2. Gene
  3. Mmp9 - matrix metallopeptidase 9 Gene

Mmp9 - matrix metallopeptidase 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81687 | Gene type: protein coding

About Mmp9

Primary_assembly 3: 153,683,858-153,692,120 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 216 orthologues, 23 paralogues and is associated with 259 phenotypes. Biased expression in Thymus (RPKM 39.9), Kidney (RPKM 35.9) and 6 other tissues.

Summary

Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Apr 2022]

Mmp9 Products(1)

mRNA Protein Name
NM_031055.2 NP_112317.2 matrix metalloproteinase-9 precursor

Mmp9 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (40 - 94)

Peptidase_M10

Peptidase_M10: pfam00413 (115 - 444)

FN2

FN2: smart00059 (223 - 271)

FN2

FN2: smart00059 (281 - 329)

FN2

FN2: smart00059 (340 - 388)

PT

PT: cl04822 (457 - 488)

PT

PT: pfam04886 (474 - 509)

HX

HX: cd00094 (516 - 706)

  • 0
  • 200
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  • 600
  • 708 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-9

92 kDa gelatinase

92-kDa type IV collagenase

GELB

MMP-9

gelatinase B

matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)

Recombinant Mmp9 Proteins

Cat. No. Product Name Accession Purity
HY-P73301 MMP-9 Protein, Rat (HEK293, His) EDL96479.1 (A20-P708) ≥95%

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0099 Edaravone 99.89% Yes
HY-B0493 Niflumic acid Inhibitor 99.88% Unkown
HY-B0012 Pamidronic acid Inhibitor 98.00% Yes
HY-B0012A Pamidronate disodium Inhibitor ≥98.0% Yes
HY-B1451 Imidapril hydrochloride Inhibitor 99.80% Yes
HY-B1451A Imidapril Inhibitor ≥99.0% Yes
Clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
HY-12170 Prinomastat 99.27% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-15768 Ilomastat Inhibitor 98.39% Phase 2
HY-106992 S 3304 Inhibitor 99.11% Phase 2
HY-19485 XL-784 Inhibitor 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
HY-N0318 Salvianolic acid A 99.72% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99351 Andecaliximab Inhibitor 95.00% Phase 3
Pre-clinical Phase
Bioactive Molecules (107)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0431 Astragaloside IV Inhibitor ≥98.0% Unkown
HY-N2117 Isoginkgetin 99.95% Unkown
HY-19956 GI254023X Inhibitor 99.67% Unkown
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-113952 Actinonin 98.61% Unkown
HY-12354 SB-3CT Inhibitor 99.59% Unkown
HY-135232 MMP-9-IN-1 Inhibitor 99.71% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-P2036A FSL-1 TFA 99.65% Unkown
HY-N0069 Solamargine 99.97% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.80% Unkown
HY-103482 JNJ0966 Inhibitor 99.39% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-W016412 Coenzyme Q0 99.88% Unkown
HY-P4373A Hepcidin-1 (mouse) (TFA) Inducer 98.94% Unkown
HY-E70005C Collagenase, Type III / Unkown
HY-N0084 Betulinaldehyde Inhibitor 98.72% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.73% Unkown
HY-N2497 Isoliquiritin apioside Inhibitor 99.87% Unkown
HY-P3513 β-Neo-Endorphin Activator 98.22% Unkown
HY-116626 SM-7368 Inhibitor 99.77% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-120213 YH-306 98.01% Unkown
HY-N3945 Glaucine 99.57% Unkown
HY-P0273A Histatin 5 TFA Inhibitor 99.98% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-124373 ND-336 Inhibitor 95.4% Unkown
HY-N3063 Pimaric acid 99.83% Unkown
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.25% Unkown
HY-117970 MMPI-1154 Inhibitor 99.87% Unkown
HY-12168 Tanomastat Inhibitor 99.5% Unkown
HY-128026 MMP-9/MMP-13 Inhibitor I Inhibitor 99.90% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-N2205 Esculentoside H Inhibitor 98.73% Unkown
HY-W001925 7-Methoxy-1-tetralone 99.93% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor 99.1% Unkown
HY-114911 Feprazone Inhibitor 99.88% Unkown
HY-119423 MMP Inhibitor II Inhibitor / Unkown
HY-131417 cis-ACCP Inhibitor ≥97.0% Unkown
HY-149848 MMP-9-IN-6 Inhibitor 99.80% Unkown
HY-161285 MMP-9/10-IN-2 Inhibitor 99.91% Unkown
HY-B0099S Edaravone-d5 98.73% Unkown
HY-N2199 Sotetsuflavone 96.75% Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 98.59% Unkown
HY-N6862 Lucideric acid A Inhibitor 98.44% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.91% Unkown
HY-P4373 Hepcidin-1 (mouse) Inducer / Unkown
HY-RS08558 Mmp9 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-116302 MMP-9-IN-9 Inhibitor 97.0% Unkown
HY-104024 MMP-9-IN-10 Inhibitor / Unkown
HY-110046 CL-82198 hydrochloride Inhibitor / Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-111172 Inotilone Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-114785 BPHA Inhibitor / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-136699 Excisanin A / Unkown
HY-143407 FAK-IN-3 Inhibitor / Unkown
HY-146216 MMP-9-IN-3 / Unkown
HY-146217 MMP-9-IN-4 / Unkown
HY-146218 MMP-9-IN-5 / Unkown
HY-147867 MMP-2/9-IN-1 Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-153913 MMP-9-IN-7 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-155960 SH491 / Unkown
HY-156247 IVMT-Rx-3 Inhibitor / Unkown
HY-157138 MMP-9-IN-8 / Unkown
HY-161284 MMP-9/10-IN-1 Inhibitor / Unkown
HY-161707 MMP2-IN-4 Inhibitor / Unkown
HY-161966 VEGFR-2-IN-52 / Unkown
HY-162038 RXP03 Inhibitor / Unkown
HY-162079 Anticancer agent 183 Inhibitor / Unkown
HY-162344 Ir-CA Inducer / Unkown
HY-163760 ZM-32 Inhibitor / Unkown
HY-164525 SD-7300 Inhibitor / Unkown
HY-168560 MMP Inhibitor 4 Inhibitor / Unkown
HY-169062 RJF02215 Inhibitor / Unkown
HY-B0012B Pamidronic acid sodium Inhibitor / Unkown
HY-N10176 D-Isofloridoside Inhibitor / Unkown
HY-N12726 Halociline Inhibitor / Unkown
HY-N6860 Lucidenic acid C Inhibitor / Unkown
HY-N7385 Nudol / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2004 FFAGLDD / Unkown
HY-P2004A FFAGLDD TFA / Unkown
HY-P2179 MMP-1/MMP-9 Substrate, Fluorogenic / Unkown
HY-P3484 Dnp-PLGLWA-DArg-NH2 TFA / Unkown
HY-P3513A β-Neo-Endorphin acetate Activator / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-RS08557 MMP9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08559 Mmp9 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W011085 CP-471474 Inhibitor / Unkown
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / Unkown
HY-111186 Flocoumafen 98.69% Unkown
HY-119110 LY52 Inhibitor / Unkown
HY-119185 AZD-6605 / Unkown
HY-122585 proMMP-9 inhibitor-3c Inhibitor / Unkown
HY-124068 LQB-118 / Unkown
HY-13564A Batimastat sodium salt Inhibitor / Unkown
HY-18694 CGS 27023A Inhibitor / Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-P0273 Histatin 5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp9 NCBI NCBI:4318