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Results for "

SRC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SHP2 (1) Src (129) 5-HT Receptor (1) Adrenergic Receptor (2) Akt (6) Antibiotic (1) Apoptosis (45) Aurora Kinase (3) Autophagy (20) Bacterial (1) Bcr-Abl (25) BCRP (1) Btk (2) c-Fms (1) c-Kit (8) c-Met/HGFR (3) c-Myc (1) CaMK (2) COX (2) Cytochrome P450 (1) DNA-PK (1) Drug Metabolite (4) EGFR (14) Endogenous Metabolite (1) Epigenetic Reader Domain (1) ERK (4) Estrogen Receptor/ERR (2) FAK (8) FGFR (15) FLT3 (3) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) FXR (1) G-quadruplex (3) Glutaminase (1) HIV (2) IGF-1R (2) iGluR (1) IKK (1) Integrin (1) Isotope-Labeled Compounds (3) JAK (5) JNK (3) LIM Kinase (LIMK) (1) LXR (1) MAP3K (1) Microtubule/Tubulin (4) MMP (3) MNK (1) mTOR (2) Necroptosis (1) NF-κB (4) NO Synthase (2) p38 MAPK (9) PAK (1) Paraptosis (2) Parasite (3) PDGFR (17) Phosphatase (3) Phosphodiesterase (PDE) (2) PI3K (5) PKA (3) PKC (5) PKD (1) Polo-like Kinase (PLK) (1) Prostaglandin Receptor (1) PROTACs (2) Raf (7) Reactive Oxygen Species (2) RET (3) Ribosomal S6 Kinase (RSK) (3) ROR (1) Secretin Receptor (1) Small Interfering RNA (siRNA) (3) STAT (10) Syk (4) TGF-β Receptor (1) Topoisomerase (2) VEGFR (22) Wnt (1)
By Research Areas:	Cancer (160) Cardiovascular Disease (6) Endocrinology (4) Infection (7) Inflammation/Immunology (29) Metabolic Disease (3) Neurological Disease (5)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

205

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Src Inhibitor 1 10+ Cited Publications SRC Kinase Inhibitor 1; SRC-l1	Src	Cancer
Src Inhibitor 1 is a potent, ATP-competitive and selective dual site *Src* tyrosine kinase inhibitor with IC₅₀ values of 44 nM for Src and 88nM for Lck.

*KB SRC* 4**	Src	Cancer
KB SRC 4 is a potent, and highly selective *c-Src* inhibitor, with a K_i of 44 nM and a K_d of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.

SRC-3-IN-2	Src	Cancer
SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity .

Src Inhibitor 3	Src	Cancer
Src Inhibitor 3 (Compound 7d) is a *Src* inhibitor with an IC₅₀ of 285 nM. Src Inhibitor 3 inhibits HepG2 cells proliferative with an IC₅₀ of 1.55 μM .

SRC-3-IN-1	Src	Cancer
SRC-3-IN-1 (compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor (IC₅₀=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research .

SRC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SRC Human Pre-designed siRNA Set A contains three designed siRNAs for SRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Src Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Src Mouse Pre-designed siRNA Set A contains three designed siRNAs for Src gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Src Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Src Rat Pre-designed siRNA Set A contains three designed siRNAs for Src gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

RR-SRC	Src	Inflammation/Immunology
RR-SRC is a substrate for src-tyrosine-specific protein kinase .

*p60c-src* Substrate**	Src Others	Others
p60c-src Substrate is an efficient and specific substrate for *p60c-src* protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

*T338C Src-IN-1*	Src	Cancer
T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase).

*p60c-src* substrate II**	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

*IGF-1R/SRC-IN-1*	IGF-1R Src	Cancer
IGF-1R/SRC-IN-1 (Compound 3b) is an inhibitor for IGF-1R (IC₅₀ is 63 μM) and *SRC* .

WH-4-023 4 Publications Verification Dual LCK/SRC inhibitor	Src	Cancer
WH-4-023 is a potent and selective dual *Lck/Src* inhibitor with IC₅₀ of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.

*pp60 (v-SRC) Autophosphorylation Site, Phosphorylated*	EGFR	Others
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is the phosphorylated peptide of an EGFR substrate. pp60 (v-SRC) Autophosphorylation Site, Phosphorylated can be used for the screening of EGFR Kinase inhibitors via phosphorylated-substrate quantification .

*T338C Src-IN-2*	Src	Cancer
T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.

PP2 Analog	Src	Cancer
PP2 Analog (compound 3) is a ATP-competitive *Src* family kinases inhibitor with the IC₅₀ values of 0.22, 0.15, 2.68, and 7 aganist of lck (64-509), src , kdr, and tie-2 .

CGP77675	Src	Cancer
CGP77675 is an orally active and potent inhibitor of *Src* family kinases. CGP77675 inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC₅₀s of 5-20 and 40 nM, respectively), and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC₅₀s of 5-20, 40, 20, 150, 1000, 310, and 290 nM, respectively. Anticancer activity .

CGP77675 hydrate	Src	Cancer
CGP77675 hydrate is an orally active and potent inhibitor of *Src* family kinases. CGP77675 hydrate inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC₅₀s of 5-20 and 40 nM, respectively),and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC₅₀s of 0.02, 0.15, 1.0, 0.31, and 0.29 μM, respectively. Anticancer activity .

Pyridostatin hydrochloride 15+ Cited Publications RR82 hydrochloride	G-quadruplex	Cancer
Pyridostatin (RR82) hydrochloride is a G-quadruplex DNA stabilizing agent (K_d=490 nM). Pyridostatin hydrochloride promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin hydrochloride targets the proto-oncogene Src. Pyridostatin hydrochloride reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells .

Pyridostatin RR82	G-quadruplex	Cancer
Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (K_d=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells .

DGY-06-116 1 Publications Verification	Src	Cancer
DGY-06-116 is an irreversible covalent, selective *Src* inhibitor with an IC₅₀ of 3nM. DGY-06-116 inhibits FGFR1 with an IC₅₀ of 8340 nM .

Pyridostatin TFA 15+ Cited Publications RR82 TFA	G-quadruplex	Cancer
Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (K_d=490 nM). Pyridostatin TFA promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin TFA targets the proto-oncogene Src. Pyridostatin TFA reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells .

Herbimycin A	Bacterial Antibiotic	Infection
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

LCB 03-0110 dihydrochloride	Src	Others
LCB 03-0110 dihydrochloride is a dihydrochloride of LCB 03-0110. LCB 03-0110 is a potent inhibitor of Src family tyrosine kinase .

HIV-IN-6	HIV Src	Infection
HIV-IN-6 is a HIV-Ⅰ viral replication inhibitor by targeting Src family kinases (SFK) that interact with Nef protein of the virus, such as Hck .

FAK inhibitor 7	FAK Src Akt Autophagy	Cancer
FAK inhibitor 7 is a type of FAK inhibitor with an IC₅₀ value of 3.58 nM. FAK inhibitor 7 can inhibit the downstream signaling cascades of FAK (like *Src* and AKT), causing ovarian cancer cells to stall in the G0/G1 phase and induce cytotoxic autophagy. FAK inhibitor 7 can also suppress tumor metastasis and growth in ovarian cancer mice .

Ponatinib 25+ Cited Publications AP24534	Bcr-Abl PDGFR VEGFR FGFR Src Autophagy	Cancer
Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC₅₀s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and *Src*, respectively .

Ponatinib hydrochloride 25+ Cited Publications AP24534 hydrochloride	Bcr-Abl FGFR PDGFR VEGFR Src Autophagy	Infection Cancer
Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC₅₀s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and *Src*, respectively .

CH6953755 3 Publications Verification	Src	Cancer
CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC₅₀ of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo .

Tetramethylcurcumin FLLL31	STAT Apoptosis	Inflammation/Immunology Cancer
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .

Ponatinib (Standard)	Bcr-Abl PDGFR VEGFR FGFR Src Autophagy	Cancer
Ponatinib (Standard) is the analytical standard of Ponatinib. This product is intended for research and analytical applications. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC₅₀s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and *Src*, respectively .

Periplocin 3 Publications Verification	Apoptosis	Inflammation/Immunology Cancer
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

Periplocin (Standard)	Apoptosis	Inflammation/Immunology Cancer
Periplocin (Standard) is the analytical standard of Periplocin. This product is intended for research and analytical applications. Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

YF-452	VEGFR	Cardiovascular Disease Cancer
YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research .

Debio 0617B	STAT JAK Bcr-Abl	Cancer
Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34 ⁺ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors .

DC-Srci-6649	Src	Others
DC-Srci-6649 is a *c-Src* kinase inhibitor that inhibits the phosphorylation and locks c-Src in the inactive state.

HL403	Epigenetic Reader Domain Src	Cancer
HL403 is a potent and dual *BRD4/Src* inhibitor. HL403 has IC₅₀ values of 133 nM for BRD4 inhibition and 4.5 nM for Src inhibition. HL403 shows anti-cancer activity .

CSK substrate	Src	Others
CSK substrate is a specific substrate for *C-terminal Src* kinase (CSK*), which binds CSK and downregulates the Src* family members. CSK substrate preferentially phosphorylates certain amino acid residues that are distinct from the conserved Src C-terminal sequence .

A 419259 trihydrochloride 2 Publications Verification RK 20449 trihydrochloride	Src Apoptosis	Cancer
A 419259 trihydrochloride is a Src family kinases inhibitor with IC₅₀s of 9 nM, 3 nM and 3 nM for *Src, Lck* and Lyn, respectively .

AP 24149	Bcr-Abl Src	Cancer
AP 24149 is a potent *Src-Abl* dual inhibitor with IC₅₀ values of 9.1, 3.6 nM for Src and Abl, respectively .

Tirbanibulin 5+ Cited Publications KX2-391; KX-01	Src Microtubule/Tubulin	Cancer
Tirbanibulin (KX2-391) is an inhibitor of *Src* that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

Tirbanibulin dihydrochloride 5+ Cited Publications KX2-391 dihydrochloride; KX-01 dihydrochloride	Src Microtubule/Tubulin	Cancer
Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of *Src* that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

Tirbanibulin Mesylate 5+ Cited Publications KX2-391 Mesylate; KX01 Mesylate	Src Microtubule/Tubulin	Cancer
Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of *Src* that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

MCB-613	Reactive Oxygen Species Paraptosis	Cancer
MCB-613 is a potent Steroid receptor coactivator *SRC* small molecule ‘stimulator’ (SMS), super-stimulates SRCs’ transcriptional activity. MCB-613 increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 is a SMS that target oncogenes can be exploited as anti-cancer agents by over-stimulating the SRC oncogenic program .

Cat. No.	Product Name	Type

HY-15764G

A 419259 (GMP) RK-20449 (GMP)	Fluorescent Dye
A 419259 GMP is the GMP grade A 419259 (HY-15764), inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC₅₀s of 9 nM, <3 nM, and <3 nM, respectively .

HY-D2204

SHP1-IN-1	Fluorescent Dyes/Probes
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe ³⁺ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) .

Cat. No.	Product Name	Type

HY-15764G

A 419259 (GMP) RK-20449 (GMP)	Biochemical Assay Reagents
A 419259 GMP is the GMP grade A 419259 (HY-15764), inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC₅₀s of 9 nM, <3 nM, and <3 nM, respectively .

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Cat. No.	Product Name	Target	Research Area

HY-P5438

Srctide	Peptides	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P3744

*pp60v-src* Autophosphorylation site**	Peptides	Others
pp60v-src Autophosphorylation site is a synthetic peptide. pp60v-src Autophosphorylation site can be used for various biochemical studies .

HY-P2513

Src Optimal Peptide Substrate	Peptides	Others
Src Optimal Peptide Substrate is a highly specific Src substrate. Src Optimal Peptide Substrate can used to measure the Src activity .

HY-P5464

SRC-1 NR box peptide	Peptides	Others
SRC-1 NR box peptide is a biological active peptide. (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II.)

HY-P5458

SRC-1 (686-700)	Peptides	Others
SRC-1 (686-700) is a biological active peptide. (This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.)

HY-P0200

RR-SRC	Src	Inflammation/Immunology
RR-SRC is a substrate for src-tyrosine-specific protein kinase .

HY-P3743

*p60c-src* Substrate**	Src Peptides	Others
p60c-src Substrate is an efficient and specific substrate for *p60c-src* protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

HY-P3773

*p60c-src* substrate II**	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

HY-P2372

*P60v-src(137-157)*	Peptides	Others
P60v-src(137-157) is a synthetic peptide that inhibits the tyrosine kinase activity of p60 ^v-src (IC₅₀: 7.5 μM) .

HY-P3771

*p60c-src* substrate II, phosphorylated**	Peptides	Others
p60c-src substrate II, phosphorylated is a pentapeptide. p60c-src substrate II, phosphorylated is a p60c-src substrate II phosphorylated polypeptide. Protein phosphorylation is an important post-translationmodification of protein that is indispensible in biological regulations .

HY-P1199

*pp60 c-src* (521-533) (phosphorylated)**	Peptides	Others
pp60 c-src (521-533) (phosphorylated) is a peptide corresponding to the pp60c-src carboxy terminal regulatory domain, phosphorylated at Tyr527 .

HY-P2548

*pp60 (v-SRC) Autophosphorylation Site, Phosphorylated*	EGFR	Others
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is the phosphorylated peptide of an EGFR substrate. pp60 (v-SRC) Autophosphorylation Site, Phosphorylated can be used for the screening of EGFR Kinase inhibitors via phosphorylated-substrate quantification .

HY-P10527

CSK substrate	Src	Others
CSK substrate is a specific substrate for *C-terminal Src* kinase (CSK*), which binds CSK and downregulates the Src* family members. CSK substrate preferentially phosphorylates certain amino acid residues that are distinct from the conserved Src C-terminal sequence .

HY-P3279

EPQpYEEIPIYL 1 Publications Verification	Src	Cancer
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains .

HY-P2547

Tyrosine Kinase Peptide 1	Src	Others
Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay .

HY-P2413

Ac-PPPHPHARIK-NH2	Peptides	Others
Ac-PPPHPHARIK-NH2 (compound S1) is a compound that inhibits the interaction between androgen receptor and Src. It can inhibit the binding of androgen or estrogen-induced receptor and Src in cancer cells, as well as the activation of related signaling pathways, and can also inhibit cell cycle progression and tumor growth.

HY-P10372

pFYN peptide	Src	Cancer
pFYN peptide is a biotin-labled phosphorylated peptide substrate derived from FYN (a Src family kinase) .

HY-P5559

ND1-YL2	PROTACs	Cancer
ND1-YL2 is a PROTAC that selectively degrades *SRC-1* via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research .

HY-P6028

GSNKSKPK-NH2	Peptides	Others
GSNKSKPK-NH2 is a model peptide based on a c-Src N-terminal peptide that can be used as NMT substrate .

HY-P6028A

GSNKSKPK-NH2 TFA	Peptides	Others
GSNKSKPK-NH2 TFA is a model peptide based on a c-Src N-terminal peptide that can be used as NMT substrate .

HY-P10665

pYEEI	Src	Cancer
pYEEI is a phosphotyrosine-containing tetrapeptide binds to Src SH2 domain with the K_d of 100 nM and with the IC₅₀ of 6.5 μM. pYEEI plays an important role in cancer research .

HY-P1200

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH	Src	Cancer
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC₅₀≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions .

HY-P1200A

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA	Src	Cancer
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC₅₀≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions .

HY-P1784

Secretin, canine	Secretin Receptor	Endocrinology
Secretin, canine is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway .

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

HY-P10521

Apolipoprotein KV domain (67-77)	VEGFR	Cancer
Apolipoprotein KV domain (67-77) is an 11-amino acid peptide identified from the KV domain of human apolipoprotein a (ApoA) with antiangiogenic and antitumor activities. Apolipoprotein KV domain (67-77) targets the angiogenic c-Src/ERK pathway by blocking activation signals received from vascular endothelial growth factor (VEGF). Apolipoprotein KV domain (67-77) can be used in cancer research .

HY-107024

Osteogenic Growth Peptide (10-14) OGP(10-14); Historphin	Src	Others
Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a *Src* inhibitor .

Species:	Human (7) Mouse (4)
Tag:	His (8) Tag Free (1) Avi (1) GST (6) Flag (2)
Source:	HEK293 (1) Sf9 insect cells (2) Sf9 insect cells (7) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73422

	Src Protein, Human (sf9, His-GST) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His-GST) is the recombinant human-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Src Protein, Human (sf9, His-GST) is 536 a.a., with molecular weight of ~81 kDa.

HY-P73423

	Src Protein, Mouse (sf9, His-GST) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Mouse	Sf9 insect cells
	Src, a non-receptor protein tyrosine kinase, displays a unique ability to phosphorylate synaptophysin with high affinity.Src Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701321

	Src Protein, Human (His) Proto-oncogene tyrosine-protein kinase SRC; Proto-oncogene c-SRC; pp60c-SRC (p60-SRC); SRC1	Human	E. coli
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. SRC Protein, Human (His) is the recombinant human-derived SRC protein, expressed by E. coli , with N-10*His labeled tag. The total length of SRC Protein, Human (His) is 535 a.a., with molecular weight of 64.2 kDa.

HY-P702724

	Src Protein, Human (sf9, His, Flag) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His, Flag) is the recombinant human-derived Src, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

HY-P75322

	CSK Protein, Mouse (sf9) Tyrosine-protein kinase CSK; C-SRC kinase; CSK	Mouse	Sf9 insect cells
	CSK protein is a non-receptor tyrosine protein kinase that regulates cell growth, differentiation, migration and immune responses by phosphorylating Src family kinases (SFK) (such as LCK, SRC, HCK, FYN, LYN, CSK or YES1) . This phosphorylation induces SFK to form an inactive conformation, thereby inhibiting signaling by receptors such as T cell receptor (TCR) and B cell receptor (BCR). CSK Protein, Mouse (sf9) is the recombinant mouse-derived CSK protein, expressed by Sf9 insect cells , with tag free. The total length of CSK Protein, Mouse (sf9) is 450 a.a., with molecular weight of ~46 kDa.

HY-P72956

	CSK Protein, Human (sf9, GST) Tyrosine-protein kinase CSK; C-SRC kinase; CSK	Human	Sf9 insect cells
	CSK is a non-receptor tyrosine protein kinase that critically regulates cell growth, differentiation, migration and immune responses by phosphorylating tyrosine residues in the C-terminal tail of Src family kinases (SFK). This induces an inactive conformation through intramolecular interactions with the SH2 domain of SFK. CSK Protein, Human (sf9, GST) is the recombinant human-derived CSK protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CSK Protein, Human (sf9, GST) is 450 a.a., with molecular weight of ~66 kDa.

HY-P72957

	CSK Protein, Mouse (sf9, His-GST) Tyrosine-protein kinase CSK; C-SRC kinase; CSK	Mouse	Sf9 insect cells
	CSK protein is a non-receptor tyrosine protein kinase that regulates cell growth, differentiation, migration and immune responses by phosphorylating Src family kinases (SFK) (such as LCK, SRC, HCK, FYN, LYN, CSK or YES1) . This phosphorylation induces SFK to form an inactive conformation, thereby inhibiting signaling by receptors such as T cell receptor (TCR) and B cell receptor (BCR). CSK Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CSK protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CSK Protein, Mouse (sf9, His-GST) is 450 a.a., with molecular weight of ~65 kDa.

HY-P702727

	FYN Protein, Human (Biotinylated, sf9, His, Flag, Avi) FYN; FYN oncogene related to SRC, FGR, YES; tyrosine-protein kinase Fyn; MGC45350; SLK; SYN; SRC-like kinase; proto-oncogene Syn; c-syn protooncogene; proto-oncogene c-Fyn; SRC/yes-related novel; tyrosine kinase p59fyn(T); OKT3-induced calcium influx regulator; p59-FYN	Human	Sf9 insect cells
	FYN Protein, Human (Biotinylated, sf9, His, Flag, Avi) is the recombinant human-derived FYN, expressed by Sf9 insect cells , with Avi, His, Flag labeled tag. The total length of FYN Protein, Human (Biotinylated, sf9, His, Flag, Avi) is 537 a.a.,

HY-P75470

	Brk Protein, Human (sf9, GST) Protein-tyrosine kinase 6; SRC-related intestinal kinase; Ptk6; Sik	Human	Sf9 insect cells
	Brk is a nonreceptor tyrosine protein kinase that regulates signaling pathways critical for epithelial tissue differentiation, normal maintenance, and tumor growth. Context-dependent functions involve a variety of substrates, including RNA-binding proteins, transcription factors, and signaling molecules. Brk Protein, Human (sf9, GST) is the recombinant human-derived Brk protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of Brk Protein, Human (sf9, GST) is 451 a.a., with molecular weight of ~70 kDa.

HY-P72856

	Brk Protein, Mouse (sf9, His-GST) Protein-tyrosine kinase 6; SRC-related intestinal kinase; Ptk6; Sik	Mouse	Sf9 insect cells
	Brk protein is a non-receptor tyrosine protein kinase that regulates signaling pathways critical for epithelial differentiation and tumor growth.Its context-dependent functions involve phosphorylating substrates such as RNA-binding proteins, transcription factors, and signaling molecules.Brk Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Brk protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P70109

	CDCP1 Protein, Human (312a.a, HEK293, His) rHuCUB domain-containing protein 1/CDCP1, His; CUB domain-containing protein 1; Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with SRC kinases; CD318; TRASK	Human	HEK293
	CDCP1 protein may be involved in cell adhesion and extracellular matrix association. Phosphorylation of CDCP1 may regulate the balance between anchorage and migration, proliferation, and differentiation. CDCP1 Protein, Human (312a.a, HEK293, His) is the recombinant human-derived CDCP1 protein, expressed by HEK293 , with C-6*His labeled tag.

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Species
Source
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Gene ID
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-12047S

Ponatinib-d8
Ponatinib-d₈ is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

HY-10181S

Dasatinib-d8
Dasatinib-d₈ is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

HY-10230S

Midostaurin-d5
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

HY-13342AS

Apatinib-d8 free base

Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[2][3][4].

HY-10158S

Bosutinib-d8
Bosutinib-d₈ is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively[1][2].

HY-133794S

Dasatinib N-oxide-d8
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].

HY-112096S

eCF506-d5
eCF506-d₅ is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally bioavailable inhibitor of the non-receptor tyrosine kinase *Src* with an IC₅₀ of less than 0.5 nM.

HY-10234S

Saracatinib-d3
Saracatinib-d3 (AZD0530-d3) (ZG5129) is the deuterium-labeled analog of Saracatinib (HY-10234). Saracatinib-d3 is an inhibitor of the *Src* kinase, which can inhibit severe sepsis caused by bacterial or various microbial infections .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80338

	Src Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Src Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to Src. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80339

	SRC1 Antibody	WB, IHC-P, IP	Human
	SRC1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 157 kDa, targeting to SRC1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human.

HY-P80514

	*Phospho-Src* (Tyr419) Antibody**	WB, FC	Human
	Phospho-Src (Tyr419) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to Phospho-Src(Y419). It can be used for WB,FC assays with tag free, in the background of Human.

HY-P80088

	Cortactin Antibody Amplaxin antibody; CTTN antibody; EMS 1 antibody; EMS1 antibody; FLJ34459 antibody; Mammary tumor and squamous cell carcinoma associated antibody; Oncogene EMS1 antibody; p80/85 SRC substrate antibody; SRC substrate cortactin antibody; SRC8_HUMAN antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	Cortactin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 62 kDa, targeting to Cortactin. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P82997

	CSK Antibody (YA2742) CSK; Tyrosine-protein kinase CSK; C-SRC kinase; Protein-tyrosine kinase CYL	WB, IHC-P	Human, Mouse, Rat
	CSK Antibody (YA2742) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2742), targeting CSK, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). CSK Antibody (YA2742) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P80681

	FYN Antibody FYN; Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; SRC-like kinase; SLK; p59-Fyn	WB	Human, Mouse, Rat
	FYN Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 61 kDa, targeting to FYN. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P82911

	*Phospho-Src* (Tyr530) Antibody (YA2656)** SRC; SRC1; Proto-oncogene tyrosine-protein kinase SRC; Proto-oncogene c-SRC; pp60c-SRC; p60-SRC	WB, IP	Rat
	Phospho-Src (Tyr530) Antibody (YA2656) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2656), targeting Phospho-Src (Tyr530), with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). Phospho-Src (Tyr530) Antibody (YA2656) can be used for WB, IP experiment in rat background.

HY-P81990

	KAT13A Antibody (YA1735) bHLHe74; mNRC 1; NCoA 1; RIP160; SRC 1	WB, IHC-P, IP	Human
	KAT13A Antibody (YA1735) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1735), targeting KAT13A, with a predicted molecular weight of 157 kDa (observed band size: 157 kDa). KAT13A Antibody (YA1735) can be used for WB, IHC-P, IP experiment in human background.

HY-P83492

	MLK3 Antibody (YA3237) MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; SRC-homology 3 domain-containing proline-rich kinase	WB, ICC/IF	Human
	MLK3 Antibody (YA3237) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3237), targeting MLK3, with a predicted molecular weight of 93 kDa (observed band size: 93 kDa). MLK3 Antibody (YA3237) can be used for WB, ICC/IF experiment in human background.

HY-P82537

	BLNK Antibody (YA2282) BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a SRC homology 2 domain protein; Cytoplasmic adapter protein; SRC homology 2 domain-containing leukocyte protein of 65 kDa	WB, IP	Human, Mouse, Rat
	BLNK Antibody (YA2282) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2282), targeting BLNK, with a predicted molecular weight of 50 kDa (observed band size: 70 kDa). BLNK Antibody (YA2282) can be used for WB, IP experiment in human, mouse, rat background.

HY-P80743

	Lck Antibody (YA712) LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal SRC kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB	Human
	Lck Antibody (YA712) is a non-conjugated and Mouse origined monoclonal antibody about 58 kDa, targeting to Lck (3E5). It can be used for WB assays with tag free, in the background of Human.

HY-P82649

	SHC Antibody (YA2394) SHC1; SHC; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; SRC homology 2 domain-containing-transforming protein C1; SH2 domain protein C1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SHC Antibody (YA2394) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2394), targeting SHC, with a predicted molecular weight of 63 kDa (observed band size: 46, 52, 66 kDa). SHC Antibody (YA2394) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-125387

TOP1210		Alkynes
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .

Cat. No.	Product Name		Classification

HY-RS13749

SRC Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SRC Human Pre-designed siRNA Set A contains three designed siRNAs for SRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13750

Src Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Src Mouse Pre-designed siRNA Set A contains three designed siRNAs for Src gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13751

Src Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Src Rat Pre-designed siRNA Set A contains three designed siRNAs for Src gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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