2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Talibegron hydrochloride

Talibegron hydrochloride  (Synonyms: ZD2079 hydrochloride)

Cat. No.: HY-15378 Purity: 99.63%
Data Sheet
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Solubility

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Talibegron hydrochloride (ZD2079 hydrochloride) is a potent β3-adrenoceptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect.

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Talibegron hydrochloride Chemical Structure

Talibegron hydrochloride Chemical Structure

CAS No. : 178600-17-4

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5 mg USD 75 In-stock
10 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Talibegron hydrochloride Related Antibodies

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View All Adrenergic Receptor Isoform Specific Products:

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α adrenergic receptor β adrenergic receptor

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Description

Talibegron hydrochloride (ZD2079 hydrochloride) is a potent β3-adrenoceptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect[1].

In Vitro

Talibegron hydrochloride (ZD2079 hydrochloride; 0.01-1000 μM) produces a concentration-dependent relaxation of phenylephrine-preconstricted isolated mesenteric arteries and causes full relaxation with 1 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Talibegron hydrochloride Related Antibodies
Molecular Weight

351.82

Formula

C18H22ClNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC1=CC=C(OCCNC[C@H](O)C2=CC=CC=C2)C=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (355.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8424 mL 14.2118 mL 28.4236 mL
5 mM 0.5685 mL 2.8424 mL 5.6847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8424 mL 14.2118 mL 28.4236 mL 71.0591 mL
5 mM 0.5685 mL 2.8424 mL 5.6847 mL 14.2118 mL
10 mM 0.2842 mL 1.4212 mL 2.8424 mL 7.1059 mL
15 mM 0.1895 mL 0.9475 mL 1.8949 mL 4.7373 mL
20 mM 0.1421 mL 0.7106 mL 1.4212 mL 3.5530 mL
25 mM 0.1137 mL 0.5685 mL 1.1369 mL 2.8424 mL
30 mM 0.0947 mL 0.4737 mL 0.9475 mL 2.3686 mL
40 mM 0.0711 mL 0.3553 mL 0.7106 mL 1.7765 mL
50 mM 0.0568 mL 0.2842 mL 0.5685 mL 1.4212 mL
60 mM 0.0474 mL 0.2369 mL 0.4737 mL 1.1843 mL
80 mM 0.0355 mL 0.1776 mL 0.3553 mL 0.8882 mL
100 mM 0.0284 mL 0.1421 mL 0.2842 mL 0.7106 mL
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Talibegron hydrochloride Related Classifications

Keywords:

Talibegron178600-17-4ZD2079ZD 2079ZD-2079Adrenergic ReceptorBeta Receptorβ3adrenoceptorpD2phenylephrinepreconstrictedmesentericarteryvasorelaxantInhibitorinhibitorinhibit

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