1. Gene
  2. H4C16 - H4 histone 16 Gene

H4C16 - H4 histone 16 Gene

Homo sapiens (human)

Also known as H4/p; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; HIST4H4

Gene ID: 121504 | Gene type: protein coding

About H4C16

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

H4C16 Products(1)

mRNA Protein Name
NM_175054.2 NP_778224.1 histone H4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9540062 GOA
enables structural constituent of chromatin IDA
IDA: Inferred from direct assay
14718166 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of megakaryocyte differentiation IDA
IDA: Inferred from direct assay
18474616 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CENP-A containing nucleosome IPI
IPI: Inferred from physical interaction
21743476 GOA
part of nucleosome IDA
IDA: Inferred from direct assay
14718166 GOA
part of nucleosome IPI
IPI: Inferred from physical interaction
20498094 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14585971 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone H4

histone 4, H4

histone cluster 4 H4

H4C16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
H4C16 P62805 H2BC21 Homo sapiens Q16778 30021884
Intra
H4C16 P62805 H3-3A Homo sapiens P84243 24183680
Intra
H4C16 P62805 L3MBTL1 Homo sapiens Q9Y468 17540172
Intra
H4C16 P62805 L3MBTL1 Homo sapiens Q9Y468 16415788
Intra
H4C16 P62805 KMT5A Homo sapiens Q9NQR1
GMS
21983900
Intra
H4C16 P62805 KMT5A Homo sapiens Q9NQR1 15933069
Cross
H4C16 P62805 LANA1 Human herpesvirus 8 Q9QR71 31759698
Intra
H4C16 P62805 CENPA Homo sapiens P49450
GMS
26167883
Intra
H4C16 P62805 HAT1 Homo sapiens O14929
TAP
19862764
Intra
H4C16 P62805 PHF20 Homo sapiens Q9BVI0 16415788
Intra
H4C16 P62805 PHF20L1 Homo sapiens A8MW92 16415788
Intra
H4C16 P62805 BRPF1 Homo sapiens P55201
ITC
25281266
Intra
H4C16 P62805 JMJD4 Homo sapiens Q9H9V9 24360279
Intra
H4C16 P62805 RAN Homo sapiens P62826 30021884
Intra
H4C16 P62805 HDAC1 Homo sapiens Q13547
GMS
21983900
Intra
H4C16 P62805 YWHAZ Homo sapiens P63104 15161933
Intra
H4C16 P62805 PRMT5 Homo sapiens O14744 20951943
Intra
H4C16 P62805 RBBP7 Homo sapiens Q16576 18571423
Intra
H4C16 P62805 RBBP7 Homo sapiens Q16576 18571423
Intra
H4C16 P62805 RBBP7 Homo sapiens Q16576
TAP
19862764
Intra
H4C16 P62805 RBBP7 Homo sapiens Q16576 28514442
Intra
H4C16 P62805 RBBP7 Homo sapiens Q16576
SPR
18571423
Intra
H4C16 P62805 SMARCA5 Homo sapiens O60264 16917504
Intra
H4C16 P62805 SMARCA5 Homo sapiens O60264 16917504
Intra
H4C16 P62805 MCM3 Homo sapiens P25205
TAP
19862764
Intra
H4C16 P62805 MCM3 Homo sapiens P25205 19862764
Intra
H4C16 P62805 SMARCB1 Homo sapiens Q12824 31759698
Intra
H4C16 P62805 H3-4 Homo sapiens Q16695 30021884
Intra
H4C16 P62805 H2AC4 Homo sapiens P04908 30021884
Intra
H4C16 P62805 MCM5 Homo sapiens P33992 19862764
Intra
H4C16 P62805 MCM5 Homo sapiens P33992
TAP
19862764
Intra
H4C16 P62805 YWHAG Homo sapiens P61981 32814053
Intra
H4C16 P62805 YWHAG Homo sapiens P61981 32814053
Intra
H4C16 P62805 YWHAG Homo sapiens P61981 32814053
Intra
H4C16 P62805 MCM2 Homo sapiens P49736
TAP
19862764
Intra
H4C16 P62805 MCM2 Homo sapiens P49736 28514442
Intra
H4C16 P62805 TP53BP1 Homo sapiens Q12888 23377543
Intra
H4C16 P62805 TP53BP1 Homo sapiens Q12888 16415788
Intra
H4C16 P62805 TP53BP1 Homo sapiens Q12888
ITC
22373579
Intra
H4C16 P62805 TP53BP1 Homo sapiens Q12888 27153538
Intra
H4C16 P62805 TP53BP1 Homo sapiens Q12888
NMR
23377543
Intra
H4C16 P62805 BPTF Homo sapiens Q12830-4 21596426
Intra
H4C16 P62805 BPTF Homo sapiens Q12830-4 21596426
Intra
H4C16 P62805 H2AX Homo sapiens P16104 30021884
Intra
H4C16 P62805 RRP1B Homo sapiens Q14684-1 19710015
Intra
H4C16 P62805 RRP1B Homo sapiens Q14684-1 19710015
Intra
H4C16 P62805 MBTD1 Homo sapiens Q05BQ5 27153538
Intra
H4C16 P62805 TLE1 Homo sapiens Q04724 24596249
Intra
H4C16 P62805 HMGA1 Homo sapiens P17096 30021884
Intra
H4C16 P62805 ASF1A Homo sapiens Q9Y294 25416956
Intra
H4C16 P62805 ASF1A Homo sapiens Q9Y294 32296183
Intra
H4C16 P62805 ASF1A Homo sapiens Q9Y294 25416956
Intra
H4C16 P62805 ASF1A Homo sapiens Q9Y294 32296183
Intra
H4C16 P62805 ASF1A Homo sapiens Q9Y294
TAP
19862764
Intra
H4C16 P62805 ASF1A Homo sapiens Q9Y294 32296183
Intra
H4C16 P62805 ASF1A Homo sapiens Q9Y294 32296183
Intra
H4C16 P62805 H3C13 Homo sapiens Q71DI3 30021884
Intra
H4C16 P62805 PRMT1 Homo sapiens Q99873 24726341
Intra
H4C16 P62805 H3C1 Homo sapiens P68431
GMS
20498094
Intra
H4C16 P62805 H3C1 Homo sapiens P68431 20739937
Intra
H4C16 P62805 H3C1 Homo sapiens P68431
DLS
20498094
Intra
H4C16 P62805 SETDB1 Homo sapiens Q15047-2 32814053
Intra
H4C16 P62805 SETDB1 Homo sapiens Q15047-2 32814053
Intra
H4C16 P62805 SETDB1 Homo sapiens Q15047-2 32814053
Intra
H4C16 P62805 BRD4 Homo sapiens O60885-1 24525235
Intra
H4C16 P62805 BRD4 Homo sapiens O60885-1 24361270
Intra
H4C16 P62805 BRD4 Homo sapiens O60885-1 24525235
Intra
H4C16 P62805 KDM4A Homo sapiens O75164
ITC
22373579
Cross
H4C16 P62805 Sfmbt Drosophila melanogaster Q9VK33
ITC
19494831
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant H4C16 Proteins

Cat. No. Product Name Accession Purity
HY-P72336 Histone H4 Protein, Human/Xenopus laevis P62805 (S2-G103) ≥95%

H4C16 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81256 Acetyl-Histone H4 Antibody (YA926) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P81256A Acetyl-Histone H4 Antibody (YA927) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P83301 MonoMethyl-Histone H4 Antibody (YA3046) WB, ICC/IF Human, Mouse