STK16 - serine/threonine kinase 16 Gene

Homo sapiens

Also known as PSK; KRCT; MPSK; TSF1; hPSK; PKL12

Gene ID: 8576 | Gene type: protein coding

About STK16

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,245,479-219,250,337 (from NCBI)

This gene has 13 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 7.6), brain (RPKM 6.9) and 25 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

STK16 Products(4)

mRNA	Protein	Name
NM_001008910.4	NP_001008910.1	serine/threonine-protein kinase 16 isoform 1
NM_001330213.2	NP_001317142.1	serine/threonine-protein kinase 16 isoform 1
NM_001330214.1	NP_001317143.1	serine/threonine-protein kinase 16 isoform 2
NM_001330215.2	NP_001317144.1	serine/threonine-protein kinase 16 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18184589	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK16 Protein Structure

Pkinase

0
100
200
305 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 16

TGF-beta-stimulated factor 1

STK16 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STK16	O75716	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	STK16	O75716	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	STK16	O75716	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	STK16	O75716	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	STK16	O75716	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	STK16	O75716	KRTAP10-5	Homo sapiens	P60370	Y2H Array	25416956
Intra	STK16	O75716	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	STK16	O75716	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	STK16	O75716	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	STK16	O75716	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	STK16	O75716	KCTD14	Homo sapiens	Q9BQ13	Validated Y2H	25416956
Intra	STK16	O75716	KCTD14	Homo sapiens	Q9BQ13	Y2H Array	25416956
Intra	STK16	O75716	KCTD14	Homo sapiens	Q9BQ13	Y2H Array	29892012
Intra	STK16	O75716	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	32296183
Intra	STK16	O75716	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	STK16	O75716	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	STK16	O75716	ZNF343	Homo sapiens	Q6P1L6	Y2H Prey Pooling	32296183
Intra	STK16	O75716	ZNF343	Homo sapiens	Q6P1L6	Y2H Array	32296183
Intra	STK16	O75716	ZNF343	Homo sapiens	Q6P1L6	Validated Y2H	32296183
Intra	STK16	O75716	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	STK16	O75716	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	STK16	O75716	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KLHL20	Homo sapiens	Q9BS75	Validated Y2H	32296183
Intra	STK16	O75716	KLHL20	Homo sapiens	Q9BS75	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KLHL20	Homo sapiens	Q9BS75	Y2H Array	32296183
Intra	STK16	O75716	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	STK16	O75716	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	STK16	O75716	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	STK16	O75716	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	STK16	O75716	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	STK16	O75716	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	STK16	O75716	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	STK16	O75716	FXR1	Homo sapiens	P51114-2	Validated Y2H	32296183
Intra	STK16	O75716	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	STK16	O75716	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	STK16	O75716	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	STK16	O75716	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	STK16	O75716	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Array	32296183
Intra	STK16	O75716	KRTAP13-2	Homo sapiens	Q52LG2	Validated Y2H	32296183
Intra	STK16	O75716	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	STK16	O75716	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	STK16	O75716	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	STK16	O75716	USP54	Homo sapiens	Q70EL1-9	Validated Y2H	32296183
Intra	STK16	O75716	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	STK16	O75716	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	STK16	O75716	NAA80	Homo sapiens	Q93015-2	Validated Y2H	32296183
Intra	STK16	O75716	MIER3	Homo sapiens	Q7Z3K6-2	Y2H Prey Pooling	32296183
Intra	STK16	O75716	MIER3	Homo sapiens	Q7Z3K6-2	Validated Y2H	32296183
Intra	STK16	O75716	MIER3	Homo sapiens	Q7Z3K6-2	Y2H Array	32296183
Intra	STK16	O75716	KCTD14	Homo sapiens	Q9BQ13-2	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KCTD14	Homo sapiens	Q9BQ13-2	Validated Y2H	32296183
Intra	STK16	O75716	KCTD14	Homo sapiens	Q9BQ13-2	Y2H Array	32296183
Intra	STK16	O75716	ATP23	Homo sapiens	Q9Y6H3	Y2H Prey Pooling	32296183
Intra	STK16	O75716	ATP23	Homo sapiens	Q9Y6H3	Validated Y2H	32296183
Intra	STK16	O75716	ATP23	Homo sapiens	Q9Y6H3	Y2H Array	32296183
Intra	STK16	O75716	RSPO4	Homo sapiens	Q2I0M5	Validated Y2H	32296183
Intra	STK16	O75716	RSPO4	Homo sapiens	Q2I0M5	Y2H Prey Pooling	32296183
Intra	STK16	O75716	RSPO4	Homo sapiens	Q2I0M5	Y2H Array	32296183
Intra	STK16	O75716	BHLHA9	Homo sapiens	Q7RTU4	Y2H Prey Pooling	32296183
Intra	STK16	O75716	BHLHA9	Homo sapiens	Q7RTU4	Validated Y2H	32296183
Intra	STK16	O75716	BHLHA9	Homo sapiens	Q7RTU4	Y2H Array	32296183
Intra	STK16	O75716	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	STK16	O75716	NOTCH2NLC	Homo sapiens	P0DPK4	Validated Y2H	32296183
Intra	STK16	O75716	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	STK16	O75716	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	STK16	O75716	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	STK16	O75716	EFHC2	Homo sapiens	Q5JST6	Y2H Array	25416956
Intra	STK16	O75716	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	25416956
Intra	STK16	O75716	TNFAIP1	Homo sapiens	Q13829	Y2H Array	25416956
Intra	STK16	O75716	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
Intra	STK16	O75716	PKNOX2	Homo sapiens	Q96KN3	Validated Y2H	32296183
Intra	STK16	O75716	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
Intra	STK16	O75716	MIIP	Homo sapiens	Q5JXC2	Y2H Array	31515488
Intra	STK16	O75716	MIIP	Homo sapiens	Q5JXC2	Validated Y2H	25416956
Intra	STK16	O75716	MIIP	Homo sapiens	Q5JXC2	Y2H Array	25416956
Intra	STK16	O75716	PRKAR1B	Homo sapiens	P31321	Validated Y2H	32296183
Intra	STK16	O75716	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	STK16	O75716	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	STK16	O75716	PTH1R	Homo sapiens	Q03431	Y2H Array	32296183
Intra	STK16	O75716	PTH1R	Homo sapiens	Q03431	Y2H Prey Pooling	32296183
Intra	STK16	O75716	PTH1R	Homo sapiens	Q03431	Validated Y2H	32296183
Intra	STK16	O75716	SKIL	Homo sapiens	P12757	Y2H Prey Pooling	25416956
Intra	STK16	O75716	SKIL	Homo sapiens	P12757	Validated Y2H	25416956
Intra	STK16	O75716	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	STK16	O75716	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	STK16	O75716	ZNF330	Homo sapiens	Q9Y3S2	Y2H Array	32296183
Intra	STK16	O75716	ZNF330	Homo sapiens	Q9Y3S2	Y2H Prey Pooling	32296183
Intra	STK16	O75716	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	STK16	O75716	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	STK16	O75716	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	STK16	O75716	DNAJA3	Homo sapiens	Q96EY1-2	Y2H Prey Pooling	25416956
Intra	STK16	O75716	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	32296183
Intra	STK16	O75716	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	32296183
Intra	STK16	O75716	SAXO1	Homo sapiens	Q8IYX7	Y2H Prey Pooling	32296183
Intra	STK16	O75716	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	32296183
Intra	STK16	O75716	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	32296183
Intra	STK16	O75716	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	32296183
Intra	STK16	O75716	SOCS2	Homo sapiens	O14508	Y2H Prey Pooling	32296183
Intra	STK16	O75716	SOCS2	Homo sapiens	O14508	Y2H Array	32296183
Intra	STK16	O75716	GABPA	Homo sapiens	Q06546	Validated Y2H	32296183
Cross	STK16	O75716	tir	Escherichia coli O157:H7	Q7DB77	Lumier	25519916
Intra	STK16	O75716	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	STK16	O75716	INCA1	Homo sapiens	Q0VD86	Validated Y2H	25416956
Intra	STK16	O75716	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	STK16	O75716	INCA1	Homo sapiens	Q0VD86	Y2H Array	25416956
Intra	STK16	O75716	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	STK16	O75716	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	STK16	O75716	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	STK16	O75716	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	STK16	O75716	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	STK16	O75716	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	STK16	O75716	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	STK16	O75716	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	STK16	O75716	DRG1	Homo sapiens	Q9Y295	Y2H Array	25416956
Intra	STK16	O75716	DRG1	Homo sapiens	Q9Y295	Validated Y2H	25416956
Intra	STK16	O75716	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
Intra	STK16	O75716	FRS3	Homo sapiens	O43559	Y2H Array	32296183
Intra	STK16	O75716	FRS3	Homo sapiens	O43559	Y2H Prey Pooling	32296183
Intra	STK16	O75716	PLA2G10	Homo sapiens	O15496	Y2H Array	32296183
Intra	STK16	O75716	PLA2G10	Homo sapiens	O15496	Y2H Prey Pooling	32296183
Intra	STK16	O75716	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	STK16	O75716	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	STK16	O75716	PLSCR1	Homo sapiens	O15162	Y2H Prey Pooling	25416956
Intra	STK16	O75716	ADAMTSL4	Homo sapiens	Q6UY14	Y2H Array	19060904
Intra	STK16	O75716	ADAMTSL4	Homo sapiens	Q6UY14	Y2H Pooling	19060904
Intra	STK16	O75716	ADAMTSL4	Homo sapiens	Q6UY14	Y2H Pooling	16189514
Intra	STK16	O75716	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	STK16	O75716	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	STK16	O75716	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	STK16	O75716	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	25416956
Intra	STK16	O75716	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956
Intra	STK16	O75716	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	STK16	O75716	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	STK16	O75716	EFEMP2	Homo sapiens	O95967	Validated Y2H	32296183
Intra	STK16	O75716	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	32296183
Intra	STK16	O75716	EFEMP2	Homo sapiens	O95967	Y2H Array	32296183
Intra	STK16	O75716	EFEMP2	Homo sapiens	O95967	Y2H Array	25416956
Intra	STK16	O75716	KCTD17	Homo sapiens	Q8N5Z5	Y2H Prey Pooling	25416956
Intra	STK16	O75716	KCTD17	Homo sapiens	Q8N5Z5	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KCTD17	Homo sapiens	Q8N5Z5	Validated Y2H	32296183
Intra	STK16	O75716	KCTD17	Homo sapiens	Q8N5Z5	Y2H Array	32296183
Intra	STK16	O75716	KCTD17	Homo sapiens	Q8N5Z5	Y2H Pooling	16189514
Intra	STK16	O75716	RPIA	Homo sapiens	P49247	Validated Y2H	25416956
Intra	STK16	O75716	RPIA	Homo sapiens	P49247	Y2H Pooling	16189514
Intra	STK16	O75716	RFX6	Homo sapiens	Q8HWS3	Validated Y2H	25416956
Intra	STK16	O75716	RFX6	Homo sapiens	Q8HWS3	Y2H Array	25416956
Intra	STK16	O75716	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	STK16	O75716	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956
Intra	STK16	O75716	CRX	Homo sapiens	O43186	Y2H Array	25416956
Intra	STK16	O75716	CRX	Homo sapiens	O43186	Y2H Prey Pooling	25416956
Intra	STK16	O75716	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	STK16	O75716	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	STK16	O75716	PLSCR3	Homo sapiens	Q9NRY6	Y2H Prey Pooling	25416956
Intra	STK16	O75716	PLSCR3	Homo sapiens	Q9NRY6	Validated Y2H	25416956
Intra	STK16	O75716	PLSCR3	Homo sapiens	Q9NRY6	Y2H Prey Pooling	32296183
Intra	STK16	O75716	PLSCR3	Homo sapiens	Q9NRY6	Validated Y2H	32296183
Intra	STK16	O75716	PLSCR3	Homo sapiens	Q9NRY6	Y2H Array	32296183
Intra	STK16	O75716	PCSK5	Homo sapiens	Q92824	Y2H Prey Pooling	25416956
Intra	STK16	O75716	ARNT2	Homo sapiens	Q9HBZ2	Y2H Prey Pooling	32296183
Intra	STK16	O75716	ARNT2	Homo sapiens	Q9HBZ2	Y2H Array	32296183
Intra	STK16	O75716	CBX3	Homo sapiens	Q13185	Y2H Prey Pooling	32296183
Intra	STK16	O75716	CBX3	Homo sapiens	Q13185	Validated Y2H	32296183
Intra	STK16	O75716	CBX3	Homo sapiens	Q13185	Y2H Array	32296183
Cross	STK16	O75716	Drg1	Mus musculus	P32233	Y2H	18184589
Cross	STK16	O75716	Drg1	Mus musculus	P32233	Pull Down	18184589
Cross	STK16	O75716	Drg1	Mus musculus	P32233	Protein Kinase Assay	18184589
Cross	STK16	O75716	Drg1	Mus musculus	P32233	Anti Bait CoIP	18184589
Intra	STK16	O75716	CFP	Homo sapiens	P27918	Y2H Array	32296183
Intra	STK16	O75716	CFP	Homo sapiens	P27918	Y2H Prey Pooling	32296183
Intra	STK16	O75716	CFP	Homo sapiens	P27918	Validated Y2H	32296183
Intra	STK16	O75716	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	STK16	O75716	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	STK16	O75716	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	STK16	O75716	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STK16 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76097	STK16 Protein, Human (His)	O75716 (M1-I305)	≥95%

Related Diseases

Diseases

Alias

Diffuse Mesangial Sclerosis

Familial Mesangial Sclerosis	Mesangial Sclerosis, Diffuse
Dms	Diffuse Isolated Mesangial Sclerosis
Isolated Diffuse Mesangial Sclerosis	Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19353	SR7826	Inhibitor	99.30%	Unkown
HY-101270	STK16-IN-1	Inhibitor	99.95%	Unkown
HY-RS13923	STK16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STK16	VGNC	VGNC:65776
Mus musculus	STK16	MGD	MGI:1313271
Rattus norvegicus	STK16	RGD	RGD:629474
Canis familiaris	STK16	VGNC	VGNC:46906
Bos taurus	STK16	VGNC	VGNC:35387
Macaca mulatta	STK16	VGNC	VGNC:77912
Others	STK16	NCBI

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