2. Gene
  3. NAA10 - N-alpha-acetyltransferase 10, NatA catalytic subunit Gene

NAA10 - N-alpha-acetyltransferase 10, NatA catalytic subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1

Gene ID: 8260 | Gene type: protein coding

About NAA10

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,929,225-153,935,037 (from NCBI)

This gene has 16 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 8 phenotypes. Ubiquitous expression in fat (RPKM 16.8), appendix (RPKM 16.4) and 25 other tissues.

Summary

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

NAA10 Products(3)

mRNA Protein Name
NM_001256119.2 NP_001243048.1 N-alpha-acetyltransferase 10 isoform 2
NM_001256120.2 NP_001243049.1 N-alpha-acetyltransferase 10 isoform 3
NM_003491.4 NP_003482.1 N-alpha-acetyltransferase 10 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to acetyltransferase activity IDA
IDA: Inferred from direct assay
15496142 GOA
contributes to peptide alpha-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
19480662 GOA
enables peptide alpha-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
25489052 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15496142 GOA
contributes to ribosome binding IDA
IDA: Inferred from direct assay
15496142 GOA
Biological Process GO Annotation Evidence Reference Source
involved in N-terminal protein amino acid acetylation IDA
IDA: Inferred from direct assay
15496142 GOA
involved in negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric IDA
IDA: Inferred from direct assay
27422821 GOA
involved in protein acetylation IDA
IDA: Inferred from direct assay
27708256 GOA
Cellular Component GO Annotation Evidence Reference Source
part of NatA complex IDA
IDA: Inferred from direct assay
19480662 GOA
part of NatA complex IPI
IPI: Inferred from physical interaction
15496142 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15496142 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15496142 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA10 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (48 - 123)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

N-alpha-acetyltransferase 10

ARD1 homolog A, N-acetyltransferase

NAA10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NAA10 P41227 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
NAA10 P41227 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
NAA10 P41227 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
NAA10 P41227 EHMT2 Homo sapiens A2ABF9
Y2H Array
25416956
Intra
NAA10 P41227 EHMT2 Homo sapiens A2ABF9
Validated Y2H
25416956
Intra
NAA10 P41227 ZBTB14 Homo sapiens O43829
Validated Y2H
25416956
Intra
NAA10 P41227 ZBTB14 Homo sapiens O43829
Y2H Array
25416956
Intra
NAA10 P41227 ZBTB14 Homo sapiens O43829
Y2H Array
32296183
Intra
NAA10 P41227 ZBTB14 Homo sapiens O43829
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 BCOR Homo sapiens Q6W2J9-4
Validated Y2H
25416956
Intra
NAA10 P41227 BCOR Homo sapiens Q6W2J9-4
Y2H Array
25416956
Intra
NAA10 P41227 NAA15 Homo sapiens Q9BXJ9
Anti Bait CoIP
15496142
Intra
NAA10 P41227 NAA15 Homo sapiens Q9BXJ9
Anti Bait CoIP
19480662
Intra
NAA10 P41227 NAA15 Homo sapiens Q9BXJ9
IF
15496142
Intra
NAA10 P41227 NAA15 Homo sapiens Q9BXJ9
Anti Tag CoIP
15496142
Intra
NAA10 P41227 NAA15 Homo sapiens Q9BXJ9
Anti Tag CoIP
33961781
Intra
NAA10 P41227 CREBRF Homo sapiens Q8IUR6
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 CREBRF Homo sapiens Q8IUR6
Validated Y2H
32296183
Intra
NAA10 P41227 CREBRF Homo sapiens Q8IUR6
Y2H Array
32296183
Intra
NAA10 P41227 DHX57 Homo sapiens Q6P158
Validated Y2H
32296183
Intra
NAA10 P41227 NAA50 Homo sapiens Q9GZZ1
Anti Tag CoIP
33961781
Intra
NAA10 P41227 NAA50 Homo sapiens Q9GZZ1
Anti Bait CoIP
16507339
Intra
NAA10 P41227 NAA50 Homo sapiens Q9GZZ1
Anti Bait CoIP
19480662
Intra
NAA10 P41227 SEMA3B Homo sapiens Q13214-2
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 SEMA3B Homo sapiens Q13214-2
Validated Y2H
32296183
Intra
NAA10 P41227 SEMA3B Homo sapiens Q13214-2
Y2H Array
32296183
Intra
NAA10 P41227 PDE4DIP Homo sapiens Q5VU43
Validated Y2H
25416956
Intra
NAA10 P41227 PDE4DIP Homo sapiens Q5VU43
Anti Tag CoIP
33961781
Intra
NAA10 P41227 ACOT12 Homo sapiens Q8WYK0
Validated Y2H
32296183
Intra
NAA10 P41227 ACOT12 Homo sapiens Q8WYK0
Y2H Array
32296183
Intra
NAA10 P41227 ACOT12 Homo sapiens Q8WYK0
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 GPATCH2L Homo sapiens Q9NWQ4-1
Y2H Array
32296183
Intra
NAA10 P41227 GPATCH2L Homo sapiens Q9NWQ4-1
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
Intra
NAA10 P41227 RAB3IP Homo sapiens Q96QF0-7
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 RAB3IP Homo sapiens Q96QF0-7
Validated Y2H
32296183
Intra
NAA10 P41227 RAB3IP Homo sapiens Q96QF0-7
Y2H Array
32296183
Intra
NAA10 P41227 KRTAP10-6 Homo sapiens P60371
Validated Y2H
32296183
Intra
NAA10 P41227 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
NAA10 P41227 NOXA1 Homo sapiens Q86UR1-2
MAPPIT
32296183
Intra
NAA10 P41227 NOXA1 Homo sapiens Q86UR1-2
Validated Y2H
32296183
Intra
NAA10 P41227 BAALC Homo sapiens Q8WXS3-2
Y2H Array
32296183
Intra
NAA10 P41227 BAALC Homo sapiens Q8WXS3-2
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 BAALC Homo sapiens Q8WXS3-2
Validated Y2H
32296183
Intra
NAA10 P41227 ARHGEF6 Homo sapiens Q15052
Anti Tag CoIP
21295525
Intra
NAA10 P41227 ARHGEF6 Homo sapiens Q15052
Pull Down
21295525
Intra
NAA10 P41227 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
NAA10 P41227 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
NAA10 P41227 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 NFE2L2 Homo sapiens Q16236
Acetylase Assay
36442525
Intra
NAA10 P41227 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
25416956
Intra
NAA10 P41227 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra
NAA10 P41227 RBCK1 Homo sapiens Q9BYM8
Validated Y2H
25416956
Intra
NAA10 P41227 MRPS11 Homo sapiens P82912
Validated Y2H
32296183
Intra
NAA10 P41227 MRPS11 Homo sapiens P82912
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 PPP2R3B Homo sapiens Q9Y5P8
Y2H Array
32296183
Intra
NAA10 P41227 PPP2R3B Homo sapiens Q9Y5P8
Validated Y2H
32296183
Intra
NAA10 P41227 PPP2R3B Homo sapiens Q9Y5P8
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 SNX33 Homo sapiens Q8WV41
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 SNX33 Homo sapiens Q8WV41
Validated Y2H
32296183
Intra
NAA10 P41227 SNX33 Homo sapiens Q8WV41
Y2H Array
32296183
Intra
NAA10 P41227 TSEN54 Homo sapiens Q7Z6J9
Validated Y2H
32296183
Intra
NAA10 P41227 NAA16 Homo sapiens Q6N069
Anti Tag CoIP
33961781
Intra
NAA10 P41227 NAA16 Homo sapiens Q6N069
Anti Tag CoIP
19480662
Intra
NAA10 P41227 NAA16 Homo sapiens Q6N069
Anti Bait CoIP
19480662
Intra
NAA10 P41227 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
NAA10 P41227 MCRS1 Homo sapiens Q96EZ8
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 MCRS1 Homo sapiens Q96EZ8
Y2H Array
32296183
Intra
NAA10 P41227 MKRN1 Homo sapiens Q9UHC7
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 MKRN1 Homo sapiens Q9UHC7
Validated Y2H
32296183
Intra
NAA10 P41227 MKRN1 Homo sapiens Q9UHC7
Y2H Array
32296183
Intra
NAA10 P41227 MDM4 Homo sapiens O15151
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 MDM4 Homo sapiens O15151
Y2H Array
32296183
Intra
NAA10 P41227 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
NAA10 P41227 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
NAA10 P41227 TAF7L Homo sapiens Q5H9L4
Validated Y2H
32296183
Intra
NAA10 P41227 TAF7L Homo sapiens Q5H9L4
Y2H Array
32296183
Intra
NAA10 P41227 TAF7L Homo sapiens Q5H9L4
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 CCDC106 Homo sapiens Q9BWC9
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 CCDC106 Homo sapiens Q9BWC9
Validated Y2H
32296183
Intra
NAA10 P41227 CCDC106 Homo sapiens Q9BWC9
Y2H Array
32296183
Intra
NAA10 P41227 ARHGEF7 Homo sapiens Q14155
Anti Bait CoIP
21295525
Intra
NAA10 P41227 CDCA5 Homo sapiens Q96FF9
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 CDCA5 Homo sapiens Q96FF9
Validated Y2H
32296183
Intra
NAA10 P41227 CDCA5 Homo sapiens Q96FF9
Y2H Array
32296183
Intra
NAA10 P41227 CALCOCO2 Homo sapiens Q13137
Validated Y2H
32296183
Intra
NAA10 P41227 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra
NAA10 P41227 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra
NAA10 P41227 CALCOCO2 Homo sapiens Q13137
Y2H Array
31515488
Intra
NAA10 P41227 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
NAA10 P41227 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
NAA10 P41227 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra
NAA10 P41227 CEP44 Homo sapiens Q9C0F1
Y2H Array
25416956
Intra
NAA10 P41227 CEP44 Homo sapiens Q9C0F1
Validated Y2H
25416956
Intra
NAA10 P41227 RCN3 Homo sapiens Q96D15
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 RCN3 Homo sapiens Q96D15
Validated Y2H
32296183
Intra
NAA10 P41227 RCN3 Homo sapiens Q96D15
Y2H Array
32296183
Intra
NAA10 P41227 CCDC174 Homo sapiens Q6PII3
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 CCDC174 Homo sapiens Q6PII3
Validated Y2H
32296183
Intra
NAA10 P41227 CCDC174 Homo sapiens Q6PII3
Y2H Array
32296183
Intra
NAA10 P41227 RAB3IP Homo sapiens Q96QF0
Y2H Array
25416956
Intra
NAA10 P41227 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
NAA10 P41227 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
NAA10 P41227 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
32296183
Intra
NAA10 P41227 PLSCR3 Homo sapiens Q9NRY6
Y2H Array
32296183
Intra
NAA10 P41227 PLSCR3 Homo sapiens Q9NRY6
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 ZNF202 Homo sapiens O95125
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 ZNF202 Homo sapiens O95125
Y2H Array
32296183
Intra
NAA10 P41227 KIFAP3 Homo sapiens Q92845
Y2H Array
32296183
Intra
NAA10 P41227 KIFAP3 Homo sapiens Q92845
Y2H Prey Pooling
32296183
Intra
NAA10 P41227 KIFAP3 Homo sapiens Q92845
Y2H Array
31515488
Intra
NAA10 P41227 KIFAP3 Homo sapiens Q92845
Validated Y2H
32296183
Intra
NAA10 P41227 PDE4DIP Homo sapiens Q5VU43-2
Validated Y2H
32296183
Intra
NAA10 P41227 PDE4DIP Homo sapiens Q5VU43-2
Y2H Array
32296183
Intra
NAA10 P41227 PDE4DIP Homo sapiens Q5VU43-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NAA10 Proteins

Cat. No. Product Name Accession Purity
HY-P77096 NAA10/ARD1 Protein, Human (sf9) P41227 (M1-S235) ≥95%
HY-P77097 NAA10/ARD1 Protein, Human (sf9, His-GST) P41227 (M1-S235) ≥95%

Related Diseases

Diseases Alias
Ogden Syndrome

OGDNS

N-Terminal Acetyltransferase Deficiency

NATD

N-Alpha-Acetyltransferase

X-Linked Malformation And Infantile Lethality Syndrome

Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
Cardiogenic Shock

Shock Cardiogenic

Shock, Cardiogenic
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Microphthalmia, Syndromic 13

X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome

MCOPS13

Maine Microphthalmos

Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation

Syndromic Microphthalmia 13

X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome

Microphthalmia, Syndromic, 13

Microphthalmia, Syndromic, Type 13
Syndromic Microphthalmia

Microphthalmia, Syndromic
Epilepsy, Familial Temporal Lobe, 6

ETL6

Familial Temporal Lobe Epilepsy 6
Microcephaly And Chorioretinopathy 2
Developmental Coordination Disorder

Motor Skills Disorders
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08985 NAA10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NAA10 VGNC VGNC:106831
Felis catus NAA10 VGNC VGNC:96704
Canis familiaris NAA10 VGNC VGNC:54174
Mus musculus NAA10 MGD MGI:1915255
Macaca mulatta NAA10 VGNC VGNC:107112
Rattus norvegicus NAA10 RGD RGD:1565315
Others NAA10 NCBI