TEAD4 - TEA domain transcription factor 4 Gene

Homo sapiens

Also known as TEF3; RTEF1; TEF-3; EFTR-2; TEFR-1; TCF13L1; hRTEF-1B

Gene ID: 7004 | Gene type: protein coding

About TEAD4

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:2,959,397-3,040,676 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 4.8), placenta (RPKM 4.3) and 23 other tissues.

Summary

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

TEAD4 Products(3)

mRNA	Protein	Name
NM_003213.4	NP_003204.2	transcriptional enhancer factor TEF-3 isoform 1
NM_201441.3	NP_958849.1	transcriptional enhancer factor TEF-3 isoform 2
NM_201443.3	NP_958851.1	transcriptional enhancer factor TEF-3 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18579750	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	18579750	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	25796446	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD4 Protein Structure

TEA

0
100
200
300
400
434 a.a.

Protein Preferred Names

Protein Names

transcriptional enhancer factor TEF-3

TEA domain family member 4

Recombinant TEAD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71535	TEAD4 Protein, Human (His)	Q15561 (74M-434E)	≥95%

Related Diseases

Diseases

Alias

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125269	TED-347	Inhibitor	98.97%	Unkown
HY-139330	MGH-CP1	Inducer	99.21%	Unkown
HY-RS14345	TEAD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-160657	DC-TEADin04		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TEAD4	VGNC	VGNC:35727
Macaca mulatta	TEAD4	VGNC	VGNC:78304
Felis catus	TEAD4	VGNC	VGNC:66056
Mus musculus	TEAD4	MGD	MGI:106907
Rattus norvegicus	TEAD4	RGD	RGD:1585671
Canis familiaris	TEAD4	VGNC	VGNC:57446
Others	TEAD4	NCBI

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