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Results for "

Mcl-1 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (40) Autophagy (4) Bacterial (1) Bcl-2 Family (94) Beta-lactamase (1) BMI1 (1) c-Myc (3) Calcium Channel (1) Caspase (3) CDK (11) Ceramidase (1) Drug Isomer (2) FLT3 (1) Fungal (1) HIV (1) Isotope-Labeled Compounds (1) JAK (2) JNK (1) LPL Receptor (1) NF-κB (2) Notch (1) P-glycoprotein (1) p38 MAPK (1) Pim (1) PROTAC Linkers (1) PROTACs (3) ROS Kinase (1) STAT (6) Survivin (3) Syk (3) VEGFR (1) Virus Protease (1) Wnt (1)
By Research Areas:	Cancer (112) Infection (3) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (1)

By Targets:

Apoptosis (40)

Autophagy (4)

Bacterial (1)

Bcl-2 Family (94)

Beta-lactamase (1)

BMI1 (1)

c-Myc (3)

Calcium Channel (1)

Caspase (3)

CDK (11)

Ceramidase (1)

Drug Isomer (2)

FLT3 (1)

Fungal (1)

HIV (1)

Isotope-Labeled Compounds (1)

JAK (2)

JNK (1)

LPL Receptor (1)

NF-κB (2)

Notch (1)

P-glycoprotein (1)

p38 MAPK (1)

Pim (1)

PROTAC Linkers (1)

PROTACs (3)

ROS Kinase (1)

STAT (6)

Survivin (3)

Syk (3)

VEGFR (1)

Virus Protease (1)

Wnt (1)

By Research Areas:

Cancer (112)

Infection (3)

Inflammation/Immunology (4)

Metabolic Disease (1)

Neurological Disease (1)

118

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155472

Mcl-1 inhibitor 17	Bcl-2 Family	Cancer
Mcl-1 inhibitor 17 is a Mcl-1 protein inhibitor. Mcl-1 inhibitor 17 can be used for the research of cancer and other diseases .

HY-145826

Mcl-1 inhibitor 8	Bcl-2 Family	Cancer
Mcl-1 inhibitor 8 is a *MCL-1* inhibitor, example 228, extracted from patent WO2019222112 .

HY-148899

Mcl-1 inhibitor 10	Bcl-2 Family	Cancer
Mcl-1 inhibitor 10 (compound 43) is a relatively strong *MCL-1* inhibitor (IC₅₀=0.67 μM). Mcl-1 inhibitor 10 interacts with specific binding sites of *MCL-1* protein to block the pro-survival signal of *MCL-1* and push cancer cells into apoptosis. Mcl-1 inhibitor 10 can be used in the study of *MCL-1* dependent cancers .

HY-170762

Mcl-1 inhibitor 21	Apoptosis Bcl-2 Family	Cancer
Mcl-1 inhibitor 21 (Example 1-36) is a *Mcl-1* inhibitor with an IC₅₀ of 328 nM. Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .

HY-153423

Mcl-1 inhibitor 12	Bcl-2 Family	Cancer
Mcl-1 inhibitor 12 (Example 10) is a *MCL-1* inhibitor (K_i: 0.22 nM). Mcl-1 inhibitor 12 can be used for the research of cancers .

HY-153423A

Mcl-1 inhibitor 13	Bcl-2 Family	Cancer
Mcl-1 inhibitor 13 (Example 9) is a *MCL-1* inhibitor (K_i: 8.2 nM). Mcl-1 inhibitor 13 can be used for the research of cancers .

HY-159588

Mcl-1 inhibitor 20	Bcl-2 Family	Cancer
Mcl-1 inhibitor 20 (compound 47) is a *Mcl-1* inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity .

HY-154962

Mcl-1 inhibitor 15	Bcl-2 Family	Cancer
Mcl-1 inhibitor 15 (Compound (Ra)-15) is a *Mcl-1* inhibitor (K_i: 0.02 nM). Mcl-1 inhibitor 15 can be used for research of cancer .

HY-162780

Mcl-1 inhibitor 19	Bcl-2 Family	Cancer
Mcl-1 inhibitor 19 (compound 26) binds to *Mcl-1, with the K_i* of 86 pM. Mcl-1 inhibitor 19 inhibits growth in H929 cells with the G_I of 43 nM .

HY-148203

Mcl-1 inhibitor 9	Bcl-2 Family	Cancer
Mcl-1 inhibitor 9 (example 2) is a myeloid cell leukemia 1 (Mcl-1) inhibitor with IC₅₀ value of 0.21889 nM. Mcl-1 inhibitor 9 shows anti-tumor activity .

HY-170763

Mcl-1 inhibitor 22	Apoptosis Bcl-2 Family	Cancer
Mcl-1 inhibitor 22 (Example 36) is a myeloid cell leukemia-1 (MCL-1) inhibitor which inhibits the antiapoptotoic activity of MCL-1 by inhibiting its interaction with proapototic proteins. Mcl-1 inhibitor 22 exhibits anti-proliferation activities against various cancer cell lines and can be utilized in cancer research .

HY-155012

Mcl-1 inhibitor 16	Bcl-2 Family	Cancer
Mcl-1 inhibitor 16 (Compound 9) is a mitochondrial targeting Platinum-based inhibitor of *Mcl-1. Mcl-1* inhibitor 1 induces Bax/Bak-dependent apoptosis in cancer cells. Mcl-1 inhibitor 16 can be used alone or together with ABT-199 (HY-15531) and shows anti-tumor activity .

HY-145825

Mcl-1 inhibitor 7	Bcl-2 Family	Cancer
Mcl-1 inhibitor 7 is a potent *Mcl-1* inhibitor, example 35, extracted from patent WO2020097577A .

HY-163293

Mcl-1 inhibitor 18	Bcl-2 Family	Cancer
Mcl-1 inhibitor 18 (compound 57) is a myeloid cell leukemia 1 (Mcl-1) inhibitor, and can be used for study of cancer .

HY-132307

Mcl-1 inhibitor 6	Bcl-2 Family Apoptosis	Cancer
Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a K_d of 0.23 nM and a K_i of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, K_d>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent .

HY-133015

Mcl-1 inhibitor 3	Bcl-2 Family	Cancer
Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic *Mcl-1* inhibitor (K_i= 0.061 nM; IC₅₀=19 nM in an OPM-2 cell viability assay). Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity . .

HY-154961

Mcl-1 inhibitor 14	Bcl-2 Family	Cancer
Mcl-1 inhibitor 14 (Compound (Ra)-10) is an inhibitor of myeloid cell leukemia-1 (MCL-1) with an K_i of 0.018 nM and can be used for anticancer research .

HY-170762B

*(-)-Mcl-1* inhibitor 21**	Apoptosis Bcl-2 Family	Cancer
(-)-Mcl-1 inhibitor 21 (Example 1-38) is a *Mcl-1* inhibitor with an IC₅₀ of 7.51 μM. (-)-Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .

HY-170763B

*(-)-Mcl-1* inhibitor 22**	Bcl-2 Family Apoptosis	Cancer
(-)-Mcl-1 inhibitor 22 (compound 38) is an *Mcl-1* inhibitor that works by blocking the interaction between *Mcl-1* and pro-apoptotic proteins, reducing the anti-apoptotic activity of *Mcl-1. (-)-Mcl-1* inhibitor 22 can be used in cancer research .

HY-170762A

*(+)-Mcl-1* inhibitor 21**	Apoptosis Bcl-2 Family	Cancer
(+)-Mcl-1 inhibitor 21 (Example 1-37) is a *Mcl-1* inhibitor with an IC₅₀ of 172 nM. (+)-Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .

HY-16695

MIM1 inhibitor of Mcl-1	Bcl-2 Family	Cancer
MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).

HY-170763A

*(+)-Mcl-1* inhibitor 22**	Apoptosis Bcl-2 Family	Cancer
(+)-Mcl-1 inhibitor 22 (Example 37) is a myeloid cell leukemia-1 (MCL-1) inhibitor which inhibits the antiapoptotoic activity of MCL-1 by inhibiting its interaction with proapototic proteins. (+)-Mcl-1 inhibitor 22 exhibits anti-proliferation activities against various cancer cell lines and can be utilized in cancer research .

HY-145825A

*(E)-Mcl-1* inhibitor 7**	Bcl-2 Family	Cancer
(E)-Mcl-1 inhibitor 7 (Example 34) is a *Mcl-1* inhibitor (K_i: <1 nM, IC₅₀: <500 nM). (E)-Mcl-1 inhibitor 7 can be used for research of cancers .

HY-164453

A-1248767	Bcl-2 Family Apoptosis	Cancer
A-1248767 is a *MCL-1* inhibitor (IC₅₀=23.9 nM; K_i=0.41 nM) with anticancer activity. A-1248767, a derivative of A-1210477 (HY-12468), binds to *MCL-1* with high affinity, induces the increase of intracellular *MCL-1* protein, and promotes tumor cell apoptosis .

HY-164452

A-1155905	Bcl-2 Family Apoptosis Caspase	Cancer
A-1155905 is a *MCL-1* inhibitor (IC₅₀=33.5 nM; K_i=0.58 nM) with anticancer activity. A-1155905 selectively binds to *MCL-1* with sufficient affinity to disrupt the MCL-1-bim complex in living cells. A-1155905-induced death of *MCL-1*-dependent cell lines is caspase-dependent and occurs via apoptosis .

HY-115928

M24	Bcl-2 Family	Cancer
M24 is a *Mcl-1* selective inhibitor. M24 exhibits good binding affinity against Mcl-1 with K_i value of 0.33 μM. M24 exhibits good anti-proliferative activity and induce apoptosis in HepG2 cells .

HY-159513

Bcl-2/Mcl-1-IN-4	Bcl-2 Family Apoptosis	Cancer
Bcl-2/Mcl-1-IN-4 (compound 20) is a dual inhibitor targeting Bcl-2 (K_i=0.49 μM) and *Mcl-1* (K_i=0.51 μM). Bcl-2/Mcl-1-IN-4 significantly inhibits cancer cell proliferation and effectively induces apoptosis in U937 cells. Bcl-2/Mcl-1-IN-4 can be used in cancer research .

HY-122721

Mcl1-IN-5	Bcl-2 Family	Cancer
Mcl1-IN-5 (compound 21) is a *MCL-1* inhibitor. Mcl1-IN-5 can be used for the research of cancers .

HY-123564

Mcl1-IN-7	Bcl-2 Family	Others
Mcl1-IN-7 (compound 11) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. By covalently targeting the non-catalytic lysine side chain of Mcl-1, it has higher potency than non-covalent counterparts and can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena.

HY-W286906

Mcl1-IN-15	Bcl-2 Family Apoptosis	Cancer
Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC₅₀ of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity .

HY-111467

Mcl1-IN-4	Bcl-2 Family	Cancer
Mcl1-IN-4 is an inhibitor of *Mcl1* with an IC₅₀ of 0.2 μM.

HY-16669

Mcl1-IN-1	Bcl-2 Family	Cancer
Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC₅₀=2.4 µM).

HY-12527

Pyridoclax 1 Publications Verification MR-29072	Bcl-2 Family	Cancer
Pyridoclax is a potential *Mcl-1* inhibitor.

HY-12468

A-1210477 15+ Cited Publications	Bcl-2 Family Apoptosis	Cancer
A-1210477 is a potent and selective inhibitor of *MCL-1* with a K_i of 0.45 nM . A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner .

HY-100762

Mcl1-IN-11	Bcl-2 Family	Cancer
Mcl1-IN-11 (Compound G) is a selective *Mcl-1* inhibitor, less potent at Bcl-2, with K_is of 0.06 and 4.2 μM, respectively .

HY-128607

Mcl1-IN-9	Bcl-2 Family	Cancer
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC₅₀ of 446 nM in reengineered BCR-ABL+ B-ALL cells and a K_i of 0.03 nM .

HY-112859

VU0661013	Bcl-2 Family	Cancer
VU661013 is a potent and selective *MCL-1* inhibitor.

HY-18628

UMI-77 2 Publications Verification	Bcl-2 Family	Cancer
UMI-77 is a selective *Mcl-1* inhibitor, which shows high binding affinity to *Mcl-1* (IC₅₀=0.31 μM). UMI-77 binds to the BH3 binding groove of *Mcl-1* with K_i of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-100763

Mcl1-IN-12	Bcl-2 Family	Cancer
Mcl1-IN-12 (Compound F) is a selective *Mcl-1* inhibitor, less potent at Bcl-2, with K_is of 0.29 and 3.1 μM, respectively. Anti-tumor activity .

HY-163681

Zamzetoclax	Bcl-2 Family	Cancer
Zamzetoclax (compound 1) is a potential *Mcl-1* inhibitor .

HY-100741

S63845 Maximum Cited Publications 83 Publications Verification	Bcl-2 Family	Cancer
S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a K_d of 0.19 nM for human MCL1 .

HY-111468

Mcl1-IN-3	Bcl-2 Family	Cancer
Mcl1-IN-3 is an inhibitor of *Mcl1* extracted from patent WO2015153959A2, compound example 57; has an IC₅₀ and K_i of 0.67 and 0.13 μM, respectively.

HY-125877

PROTAC Mcl1 degrader-1 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively *Mcl-1* (Bcl-2 family member) inhibitor with an IC₅₀ of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC₅₀ of 0.54 μM .

HY-18628S

UMI-77-d4	Isotope-Labeled Compounds Bcl-2 Family	Cancer
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-161732

GQN-B37-E	Bcl-2 Family	Cancer
GQN-B37-E is a potent selective binder and inhibitor of *MCL-1. GQN-B37-E binds to the BH3-domain-binding pocket in MCL-1. GQN-B37-E exhibits binding affinity for MCL-1* at the submicromolar range (K_i = 0.6 μM) without apparent binding to BCL-2 or BCL-XL .

HY-129702

MCL-1/BCL-2-IN-4	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor .

HY-129700

MCL-1/BCL-2-IN-2	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor .

HY-162858

BRD-810	Caspase	Cancer
BRD-810 is a highly selective *MCL1* inhibitor. BRD-810 can bind to the BH3 groove of MCL1 and block the sequestration of pro-apoptotic proteins, quickly inducing caspase activation in MCL1-dependent cell lines. BRD-810 shows anti-tumor activity in models of blood cancers and solid tumors .

HY-12422

Voruciclib	CDK	Cancer
Voruciclib is an orally active and selective CDK inhibitor with K_i values of 0.626 nM-9.1 nM. Voruciclib potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL) .

HY-12422A

Voruciclib hydrochloride	CDK	Cancer
Voruciclib hydrochloride is an orally active and selective CDK inhibitor with K_i values of 0.626 nM-9.1 nM. Voruciclib hydrochloride potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib hydrochloride represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0087

Gambogic Acid 4 Publications Verification Beta-Guttiferrin	Structural Classification Natural Products Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and *Mcl-1* with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N8146

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	STAT
Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper . Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc .

HY-N0763

Angelicin 5+ Cited Publications Isopsoralen	Structural Classification Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and *Mcl-1, while activating caspase-9* and caspase-3.

HY-N0087R

Gambogic Acid (Standard)	Structural Classification Natural Products Guttiferae Plants Garcinia hanburyi Hook. f.	Bcl-2 Family Autophagy
Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N3913

Furowanin A	Structural Classification Flavonoids Leguminosae Source classification Plants Derris taiwaniana (Hayata) Z. Q. Song Isoflavones	STAT Bcl-2 Family
Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits *STAT3/Mcl-1* axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells .

Cat. No.	Product Name	Chemical Structure

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

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