1. Gene
  2. Tert - telomerase reverse transcriptase Gene

Tert - telomerase reverse transcriptase Gene

Rattus norvegicus
Gene ID: 301965 | Gene type: protein coding

About Tert

Primary_assembly 1: 29,637,506-29,659,561 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 188 orthologues and is associated with 103 phenotypes. Biased expression in Liver (RPKM 26.6), Thymus (RPKM 16.6) and 8 other tissues.

Summary

Predicted to enable several functions, including chaperone binding activity; nucleic acid binding activity; and nucleotidyltransferase activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of transdifferentiation; and positive regulation of vascular associated smooth muscle cell migration. Located in mitochondrion and nucleus. Used to study chronic kidney disease and transient cerebral ischemia. Biomarker of hepatocellular carcinoma and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase Reverse Transcriptase). [provided by Alliance of Genome Resources, Apr 2022]

Tert Products(1)

mRNA Protein Name
NM_053423.2 NP_445875.1 telomerase reverse transcriptase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23184978 RGD
enables telomerase activity IDA
IDA: Inferred from direct assay
9665809 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
24376652 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
9344766 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20138964 RGD
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
23013219 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
23968592 RGD
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
24376652 RGD
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
23013219 RGD
involved in positive regulation of transdifferentiation IMP
IMP: Inferred from mutant phenotype
24376652 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
24376652 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
24376652 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
21181359 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
21937513 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tert Protein Structure

Telomerase_RBD

Telomerase_RBD: pfam12009 (453 - 584)

TERT

TERT: cd01648 (819 - 932)

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  • 1129 a.a.
Protein Preferred Names Protein Names

telomerase reverse transcriptase

telomerase catalytic subunit

Orthologs Information

Species Symbol Source ID
Homo sapiens Tert NCBI NCBI:7015
Mus musculus Tert NCBI NCBI:21752