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Results for "

Antileukemic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (4) Apoptosis (25) Arginase (4) Autophagy (8) Bacterial (5) Bcl-2 Family (1) Bcr-Abl (2) BCRP (1) Biochemical Assay Reagents (1) BMI1 (1) c-Myc (3) Casein Kinase (2) Caspase (1) CDK (2) CMV (1) CRM1 (2) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (2) DNA/RNA Synthesis (9) Drug Intermediate (1) Endogenous Metabolite (5) Epigenetic Reader Domain (1) Fat Mass and Obesity-associated Protein (FTO) (2) Flavivirus (1) FLT3 (4) Fungal (3) HDAC (4) Histone Demethylase (1) Histone Methyltransferase (5) HSV (1) Interleukin Related (2) IRAK (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) Nucleoside Antimetabolite/Analog (8) Orthopoxvirus (1) Parasite (2) PI3K (1) Pim (1) Pyroptosis (1) Reactive Oxygen Species (1) RUNX (1) SHMT (1) Src (1) STAT (2) Topoisomerase (6)
By Research Areas:	Cancer (81) Infection (9) Inflammation/Immunology (6) Metabolic Disease (6)

By Targets:

Antibiotic (4)

Apoptosis (25)

Arginase (4)

Autophagy (8)

Bacterial (5)

Bcl-2 Family (1)

Bcr-Abl (2)

BCRP (1)

Biochemical Assay Reagents (1)

BMI1 (1)

c-Myc (3)

Casein Kinase (2)

Caspase (1)

CDK (2)

CMV (1)

CRM1 (2)

Cytochrome P450 (1)

DNA Alkylator/Crosslinker (1)

DNA Methyltransferase (2)

DNA/RNA Synthesis (9)

Drug Intermediate (1)

Endogenous Metabolite (5)

Epigenetic Reader Domain (1)

Fat Mass and Obesity-associated Protein (FTO) (2)

Flavivirus (1)

FLT3 (4)

Fungal (3)

HDAC (4)

Histone Demethylase (1)

Histone Methyltransferase (5)

HSV (1)

Interleukin Related (2)

IRAK (1)

Isotope-Labeled Compounds (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (1)

Nucleoside Antimetabolite/Analog (8)

Orthopoxvirus (1)

Parasite (2)

PI3K (1)

Pim (1)

Pyroptosis (1)

Reactive Oxygen Species (1)

RUNX (1)

SHMT (1)

Src (1)

STAT (2)

Topoisomerase (6)

By Research Areas:

Cancer (81)

Infection (9)

Inflammation/Immunology (6)

Metabolic Disease (6)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118144

PD166326	BCRP Src	Cancer
PD166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases, with IC₅₀s of 6 nM and 8 nM for Src and Abl, respectively. PD166326 exhibits antileukemic activity .

HY-102048

STAT5-IN-2 2 Publications Verification	STAT Apoptosis	Cancer
STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect .

HY-15003

ATH686	FLT3 Apoptosis	Cancer
ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects .

HY-N7549

Dehydrobruceantin	Others	Cancer
Dehydrobruceantin has potential antileukemic activity .

HY-116799

NSC 145669	Microtubule/Tubulin	Cancer
NSC 145669 is an inhibitor for tubulin polymerization with IC₅₀ of 1.7 μM. NSC 145669 exhibits cytotoxicity in cancer cells and reveals antileukemic efficacy in mice .

HY-111008

Trimidox VF-233	DNA/RNA Synthesis	Cancer
Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-111008A

Trimidox hydrochloride VF-233 hydrochloride	DNA/RNA Synthesis	Cancer
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-117237

Hisphen MD 1	Biochemical Assay Reagents	Cancer
Hisphen is a chemical mutagen that can affect the grain protein content . Hisphen also has antileukemic activities .

HY-N7153

10-Hydroxycanthin-6-one	Others	Cancer
10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent .

HY-135771

Avarone (+)-Avarone	Others	Cancer
Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity .

HY-125067

Yadanzioside P	Others	Cancer
Yadanzioside P is an *antileukemic* quassinoid glycoside. Yadanzioside P can be isolated from the seeds of Brucea javanica (L.). Yadanzioside P can be used for the research of cancer .

HY-117996

KPT-251	CRM1 Apoptosis	Cancer
KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity .

HY-155390

Caspase-3 activator 3	Caspase Apoptosis	Cancer
Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC₅₀ values of 42.89 and 33.61 μM, respectively .

HY-143278

FLT3-IN-13	Topoisomerase FLT3 Apoptosis	Cancer
FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and FLT3 dual inhibitor with IC₅₀ values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induce apoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia .

HY-109117

Iadademstat 4 Publications Verification ORY-1001	Histone Demethylase	Cancer
Iadademstat (ORY-1001) is a highly potent, orally active and selective LSD1 (KDM1A) inhibitor with antileukemic activity. Iadademstat can be used for relapsed or refractory acute myeloid leukemia research .

HY-115754

S-(N-PhenethylthiocarbaMoyl)-L-cysteine PEITC-Cys	DNA/RNA Synthesis Cytochrome P450	Cancer
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells . S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor .

HY-122295

Dehydroleucodine	Apoptosis	Inflammation/Immunology Cancer
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-135231

NL-1 2 Publications Verification	Mitochondrial Metabolism Autophagy	Cancer
NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC₅₀s of 47.35 μM and 56.26 μM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway .

HY-126205

Deacetyleupaserrin	Others	Cancer
Deacetyleupaserrin is a sesquiterpenoid with antileukemic activity that can be isolated from Eupatorium semiserratum .

HY-N3401

Lasiodiplodin	Others	Cancer
Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens .

HY-133900

Deoxyharringtonine	Others	Cancer
Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity .

HY-N3171A

(+)-Nortrachelogenin Wikstromol	Apoptosis PI3K	Cancer
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

HY-135190

(-)-Cedrene 2 Publications Verification α-cedrene	Bacterial	Infection Metabolic Disease Cancer
(-)-Cedrene (α-cedrene) is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities .

HY-17381

Idarubicin hydrochloride 10+ Cited Publications 4-Demethoxydaunorubicin hydrochloride	Topoisomerase Bacterial Fungal Autophagy Antibiotic DNA/RNA Synthesis c-Myc	Infection Cancer
Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.

HY-13677

6-Mercaptopurine 5+ Cited Publications Mercaptopurine; 6-MP	Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

HY-U00095

Hepsulfam NCI 329680; ZINC01574758	DNA Alkylator/Crosslinker	Cancer
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC₅₀ of 0.91 μg/mL in a panel of different tumors.

HY-169091

TS-002266	DNA/RNA Synthesis	Cancer
TS-002266 is a small molecule TUT4/7 inhibitor with anti-leukemic effects. TS-002266 is promising for research of cancers .

HY-N0838

Cephalotaxine (-)-Cephalotaxine; ZINC19795976	Flavivirus	Infection Cancer
Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity .

HY-13677A

6-Mercaptopurine hydrate 5+ Cited Publications Mercaptopurine hydrate; 6-MP hydrate	Nucleoside Antimetabolite/Analog	Cancer
6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-N10071

Poricoic acid G	Others	Cancer
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-N8402

Germacrone 4,5-epoxide	Others	Cancer
Germacrone 4,5-epoxide is a sesquiterpene that can be isolated from Curcuma cf. viridiflora. Germacrone 4,5-epoxide has excellent anti-leukemic activities .

HY-123523

Enocitabine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis CMV	Infection Cancer
Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities .

HY-17381R

Idarubicin (hydrochloride) (Standard)	Topoisomerase Bacterial Fungal Autophagy Antibiotic DNA/RNA Synthesis c-Myc	Infection Cancer
Idarubicin (hydrochloride) (Standard) is the analytical standard of Idarubicin (hydrochloride). This product is intended for research and analytical applications. Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.

HY-149334

ZLD115	Fat Mass and Obesity-associated Protein (FTO)	Metabolic Disease
ZLD115 (compound 44) is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). ZLD115 is an antileukemic agent, exhibiting antiproliferative activity against leukemic cell lines .

HY-119361

(Rac)-Deox B 7,4 (Rac)-Deoxysappanone B 7,4' dimethyl ether	Microtubule/Tubulin	Cancer
(Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity .

HY-141430

AS-85	Histone Methyltransferase	Cancer
AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC₅₀=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the K_d value of 0.78 µM .

HY-13677R

6-Mercaptopurine (Standard)	Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine (Standard) is the analytical standard of 6-Mercaptopurine. This product is intended for research and analytical applications. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

HY-112885A

nor-NOHA acetate Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism .

HY-13677S

6-Mercaptopurine-d2 Mercaptopurine-d₂; 6-MP-d₂	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine-d₂ is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent[1][2].

HY-153274

CWI1-2	Apoptosis	Cancer
CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .

HY-153274A

CWI1-2 hydrochloride	Apoptosis	Cancer
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .

HY-123954

BTX-A51 Casein Kinase inhibitor A51	Casein Kinase CDK Apoptosis	Cancer
BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-160787

NCGC1481	FLT3 IRAK	Cancer
NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC₅₀ values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity .

HY-112885C

nor-NOHA dihydrochloride 2 Publications Verification Nω-Hydroxy-nor-L-arginine dihydrochloride	Apoptosis Arginase	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA dihydrochloride is a selective and reversible arginase inhibitor. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride can used in study endothelial dysfunction, immunosuppression and metabolism .

HY-168182

Menin-MLL inhibitor 34	Epigenetic Reader Domain	Cancer
Menin-MLL inhibitor 34 (Compound 37) is a selective and potent Menin-MLL inhibitor, with an IC₅₀ of 18.21 nM for Menin. Menin-MLL inhibitor 34 has long-lasting anti-leukemic effects by reducing Menin protein levels and down-regulating MEN1 transcription .

HY-112885

nor-NOHA Nω-Hydroxy-nor-L-arginine	Apoptosis Arginase	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-13677S1

6-Mercaptopurine-13C2,15N Mercaptopurine-¹³C₂,¹⁵N; 6-MP-¹³C₂,¹⁵N	Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-13677AR

6-Mercaptopurine hydrate (Standard)	Nucleoside Antimetabolite/Analog	Cancer
6-Mercaptopurine hydrate (Standard) is the analytical standard of 6-Mercaptopurine hydrate. This product is intended for research and analytical applications. 6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-119827

Moflomycin F 860191	Topoisomerase	Cancer
Moflomycin (F 860191) is a compound with strong anti-leukemic activity and low mutagenicity. Moflomycin has an antiproliferative effect on the leukemic cell line HL60 in vitro (IC₅₀=2.9 nM) . Moflomycin enhances topoisomerase II-induced DNA breaks and free radical production .

HY-134333

ICCB280	Apoptosis	Cancer
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc) .

Cat. No.	Product Name	Target	Research Area

HY-P99412

Lusvertikimab OSE-127	Interleukin Related	Cancer
Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research .

Cat. No.	Product Name	Category	Target	Chemical Structure