1. Gene
  2. YWHAH - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Gene

YWHAH - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Gene

Homo sapiens

Also known as YWHA1

Gene ID: 7533 | Gene type: protein coding

About YWHAH

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:31,944,535-31,957,603 (from NCBI)

This gene has 6 transcripts (splice variants), 124 orthologues and 6 paralogues. Broad expression in brain (RPKM 343.5), lung (RPKM 62.6) and 22 other tissues.

Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

YWHAH Products(1)

mRNA Protein Name
NM_003405.4 NP_003396.1 2014/3/3 protein eta
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
17255105 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17085597 GOA
enables nuclear glucocorticoid receptor binding IPI
IPI: Inferred from physical interaction
9079630 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10713667 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
11953308 GOA
enables sodium channel regulator activity IDA
IDA: Inferred from direct assay
16728661 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
11953308 GOA
Biological Process GO Annotation Evidence Reference Source
involved in glucocorticoid catabolic process IDA
IDA: Inferred from direct assay
15790729 GOA
involved in membrane depolarization during action potential IDA
IDA: Inferred from direct assay
16728661 GOA
involved in nuclear receptor-mediated glucocorticoid signaling pathway IDA
IDA: Inferred from direct assay
15790729 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15790729 GOA
involved in regulation of sodium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
16728661 GOA
involved in regulation of sodium ion transport IDA
IDA: Inferred from direct assay
16728661 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
31906564 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16728661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YWHAH Protein Structure

14-3-3

14-3-3: 14-3-3 protein (4 - 241)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

14-3-3 protein eta

14-3-3 eta

YWHAH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
YWHAH Q04917 CDK14 Homo sapiens O94921
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 CDK14 Homo sapiens O94921
Y2H
16775625
Intra
YWHAH Q04917 CDK14 Homo sapiens O94921
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 CCNY Homo sapiens Q8ND76
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 CDC25B Homo sapiens P30305
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 CDC25B Homo sapiens P30305
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 CDC25B Homo sapiens P30305
Y2H
10713667
Intra
YWHAH Q04917 INPP5E Homo sapiens Q9NRR6
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 INPP5E Homo sapiens Q9NRR6
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 INPP5E Homo sapiens Q9NRR6
Anti Tag CoIP
35271311
Intra
YWHAH Q04917 CCDC125 Homo sapiens Q86Z20
Validated Y2H
32296183
Intra
YWHAH Q04917 PRKD2 Homo sapiens Q9BZL6
Pull Down
17962809
Intra
YWHAH Q04917 PRKD2 Homo sapiens Q9BZL6
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 PRR5 Homo sapiens P85299
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 PRR5 Homo sapiens P85299
BioID
36931259
Intra
YWHAH Q04917 SSX2IP Homo sapiens Q9Y2D8
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 SSX2IP Homo sapiens Q9Y2D8
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 SSX2IP Homo sapiens Q9Y2D8
BioID
36931259
Intra
YWHAH Q04917 SPG11 Homo sapiens Q96JI7
Y2H
37871017
Intra
YWHAH Q04917 NHSL2 Homo sapiens Q5HYW2
Validated Y2H
32296183
Intra
YWHAH Q04917 PRKCI Homo sapiens P41743
Anti Tag CoIP
14676191
Intra
YWHAH Q04917 PRKCI Homo sapiens P41743
TAP
17979178
Intra
YWHAH Q04917 PRKCI Homo sapiens P41743
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 PARD6B Homo sapiens Q9BYG5
Anti Tag CoIP
14676191
Intra
YWHAH Q04917 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
14676191
Intra
YWHAH Q04917 MARK4 Homo sapiens Q96L34
Anti Tag CoIP
16959763
Intra
YWHAH Q04917 MARK4 Homo sapiens Q96L34
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 MARK4 Homo sapiens Q96L34
Anti Tag CoIP
14676191
Intra
YWHAH Q04917 RAF1 Homo sapiens P04049
Anti Tag CoIP
26496610
Intra
YWHAH Q04917 RAF1 Homo sapiens P04049
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 RAF1 Homo sapiens P04049
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 RAF1 Homo sapiens P04049
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 RAF1 Homo sapiens P04049
TAP
17979178
Intra
YWHAH Q04917 RAF1 Homo sapiens P04049
Biochemical
11697890
Intra
YWHAH Q04917 RAF1 Homo sapiens P04049
Anti Tag CoIP
35271311
Intra
YWHAH Q04917 MAP3K3 Homo sapiens Q99759
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 MAP3K3 Homo sapiens Q99759
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 MAP3K3 Homo sapiens Q99759
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 HDAC4 Homo sapiens P56524
CoIP
18045992
Intra
YWHAH Q04917 HDAC4 Homo sapiens P56524
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 HDAC4 Homo sapiens P56524
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 HDAC4 Homo sapiens P56524
BioID
36931259
Intra
YWHAH Q04917 HDAC4 Homo sapiens P56524
Anti Tag CoIP
26496610
Intra
YWHAH Q04917 HDAC4 Homo sapiens P56524
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 HDAC4 Homo sapiens P56524
TAP
17979178
Intra
YWHAH Q04917 YWHAE Homo sapiens P62258
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 YWHAE Homo sapiens P62258
BioID
36931259
Intra
YWHAH Q04917 YWHAE Homo sapiens P62258
Anti Tag CoIP
26496610
Intra
YWHAH Q04917 YWHAE Homo sapiens P62258
Anti Tag CoIP
35271311
Intra
YWHAH Q04917 YWHAE Homo sapiens P62258
Y2H Pooling
20936779
Intra
YWHAH Q04917 YWHAE Homo sapiens P62258
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
YWHAH Q04917 YWHAE Homo sapiens P62258
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 NEK1 Homo sapiens Q96PY6
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 NEK1 Homo sapiens Q96PY6
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 NEK1 Homo sapiens Q96PY6
BioID
36931259
Intra
YWHAH Q04917 NEK1 Homo sapiens Q96PY6
Y2H
14690447
Intra
YWHAH Q04917 NEK1 Homo sapiens Q96PY6
Anti Tag CoIP
35271311
Intra
YWHAH Q04917 FGD6 Homo sapiens Q6ZV73
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 FGD6 Homo sapiens Q6ZV73
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 FGD6 Homo sapiens Q6ZV73
BioID
36931259
Intra
YWHAH Q04917 MAP3K5 Homo sapiens Q99683
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 MAP3K5 Homo sapiens Q99683
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
TAP
17979178
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
BioID
36931259
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
14676191
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
16959763
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
CoIP
19553522
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 MARK2 Homo sapiens Q7KZI7
Anti Tag CoIP
35271311
Intra
YWHAH Q04917 CBL Homo sapiens P22681
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 CBL Homo sapiens P22681
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 CBL Homo sapiens P22681
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 CBL Homo sapiens P22681
Biochemical
11697890
Intra
YWHAH Q04917 KANK1 Homo sapiens Q14678-2
Pull Down
18458160
Intra
YWHAH Q04917 CAMKK1 Homo sapiens Q8N5S9
Anti Bait CoIP
18242179
Intra
YWHAH Q04917 CAMKK1 Homo sapiens Q8N5S9
Pull Down
18242179
Intra
YWHAH Q04917 CAMKK1 Homo sapiens Q8N5S9
Anti Tag CoIP
36931259
Cross
YWHAH Q04917 Rnd3 Mus musculus P61588
Anti Tag CoIP
23622247
Intra
YWHAH Q04917 BAD Homo sapiens Q92934
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 BAD Homo sapiens Q92934
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 BAD Homo sapiens Q92934
Y2H
21988832
Intra
YWHAH Q04917 BAD Homo sapiens Q92934
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 BAD Homo sapiens Q92934
TAP
17979178
Intra
YWHAH Q04917 MARK3 Homo sapiens P27448
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 MARK3 Homo sapiens P27448
Anti Tag CoIP
14676191
Intra
YWHAH Q04917 MARK3 Homo sapiens P27448
TAP
17979178
Intra
YWHAH Q04917 MARK3 Homo sapiens P27448
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 MARK3 Homo sapiens P27448
Anti Tag CoIP
35271311
Intra
YWHAH Q04917 MARK3 Homo sapiens P27448
BioID
36931259
Intra
YWHAH Q04917 MARK3 Homo sapiens P27448
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5
Pull Down
15677482
Intra
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5
BioID
36931259
Intra
YWHAH Q04917 NEDD4L Homo sapiens Q96PU5
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 AKT1S1 Homo sapiens Q96B36
TAP
17979178
Intra
YWHAH Q04917 AKT1S1 Homo sapiens Q96B36
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 AKT1S1 Homo sapiens Q96B36
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 AKT1S1 Homo sapiens Q96B36
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 PLK4 Homo sapiens O00444
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 CSNK1E Homo sapiens P49674
Pull Down
19860830
Intra
YWHAH Q04917 CSNK1E Homo sapiens P49674
BioID
36931259
Intra
YWHAH Q04917 CSNK1E Homo sapiens P49674
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 PARD6A Homo sapiens Q9NPB6
Anti Tag CoIP
14676191
Intra
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
33961781
Intra
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
14676191
Intra
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0
TAP
17979178
Intra
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
36931259
Intra
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
35271311
Intra
YWHAH Q04917 PARD3 Homo sapiens Q8TEW0
BioID
36931259
Intra
YWHAH Q04917 ATXN1 Homo sapiens P54253
Anti Tag CoIP
28514442
Intra
YWHAH Q04917 ATXN1 Homo sapiens P54253
BioID
36931259
Intra
YWHAH Q04917 SNCA Homo sapiens P37840-1
FPS
24895406
Intra
YWHAH Q04917 SNCA Homo sapiens P37840-1
AFM
24895406
Intra
YWHAH Q04917 SNCA Homo sapiens P37840-1
TEM
24895406
Intra
YWHAH Q04917 SNCA Homo sapiens P37840-1
Electrophoresis
24895406
Intra
YWHAH Q04917 SNCA Homo sapiens P37840
Confocal
24895406
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant YWHAH Proteins

Cat. No. Product Name Accession Purity
HY-P71682 14-3-3 eta Protein, Human (GST) Q04917 (R4-N246) ≥95%

YWHAH Antibodies

Cat. No. Product Name Application Reactivity
HY-P80525 14-3-3 eta Antibody (YA838) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Early-Onset Schizophrenia

Early Onset Schizophrenia

Deafness, Autosomal Dominant 64

DFNA64

Autosomal Dominant Nonsyndromic Deafness 64

Autosomal Dominant Deafness 64

Deafness, Autosomal Dominant, 64

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 64

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 64

Deafness, Autosomal Dominant, Type 64

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel

Smooth Muscle Connective Tissue Tumor

Leiomyosarcoma Of Small Intestine

Neurofibromatosis, Type I

Von Recklinghausen Disease

Neurofibromatosis 1

Neurofibromatosis, Type 1

NF1

Neurofibromatosis, Peripheral Type

Neurofibromatosis Type I

Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

Familial Spinal Neurofibromatosis

Fsnf

Peripheral Neurofibromatosis

Von Recklinghausen'S Neurofibromatosis

Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

Neurofibromatosis Peripheral Type

Von Recklinghausen Syndrome

Neurofibromatosis Type 1

Von Recklinghausen Neuropathy

Nf1 - [Neurofibromatosis Type 1]

Recklinghausen Disease

Sudden Infant Death Syndrome

SIDS

Sudden Infant Death Syndrome, Susceptibility To

Cot Death

Crib Death

Sudden Death Of Nonspecific Cause In Infancy

Sudden Infant Death

Death, Sudden, Syndrome, Infant

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris YWHAH VGNC VGNC:52975
Macaca mulatta YWHAH VGNC VGNC:78821
Mus musculus YWHAH MGD MGI:109194
Felis catus YWHAH VGNC VGNC:67156
Bos taurus YWHAH VGNC VGNC:97330
Rattus norvegicus YWHAH RGD RGD:3978
Others YWHAH NCBI