NAA10 - N-alpha-acetyltransferase 10, NatA catalytic subunit Gene

Homo sapiens

Also known as TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1

Gene ID: 8260 | Gene type: protein coding

About NAA10

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,929,225-153,935,037 (from NCBI)

This gene has 16 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 8 phenotypes. Ubiquitous expression in fat (RPKM 16.8), appendix (RPKM 16.4) and 25 other tissues.

Summary

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

NAA10 Products(3)

mRNA	Protein	Name
NM_001256119.2	NP_001243048.1	N-alpha-acetyltransferase 10 isoform 2
NM_001256120.2	NP_001243049.1	N-alpha-acetyltransferase 10 isoform 3
NM_003491.4	NP_003482.1	N-alpha-acetyltransferase 10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to acetyltransferase activity	IDA IDA: Inferred from direct assay	15496142	GOA
contributes to peptide alpha-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	19480662	GOA
enables peptide alpha-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	25489052	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15496142	GOA
contributes to ribosome binding	IDA IDA: Inferred from direct assay	15496142	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-terminal protein amino acid acetylation	IDA IDA: Inferred from direct assay	15496142	GOA
involved in negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric	IDA IDA: Inferred from direct assay	27422821	GOA
involved in protein acetylation	IDA IDA: Inferred from direct assay	27708256	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NatA complex	IDA IDA: Inferred from direct assay	19480662	GOA
part of NatA complex	IPI IPI: Inferred from physical interaction	15496142	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15496142	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15496142	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA10 Protein Structure

Acetyltransf_1

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

N-alpha-acetyltransferase 10

ARD1 homolog A, N-acetyltransferase

Recombinant NAA10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77096	NAA10/ARD1 Protein, Human (sf9)	P41227 (M1-S235)	≥95%
HY-P77097	NAA10/ARD1 Protein, Human (sf9, His-GST)	P41227 (M1-S235)	≥95%

Related Diseases

Diseases

Alias

Ogden Syndrome

OGDNS	N-Terminal Acetyltransferase Deficiency
NATD	N-Alpha-Acetyltransferase
X-Linked Malformation And Infantile Lethality Syndrome	Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome

Microphthalmia, Syndromic 1

MCOPS1	Lenz Microphthalmia Syndrome
Lenz Dysplasia	Mcops4
Syndromic Microphthalmia 1	Lenz Microphthalmia
Maa	Microphthalmia Or Anophthalmos With Associated Anomalies
Syndromic Microphthalmia Type 4	Microphthalmia, Syndromic 4
Microphthalmia, Syndromic 4, Formerly	Mcops4, Formerly
Anop1, Formerly	Maa, Formerly
Lenz Type Microphthalmia	Syndromic Microphthalmia 4
Microphthalmia Lenz Type	Microphthalmia Syndromic 1
Syndromic Microphthalmia Type 1	Microphthalmia Syndromic 4
Microphthalmia With Ankyloblepharon And Intellectual Disability	Microphthalmia, Lenz Type
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome	Microphthalmia, Syndromic, 1
Anop1	Microphthalmia, Syndromic, Type 1

Cardiogenic Shock

Shock Cardiogenic

Shock, Cardiogenic

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Microphthalmia, Syndromic 13

X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome	MCOPS13
Maine Microphthalmos	Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation
Syndromic Microphthalmia 13	X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome
Microphthalmia, Syndromic, 13	Microphthalmia, Syndromic, Type 13

Syndromic Microphthalmia

Microphthalmia, Syndromic

Epilepsy, Familial Temporal Lobe, 6

ETL6	Familial Temporal Lobe Epilepsy 6

Microcephaly And Chorioretinopathy 2

Developmental Coordination Disorder

Motor Skills Disorders

Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08985	NAA10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NAA10	VGNC	VGNC:106831
Felis catus	NAA10	VGNC	VGNC:96704
Canis familiaris	NAA10	VGNC	VGNC:54174
Mus musculus	NAA10	MGD	MGI:1915255
Macaca mulatta	NAA10	VGNC	VGNC:107112
Rattus norvegicus	NAA10	RGD	RGD:1565315
Others	NAA10	NCBI

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