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Results for "

5-HT2C receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (117) Adrenergic Receptor (11) Androgen Receptor (1) Apoptosis (3) Autophagy (1) Dopamine Receptor (20) Endogenous Metabolite (6) GABA Receptor (1) Histamine Receptor (10) Isotope-Labeled Compounds (7) mAChR (3) Melatonin Receptor (7) Monoamine Oxidase (1) Orexin Receptor (OX Receptor) (2) Parasite (1) Phosphatase (1) Potassium Channel (2) Serotonin Transporter (1) Sigma Receptor (1) Sodium Channel (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (6) Endocrinology (10) Infection (3) Inflammation/Immunology (10) Metabolic Disease (10) Neurological Disease (107)

By Targets:

5-HT Receptor (117)

Adrenergic Receptor (11)

Androgen Receptor (1)

Apoptosis (3)

Autophagy (1)

Dopamine Receptor (20)

Endogenous Metabolite (6)

GABA Receptor (1)

Histamine Receptor (10)

Isotope-Labeled Compounds (7)

mAChR (3)

Melatonin Receptor (7)

Monoamine Oxidase (1)

Orexin Receptor (OX Receptor) (2)

Parasite (1)

Phosphatase (1)

Potassium Channel (2)

Serotonin Transporter (1)

Sigma Receptor (1)

Sodium Channel (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (6)

Endocrinology (10)

Infection (3)

Inflammation/Immunology (10)

Metabolic Disease (10)

Neurological Disease (107)

127

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156601

Bexicaserin	Others	Others
Bexicaserin (Compound 3) is a 5-HT2C receptor agonist with potential for studying obesity and psychiatric-related diseases .

HY-133113

7-Desmethyl-agomelatine 1 Publications Verification	5-HT Receptor	Neurological Disease
7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C .

HY-124821

VA012	5-HT Receptor	Neurological Disease Metabolic Disease
VA012 (compound 11) is a positive allosteric modulator (PAM) of the serotonin *5-HT_2C* receptor. VA012 reduces food intake and body weight gain without causing CNS-related malaise during subchronic administration. VA012 can be utilized in obesity research .

HY-119103

PF-03246799	5-HT Receptor	Neurological Disease
PF-03246799 (PF-3246799) is a potent and selective **5-HT2C receptor agonist with an EC₅₀ of 190 nM and a K_i** of 160 nM. PF-03246799 shows selectivity for 5-HT2C over 5-HT2A and 5-HT2B receptors. PF-03246799 has the potential for stress urinary incontinence (SUI) research .

HY-A0172

Captodiame Captodiamine	5-HT Receptor Dopamine Receptor Sigma Receptor	Neurological Disease
Captodiame (Captodiamine) is a **5-HT_2c receptor antagonist and sigma-1** and D3 dopamine receptor agonist. Captodiame shows antidepressant effect .

HY-116524

PF-04781340	5-HT Receptor	Neurological Disease
PF-04781340 is a potent and selective **5-HT2C receptor** agonist. PF-04781340 is orally available and have central nervous system penetrant profile .

HY-133858

25N-NBOMe hydrochloride	5-HT Receptor	Neurological Disease
25N-NBOMe hydrochloride, a 2C-N derivative, is a 5-HT2A and **5-HT2C receptors agonist with K_i** values of 0.144 nM and 1.06 nM, respectively. 25N-NBOMe hydrochloride has little to no efficacy at inducing release of preloaded neurotransmitter from recombinant dopamine, serotonin and norepinephrine transporters .

HY-169001

5-HT2A/5-HT2C inverse agonist 1	5-HT Receptor	Neurological Disease
5-HT2A/5-HT2C inverse agonist 1 is a potent and dual 5-HT2A and *5-HT2C* receptor inverse agonist with a hERG inhibitions, thus avoiding cardiovascular risks. 5-HT2A/5-HT2C inverse agonist 1 shows significant antipsychotic efficacy in the MK-801 (HY-15084B)-induced mouse model. 5-HT2A/5-HT2C inverse agonist 1 is promising for research of psychosis .

HY-124947

PF-4522654	5-HT Receptor	Neurological Disease
PF-4522654 is a potent, selective and brain-permeable **5-HT_2C receptor agonist with an EC₅₀ of 16 nM and a K_i** of 8 nM. PF-4522654 shows no measurable functional agonism at no 5-HT_2A and 5-HT_2B receptors. PF-4522654 can be used for the study of stress urinary incontinence (SUI) .

HY-167677

ASP-2205	5-HT Receptor	Neurological Disease
ASP-2205 is a *5-HT_2C* receptor agonist (human *5-HT_2C* receptor, EC₅₀=0.85 nM; rat *5-HT_2C* receptor, EC₅₀=2.5 nM). ASP-2205 enhances the pudendal nerve-mediated urethral closure reflex through the *5-HT_2C* receptor, thereby preventing urinary incontinence .

HY-100330

YM348	5-HT Receptor	Metabolic Disease
YM348 is a potent and orally active **5-HT_2C receptor agonist, which shows a high affinity for cloned human 5-HT_2C receptor (K_i**: 0.89 nM).

HY-101630

Deramciclane EGIS-3886	5-HT Receptor	Neurological Disease
Deramciclane has a high affinity for 5-HT_2A and *5-HT_2C* receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT_2C receptors without direct stimulatory agonist.

HY-156532C

(-)-5-HT2C agonist-3	5-HT Receptor	Neurological Disease
(-)-5-HT2C agonist-3 (compound (–)-19) is a *5-HT_2C* selective agonist with G_q signaling preference, with EC₅₀ values ??for 5-HT₂ receptors of *5-HT_2C: 103 nM; 5-HT_2B: 570 nM; 5-HT_2A: 72 nM. (-)-5-HT2C* agonist-3 can be used in antipsychotic research .

HY-103140

Ro60-0175 fumarate	5-HT Receptor	Neurological Disease
Ro60-0175 fumarate is a potent and selective agonist of *5-HT_2C* receptor .

HY-15401

WAY 163909	5-HT Receptor	Cancer
WAY 163909 is a potent and selective **5-HT(2C) receptor agonist with a K_i** of 10.5±1.1 nM.

HY-111200

Vabicaserin hydrochloride 2 Publications Verification SCA 136	5-HT Receptor	Neurological Disease
Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT_2C) *receptor*-selective agonist with an EC₅₀ of 8 nM.

HY-100171

PRX933 hydrochloride GW876167 hydrochloride; BVT-933 hydrochloride	5-HT Receptor	Cardiovascular Disease
PRX933 hydrochloride is a **5-HT_2c receptor** agonist extracted from patent WO 2014140631 A1.

HY-118450

FR260010 free base	5-HT Receptor	Neurological Disease
FR260010 free base is a selective **5-HT_2C receptor antagonist, with a K_i** value of 1.1 nM .

HY-103112

SB 243213 hydrochloride	5-HT Receptor	Neurological Disease
SB 243213 hydrochloride is an orally active, selective and high-affinity **5-HT_2C receptor antagonist with a pK_i of 9.37 and a pK_b** of 9.8 for human 5-HT_2C receptor. SB 243213 hydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders .

HY-103112A

SB 243213 dihydrochloride	5-HT Receptor	Neurological Disease
SB 243213 dihydrochloride is an orally active, selective and high-affinity **5-HT_2C receptor antagonist with a pK_i of 9.37 and a pK_b** of 9.8 for human 5-HT_2C receptor. SB 243213 dihydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders .

HY-103112B

SB 243213	5-HT Receptor	Neurological Disease
SB 243213 is an orally active, selective and high-affinity **5-HT_2C receptor antagonist with a pK_i of 9.37 and a pK_b** of 9.8 for human 5-HT_2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders .

HY-156601A

(S)-Bexicaserin	5-HT Receptor	Neurological Disease
(S)-Bexcaserin (compound 2) is a *5-HT_2C* receptor agonist with potential for studying obesity and psychiatric-related diseases .

HY-123838

Ro60-0175	5-HT Receptor	Neurological Disease
Ro60-0175 is a potent and selective agonist of *5-HT_2C* receptor. Ro60-0175 reduces self-administration .

HY-101630A

Deramciclane fumarate EGIS-3886 fumarate	5-HT Receptor	Others
Deramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of **5-HT_2C Receptor with an IC₅₀** of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis .

HY-103135

SB 206553 hydrochloride	5-HT Receptor	Neurological Disease
SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT_2B / 5-HT_2C receptor antagonist (rat 5-HT_2B pA2 = 8.89, human 5-HT_2C pKi = 7.92) . SB 206553 possesses anxiolytic-like properties .

HY-103138A

(Rac)-WAY-161503	5-HT Receptor	Neurological Disease Metabolic Disease
(Rac)-WAY-161503 is a potent, selective, highly affinity **5-HT_2C receptor agonist with a K_i** of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects .

HY-103138

(Rac)-WAY-161503 hydrochloride	5-HT Receptor	Neurological Disease Metabolic Disease
(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity **5-HT_2C receptor agonist with a K_i** of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects .

HY-17038

Agomelatine 4 Publications Verification S-20098	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-17038A

Agomelatine hydrochloride 4 Publications Verification S-20098 hydrochloride	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine hydrochloride is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-101365

RS-102221	5-HT Receptor	Neurological Disease
RS-102221 is a selective **5-HT2C receptor antagonist (K_i=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A** and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats .

HY-101365A

RS-102221 hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
RS-102221 hydrochloride is a selective **5-HT2C receptor antagonist (K_i=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A** and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats .

HY-N0145R

Puerarin (Standard)	5-HT Receptor	Inflammation/Immunology Cancer
Puerarin (Standard) is the analytical standard of Puerarin. This product is intended for research and analytical applications. Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.

HY-103120

Org37684	5-HT Receptor	Neurological Disease
Org37684 is a highly potent **5-HT_2C receptor agonist (pEC₅₀*=8.17). Org37684 exhibits a rank order of potency of 5-HT_2C>5-HT_2B>5-HT_2A.* Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC₅₀=7.96) and ten times for the 5-HT_2A (pEC₅₀=7.11) receptor .

HY-17038B

Agomelatine (L(+)-Tartaric acid) 4 Publications Verification S-20098 L(+)-Tartaric acid	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine L(+)-Tartaric acid is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-133111

3-Hydroxy agomelatine	5-HT Receptor	Neurological Disease
3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a **5-HT_2C receptor antagonist with an IC₅₀ of 3.2 μM and a K_i** of 1.8 μM .

HY-117118A

AC-90179	5-HT Receptor	Neurological Disease
AC-90179 is a selective 5-HT2A receptor inverse agonist (K_i = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound .

HY-118339

PF-4479745	5-HT Receptor	Cardiovascular Disease Cancer
PF-4479745 is a potent and selective *5-HT_2C* receptor agonist (EC₅₀: 10 nM, k_i: 15 nM). PF-4479745 can be used in the research of cardiovascular disease like hypertension .

HY-B0102C

(R)-Fluoxetine hydrochloride	Serotonin Transporter	Neurological Disease
(R)-Fluoxetine hydrochloride, an antidepressant, is serotonin reuptake inhibitor (SSRI). (R)-Fluoxetine hydrochloride has modest affinity at the 5-HT_2A and 5-HT_2C receptors .

HY-17038S1

Agomelatine-d4 S-20098-d₄	Isotope-Labeled Compounds Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine-d₄ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

HY-17038S2

Agomelatine-d3 S-20098-d₃	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine-d₃ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

HY-17038R

Agomelatine (Standard)	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatine (Standard) is the analytical standard of Agomelatine. This product is intended for research and analytical applications. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-15401A

WAY 163909 hydrochloride	5-HT Receptor	Others
WAY-163909 hydrochloride is a potent 5-hydroxytryptamine receptor 2C (5-HT2C) agonist with an EC50 of 8 nM and a maximum efficacy of 90%, while displaying minimal activity at 5-HT2A receptors. Its selectivity is further demonstrated by Ki values of 10.5 nM for 5-HT2C, alongside higher Ki values for 5-HT2A (212 nM), 5-HT7 (343 nM), and 5-HT2B (485 nM), and it lacks significant activity at various other receptors.

HY-103155

SB-221284	5-HT Receptor	Neurological Disease
SB 221284 is a selective *5-HT_2C/2B* receptor antagonist with pK_i values are 6.4, 7.9 and 8.6 for 5-HT_2A, 5-HT_2B and *5-HT_2C* receptors, respectively. SB 221284 can be used for the research of neurological disease .

HY-16687B

Eltoprazine dihydrochloride DU 28853 dihydrochloride	5-HT Receptor	Neurological Disease
Eltoprazine (DU 28853) dihydrochloride is a 5-HT1A/5-HT1B receptors agonist and a **5-HT2C receptor** antagonist. Eltoprazine dihydrochloride shows antiaggressive and anxiogenic effects .

HY-16687

Eltoprazine DU 28853	5-HT Receptor	Neurological Disease
Eltoprazine (DU 28853) is a 5-HT1A/5-HT1B receptors agonist and a **5-HT2C receptor** antagonist. Eltoprazine shows antiaggressive and anxiogenic effects .

HY-16687A

Eltoprazine hydrochloride DU 28853 hydrochloride	5-HT Receptor	Neurological Disease
Eltoprazine (DU 28853) hydrochloride is a 5-HT1A/5-HT1B receptors agonist and a **5-HT2C receptor** antagonist. Eltoprazine hydrochloride shows antiaggressive and anxiogenic effects .

HY-133024

Flumexadol	5-HT Receptor	Neurological Disease
Flumexadol is a selective and affinity **5-HT_2C receptor agonist with a K_i** of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT_2A receptor. Flumexadol is an orally active non-narcotic analgesic .

HY-N8200

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Inflammation/Immunology
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a *5-HT2C* receptor agonist . ..

HY-132225

SB 206553	5-HT Receptor	Inflammation/Immunology
SB 206553 is a 5-HT_2C inverse agonist. SB 206553 can attenuate methamphetamine-seeking in rats. SB 206553 has activity for 5-HT2 receptor ligands in HEK-293 or CHO-K1 cells expressing human recombinant 5-HT2 receptors with pKi values of 5.6 nM (5-HT_2A), 7.7 nM (5-HT_2B) and 7.8 nM (5-HT_2C), respectively. SB 206553 can be used for the research of psychostimulant abuse disorders .

HY-15543A

CP-809101 hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
CP-809101 hydrochloride is a potent and highly selective *5-HT_2C* receptor agonist, with pEC₅₀s of 9.96, 7.19 and 6.81 M for human *5HT_2C, 5HT_2B* and 5HT_2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence .

Cat. No.	Product Name	Type

HY-15401A

WAY 163909 hydrochloride

Biochemical Assay Reagents

WAY-163909 hydrochloride is a potent 5-hydroxytryptamine receptor 2C (5-HT2C) agonist with an EC50 of 8 nM and a maximum efficacy of 90%, while displaying minimal activity at 5-HT2A receptors. Its selectivity is further demonstrated by Ki values of 10.5 nM for 5-HT2C, alongside higher Ki values for 5-HT2A (212 nM), 5-HT7 (343 nM), and 5-HT2B (485 nM), and it lacks significant activity at various other receptors.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17038

Agomelatine 4 Publications Verification S-20098	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-17038A

Agomelatine hydrochloride 4 Publications Verification S-20098 hydrochloride	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine hydrochloride is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-17038B

Agomelatine (L(+)-Tartaric acid) 4 Publications Verification S-20098 L(+)-Tartaric acid	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine L(+)-Tartaric acid is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-N0145

Puerarin Maximum Cited Publications 15 Publications Verification	Structural Classification Flavonoids Pueraria edulis Pampan. Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	5-HT Receptor
Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV)-vagus nerve pathway, which in turn leads to decreased fat absorption .

HY-N0049

Nuciferine 5 Publications Verification	Structural Classification Alkaloids Aporphine Alkaloids other families Source classification Plants Isoquinoline Alkaloids	Parasite 5-HT Receptor Dopamine Receptor
Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), *5-HT_2C* (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-N0145R

Puerarin (Standard)	Structural Classification Flavonoids Pueraria edulis Pampan. Leguminosae Source classification Phenols Polyphenols Plants Isoflavones	5-HT Receptor
Puerarin (Standard) is the analytical standard of Puerarin. This product is intended for research and analytical applications. Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.

HY-17038R

Agomelatine (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Endogenous metabolite	Melatonin Receptor 5-HT Receptor Endogenous Metabolite
Agomelatine (Standard) is the analytical standard of Agomelatine. This product is intended for research and analytical applications. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective **5-HT2C receptor antagonist with pK_i*s of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C* receptors, respectively .

HY-N8200

Cassiaside B2	Monophenols Classification of Application Fields Cassia obtusifolia L. Source classification Phenols Caesalpiniaceae Plants Disease Research Fields Inflammation/Immunology	Phosphatase Monoamine Oxidase 5-HT Receptor
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a *5-HT2C* receptor agonist . ..

HY-N0049R

Nuciferine (Standard)	Structural Classification Alkaloids other families Source classification Plants	5-HT Receptor Dopamine Receptor
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT_2A (IC₅₀=478 nM), *5-HT_2C* (IC₅₀=131 nM), and 5-HT_2B (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

Cat. No.	Product Name	Chemical Structure

HY-17038S2

Agomelatine-d3
Agomelatine-d₃ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

HY-133111S

3-Hydroxy agomelatine-d3
3-Hydroxy agomelatine-d₃ is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM[1].

HY-B0781S

Promethazine-d4 hydrochloride
Promethazine-d₄ (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

HY-17038S1

Agomelatine-d4
Agomelatine-d₄ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

HY-B0781S1

Promethazine-d3 hydrochloride

Promethazine-d₃ (hydrochloride) is deuterium labeled Promethazine (hydrochloride). Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors .

HY-14264S

Cyamemazine-d6
Cyamemazine-d₆ is the deuterium labeled Cyamemazine. Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity[1][2].

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].

HY-B0031S3

Quetiapine-d8 hemifumarate

Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

HY-B0031S4

Quetiapine hemifumarate-d8

Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2].

HY-B0031S5

Quetiapine-d4-1 fumarate

Quetiapine-d₄-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-14153S

Tegaserod-d11

Tegaserod-d₁₁ is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

HY-10564S

Sarpogrelate-d3 hydrochloride

Sarpogrelate-d₃ (hydrochloride) is the deuterium labeled Sarpogrelate hydrochloride. Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis[1][2][3].

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