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Results for "

BDNF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (2) Akt (1) AMPK (1) Apoptosis (1) Autophagy (1) Endogenous Metabolite (1) ERK (1) GABA Receptor (1) Glucocorticoid Receptor (1) iGluR (3) Isotope-Labeled Compounds (1) mAChR (1) mGluR (2) Monoamine Oxidase (1) mTOR (1) NF-κB (3) Orexin Receptor (OX Receptor) (1) p38 MAPK (1) Phosphodiesterase (PDE) (3) Reactive Oxygen Species (3) Small Interfering RNA (siRNA) (2) TNF Receptor (1) Toll-like Receptor (TLR) (1) Trk Receptor (6)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Endocrinology (2) Infection (1) Inflammation/Immunology (3) Neurological Disease (32)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor	Neurological Disease
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-N7981

Pratensein	NF-κB	Neurological Disease
Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels .

HY-132993

Hcyb1	Phosphodiesterase (PDE)	Neurological Disease
Hcyb1 is a highly selective, orally active PDE2 inhibitor. Hcyb1 has a highly selective inhibition of PDE2A (IC₅₀=0.57 μM) and over 250-fold selectivity against other recombinant PDE family members. Hcyb1 produces neuroprotective and antidepressant‐like effects most likely mediated by cAMP/cGMP-CREB-BDNF signaling .

HY-RS01460

BDNF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BDNF Human Pre-designed siRNA Set A contains three designed siRNAs for BDNF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BDNF Human Pre-designed siRNA Set A BDNF Human Pre-designed siRNA Set A

HY-RS16220

Bdnf Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bdnf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bdnf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bdnf Mouse Pre-designed siRNA Set A Bdnf Mouse Pre-designed siRNA Set A

HY-120306

HHL-6	Others	Neurological Disease
HHL-6 can regulate the overexpression of c-Fos and *BDNF* proteins. HHL-6 has potent anticonvulsant and antiepileptogenic effects .

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-W101298S

(Leu-13C6,15N)-Ile-OH TFA L-Leucyl-¹³C₆,¹⁵N-L-isoleucine TFA	Isotope-Labeled Compounds	Neurological Disease
(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .

HY-146524

TRK-IN-18	Trk Receptor	Cancer
TRK-IN-18 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7) .

HY-146523

TRK-IN-17	Trk Receptor	Cancer
TRK-IN-17 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-17 has the potential for the research of cancer diseases (extracted from patent WO2021148807A1, compound 3) .

HY-102091A

(2R,4R)-APDC hydrate (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate	mGluR	Neurological Disease
(2R,4R)-APDC hydrate ((2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate) is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC hydrate affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC hydrate can be used in the study of epilepsy and other neurological diseases .

HY-122742

HBT1	iGluR	Neurological Disease
HBT1 is a potent α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiator. HBT1 bonds with S518 in the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. HBT1 did not show remarkable bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons .

HY-120251A

Leteprinim potassium AIT-082	Reactive Oxygen Species	Neurological Disease
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species .

HY-120251

Leteprinim AIT-082 free acid	Reactive Oxygen Species	Neurological Disease
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species .

HY-N3298

Meranzin	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-N3298R

Meranzin (Standard)	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Meranzin (Standard) is the analytical standard of Meranzin. This product is intended for research and analytical applications. Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-123222

CGP 56999	GABA Receptor	Neurological Disease
CGP 56999 is a potent antagonist GABA(B) receptor, with the IC₅₀ of 0.002 μM. CGP 56999 increased the levels of BDNF mRNA in the brain in vivo and in vitro .

HY-W013372

7,8-Dihydroxyflavone 10+ Cited Publications	Trk Receptor Apoptosis	Neurological Disease
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases .

HY-153383

PDCD4-IN-1	Others	Cancer
PDCD4-IN-1(compound 20031600) is a PDCD4 inhibitor with a K_d value of 350 nM, which can promote the expression of BDNF in hippocampal neuron cell HT-22 .

HY-139806

SRA880 free base	Others	Others
SRA880 (free base) is a compound with antidepressant-modulating effects. It is a somatostatin-1 autoreceptor antagonist that can synergize with imipramine to produce antidepressant-like effects and affect BDNF mRNA expression and phosphorylation of related proteins.

HY-N6076

Tenuifoliside A	ERK	Neurological Disease
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the *ERK/CREB/BDNF* signal pathway in C6 cells .

HY-164461

AZD6918	Trk Receptor	Cancer
AZD6918 is an orally active and selective Trk tyrosine kinase inhibitor. AZD6918 induces cell death as a single agent and attenuates BDNF/TrkB-induced protection from Etoposide (HY-13629) in vitro. AZD6918 can be used for the research of neuroblastoma .

HY-N11872

Suffruticosol A	Others	Neurological Disease
Suffruticosol A is a neuroprotective agent that restores scopolamine-induced cellular neurodegenerative damage. Suffruticosol A ameliorates hippocampal cholinergic deficits and partially enhances BDNF signaling. Suffruticosol A has neuromodulatory effects in a Scopolamine (HY-N0296)-induced model, restoring memory and cognitive performance in mice. Suffruticosol A can be isolated from seeds of P. lactiflora .

HY-110166

PD 90780 1 Publications Verification	Others	Neurological Disease
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75 ^NTR. PD 90780 inhibits NGF-p75 ^NTR interaction with IC₅₀s of 23.1 and 1.8 µM in PC12 cells and PC12 ^nnr5 cells, respectively .

HY-114384B

NV-5138 hydrochloride 5 Publications Verification	mTOR	Neurological Disease
NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies .

HY-N4161

Euparin	Reactive Oxygen Species	Infection Neurological Disease
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-157792

Antidepressant agent 6	mAChR	Neurological Disease
Antidepressant agent 6 (S-3a) is a lead compound with potent and sustained antidepressant effects. Antidepressant agent 6 (S-3a) displays high cognitive safety margin.Antidepressant agent 6 (S-3a) antagonizes M1 receptors and elevates BDNF levels, suggesting its potential as an antidepressant for further exploration .

HY-121012

(rac)-AG-205	NF-κB Akt	Endocrinology
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway .

HY-124591

TC-2153	5-HT Receptor Monoamine Oxidase	Neurological Disease
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling .

HY-160921

Capeserod SL65.0155 free base	5-HT Receptor	Neurological Disease
Capeserod (SL65.0155 free base) is an agonist for serotonin receptor (5-HT receptor), with a K_i of 0.6 nM for 5-HT₄ receptor. Capeserod enhances expression of phopshorilated cAMP-response element binding protein (p-CREB), vascular endothelium growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and B cell lymphoma-2 (Bcl-2) proteins in hippocampus, and exhibits antidepressant-like efficacy in Wistar rats models .

HY-102091

(2R,4R)-APDC (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid	mGluR	Neurological Disease
(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases .

HY-106224B

Orexin A (human, rat, mouse) (acetate) 5+ Cited Publications Hypocretin-1 (human, rat, mouse) (acetate)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging .

HY-123439

FTY720-C2	Others	Neurological Disease
FTY720-C2 is a derivative of FTY72 (HY-12005). FTY720-C2 promotes the expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) in multiple system atrophy (MSA) models, without causing immunosuppression. FTY720-C2 improves motor dysfunction and reduces the levels of insoluble alpha-synuclein (αSyn) in MSA mouse models. FTY720-C2 is blood-brain barrier penetrate .

HY-N2038

3,5,6,7,8,3',4'-Heptemthoxyflavone	Phosphodiesterase (PDE)	Neurological Disease Cancer
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-B1618

Corticosterone Maximum Cited Publications 29 Publications Verification 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Glucocorticoid Receptor Endogenous Metabolite iGluR	Neurological Disease Inflammation/Immunology Endocrinology
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-N2055

Kaempferol 3-O-sophoroside	Toll-like Receptor (TLR) NF-κB TNF Receptor AMPK	Neurological Disease Inflammation/Immunology
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases .

HY-100115

TA-02 2 Publications Verification	p38 MAPK Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC₅₀ of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295) .

HY-N2038R

3,5,6,7,8,3',4'-Heptemthoxyflavone (Standard)	Phosphodiesterase (PDE)	Neurological Disease Cancer
3,?5,?6,?7,?8,?3',?4'-Heptemthoxyflavone (Standard) is the analytical standard of 3,?5,?6,?7,?8,?3',?4'-Heptemthoxyflavone. This product is intended for research and analytical applications. 3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-111527

PPZ2	Others	Neurological Disease
PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects .

HY-139897

CX 717	iGluR	Neurological Disease
CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD) .

Cat. No.	Product Name	Target	Research Area

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor	Neurological Disease
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-106224B

Orexin A (human, rat, mouse) (acetate) Maximum Cited Publications 6 Publications Verification Hypocretin-1 (human, rat, mouse) (acetate)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging .

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-P1146

Semax	Peptides	Neurological Disease
Semax is a nootropic neuroprotective peptide. Semax can be used in the research of brain stroke .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7981

Pratensein	Trifolium pratense L. Flavonoids Leguminosae Source classification Phenols Polyphenols Plants Isoflavones	NF-κB
Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels .

HY-N3298

Meranzin	Cardiovascular Disease other families Classification of Application Fields Neurological Disease Source classification Coumarins Phenylpropanoids Plants Disease Research Fields	Adrenergic Receptor
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-W013372

7,8-Dihydroxyflavone 10+ Cited Publications	Structural Classification Flavonoids Flavones Source classification Phenols Polyphenols Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Trk Receptor Apoptosis
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases .

HY-N6076

Tenuifoliside A	Triterpenes Structural Classification Monophenols Terpenoids Source classification Polygalaceae Phenols Plants Polygala tenuifolia Willd.	ERK
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the *ERK/CREB/BDNF* signal pathway in C6 cells .

HY-N4161

Euparin	Monophenols Source classification Phenols Plants Compositae Guilandina minax (Hance) G. P. Lewis	Reactive Oxygen Species
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-N2038

3,5,6,7,8,3',4'-Heptemthoxyflavone	Structural Classification Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Phosphodiesterase (PDE)
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-B1618

Corticosterone 25+ Cited Publications 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-N2055

Kaempferol 3-O-sophoroside	Panax ginseng C. A. Meyer Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Araliaceae	Toll-like Receptor (TLR) NF-κB TNF Receptor AMPK
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases .

HY-N3298R

Meranzin (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	Adrenergic Receptor
Meranzin (Standard) is the analytical standard of Meranzin. This product is intended for research and analytical applications. Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-N11872

Suffruticosol A	Structural Classification Paeonia lactiflora Pall. Source classification Phenols Polyphenols Plants Paeoniaceae	Others
Suffruticosol A is a neuroprotective agent that restores scopolamine-induced cellular neurodegenerative damage. Suffruticosol A ameliorates hippocampal cholinergic deficits and partially enhances BDNF signaling. Suffruticosol A has neuromodulatory effects in a Scopolamine (HY-N0296)-induced model, restoring memory and cognitive performance in mice. Suffruticosol A can be isolated from seeds of P. lactiflora .

HY-N2038R

3,5,6,7,8,3',4'-Heptemthoxyflavone (Standard)	Structural Classification Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Phosphodiesterase (PDE)
3,?5,?6,?7,?8,?3',?4'-Heptemthoxyflavone (Standard) is the analytical standard of 3,?5,?6,?7,?8,?3',?4'-Heptemthoxyflavone. This product is intended for research and analytical applications. 3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

Recombinant Proteins Recommended:

Brain Derived Neurotrophic Factor (BDNF)

Species:	Human (9) Mouse (4) Rat (3) Canine (2)
Tag:	His (8) Tag Free (3) Avi (1) Fc (3) Flag (1)
Source:	HEK293 (10) CHO (1) Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P7116A

	BDNF Protein, Human 5+ Cited Publications rHuBDNF/Brain-derived neurotrophic factor; Abrineurin	Human	E. coli
	Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Human is a recombinant human BDNF (H129-R247) without tag, which is produced in E.coli.

HY-P7116

	BDNF Protein, Human (CHO) rHuBDNF/Brain-derived neurotrophic factor; Abrineurin	Human	CHO
	BDNF Protein, Human (CHO) is a neurotrophin binding to the high-affinity tropomyosin-related receptor kinase B (TrkB) receptor to regulate neurodevelopmental processes, including neuronal survival, neuronal differentiation, and synaptic plasticity.

HY-P72489

	BDNF Protein, Human (R125A, R127A, R128A) Brain-derived neurotrophic factor; BDNF; Abrineurin; ProBDNF	Human	E. coli
	Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Human (R125A, R127A, R128A) is a recombinant human BDNF (A19-R247) with R125A, R127A, R128A mutations, and without tag, which is produced in E.coli.

HY-P74383

	BDNF Protein, Mouse (R129A, R130A, HEK293, His, Solution) 2 Publications Verification Brain-derived neurotrophic factor; BDNF; ProBDNF	Mouse	HEK293
	Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Mouse (R129A, R130A, HEK293, His) is a recombinant mouse BDNF (M1-R249, R129A, R130A) with C-terminal His tag, which is produced in HEK293.

HY-P74383A

	BDNF Protein, Mouse (R129A, R130A, HEK293, C-His) Brain-derived neurotrophic factor; BDNF; ProBDNF	Mouse	HEK293
	BDNF protein is an important signaling molecule that activates NTRK2 downstream cascades and affects multiple roles in neuronal development and function. It promotes survival and differentiation of the peripheral and central nervous system, affecting axonal and dendritic growth. BDNF Protein, Mouse (R129A, R130A, HEK293, C-His) is the recombinant mouse-derived BDNF protein, expressed by HEK293 , with C-6*His labeled tag and R129A, R130A, , , mutation. The total length of BDNF Protein, Mouse (R129A, R130A, HEK293, C-His) is 231 a.a., with molecular weight of ~35-42 kDa.

HY-P72489Y

	BDNF Protein, Human (R125A, R127A, R128A, solution) Brain-derived neurotrophic factor; BDNF; Abrineurin; ProBDNF	Human	E. coli
	Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. BDNF Protein, Human (R125A,R127A,R128A) is a recombinant human BDNF (A19-R247) with R125A, R127A, R128A mutations, and without tag, which is produced in E.coli.

HY-P700158AF

	*Animal-Free BDNF* Protein, Human/Mouse (His)** rain-derived neurotrophic factor; BDNF; Abrineurin; ProBDNF	Human;Mouse	E. coli
	Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. Animal-Free BDNF Protein, Human/Mouse (His) is an animal-free recombinant human/muose BDNF (H129-R247) with C-terminal His tag, which is produced in E.coli.

HY-P73461

	TrkB Protein, Canine (HEK293, His) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB	Canine	HEK293
	TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, His) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Canine (HEK293, His) is 399 a.a., with molecular weight of ~60-78 kDa.

HY-P73574

	TrkB Protein, Rat (HEK293, His) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB	Rat	HEK293
	TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems.As a receptor for BDNF and NTF4, it regulates survival through NTF3.TrkB Protein, Rat (HEK293, His) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-His labeled tag.

HY-P7116G

	*GMP BDNF* Protein, Human** rHuBDNF/Brain-derived neurotrophic factor; Abrineurin	Human	E. coli
	Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. GMP BDNF Protein, Human is a recombinant human BDNF (H129-R247) without tag, which is produced in E.coli.

HY-P73575

	TrkB Protein, Rat (HEK293, Fc) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB	Rat	HEK293
	TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems.As a receptor for BDNF and NTF4, it regulates survival through NTF3.TrkB Protein, Rat (HEK293, Fc) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73576

	TrkB Protein, Canine (HEK293, Fc) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB	Canine	HEK293
	TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73462

	TrkB Protein, Human (HEK293, His-Fc) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB	Human	HEK293
	The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-hFc, C-His, C-10*His labeled tag.

HY-P73574A

	TrkB Protein, Rat (HEK293, C-His) BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB	Rat	HEK293
	TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems.As a receptor for BDNF and NTF4, it regulates survival through NTF3.TrkB Protein, Rat (HEK293, C-His) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72436

	TrkB Protein, Mouse (398a.a, HEK293, His) BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; Trk-B; Neurotrophic Tyrosine Kinase Receptor Type 2; TrkB Tyrosine Kinase; NTRK2; TRKB	Mouse	HEK293
	TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag.

HY-P70793

	TrkB Protein, Human (HEK293, His) BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; Trk-B; Neurotrophic Tyrosine Kinase Receptor Type 2; TrkB Tyrosine Kinase; Tropomyosin-Related Kinase B; NTRK2; TRKB	Human	HEK293
	The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P702763

	NTRK2/TrkB Protein, Human (Biotinylated, sf9, Flag, Avi) NTRK2; neurotrophic tyrosine kinase, receptor, type 2; BDNF/NT-3 growth factors receptor; trk-B; GP145-TrkB/GP95-TrkB; trkB tyrosine kinase; Neural receptor protein-tyrosine kinase (trkB); Tkrb; trkB; TRKB1; RATTRKB1	Human	Sf9 insect cells

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HY-W101298S

(Leu-13C6,15N)-Ile-OH TFA
(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .

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HY-P80567

	BDNF Antibody BDNF; MGC34632; Abrineurin; ANON2; Brain Derived Neurotrophic Factor; Neurotrophin; BULN2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	BDNF Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 28 kDa, targeting to BDNF. It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80862

	Phospho-TrkA/B (Tyr490/Tyr516) Antibody NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B	WB	Human, Mouse, Rat
	Phospho-TrkA/B (Tyr490/Tyr516) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 92 kDa, targeting to Phospho-TrkA/B (Tyr490/Tyr516). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.