Mmp9 - matrix metallopeptidase 9 Gene

Rattus norvegicus

Gene ID: 81687 | Gene type: protein coding

About Mmp9

Primary_assembly 3: 153,683,858-153,692,120 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 216 orthologues, 23 paralogues and is associated with 259 phenotypes. Biased expression in Thymus (RPKM 39.9), Kidney (RPKM 35.9) and 6 other tissues.

Summary

Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Apr 2022]

Mmp9 Products(1)

mRNA	Protein	Name
NM_031055.2	NP_112317.2	matrix metalloproteinase-9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibronectin binding	IPI IPI: Inferred from physical interaction	18039280	RGD
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	11826121	RGD
enables peptidase activity	IDA IDA: Inferred from direct assay	8531210	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17148685	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9732233	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cell-matrix adhesion	IEP IEP: Inferred from expression pattern	20218972	RGD
involved in cellular response to cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	12963432	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	19909738	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	16046515	RGD
involved in cellular response to iron(III) ion	IEP IEP: Inferred from expression pattern	21683124	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	21683124	RGD
involved in cellular response to low-density lipoprotein particle stimulus	IEP IEP: Inferred from expression pattern	19554388	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	22410640	RGD
involved in collagen catabolic process	IDA IDA: Inferred from direct assay	22410640	RGD
involved in heart development	IDA IDA: Inferred from direct assay	12061388	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	9733107	RGD
involved in macrophage chemotaxis	IDA IDA: Inferred from direct assay	20110414	RGD
involved in modification of synaptic structure, modulating synaptic transmission	EXP EXP: Inferred from Experiment	19047646	RGD
involved in modification of synaptic structure, modulating synaptic transmission	IDA IDA: Inferred from direct assay	19047646	RGD
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	22490164	RGD
involved in ossification	IEP IEP: Inferred from expression pattern	15883642	RGD
involved in parturition	IEP IEP: Inferred from expression pattern	7492685	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19948826	RGD
involved in positive regulation of leukocyte migration	IDA IDA: Inferred from direct assay	16698855	RGD
involved in positive regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17493927	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	11788364	RGD
involved in proteolysis	IDA IDA: Inferred from direct assay	20110414	RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IDA IDA: Inferred from direct assay	19420267	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19889233	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17603938	RGD
involved in response to high light intensity	IEP IEP: Inferred from expression pattern	17854381	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	19099751	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	17289933	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17452115	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17158349	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	19879865	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	17650800	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17114644	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	15642321	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	19099751	RGD
involved in response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	17704356	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	17164434	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16846501	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17603938	RGD
involved in tissue remodeling	IDA IDA: Inferred from direct assay	16740171	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	19047646	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	19047646	RGD
is active in extracellular matrix of synaptic cleft	IDA IDA: Inferred from direct assay	18332222	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	17603938	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18332222	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	18332222	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16935996	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp9 Protein Structure

PG_binding_1

Peptidase_M10

FN2

0
200
400
600
708 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-9

92 kDa gelatinase	92-kDa type IV collagenase
GELB	MMP-9
gelatinase B	matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)

Recombinant Mmp9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73301	MMP-9 Protein, Rat (HEK293, His)	EDL96479.1 (A20-P708)	≥95%

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0099	Edaravone		99.89%	Yes
HY-B0493	Niflumic acid	Inhibitor	99.88%	Unkown
HY-B0012	Pamidronic acid	Inhibitor	99.05%	Yes
HY-B0012A	Pamidronate disodium	Inhibitor	≥98.0%	Yes
HY-B1451	Imidapril hydrochloride	Inhibitor	99.80%	Yes
HY-B1451A	Imidapril	Inhibitor	≥99.0%	Yes

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.81%	Phase 3
HY-12170	Prinomastat		99.27%	Phase 3
HY-12170A	Prinomastat hydrochloride		98.18%	Phase 3
HY-15768	Ilomastat	Inhibitor	98.39%	Phase 2
HY-106992	S 3304	Inhibitor	99.11%	Phase 2
HY-19485	XL-784	Inhibitor	98.13%	Phase 2
HY-112160	XL-784 free base	Inhibitor	/	Phase 2
HY-N0318	Salvianolic acid A		99.72%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99351	Andecaliximab	Inhibitor	95.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (112)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0431	Astragaloside IV	Inhibitor	99.93%	Unkown
HY-N2117	Isoginkgetin		99.95%	Unkown
HY-19956	GI254023X	Inhibitor	99.67%	Unkown
HY-13564	Batimastat	Inhibitor	98.92%	Unkown
HY-12354	SB-3CT	Inhibitor	99.59%	Unkown
HY-113952	Actinonin		98.61%	Unkown
HY-135232	MMP-9-IN-1	Inhibitor	99.71%	Unkown
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-P2036A	FSL-1 TFA		99.65%	Unkown
HY-103482	JNJ0966	Inhibitor	99.39%	Unkown
HY-N0069	Solamargine		99.97%	Unkown
HY-N1463	Luteolin 7-O-glucuronide	Inhibitor	99.80%	Unkown
HY-103444	ARP-100	Inhibitor	≥99.0%	Unkown
HY-E70005C	Collagenase, Type III		/	Unkown
HY-P4373A	Hepcidin-1 (mouse) (TFA)	Inducer	98.94%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-N0084	Betulinaldehyde	Inhibitor	98.72%	Unkown
HY-N1454	Apigenin-7-glucuronide	Inhibitor	99.73%	Unkown
HY-P3513	β-Neo-Endorphin	Activator	99.32%	Unkown
HY-W016412	Coenzyme Q0		99.88%	Unkown
HY-116626	SM-7368	Inhibitor	99.77%	Unkown
HY-131498	MOCAc-PLGL(Dpa)AR		99.86%	Unkown
HY-N2497	Isoliquiritin apioside	Inhibitor	99.87%	Unkown
HY-114091	PF-00356231 hydrochloride	Inhibitor	99.52%	Unkown
HY-N3945	Glaucine		99.57%	Unkown
HY-120213	YH-306		98.34%	Unkown
HY-124373	ND-336	Inhibitor	95.4%	Unkown
HY-P0273A	Histatin 5 TFA	Inhibitor	99.98%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-N3063	Pimaric acid		98.76%	Unkown
HY-116399	MMP-2/MMP-9-IN-1	Inhibitor	99.25%	Unkown
HY-117970	MMPI-1154	Inhibitor	99.87%	Unkown
HY-119423	MMP Inhibitor II	Inhibitor	≥99.0%	Unkown
HY-12168	Tanomastat	Inhibitor	99.7%	Unkown
HY-147746	MMP2-IN-3	Inhibitor	99.64%	Unkown
HY-W001925	7-Methoxy-1-tetralone		99.93%	Unkown
HY-114911	Feprazone	Inhibitor	99.88%	Unkown
HY-128026	MMP-9/MMP-13 Inhibitor I	Inhibitor	99.90%	Unkown
HY-147745	MMP2-IN-2	Inhibitor	98.80%	Unkown
HY-161285	MMP-9/10-IN-2	Inhibitor	99.91%	Unkown
HY-N2205	Esculentoside H	Inhibitor	98.73%	Unkown
HY-N6862	Lucideric acid A	Inhibitor	98.44%	Unkown
HY-110116	SD-2590 hydrochloride	Inhibitor	99.1%	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-114785	BPHA	Inhibitor	/	Unkown
HY-131417	cis-ACCP	Inhibitor	≥97.0%	Unkown
HY-149848	MMP-9-IN-6	Inhibitor	99.80%	Unkown
HY-B0099S	Edaravone-d5		98.73%	Unkown
HY-N2199	Sotetsuflavone		96.75%	Unkown
HY-N5136	25(R,S)-Ruscogenin	Inhibitor	99.83%	Unkown
HY-P1789A	CTTHWGFTLC, CYCLIC TFA	Inhibitor	98.91%	Unkown
HY-P4373	Hepcidin-1 (mouse)	Inducer	/	Unkown
HY-RS08557	MMP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08558	Mmp9 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W011085	CP-471474	Inhibitor	99.2%	Unkown
HY-116302	MMP-9-IN-9	Inhibitor	97.0%	Unkown
HY-104024	MMP-9-IN-10	Inhibitor	/	Unkown
HY-110046	CL-82198 hydrochloride	Inhibitor	/	Unkown
HY-111172	Inotilone	Inhibitor	/	Unkown
HY-114091A	PF-00356231	Inhibitor	/	Unkown
HY-114396	BR351	Inhibitor	/	Unkown
HY-12168B	(Rac)-Tanomastat	Inhibitor	/	Unkown
HY-124373A	(R)-ND-336	Inhibitor	/	Unkown
HY-136699	Excisanin A		/	Unkown
HY-143407	FAK-IN-3	Inhibitor	/	Unkown
HY-146216	MMP-9-IN-3		/	Unkown
HY-146217	MMP-9-IN-4		/	Unkown
HY-146218	MMP-9-IN-5		/	Unkown
HY-147867	MMP-2/9-IN-1	Inhibitor	/	Unkown
HY-152030	Tubulin/MMP-IN-2		/	Unkown
HY-153913	MMP-9-IN-7	Inhibitor	/	Unkown
HY-155721	22-(4′-py)-JA	Inhibitor	/	Unkown
HY-155960	SH491		/	Unkown
HY-156247	IVMT-Rx-3	Inhibitor	/	Unkown
HY-157138	MMP-9-IN-8		/	Unkown
HY-161284	MMP-9/10-IN-1	Inhibitor	/	Unkown
HY-161707	MMP2-IN-4	Inhibitor	/	Unkown
HY-161966	VEGFR-2-IN-52		/	Unkown
HY-162038	RXP03	Inhibitor	/	Unkown
HY-162079	Anticancer agent 183	Inhibitor	/	Unkown
HY-162344	Ir-CA	Inducer	/	Unkown
HY-163760	ZM-32	Inhibitor	/	Unkown
HY-164525	SD-7300	Inhibitor	/	Unkown
HY-168560	MMP Inhibitor 4	Inhibitor	/	Unkown
HY-168605	DH-18		/	Unkown
HY-169062	RJF02215	Inhibitor	/	Unkown
HY-B0012B	Pamidronic acid sodium	Inhibitor	/	Unkown
HY-N10176	D-Isofloridoside	Inhibitor	/	Unkown
HY-N12726	Halociline	Inhibitor	/	Unkown
HY-N2497R	Isoliquiritin apioside (Standard)	Inhibitor	/	Unkown
HY-N6860	Lucidenic acid C	Inhibitor	/	Unkown
HY-N7385	Nudol		/	Unkown
HY-P1789	CTTHWGFTLC, CYCLIC	Inhibitor	/	Unkown
HY-P2004	FFAGLDD		/	Unkown
HY-P2004A	FFAGLDD TFA		/	Unkown
HY-P2179	MMP-1/MMP-9 Substrate, Fluorogenic		/	Unkown
HY-P3484	Dnp-PLGLWA-DArg-NH2 TFA		/	Unkown
HY-P3513A	β-Neo-Endorphin acetate	Activator	/	Unkown
HY-P4574	VPLSLYSG		/	Unkown
HY-P4905	Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2	Inhibitor	/	Unkown
HY-RS08559	Mmp9 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W277900	2-Methoxy-2,4-diphenylfuran-3-one		/	Unkown
HY-111186	Flocoumafen		98.69%	Unkown
HY-119110	LY52	Inhibitor	/	Unkown
HY-119185	AZD-6605		/	Unkown
HY-122585	proMMP-9 inhibitor-3c	Inhibitor	/	Unkown
HY-124068	LQB-118		/	Unkown
HY-13564A	Batimastat sodium salt	Inhibitor	/	Unkown
HY-18694	CGS 27023A	Inhibitor	/	Unkown
HY-35513	3-Aminobenzene-1,2-diol	Inhibitor	/	Unkown
HY-43586	BR351 precursor	Inhibitor	/	Unkown
HY-P0273	Histatin 5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mmp9	NCBI	NCBI:4318

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