enhancer factor TEF-3 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18579750 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in hippo signaling IDA
IDA: Inferred from direct assay
18579750 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
25796446 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD4 Protein Structure

TEA

TEA: TEA/ATTS domain family (15 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 434 a.a.
Protein Preferred Names Protein Names

transcriptional enhancer factor TEF-3

TEA domain family member 4

TEAD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TEAD4 Q15561 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
TEAD4 Q15561 KRT40 Homo sapiens Q6A162
Validated Y2H
26871637
Intra
TEAD4 Q15561 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
TEAD4 Q15561 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 KRT40 Homo sapiens Q6A162
Y2H Array
26871637
Intra
TEAD4 Q15561 HOMEZ Homo sapiens Q8IX15-3
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 HOMEZ Homo sapiens Q8IX15-3
Validated Y2H
26871637
Intra
TEAD4 Q15561 HOMEZ Homo sapiens Q8IX15-3
Y2H Array
26871637
Intra
TEAD4 Q15561 YAP1 Homo sapiens P46937
Comig Non-Denat Gel
26592798
Intra
TEAD4 Q15561 YAP1 Homo sapiens P46937
ITC
26592798
Intra
TEAD4 Q15561 YAP1 Homo sapiens P46937
BLI
24525233
Intra
TEAD4 Q15561 YAP1 Homo sapiens P46937
Anti Tag CoIP
33961781
Intra
TEAD4 Q15561 YAP1 Homo sapiens P46937
Pull Down
24525233
Intra
TEAD4 Q15561 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
TEAD4 Q15561 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
26871637
Intra
TEAD4 Q15561 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
TEAD4 Q15561 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
26871637
Intra
TEAD4 Q15561 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
TEAD4 Q15561 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
TEAD4 Q15561 VGLL3 Homo sapiens A8MV65-2
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 VGLL3 Homo sapiens A8MV65-2
Y2H Array
32296183
Intra
TEAD4 Q15561 RUNDC3A Homo sapiens Q59EK9-3
Validated Y2H
26871637
Intra
TEAD4 Q15561 RUNDC3A Homo sapiens Q59EK9-3
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 RUNDC3A Homo sapiens Q59EK9-3
Y2H Array
26871637
Intra
TEAD4 Q15561 CCDC125 Homo sapiens Q86Z20
Validated Y2H
32296183
Intra
TEAD4 Q15561 CCDC125 Homo sapiens Q86Z20
Y2H Array
32296183
Intra
TEAD4 Q15561 CCDC125 Homo sapiens Q86Z20
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 VGLL1 Homo sapiens Q99990
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 VGLL1 Homo sapiens Q99990
Validated Y2H
32296183
Intra
TEAD4 Q15561 VGLL1 Homo sapiens Q99990
Y2H Array
32296183
Intra
TEAD4 Q15561 RUNX1 Homo sapiens Q01196-8
Y2H Array
32296183
Intra
TEAD4 Q15561 RUNX1 Homo sapiens Q01196-8
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
TEAD4 Q15561 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
TEAD4 Q15561 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 HAUS1 Homo sapiens Q96CS2
Validated Y2H
32296183
Intra
TEAD4 Q15561 HAUS1 Homo sapiens Q96CS2
Y2H Array
32296183
Intra
TEAD4 Q15561 CCDC172 Homo sapiens P0C7W6
Y2H Array
26871637
Intra
TEAD4 Q15561 CCDC172 Homo sapiens P0C7W6
Validated Y2H
26871637
Intra
TEAD4 Q15561 CCDC172 Homo sapiens P0C7W6
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 VPS52 Homo sapiens Q8N1B4
Y2H Array
26871637
Intra
TEAD4 Q15561 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 VPS52 Homo sapiens Q8N1B4
Validated Y2H
26871637
Intra
TEAD4 Q15561 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
TEAD4 Q15561 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 PNMA1 Homo sapiens Q8ND90
Y2H Array
26871637
Intra
TEAD4 Q15561 PNMA1 Homo sapiens Q8ND90
Validated Y2H
26871637
Intra
TEAD4 Q15561 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
TEAD4 Q15561 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
TEAD4 Q15561 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 TRAF1 Homo sapiens Q13077
Y2H Array
26871637
Intra
TEAD4 Q15561 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 TRAF1 Homo sapiens Q13077
Validated Y2H
26871637
Intra
TEAD4 Q15561 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
TEAD4 Q15561 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Intra
TEAD4 Q15561 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra
TEAD4 Q15561 VGLL4 Homo sapiens Q14135
Pull Down
24525233
Intra
TEAD4 Q15561 VGLL4 Homo sapiens Q14135
Anti Tag CoIP
24525233
Intra
TEAD4 Q15561 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
TEAD4 Q15561 SESTD1 Homo sapiens Q86VW0
Validated Y2H
32296183
Intra
TEAD4 Q15561 SESTD1 Homo sapiens Q86VW0
Y2H Array
32296183
Intra
TEAD4 Q15561 SESTD1 Homo sapiens Q86VW0
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 GOLGA2 Homo sapiens Q08379
Validated Y2H
26871637
Intra
TEAD4 Q15561 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 GOLGA2 Homo sapiens Q08379
Y2H Array
26871637
Intra
TEAD4 Q15561 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
TEAD4 Q15561 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
TEAD4 Q15561 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 RASSF10 Homo sapiens A6NK89
Y2H Array
32296183
Intra
TEAD4 Q15561 RASSF10 Homo sapiens A6NK89
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 SAT1 Homo sapiens P21673
Y2H Array
32296183
Intra
TEAD4 Q15561 SAT1 Homo sapiens P21673
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 TRIM27 Homo sapiens P14373
Y2H Array
26871637
Intra
TEAD4 Q15561 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
TEAD4 Q15561 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
26871637
Intra
TEAD4 Q15561 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 TRIM27 Homo sapiens P14373
Validated Y2H
26871637
Intra
TEAD4 Q15561 VTA1 Homo sapiens Q9NP79
Anti Tag CoIP
28514442
Intra
TEAD4 Q15561 VTA1 Homo sapiens Q9NP79
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 VTA1 Homo sapiens Q9NP79
Validated Y2H
32296183
Intra
TEAD4 Q15561 VTA1 Homo sapiens Q9NP79
Y2H Array
32296183
Intra
TEAD4 Q15561 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
32296183
Intra
TEAD4 Q15561 DYDC1 Homo sapiens Q8WWB3
Y2H Array
32296183
Intra
TEAD4 Q15561 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra
TEAD4 Q15561 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
TEAD4 Q15561 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
TEAD4 Q15561 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
TEAD4 Q15561 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 WWTR1 Homo sapiens Q9GZV5
Anti Tag CoIP
33961781
Intra
TEAD4 Q15561 WWTR1 Homo sapiens Q9GZV5
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 WWTR1 Homo sapiens Q9GZV5
Anti Tag CoIP
28514442
Intra
TEAD4 Q15561 WWTR1 Homo sapiens Q9GZV5
Y2H Pooling
16189514
Intra
TEAD4 Q15561 WWTR1 Homo sapiens Q9GZV5
Y2H Array
32296183
Intra
TEAD4 Q15561 WWTR1 Homo sapiens Q9GZV5
Anti Tag CoIP
20972459
Intra
TEAD4 Q15561 WWTR1 Homo sapiens Q9GZV5
Y2H Array
31515488
Intra
TEAD4 Q15561 WWTR1 Homo sapiens Q9GZV5
Validated Y2H
32296183
Intra
TEAD4 Q15561 CEP55 Homo sapiens Q53EZ4
Validated Y2H
32296183
Intra
TEAD4 Q15561 CEP55 Homo sapiens Q53EZ4
Y2H Array
31515488
Intra
TEAD4 Q15561 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
32296183
Intra
TEAD4 Q15561 CEP55 Homo sapiens Q53EZ4
Y2H Array
32296183
Intra
TEAD4 Q15561 CEP55 Homo sapiens Q53EZ4
Y2H
21516116
Cross
TEAD4 Q15561 Vgll4 Mus musculus Q80V24
Pull Down
24525233
Intra
TEAD4 Q15561 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
TEAD4 Q15561 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TEAD4 Proteins

Cat. No. Product Name Accession Purity
HY-P71535 TEAD4 Protein, Human (His) Q15561 (74M-434E) ≥95%

Related Diseases

Diseases Alias
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125269 TED-347 Inhibitor 98.97% Unkown
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-RS14345 TEAD4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-160657 DC-TEADin04 / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TEAD4 VGNC VGNC:35727
Macaca mulatta TEAD4 VGNC VGNC:78304
Felis catus TEAD4 VGNC VGNC:66056
Mus musculus TEAD4 MGD MGI:106907
Rattus norvegicus TEAD4 RGD RGD:1585671
Canis familiaris TEAD4 VGNC VGNC:57446
Others TEAD4 NCBI