1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. PARP

PARP

PARP

poly ADP ribose polymerase

PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. The PARP family comprises 17 members. They have all very different structures and functions in the cell. PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2) have a confirmed PARP activity. Others include PARP3, PARP6, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. PARP is found in the cell’s nucleus. The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16106A
    (8R,9S)-Talazoparib
    Inhibitor 98.28%
    (8R,9S)-Talazoparib ((8R,9S)-BMN-673) is an enantiomer of Talazoparib. (8R,9S)-Talazoparib is an PARP1 inhibitor, with an IC50 of 144 nM.
    (8R,9S)-Talazoparib
  • HY-N1970
    5,7-Dihydroxychromone
    Activator 99.94%
    5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells.
    5,7-Dihydroxychromone
  • HY-117889
    PARP14 inhibitor H10
    Inhibitor 98.04%
    PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis.
    PARP14 inhibitor H10
  • HY-10619D
    Niraparib (R-enantiomer)
    Inhibitor 99.69%
    Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM.
    Niraparib (R-enantiomer)
  • HY-13326
    ASP3026
    99.88%
    ASP3026 is a selective and orally active inhibitor of anaplastic lymphoma kinase (ALK). ASP3026 is a selective and oral active anaplastic lymphoma kinase (ALK) inhibitor with a IC50 value of 3.5 nM. ASP3026 can inhibit the phosphorylation of IGF-1R, STAT3, AKT and JNK proteins, and induce the cleavage of caspase 3 and PARP. It also inhibited ROS and ACK. ASP3026 can be used in anti-tumor research.
    ASP3026
  • HY-120115
    PARPi-FL
    Inhibitor 99.74%
    PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance.
    PARPi-FL
  • HY-114324
    PROTAC PARP1 degrader
    Inhibitor 99.74%
    PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. PROTAC PARP1 degrader induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader consists of E3 ubiquitinase ligand MDM2 ligand (HY-128836), blue part; target protein ligand PAPR1 ligand (HY-171543), pink part; PROTAC linker N3-PEG4-C2-NH2 (HY-128834), black part.
    PROTAC PARP1 degrader
  • HY-115552
    Simmiparib
    Inhibitor 99.51%
    Simmiparib is a highly potent and orally active PARP1 and PARP2 inhibitor with IC50 values of 1.75 nM and 0.22 nM, respectively. Simmiparib has more potent PARP1/2 inhibition than its parent Olaparib (HY-10162). Simmiparib induces DNA double-strand breaks (DSB) accumulation and G2/M arrest in homologous recombination repair (HR)-deficient cells, thereby inducing apoptosis. Simmiparib exhibits remarkable anticancer activities in cells and nude mice bearing xenografts.
    Simmiparib
  • HY-132297A
    PARP1-IN-5 dihydrochloride
    Inhibitor
    PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
    PARP1-IN-5 dihydrochloride
  • HY-10614
    A-966492
    Inhibitor 99.95%
    A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.
    A-966492
  • HY-122661
    Mefuparib hydrochloride
    Inhibitor 98.62%
    Mefuparib hydrochloride (MPH) is an orally active, substrate-competitive and selective PARP1/2 inhibitor with IC50s of 3.2 nM and 1.9 nM, respectively. Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo.
    Mefuparib hydrochloride
  • HY-110077
    API-1
    Inducer 99.62%
    API-1 is a potent selective Akt/PKB inhibitor that reduces the level of phosphorylated Akt (IC50 = 0.8 μM). API-1 binds to the PH domain and inhibits Akt membrane translocation. API-1 induces c-FLIP degradation. API-1 reduces cell proliferation and induces apoptosis. API-1 decreases tumor growth in mouse xenograft model.
    API-1
  • HY-148754
    PARP10-IN-3
    Inhibitor 98.89%
    PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC50s of 1.7 μM for human PARP2 and human PARP15, respectively.
    PARP10-IN-3
  • HY-W051513
    2-Methylquinazolin-4-ol
    Inhibitor 99.98%
    2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM.
    2-Methylquinazolin-4-ol
  • HY-146502
    PARP10/15-IN-3
    Inhibitor 99.98%
    PARP10/15-IN-3 (Compound 8a) is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.14 µM and 0.40 µM against PARP10 and PARP15, respectively. PARP10/15-IN-3 is able to enter cells and rescue cells from apoptosis.
    PARP10/15-IN-3
  • HY-10619E
    Niraparib tosylate hydrate
    Inhibitor 99.97%
    Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.
    Niraparib tosylate hydrate
  • HY-149800
    PARP-1-IN-3
    Inhibitor 99.30%
    PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer.
    PARP-1-IN-3
  • HY-N1931
    Epifriedelanol
    Inhibitor ≥98.0%
    Epifriedelanol is a triterpenoid found in the root bark of Ulmus davidiana. Epifriedelanol induces apoptosis in DU145 cells. Epifriedelanol has antitumor and anti-inflammatory activities. Epifriedelanol inhibits cellular senescence in human primary cells.
    Epifriedelanol
  • HY-113352
    7-Methylguanine
    Inhibitor 99.97%
    7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions.
    7-Methylguanine
  • HY-160937
    AZD-9574-acid
    Inhibitor
    AZD-9574-acid (70D), a PPAR-1 inhibitor, can be used for the synthesis of PROTAC (CAS 2923686-70-6).
    AZD-9574-acid
Cat. No. Product Name / Synonyms Application Reactivity

PARP

PARP1

PARP2

PARP3

PARP4

TNKS1/PARP5A

TNKS2/PARP5B

PARP7

PARP10

PARP14

PARP15

PARP12

PARP16

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PARP Inducers, Degraders, Inhibitors & Activators
Product NamePARPPARP1PARP2PARP3PARP4TNKS1/PARP5ATNKS2/PARP5BPARP7PARP10PARP14PARP15PARP12PARP16Purity    
Olaparib 
PARP-1, IC50: 5 nM
PARP-2, IC50: 1 nM
  
tankyrase-1, IC50: 1.5 μM
       99.98%
XAV-939 
ARTD1, IC50: 5500 nM
ARTD2, IC50: 479 nM
  
TNKS1, IC50: 5 nM
TNKS2, IC50: 2 nM
      99.91%
Talazoparib 
PARP1, Ki: 1.2 nM
PARP2, Ki: 0.87 nM
          99.89%
Niraparib 
PARP-1, IC50: 3.8 nM
PARP-2, IC50: 2.1 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
       99.96%
Saruparib 
PARP1, IC50: 3 nM
PARP2, IC50: 1400 nM
          99.76%
IRF1-IN-1 
PARP-1
           99.72%
IRF1-IN-2 
PARP-1
           99.83%
Rucaparib 
PARP-1, Ki: 1.4 nM
           99.97%
Chlorin e6 
PARP-1
           98.38%
Veliparib 
PARP-1, Ki: 5.2 nM
PARP-2, Ki: 2.9 nM
          99.78%
PJ34
PARP, IC50: 110 nM
PARP-1, IC50: 110 nM
PARP-2, IC50: 86 nM
          98.11%
KSQ-4279 
PARP1
           99.95%
RBN-2397       
PARP-7, IC50: 3 nM
PARP-7, Kd: 1 nM
     99.86%
Pamiparib
PARP
            99.97%
Dehydrocorydaline
PARP
            99.77%
RBN012759    
PARP4, IC50: 10 μM
  
PARP7, IC50: 4 μM
PARP10, IC50: 1 μM
PARP14, IC50: <3 nM
   99.80%
Fluzoparib 
PARP-1, IC50: 1.46±0.72  nM
           99.96%
SK-575 
PARP1, IC50: 2.30 nM
           99.86%
Rucaparib phosphate 
PARP-1, Ki: 1.4 nM
           99.76%
Niraparib hydrochloride 
PARP-1, IC50: 3.8 nM
PARP-2, IC50: 2.1 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
       99.41%
Niraparib tosylate 
PARP-1, IC50: 3.8 nM
PARP-2, IC50: 2.1 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
       99.99%
NVP-TNKS656  
PARP2, IC50: 32 μM
   
TNKS2, IC50: 6 nM
      99.66%
3-Aminobenzamide
PARP, IC50: 50 nM
            99.99%
G007-LK     
TNKS1, IC50: 46 nM
TNKS2, IC50: 25 nM
      99.24%
AG14361 
PARP-1, Ki: 0.5 nM
           99.44%
Peiminine 
PARP-1
           99.94%
WIKI4      
TNKS2, IC50: 26 nM
      99.93%
Paris saponin VII 
PARP-1
           99.96%
Stenoparib 
PARP1, IC50: 2 nM
PARP2, IC50: 1 nM
  
TNKS1, IC50: 50 nM
TNKS2, IC50: 50 nM
      ≥98.0%
DPQ 
PARP-1
           ≥99.0%
Triclabendazole
PARP
            98.72%
Rucaparib monocamsylate 
PARP-1, Ki: 1.4 nM
           99.82%
PJ34 hydrochloride
PARP, IC50: 110 nM
PARP-1, IC50: 110 nM
PARP-2, IC50: 86 nM
          99.91%
BGP-15
PARP, IC50: 120 μM
            ≥98.0%
RBN-3143 
PARP1, IC50: >100000 nM
PARP2, IC50: >100000 nM
PARP3, IC50: >100000 nM
PARP4, IC50: 42700 nM
   
PARP10, IC50: 1600 nM
PARP14, IC50: 4 nM
PARP15, IC50: 4200 nM
  99.24%
AZD-2461 
PARP1, IC50: 5 nM
PARP2, IC50: 2 nM
PARP3, IC50: 200 nM
         99.79%
OUL35        
ARTD10/PARP10, IC50: 329 nM
    99.80%
OUL232 
PARP1, IC50: 15 μM
PARP2, IC50: 10 μM
PARP3, IC50: 50 μM
PARP4, IC50: 11 μM
TNKS1, IC50: 5.4 μM
TNKS2, IC50: 10 μM
PARP7, IC50: 83 nM
PARP10, IC50: 7.8 nM
PARP14, IC50: 300 nM
PARP15, IC50: 56 nM
  99.86%
UPF 1069 
PARP-1, IC50: 8 μM
PARP-2, IC50: 0.3 μM
          99.10%
Veliparib dihydrochloride 
PARP-1, Ki: 5.2 nM
PARP-2, Ki: 2.9 nM
          99.98%
iRucaparib-AP6 
PARP1, DC50: 82 nM
           99.27%
DB008            
PARP16, IC50: 0.27 μM
98.78%
RK-287107     
tankyrase-1, IC50: 14.3 nM
tankyrase-2, IC50: 10.6 nM
      99.81%
ME0328 
ARTD1/PARP1, IC50: 6.3 μM
ARTD2/PARP2, IC50: 10.8 μM
ARTD3/PARP3, IC50: 0.89 μM
 
ARTD5/TNKS1, IC50: 47.3 μM
ARTD6/TNKS2, IC50: 34.3 μM
 
ARTD10/PARP10, IC50: 71.3 μM
    99.64%
Iniparib 
PARP1
           99.74%
1,5-Isoquinolinediol
PARP, IC50: 0.18-0.37 μM
            99.33%
AZ6102 
PARP1, IC50: 2 μM
PARP2, IC50: 0.5 μM
  
TNKS1, IC50: 3 nM
TNKS2, IC50: 2 nM
      99.65%
Venadaparib 
PARP1, IC50: 1.4 nM
PARP2, IC50: 1 nM
          98.11%
JW 55     
TNKS1, IC50: 1.9 μM
TNKS2, IC50: 0.83 μM
      98.95%
5,​7,​4'-​Trimethoxyflavone
PARP
            99.65%
MN-64 
ARTD1, IC50: 19.1 μM
ARTD2, IC50: 39.4 μM
  
TNKS1, IC50: 6 nM
TNKS2, IC50: 72 nM
      99.61%
OM-153     
TNKS1, IC50: 13 nM
TNKS2, IC50: 2 nM
      99.59%
N-Descyclopropanecarbaldehyde Olaparib
PARP
            99.27%
NMS-P118 
PARP-1, Kd: 9 nM
PARP-2, Kd: 1390 nM
          99.54%
Gomisin N 
PARP-1
           99.94%
PARP7-IN-16 
PARP-1, IC50: 0.94 nM
PARP-2, IC50: 0.87 nM
    
PARP-7, IC50: 0.21 nM
     99.91%
PARP7-IN-15       
PARP7, IC50: 0.56 nM
     98.22%
Nesuparib  
PARP2, IC50: 2 nM
  
tankyrase-1, IC50: 5 nM
tankyrase-2, IC50: 1 nM
      99.54%
PARP10/15-IN-1        
PARP10, IC50: 160 nM
 
PARP15, IC50: 370 nM
  
K-756     
TNKS1, IC50: 31 nM
TNKS2, IC50: 36 nM
      99.25%
INO-1001
PARP
            98.86%
BYK204165 
hPARP-1, pIC50: 7.35
mPARP-2, pIC50: 5.38
          98.66%
MSC2504877 
PARP1, IC50: 0.54 μM
           98.50%
(8R,9S)-Talazoparib 
PARP-1, IC50: 144 nM
           98.28%
5,7-Dihydroxychromone
PARP
            99.94%
PARP14 inhibitor H10         
PARP14, IC50: 490 nM
   98.04%
Niraparib (R-enantiomer) 
PARP-1, IC50: 2.4 nM
           99.69%
ASP3026 
PARP1
           99.88%
PROTAC PARP1 degrader 
PARP1
           99.74%
Simmiparib 
PARP1, IC50: 0.74 nM
PARP2, IC50: 0.22 nM
          99.51%
PARP1-IN-5 dihydrochloride 
PARP-1, IC50: 14.7 nM
PARP-2, IC50: 0.9 μM
          
A-966492 
PARP-1, Ki: 1 nM
PARP-2, Ki: 1.5 nM
          99.95%
Mefuparib hydrochloride 
PARP1, IC50: 3.2 nM
PARP2, IC50: 1.9 nM
  
TNKS1, IC50: 1.6 μM
TNKS2, IC50: 1.3 μM
      98.62%
API-1
PARP
            99.62%
PARP10-IN-3 
human PARP1, IC50: >100 μM
human PARP2, IC50: 1.7 μM
human PARP3, IC50: >100 μM
human PARP4, IC50: 7 μM
human TNKS1, IC50: 21 μM
human TNKS2, IC50: 6.5 μM
 
human PARP10, IC50: 480 nM
human PARP14, IC50: 41 μM
human PARP15, IC50: 1.7 μM
human PARP12, IC50: >10 μM
human PARP16, IC50: >10 μM
98.89%
PARP10/15-IN-3        
PARP10, IC50: 0.14 μM
 
PARP15, IC50: 0.40 μM
  99.98%
Niraparib tosylate hydrate 
PARP-1, IC50: 3.8 nM
PARP-2, IC50: 2.1 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
       99.97%
PARP-1-IN-3 
PARP-1, IC50: 0.25 nM
PARP-2, IC50: 2.34 nM
          99.30%
7-Methylguanine 
PARP-1, Ki: 61 μM
           99.97%
GeA-69         
PARP14, Kd: 2.1 μM
   99.91%
NMS-P515 
PARP-1, Kd: 16 nM
PARP-1, IC50: 27 nM (in Hela cells)
           98.18%
TIQ-A  
PARP2, IC50: 210 nM
   
TNKS2, IC50: 24 nM
 
PARP10, IC50: >10 μM
PARP14, IC50: >10 μM
PARP15, IC50: 230 nM
  99.85%
ART-IN-1  
PARP2, IC50: 19 μM
   
TNKS2, IC50: 22 μM
 
PARP10, IC50: 2.4 μM
PARP14, IC50: >100 μM
PARP15, IC50: 1.1 μM
  98.91%
PARP7-IN-16 free base 
PARP1, IC50: 0.94 nM
PARP2, IC50: 0.87 nM
    
PARP7, IC50: 0.21 nM
     99.40%
PROTAC PARP1 degrader-1 
PARP-1
           99.86%
PARP1-IN-29 
PARP-1, IC50: 6.3 nM
           
PARP10/15-IN-2        
PARP10, IC50: 0.15 μM
 
PARP15, IC50: 0.37 μM
  99.00%
DR2313 
PARP-1, IC50: 0.20 μM
PARP-2, IC50: 0.24 μM
          99.66%
YCH1899 
PARP-1, IC50: <0.001 nM
PARP-2, IC50: <0.001 nM
PARP3, IC50: 1.1 nM
PARP4, IC50: 1.0 nM
TNKS1, EC50: 3.8 nM
TNKS2, IC50: 12.4 nM
PARP-7, IC50: 7.3 nM
ARTD10/PARP10, IC50: 10.8 nM
PARP14, IC50: 35.914 μM
PARP15, IC50: 51.623 nM
human PARP12, IC50: 14.1 nM
 99.39%
PARP-1-IN-2 
PARP-1, IC50: 149 ± 11.0 nM
           99.48%
PARP1-IN-11 
PARP1, IC50: 0.082 μM
           98.58%
PARP-2-IN-1  
PARP-2, IC50: 11.5 nM
          99.56%
PARP/PI3K-IN-1 
PARP-1, pIC50: 8.22
PARP-2, pIC50: 8.44
          99.43%
PARP7-IN-17       
PARP7
     
E7016
PARP
            98.46%
PARP10-IN-2 
human PARP1, IC50: >100 μM
human PARP2, IC50: 27 μM
human PARP3, IC50: >100 μM
human PARP4, IC50: >100 μM
human TNKS1, IC50: >100 μM
human TNKS2, IC50: >100 μM
 
human PARP10, IC50: 3.64 μM
human PARP14, IC50: >100 μM
human PARP15, IC50: 11 μM
human PARP12, IC50: >10 μM
human PARP16, IC50: >10 μM
98.02%
Anticancer agent 43 
PARP1
           98.58%
Rucaparib tartrate 
PARP-1, Ki: 1.4 nM
           
Rucaparib camsylate 
PARP-1, Ki: 1.4 nM
           
PARP1-IN-5 
PARP-1, IC50: 14.7 nM
PARP-2, IC50: 0.9 μM
          
Venadaparib hydrochloride 
PARP1, IC50: 1.4 nM
PARP2, IC50: 1 nM
          
Rucaparib acetate 
PARP-1, Ki: 1.4 nM
           
BPA-B9
PARP
            
Rucaparib hydrochloride 
PARP-1, Ki: 1.4 nM
           
PARP1-IN-9 
PARP1, IC50: 30.51 nM
           
PARP-2-IN-3  
PARP-2, IC50: 0.07 μM
          
PARP1-IN-33 
PARP1, IC50: 0.41 nM
           99.87%
OM-1700     
TNKS1, IC50: 127 nM
TNKS2, IC50: 14 nM
      
TOPOI/PARP-1-IN-2 
PARP-1, IC50: 32.2 nM
PARP-2, IC50: 2844 nM
          
Antitumor agent-170       
PARP7, IC50: 7.05 nM
     
ARTD10/PARP10-IN-1 
ARTD1/PARP1, IC50: 4.4 μM
      
ARTD10/PARP10, IC50: 0.8 μM
ARTD8/PARP14, IC50: 1.6 μM
ARTD7/PARP15, IC50: 1.7 μM
  
PARP1/BRD4-IN-1 
PARP1, IC50: 49 nM
           
TC-E 5001     
TNKS1, Ki: 79 nM
TNKS2, Ki: 28 nM
      
ZINC20906412        
PARP10
    
PARP1/CDK12-IN-1 
PARP1, IC50: 34 nM
           
PARPYnD 
PARP1
PARP2
          
PARP7-IN-22       
PARP-7, IC50: 0.6 nM
     
DLC-50 
PARP1, IC50: 1.2 nM
           
(rac)-Talazoparib 
PARP1, Ki: 1.2 nM
PARP2, Ki: 0.87 nM
          
PARP1-IN-8 
PARP-1, IC50: 97 nM
           99.29%
AZ0108 
PARP1, IC50: 0.03 μM
PARP2, IC50: 0.03 μM
PARP3, IC50: 2.8 μM
 
TNKS1, IC50: 3.2 μM
       
PARP7-IN-12       
PARP7, IC50: 7.836 nM
     
PARP/EZH2-IN-2 
PARP1, IC50: 6.89 ± 0.7 nM
           
DPQ hydrochloride 
PARP-1
           
PARP1/BRD4-IN-2 
PARP1, IC50: 197 nM
           
PARP1-IN-14 
PARP1, IC50: 0.6 ± 0.1 nM
           
PARP7-IN-23       
PARP7
     
Tankyrase-IN-4     
TNKS1, IC50: 0.8 nM
       
PARP1-IN-21 
PARP1
           
Anticancer agent 64
PARP
            
KSQ-4279 (gentisate) 
PARP1
           
Antitumor agent-169       
PARP7, IC50: 2.5 nM
     
PROTAC PARP1 degrader-4 
PARP1
           
Tankyrase-IN-3     
TNKS1, IC50: 22 nM
       
NDs-IN-1 
hPARP-1
PARP-2
          
KU-0058948 hydrochloride 
PARP-1, IC50: 3.4 nM
           
PARP1-IN-18 
PARP1, IC50: 2.7 nM
           
PARP1-IN-34 
PARP1, IC50: 0.32 nM
PARP2, IC50: 326 nM
          
PARP/EZH2-IN-1 
PARP-1, IC50: 6.87 nM
           
PARP7-IN-24       
PARP7
     
PARP-1-IN-23 
PARP-1, IC50: 12.38 nM
           
PARP-2/1-IN-2 
PARP1, Ki: 5 nM
PARP2, Ki: 2 nM
          
PARP1/BRD4-IN-3 
PARP1, IC50: 2019 nM
           
OUL245 
PARP-1, IC50: 570 nM
PARP2, IC50: 44 nM
PARP3, IC50: 8.8 μM
PARP4, IC50: 6.0 μM
TNKS1, IC50: 1.6 μM
TNKS2, IC50: 370 μM
 
PARP10, IC50: 2.9 μM
PARP14, IC50: 6.7 μM
PARP15, IC50: 2.0 μM
  
PARP1/c-Met-IN-1 
PARP1, IC50: 3.3 nM
           
PARP1-IN-22 
PARP1
           
PARP1-IN-10 
PARP1, IC50: 50.62 nM ([1])
           
SK-575-NEG 
PARP-1, IC50: 2.64 nM
           
PARP1/2/TNKS1/2-IN-1 
PARP-1, IC50: 0.25 nM
PARP-2, IC50: 1.2 nM
  
TNKS1, IC50: 13.5 nM
TNKS2, IC50: 4.15 nM
      
PARP-1/HDAC-IN-1 
PARP-1, IC50: 68.90 nM
           
PARP1/2-IN-3 
PARP-1, IC50: 0.2235 nM
           
PARP1-IN-17 
PARP-1
           
PARP-1/2/7-IN-1 
PARP1
PARP2
    
PARP7
     
PARP1-IN-30 
PARP1
           
ARTD10/PARP10-IN-2 
ARTD1/PARP1, IC50: 9.7 μM
      
ARTD10/PARP10, IC50: 2.0 μM
ARTD8/PARP14, IC50: >20 μM
ARTD7/PARP15, IC50: >20 μM
  
PARP1-IN-20 
PARP1, IC50: 4.62 nM
           
PARP1-IN-12 
PARP-1, IC50: 2.99 nM
           
PARP1-IN-35 
PARP1, IC50: 0.2 nM
PARP2, IC50: 122 nM
          
PROTAC PARP1 degrader-3 
PARP-1, DC50: 58.14 nM
           
CEP-9722 
PARP-1, IC50: 20 nM
PARP-2, IC50: 6 nM
          
PARP7-IN-21       
PARP7
     
CDK9/PARP-IN-1 
PARP1, IC50: 107 nM
           
EB-47 
ARTD1/PARP1, IC50: 45 nM
           
ST7710AA1 
PARP-1, IC50: 0.07 μM
           
KU-0058948 
PARP-1, IC50: 3.4 nM
           
Benzo[c][1,8]naphthyridin-6(5H)-one 
PARP-1, IC50: 0.311 μM
           
PARP1-IN-37 
PARP1, IC50: 24 nM
           
BSI-401 
PARP-1
           
UPF-1035 
PARP-1, IC50: 9 μM
PARP-2, IC50: 0.15 μM
          
EXQ-2d     
TNKS1, IC50: 48.8 nM
TNKS2, IC50: 13.8 nM
      
KU-0058684 
PARP-1, IC50: 3.2 nM
           
WD2000-012547 
PARP-1, pKi: 8.221