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Results for "

Immunogenicity

" in MedChemExpress (MCE) Product Catalog:

57

Inhibitors & Agonists

3

Screening Libraries

18

Biochemical Assay Reagents

22

Peptides

3

Inhibitory Antibodies

3

Natural
Products

13

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-157745

    mPEG-SC (MW 40000); mPEG-Succinimidyl ester (MW 40000)

    Biochemical Assay Reagents Others
    m-PEG-NHS ester (MW 40000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects .
    m-PEG-NHS ester (MW 40000)
  • HY-Y0873
    PEG300
    85+ Cited Publications

    Polyethylene glycol 300

    Biochemical Assay Reagents Others
    PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
    PEG300
  • HY-W587780

    SMX-NO

    Others Inflammation/Immunology
    Sulfamethoxazole-NO (SMX-NO) is the major immunogen in sulfonamide allergy, producing modest ascorbic acid depletion and hemoglobin adduct formation. Sulfamethoxazole-NO haptens tissue proteins and is immunogenic in rodents .
    Sulfamethoxazole-NO
  • HY-153545

    Others Cancer
    9-Amino-NeuAc is a substrate of synthase. 9-Amino-NeuAc can be converted to CMP9-amino-NeuAc, activated to the corresponding CMPglycoside and transferred to asialoglycoprotein. 9-Amino-NeuAc can be used to target liposome synthesis while modulating tumor surface immunogenicity .
    9-Amino-NeuAc
  • HY-157174

    Others Inflammation/Immunology
    Mannosamine-desthiobiotin adduct (compound MDTBA) is a carrier immunogenicity-reducing hapten that reduces the immunogenicity of protein carriers upon conjugation to available free amines on the carrier protein surface. Conjugation of Mannosamine-desthiobiotin adduct to hsIgG significantly (>1-fold) reduced the immunogenicity of hsIgG. Mannosamine-desthiobiotin adduct can be used in antigen design research .
    Mannosamine–desthiobiotin adduct
  • HY-159671B

    3D-MPL (14) ammonium

    Toll-like Receptor (TLR) Inflammation/Immunology
    3D-Monophosphoryl Lipid (14) (ammonium) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
    3D-Monophosphoryl Lipid (14) ammonium
  • HY-159672B

    3D-MPL (12,16) triethylamine

    Toll-like Receptor (TLR) Inflammation/Immunology
    3D-Monophosphoryl Lipid (12,16) (triethylamine) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
    3D-Monophosphoryl Lipid (12,16) triethylamine
  • HY-W782032A

    3D-MPLA-5 free acid

    Toll-like Receptor (TLR) Inflammation/Immunology
    3D-Monophosphoryl Lipid A-5 (free acid) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
    3D-Monophosphoryl Lipid A-5 free acid
  • HY-159671A

    3D-MPL (14) triethylamine

    Toll-like Receptor (TLR) Inflammation/Immunology
    3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) triethylamine is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
    3D-Monophosphoryl Lipid (14) triethylamine
  • HY-16129

    Calmodulin Cancer
    CBP-501 is a cell-permeable and calmodulin-binding peptide that enhances the influx of platinum agents into tumor cells and tumor immunogenicity. CBP-501 can be utilized in cancer research .
    CBP-501
  • HY-P1778

    HPV Infection
    HPV16 E7 (86-93) is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) is immunogenic in cervical carcinomas .
    HPV16 E7 (86-93)
  • HY-P1778A

    HPV Infection
    HPV16 E7 (86-93) TFA is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) TFA is immunogenic in cervical carcinomas .
    HPV16 E7 (86-93) (TFA)
  • HY-141514
    MSA-2 dimer
    1 Publications Verification

    STING Inflammation/Immunology Cancer
    MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .
    MSA-2 dimer
  • HY-159700

    Liposome Infection
    AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model .
    AA3-DLin
  • HY-151503

    Autophagy Cancer
    MPM-1, a marine Eusynstyelamides mimic, is a potent anticancer agent. MPM-1 can rapidly kill cancer cells in vitro by inducing a necrosis-like death. MPM-1 has the ability to induce immunogenic cell death. MPM-1 causes perturbation of autophagy and lysosomal swelling in cancer cells .
    MPM-1
  • HY-115670
    GW280264X
    3 Publications Verification

    MMP Inflammation/Immunology Cancer
    GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .
    GW280264X
  • HY-P9932

    ETI 204

    Bacterial Infection Cardiovascular Disease
    Obiltoxaximab (ETI 204) is the second and potent anti-protective antigen (PA) monoclonal antibody with immunogenicity. Obiltoxaximab plays a central role in anthrax toxin assembly and target cell intoxication, promoting survival, and inhibiting bacterial spread to the periphery in animal models. Obiltoxaximab can be used in the research of inhalational anthrax, bacteremia and toxemia .
    Obiltoxaximab
  • HY-101925
    CM-272
    3 Publications Verification

    Histone Methyltransferase DNA Methyltransferase Apoptosis Cancer
    CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death .
    CM-272
  • HY-107634

    Avridine

    Others Infection Inflammation/Immunology
    CP-20961 is a potent synthetic non-immunogenic adjuvant that induces arthritis .
    CP-20961
  • HY-Y0873K

    Polyethylene glycol 200

    Biochemical Assay Reagents Others
    PEG200 (Polyethylene glycol 200), a neutral polymer of molecular weight 200, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
    PEG200
  • HY-W782032

    3D-MPLA-5

    Toll-like Receptor (TLR) Others Inflammation/Immunology
    3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) is a TLR agonist that can be used as an adjuvant for vaccines to enhance their immunogenicity .
    3D-Monophosphoryl Lipid A-5
  • HY-W782032B

    3D-MPLA-5 triethylamine

    Toll-like Receptor (TLR) Inflammation/Immunology
    3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) triethylamine is a TLR agonist that can be used as an adjuvant for vaccines to enhance their immunogenicity .
    3D-Monophosphoryl Lipid A-5 triethylamine
  • HY-159670B

    MPLA-12 triethylamine

    Toll-like Receptor (TLR) Inflammation/Immunology
    Monophosphoryl Lipid A-12 (triethylamine) is a toll-like receptor 4 agonist. Monophosphoryl Lipid A-12 (triethylamine) can be used for the research of immunization and vaccine .
    Monophosphoryl Lipid A-12 triethylamine
  • HY-159670A

    MPLA-12 free acid

    Toll-like Receptor (TLR) Inflammation/Immunology
    Monophosphoryl Lipid A-12 (free acid) is a toll-like receptor 4 agonist. Monophosphoryl Lipid A-12 (free acid) can be used for the research of immunization and vaccine .
    Monophosphoryl Lipid A-12 free acid
  • HY-112582A

    1-Methylpseudouridine-5′-triphosphate

    Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
    N1-Methylpseudouridine-5′-triphosphate
  • HY-112582C

    1-Methylpseudouridine-5′-triphosphate trisodium

    Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability .
    N1-Methylpseudouridine-5′-triphosphate trisodium
  • HY-112582B

    1-Methylpseudouridine-5′-triphosphate tetralithium

    DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) tetralithium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability .
    N1-Methylpseudouridine-5′-triphosphate tetralithium
  • HY-157262

    Others Infection
    Methyl isonicotinate-(CH2)2-COOH (hapten 2b) is a hapten that can be activated with NHS and DCC. Methyl isonicotinate-(CH2)2-COOH has more immunogenicity and hydrophobicity .
    Methyl isonicotinate-(CH2)2-COOH
  • HY-141567

    Pseudo-UTP

    DNA/RNA Synthesis Others
    pseudouridine-5’-triphosphate (Pseudo-UTP) is one of the most commonly used modified nucleoside for the polymerase-mediated synthesis of RNA molecules. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties .
    .
    Pseudouridine 5'-triphosphate
  • HY-141567A
    Pseudouridine 5'-triphosphate trisodium
    1 Publications Verification

    Pseudo-UTP trisodium

    DNA/RNA Synthesis Others
    Pseudouridine-5’-triphosphate (Pseudo-UTP) is one of the most commonly used modified nucleoside for the polymerase-mediated synthesis of RNA molecules. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties .
    .
    Pseudouridine 5'-triphosphate trisodium
  • HY-155909

    mPEG-SC (MW 3400); mPEG-Succinimidyl ester (MW 3400)

    Biochemical Assay Reagents Others
    m-PEG-NHS ester (MW 3400) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.
    m-PEG-NHS ester (MW 3400)
  • HY-155909A

    mPEG-SC (MW 1000); mPEG-Succinimidyl ester (MW 1000)

    Biochemical Assay Reagents Others
    m-PEG-NHS ester (MW 1000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.
    m-PEG-NHS ester (MW 1000)
  • HY-155909B

    mPEG-SC (MW 550); mPEG-Succinimidyl ester (MW 550)

    Biochemical Assay Reagents Others
    m-PEG-NHS ester (MW 550) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.
    m-PEG-NHS ester (MW 550)
  • HY-155909C

    mPEG-SC (MW 350); mPEG-Succinimidyl ester (MW 350)

    Biochemical Assay Reagents Others
    m-PEG-NHS ester (MW 350) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.
    m-PEG-NHS ester (MW 350)
  • HY-W591424

    mPEG-SC (MW 2000); mPEG-Succinimidyl ester (MW 2000)

    Biochemical Assay Reagents Others
    m-PEG-NHS ester (MW 2000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.
    m-PEG-NHS ester (MW 2000)
  • HY-161693

    G-quadruplex DNA/RNA Synthesis Apoptosis Cancer
    Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells .
    Telomeric G4s ligand 1
  • HY-109506
    DPPC
    5 Publications Verification

    129Y83

    Liposome Endogenous Metabolite Others
    DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .
    DPPC
  • HY-109506R

    Liposome Endogenous Metabolite Others
    DPPC (Standard) is the analytical standard of DPPC. This product is intended for research and analytical applications. DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .
    DPPC (Standard)
  • HY-B1521
    Aluminum Hydroxide
    2 Publications Verification

    NOD-like Receptor (NLR) Cardiovascular Disease Inflammation/Immunology
    Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum hydroxide-based adjuvant researches include the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines .
    Aluminum Hydroxide
  • HY-149631

    HDAC Cancer
    HFY-4A is a HDAC inhibitor. HFY-4A inhibits breast cancer cell proliferation, migration, and invasion, and induces cell apoptosis. HFY-4A induces immunogenic cell death (ICD). HFY-4A inhibits tumor growth in breast cancer xenograft mouse models .
    HFY-4A
  • HY-162958

    Apoptosis TrxR Cancer
    Photosensitizer-6 (Compound 4) is a gold (I) complex and exhibits inhibitory activity against TrxR. Photosensitizer-6 induces apoptosis in 4T1 cell, targets and eradicates tumors through chemo-phototherapy and immunogenic cell death under light exposure. Photosensitizer-6 can be used for tumor imaging .
    Photosensitizer-6
  • HY-P4037

    HCV Infection
    HCV Core Protein (107-114) is a least immunogenic residue of the major linear HCV core regions. HCV Core Protein (107-114) is identified as the binding site within the region 101-118, which contains two residues differing between genotypes Ⅰ/Ⅱ and Ⅲ/Ⅵ. HCV Core Protein (107-114) might be a potential site for dissemination of HCV serotypes .
    HCV Core Protein (107-114)
  • HY-B1521R

    NOD-like Receptor (NLR) Inflammation/Immunology
    Aluminum Hydroxide (Standard) is the analytical standard of Aluminum Hydroxide. This product is intended for research and analytical applications. Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum hydroxide-based adjuvant researches include the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines .
    Aluminum Hydroxide (Standard)
  • HY-13735H

    Acriquine acetate

    Others Cancer
    Quinacrine (Acriquine) acetate is a small molecule modulator of the cGAS-STING-TBK1 signaling pathway, possessing immune stimulatory activity. Quinacrine acetate has been explored for its potential therapeutic applications in enhancing anti-tumor immunity. Quinacrine acetate can improve the effectiveness of cancer immunotherapies by addressing the poor immunogenicity of various tumors. Quinacrine acetate also presents a promising strategy for overcoming the limitations associated with immune checkpoint inhibitors in cancer treatment.
    Quinacrine acetate
  • HY-P99683

    SGN-LIV1A

    Antibody-Drug Conjugates (ADCs) Cancer
    Ladiratuzumab vedotin (SGN-LIV1A) is a LIV-1 targeting antibody drug conjugate (ADC) (IC50: 5.6 nM for LIV-1). Ladiratuzumab vedotin consists of humanized IgG1 monoclonal antibody, MMAE and a protease-cleavable linker. Ladiratuzumab vedotin can drive immunogenic cell death (ICD) to elicit an immune response. Ladiratuzumab vedotin can be used for research of breast cancer .
    Ladiratuzumab vedotin
  • HY-145414

    Others Cancer
    DYSP-C34 is a potent, biocompatible, and ultrasound (US)-triggered multifunctional molecular machine. DYSP-C34 has multiple favorable properties, such as improved lipophilic/hydrophilic balance, intensified US-induced ROS production capacity, and better cellular permeability, resulting in the excellent tumor target efficiency and notable sonodynamic therapy (SDT)-mediated tumor regression. DYSP-C34 exhibits mild immunogenicity by stimulating APCs directly .
    DYSP-C34
  • HY-P99687

    AMG 256

    PD-1/PD-L1 Cancer
    Latikafusp (AMG 256) is a bifunctional fusion protein comprising a PD-1-targeting antibody and IL-21 mutein designed to deliver IL-21 pathway stimulation to PD-1+ cells. Latikafusp is designed to prime and extend the activity of cytotoxic and memory T cells and induce anti-tumor immunity. Latikafusp has the potential for solid tumors research .Latikafusp may lead to the development of immunogenicity-mediated responses .
    Latikafusp
  • HY-162863

    Apoptosis Cancer
    ERK-MYD88 interaction inhibitor 1 is an ERK-MYD88 interaction inhibitor. ERK-MYD88 interaction inhibitor 1 can induce an HRI-mediated integrated stress response (ISR), leading to cancer cell-specific immunogenic cell apoptosis (apoptosis). ERK-MYD88 interaction inhibitor 1 can induce anti-tumor T cell responses in Lewis lung cancer mice, exhibiting anti-tumor activity .
    ERK-MYD88 interaction inhibitor 1
  • HY-W339645

    (S)-Naproxen ethyl ester

    COX Inflammation/Immunology
    Naproxen ethyl ester ((S)-Naproxen ethyl ester) is a nonsteroidal anti-inflammatory drug with activity in relieving pain, fever, swelling and stiffness. Naproxen ethyl ester exerts its effects by inhibiting non-selective cyclooxygenase (COX). The R-(-)-isomer of Naproxen ethyl ester shows stronger immunogenicity, and the Michaelis-Menten parameter of its catalytic reaction is K(M)=6.67 mM, and the catalytic efficiency is 5.8 x 10^4 times higher than that of the non-catalytic reaction .
    Naproxen ethyl ester
  • HY-162264

    Microtubule/Tubulin Proton Pump Apoptosis Inflammation/Immunology Cancer
    Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration .
    Tubulin polymerization/V-ATPase-IN-1

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