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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

B16 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (4) Antibiotic (7) Apoptosis (19) Atg7 (1) Atg8/LC3 (1) Autophagy (2) Bacterial (13) BCRP (1) c-Myc (2) Calcium Channel (1) Caspase (2) CDK (2) COX (1) DNA/RNA Synthesis (2) Dopamine Receptor (1) Drug Derivative (2) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (5) Epigenetic Reader Domain (1) ERK (7) Estrogen Receptor/ERR (1) Ferroptosis (1) Fluorescent Dye (3) Fungal (2) Glucosylceramide Synthase (GCS) (2) Glyoxalase (GLO) (1) GSK-3 (1) HDAC (3) Herbicide (2) HIV (3) HSV (1) Interleukin Related (1) JNK (2) LPL Receptor (1) MDM-2/p53 (1) Melanocortin Receptor (7) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) NO Synthase (1) NOD-like Receptor (NLR) (1) p38 MAPK (6) Parasite (1) PD-1/PD-L1 (4) Phosphatase (3) Phosphodiesterase (PDE) (1) PI3K (1) Platelet-activating Factor Receptor (PAFR) (1) PROTACs (3) Ras (1) Reactive Oxygen Species (1) RIP kinase (1) ROCK (1) Src (2) STAT (4) Toll-like Receptor (TLR) (1) Topoisomerase (4) Tyrosinase (6) VEGFR (1)
By Research Areas:	Cancer (89) Cardiovascular Disease (3) Infection (17) Inflammation/Immunology (13) Metabolic Disease (6) Neurological Disease (5)
Click Chemistry:	DBCO (1)
Oligonucleotides:	Fillers (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N14739

Dykellic acid	Ras	Cancer
Dykellic acid is a RhoA inhibitor. Dykellic acid can inhibit the migration and motility of B16 cells and the tube formation of HUVECs. Dykellic acid is promising for research of cancers .

HY-117231

RM 06	Others	Cancer
RM 06 is an immunomodulator with a peptidyl hypoxanthine structure that significantly reduces the number of lung metastases of B16 melanoma cells in mice after lethal irradiation and bone marrow reconstitution by stimulating the activity of natural killer (NK) cells .

HY-116392A

(−)-L-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
(−)-L-threo-PDMP hydrochloride is the hydrochloride form of (−)-L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells .

HY-134046

(-)-Isodocarpin Isodocarpin	Melanocortin Receptor	Metabolic Disease
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA .

HY-114585

Sperabillin A	Bacterial	Infection Cancer
Sperabillin A is an antibacterial agent against gram-positive and gram-negative bacteria. Sperabillin A shows strong inhibition of human umbilical vein endothelial (HUVE) cell proliferation. Sperabillin A also shows anti-tumor acfivity against B16 melanoma in mouse .

HY-N2902

Artocarpin	Others	Cancer
Artocarpin is an isoprenoid-substituted flavonoid, that can be isolated from the wood of Artocarpus heterophyllus. Artocarpin inhibits melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. The presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells .

HY-168714

Microtubule inhibitor 12	Microtubule/Tubulin Apoptosis	Cancer
Microtubule inhibitor 12 (Compound 2k) is an inhibitor for microtubule polymerization with an IC₅₀ of 22.23 μM. Microtubule inhibitor 12 arrests the cell cycle of B16-F10 at G2/M phase, induces apoptosis in B16-F10, and inhibits cell migration. Microtubule inhibitor 12 inhibits the proliferation of cancer cells B16-f10, A549, HepG2 and MCF-7, with IC₅₀s of 0.098, 0.135, 0.109, and 0.259 μM, respectively. Microtubule inhibitor 12 exhibits antitumor efficacy in mouse model .

HY-N14438

Furaquinocin A	Others	Cancer
Furaquinocin A can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

HY-147973

IZTZ-1	c-Myc Apoptosis	Cancer
IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research .

HY-N14439

Furaquinocin B	Others	Cancer
Furaquinocin B can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

HY-N14440

Furaquinocin C	Others	Cancer
Furaquinocin CA can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .

HY-N13879

Amphistin	Melanocortin Receptor	Cancer
Amphistin is a melanogenesis inhibitor found in actinomycete. Amphistin inhibits the melanogenesis of B16 melanoma cells without affecting the growth of the cell .

HY-N12431

Machilin A	Others	Cancer
Machilin A is a lignan isolated from the methanolic extract of Phoebe bark. Machilin A inhibits melanin biosynthesis in B-16 mouse melanoma cells with an IC₅₀ of 39.9 μM.

HY-N14435

Pradimicin Q	Antibiotic Fungal	Infection
Pradimicin Q is an antibiotic. The cytotoxicity (IC₅₀) to human colon HCT-116 cells and murine melanoma B16-F10 cells are 75 and 100 μg/mL, respectively .

HY-N9339

Norglaucine (+)-Norglaucine	Others	Cancer
Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .

HY-N14221

Eponemycin	Antibiotic DNA/RNA Synthesis	Infection Cancer
Eponemycin is an antibiotic that exhibits antitumor activity. Eponemycin exhibits cytotoxicity in cancer cells B16-F10, L1210, P388 and HCT-116 with IC₅₀ of 0.0017, 0.01, 0.031 and 0.0097 µg/mL, respectively. Eponemycin inhibits the DNA synthesis in B16-F10 and Mitomycin C with IC₅₀ of 0.1 µg/mL and 0.41 µg/mL .

HY-113612A

Cytostatin sodium	Apoptosis Phosphatase	Cancer
Cytostatin sodium is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC₅₀ value of 210 nM. Cytostatin sodium exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin sodium can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin sodium belongs to the family of natural product fosriecin .

HY-113612

Cytostatin	Phosphatase Apoptosis	Cancer
Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC₅₀ value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin .

HY-N10337

Norjuziphine (-)-Norjuziphine	Drug Derivative	Cancer
Norjuziphine is an alkaloid found in the lotus flower (Nelumbo nucifera). Norjuziphine inhibits the melanogenesis of murine B16 melanoma 4A5 cells stimulated by Theophylline (HY-B0809) (IC₅₀=14.4 μM). Norjuziphine is promising for research of skin whitening and related skin pigmentation diseases .

HY-N0202

Atractylenolide II 3 Publications Verification Asterolide	ERK Apoptosis p38 MAPK Akt Src STAT	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Atractylenolide II (Asterolide) is a sesquiterpenoid compound. Atractylenolide II can induce G1 phase cell cycle arrest and apoptosis in B16 melanoma cells. Atractylenolide II is an orally effective anticancer agent that can exert anti-melanoma effects by inhibiting the STAT3 signaling pathway. In addition, Atractylenolide II has been shown to ameliorate myocardial fibrosis, oxidative stress, and neuroprotective activity .

HY-N14222

Epopromycin A	Antibiotic Herbicide	Infection Cancer
Epopromycin A inhibits the cell wall synthesis of lettuce protoplasts, thereby exhibiting herbicidal activity. Epopromycin A exhibits cytotoxicity in B16 melanoma cell with an IC₅₀ of 0.003 µg/mL .

HY-116392F

D-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
D-threo-PDMP hydrochloride is a glucosylceramide (GlcCer) synthase inhibitor that inhibits glucosylceramide (GlcCer) and lactosylceramide (LacCer) levels in B16 melanoma cells. D-threo-PDMP hydrochloride lacks reactivity to the other two surface antigens anti-melanoma monoclonal antibodies M562 and M622 and the major histocompatibility antigen anti-H-2KbDb monoclonal antibody, so it is specific for B16 melanoma sex .

HY-N14236

Epopromycin B	Herbicide	Infection Cancer
Epopromycin B inhibits the cell wall synthesis of lettuce protoplasts, thereby exhibiting herbicidal activity. Epopromycin B exhibits cytotoxicity in B16 melanoma cell with an IC₅₀ of 0.003 µg/mL .

HY-N7085

Citropten 5,7-Dimethoxycoumarin; Limettin	JNK p38 MAPK ERK	Neurological Disease Inflammation/Immunology Cancer
Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .

HY-162766

Antitumor agent-184	Apoptosis	Cancer
Antitumor agent-184 (compound 12aa) induces cell apoptosis, with the IC₅₀s of 2.35 μM, 7.32 μM and 10.31 μM in B16-F10 cells, 4T1 cells and CT26 cells, respectively .

HY-168101

ERα degrader 11	Estrogen Receptor/ERR	Cancer
ERα degrader 11 (compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to investigate ER status in ER-positive breast cancer cells .

HY-136295

Quinaldopeptin	Antibiotic Bacterial	Infection Inflammation/Immunology
Quinaldopeptin, a quinomycin antibiotic isolated from the culture of Streptoverticillium album strain, is highly active against Gram-positive bacteria and anaerobes and strongly cytotoxic against cultured B16 melanoma cells .

HY-N3643

Cryptomeridiol	Platelet-activating Factor Receptor (PAFR)	Cancer
Cryptomeridiol is a platelet-activating factor (PAF) receptor binding inhibitor. Cryptomeridiol has melanogenesis inhibitory activity in the α-MSH (HY-P0252)-stimulated B16 melanoma cells .

HY-N14095

Curromycin A	Bacterial HIV	Infection Cancer
Curromycin A has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin A can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

HY-N3200

Neorauflavane	Tyrosinase	Cancer
Neorauflavane is a potent tyrosinase inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells .

HY-N14110

Curromycin B	Bacterial HIV	Infection
Curromycin B has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin B can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

HY-163287

QPy-TPA	Fluorescent Dye	Others
QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm .

HY-163286

BODIQPy-TPA	Fluorescent Dye Ferroptosis	Others
BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-149950

Anticancer agent 106	Apoptosis	Cancer
Anticancer agent 106 (compound 10ic) is an anticancer agent that induces apoptosis in B16-F10 melanoma cells. Anticancer agent 106 also potently inhibits metastatic nodules in a mouse model of lung metastatic melanoma. Anticancer agent 106 can be used in the study of cancer, especially lung metastatic melanoma .

HY-121412

Lankacidin C	Antibiotic Bacterial	Infection Cancer
Lankacidin C is an inhibitor of protein synthesis in vitro. Lankacidin C inhibits the activity of L1210 leukemia, B16 melanoma and 6C3 HED/OG lymphosarcoma cell lines. Lankacidin C has antibacterial activity and antitumor activity .

HY-N9521

3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside	Others	Cancer
3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside, a saponin, is isolated from Polaskia chichipe Backbg. 3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside shows ability to inhibit melanin biosynthesis by B16 melanoma cell with inhibitory activity 84.2% at 100μM[1].

HY-157323

HDAC6-IN-28	HDAC Apoptosis	Cancer
HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC₅₀ of 261 nM. HDAC6-IN-28 significantly induces apoptosis and S-phase arrest in B16-F10 cells. HDAC6-IN-28 efficiently increases the expression of acetylated-α-tubulin in vitro and in vivo .

HY-W471938

Antiproliferative agent-35	Drug Derivative	Cancer
Antiproliferative agent-35 (Compound 4) is an anticancer agent derivated from Esculetin (HY-N0284). Antiproliferative agent-35 inhibits the proliferation of B16 and A549 cells, with IC₅₀s of 13.2 and 9.2 μM resspectively .

HY-156085

LP23	PD-1/PD-L1	Cancer
LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC₅₀: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg) .

HY-N14530

Cremeomycin	Bacterial	Infection Cancer
Cremeomycin has anti-Gram-positive bacteria activity including methicillin-resistant Staphylococcus aureus (MRSA), MIC is 0.2-0.39 μg/mL. Cremeomycin shows cytotoxicity to mouse tumor cell lines P388, L1210, IMC, S180, B16 and SS3 in vitro .

HY-N14144

Cremimycin	Bacterial	Infection Cancer
Cremimycin has anti-Gram-positive bacteria activity including methicillin-resistant Staphylococcus aureus (MRSA), MIC is 0.2-0.39 μg/mL. Cremimycin shows cytotoxicity to mouse tumor cell lines P388, L1210, IMC, S180, B16 and SS3 in vitro .

HY-156092

Antitumor photosensitizer-4	BCRP Apoptosis	Cancer
Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells .

HY-W721119

7-Methylsulfinylheptyl isothiocyanate	p38 MAPK Autophagy	Inflammation/Immunology Cancer
7-Methylsulfinylheptyl isothiocyanate is an activator for MAPK signaling pathway, which downregulates the melanogenesis related proteins and suppresses the melanin synthesis in B16-F1 cells. 7-Methylsulfinylheptyl isothiocyanate induces autophagy. 7-Methylsulfinylheptyl isothiocyanate is an inducer for phase II enzyme, which exhibits chemoprotective effect against carcinogen. 7-Methylsulfinylheptyl isothiocyanate can be used as cosmetic ingredient for skin whitening and anti-inflammation .

HY-139061

Palmitoyl 3-carbacyclic phosphatidic acid	LPL Receptor ROCK	Cancer
Palmitoyl 3-carbacyclic phosphatidic acid (HY-139061) is a palmitoylated Carba-like cyclophosphatidic acid and an analog of lysophosphatidic acid (LPA). Palmitoyl 3-carbacyclic phosphatidic acid has different functions from LPA and can inhibit the activation of RhoA and inhibit the migration of melanoma cells. Palmitoyl 3-carbacyclic phosphatidic acid effectively inhibited experimental lung metastasis and reduced the number of tumor nodules in a B16-F0 xenograft mouse model .

HY-N3773

Dodoviscin A	Tyrosinase	Cancer
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin .

HY-N14126

Chlovalicin	Others	Cancer
Chlovalicin is found in the strain of Sporothrix sp. FO-4649. In the presence of 0.2 U/mL IL-6, Chlovalicin inhibits the growth of L6-dependent MH60 cells with lC₅₀ of 7.5 μM. Chlovalicin also inhibits the growth of B16 melanoma cells with lC₅₀ of 38 μM. Chlovalicin also displays inhibitory activity on osteoclastogenesis .

HY-N14722

Lactonamycin	Bacterial	Infection Cancer
Lactonamycin had strong activity against Gram-positive bacteria including Staphylococcus, Streptococcus, Enterococcus, MRSA (MIC of 0.39-0.78 μg/mL) and VRE (MIC of 0.39-0.78 μg/mL). Lactonamycin also has inhibitory effect on L-1210, P388, S180, FS-3, Ehrlich, B16-BL5 and other tumor cell lines (IC₅₀s of 0.06-3.3 μg/mL) .

HY-N1434

Methyl p-coumarate Methyl 4-hydroxycinnamate	Fungal	Infection Cancer
Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens .

HY-169392

D5B	PD-1/PD-L1	Cancer
D5B is a potent and selective PD-L1 inhibitor. D5B has been modified by DBCO. The EC₅₀ of D5B degrading PD-L1 in 4T1 and B16-F10 tumor cells are 5.4 μM and 6.2 μM, respectively. D5B can block PD-L1/PD-1 interaction and has anti-tumor activity .

HY-N14237

Epoxyquinomicin A	Antibiotic Bacterial	Infection Inflammation/Immunology Cancer
Epoxyquinomicin A is an antibiotic that can be isolated from Amycolatopsis sp. Epoxyquinomicin A exhibits inhibitory activity against Micrococcus luteus, Bacillus subtilis, Pasteurella piscicida and Staphylococcus aureus with a MIC of 3-12.5 µg/mL. Epoxyquinomicin A exhibits cytotoxicity in cancer cell L1210, B16 and S180 with IC₅₀ of 2-8 µg/mL. Epoxyquinomicin A exhibits anti-inflammatory effects against collagen-induced arthritis .

Cat. No.	Product Name	Type

HY-D0168

Orcinol

3,5-Dihydroxytoluene

Dyes

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

HY-163287

QPy-TPA	Dyes
QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm .

HY-163286

BODIQPy-TPA	Dyes
BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

Cat. No.	Product Name	Type

HY-W015715

5-Methylresorcinol monohydrate Orcinol monohydrate	Indicators
5-Methylresorcinol monohydrate (Orcinol monohydrate) is a tyrosinase inhibitor. 5-Methylresorcinol monohydrate shows cytotoxicity. 5-Methylresorcinol monohydrate also is an oral active and cross the blood-brain barrier anxiolytic agent .

Cat. No.	Product Name	Target	Research Area

HY-P2336A

CCZ01048 TFA 2 Publications Verification	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .

HY-P3245A

HXR9 hydrochloride	Apoptosis	Cancer
HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 hydrochloride antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 hydrochloride selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

HY-137874

L-Glutamic γ-monohydroxamate	Peptides	Metabolic Disease Cancer
L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo .

HY-P2336

CCZ01048	Melanocortin Receptor	Cancer
CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma .

HY-P3245

HXR9	Apoptosis	Cancer
HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

Cat. No.	Product Name	Category	Target	Chemical Structure