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Results for "

Cyclic Peptide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) ADC Cytotoxin (2) Adrenergic Receptor (2) Amino Acid Derivatives (4) Antibiotic (11) Apoptosis (2) Arp2/3 Complex (3) Autophagy (1) Bacterial (15) Biochemical Assay Reagents (6) Calcium Channel (2) Carbonic Anhydrase (1) CFTR (1) Chloride Channel (1) Complement System (4) COX (1) CXCR (3) DNA/RNA Synthesis (2) Drug Intermediate (1) EGFR (2) Elastase (1) Endogenous Metabolite (4) Endothelin Receptor (1) ERK (3) Factor Xa (1) Fluorescent Dye (3) Fungal (5) G Protein-coupled Receptor Kinase (GRK) (1) Glycoprotein VI (1) Guanylate Cyclase (2) HIF/HIF Prolyl-Hydroxylase (2) HIV (1) HIV Protease (1) iGluR (2) Influenza Virus (1) Integrin (7) JNK (1) LAG-3 (2) LDLR (1) Melanocortin Receptor (2) MMP (2) Neurokinin Receptor (1) NO Synthase (7) Oxytocin Receptor (1) Parasite (3) PCSK9 (1) PI3K (2) PKA (1) PKC (2) Potassium Channel (1) Proteasome (4) Radionuclide-Drug Conjugates (RDCs) (2) Raf (2) Ras (3) Reactive Oxygen Species (1) SARS-CoV (1) Ser/Thr Protease (1) Somatostatin Receptor (1) Src (1) STING (1) TNF Receptor (2) Trk Receptor (1) Urotensin Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (46) Cardiovascular Disease (11) Endocrinology (5) Infection (33) Inflammation/Immunology (14) Metabolic Disease (4) Neurological Disease (13)

By Targets:

Amyloid-β (1)

ADC Cytotoxin (2)

Adrenergic Receptor (2)

Amino Acid Derivatives (4)

Antibiotic (11)

Apoptosis (2)

Arp2/3 Complex (3)

Autophagy (1)

Bacterial (15)

Biochemical Assay Reagents (6)

Calcium Channel (2)

Carbonic Anhydrase (1)

CFTR (1)

Chloride Channel (1)

Complement System (4)

COX (1)

CXCR (3)

DNA/RNA Synthesis (2)

Drug Intermediate (1)

EGFR (2)

Elastase (1)

Endogenous Metabolite (4)

Endothelin Receptor (1)

ERK (3)

Factor Xa (1)

Fluorescent Dye (3)

Fungal (5)

G Protein-coupled Receptor Kinase (GRK) (1)

Glycoprotein VI (1)

Guanylate Cyclase (2)

HIF/HIF Prolyl-Hydroxylase (2)

HIV (1)

HIV Protease (1)

iGluR (2)

Influenza Virus (1)

Integrin (7)

JNK (1)

LAG-3 (2)

LDLR (1)

Melanocortin Receptor (2)

MMP (2)

Neurokinin Receptor (1)

NO Synthase (7)

Oxytocin Receptor (1)

Parasite (3)

PCSK9 (1)

PI3K (2)

PKA (1)

PKC (2)

Potassium Channel (1)

Proteasome (4)

Radionuclide-Drug Conjugates (RDCs) (2)

Raf (2)

Ras (3)

Reactive Oxygen Species (1)

SARS-CoV (1)

Ser/Thr Protease (1)

Somatostatin Receptor (1)

Src (1)

STING (1)

TNF Receptor (2)

Trk Receptor (1)

Urotensin Receptor (1)

Virus Protease (1)

By Research Areas:

Cancer (46)

Cardiovascular Disease (11)

Endocrinology (5)

Infection (33)

Inflammation/Immunology (14)

Metabolic Disease (4)

Neurological Disease (13)

126

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

108

Peptides

Natural
Products

*SPSB2-iNOS inhibitory cyclic* peptide-1**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

*SPSB2-iNOS inhibitory cyclic* peptide-1 TFA**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-1(HY-P10383). SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

*SPSB2-iNOS inhibitory cyclic* peptide-2 TFA**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-2 (HY-P10384). SPSB2-iNOS inhibitory cyclic peptide-2 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 TFA is reduction-resistant and oxidatively stable .

*LAG-3 cyclic* peptide inhibitor C25**	LAG-3	Cancer
LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a K_d value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8 ⁺ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer .

*SPSB2-iNOS inhibitory cyclic* peptide-3 TFA**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-3 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-3 (HY-P10385). SPSB2-iNOS inhibitory cyclic peptide-3 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM .

*LAG-3 cyclic* peptide inhibitor 12**	LAG-3	Inflammation/Immunology Cancer
LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC₅₀ value of 4.45 μM and a K_i value of 2.66 µM .

*SPSB2-iNOS inhibitory cyclic* peptide-2**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 (Compound CP2) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 is reduction-resistant and oxidatively stable .

*SPSB2-iNOS inhibitory cyclic* peptide-3**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-3 (Compound CP3) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM .

Omphalotin A	Parasite	Infection
Omphalotin A is a cyclic peptide, and shows nematicidal activity .

Boc-Glu-Ofm	Amino Acid Derivatives	Others
Boc-Glu-Ofm is a peptide. Boc-Glu-Ofm has been used for the synthesis of ester insulin and cyclic peptide mixtures .

Mibenratide	Adrenergic Receptor	Cardiovascular Disease
Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research .

Mibenratide TFA	Adrenergic Receptor	Cardiovascular Disease
Mibenratide TFA, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide TFA can be used for heart failure research .

Berninamycin D	Endogenous Metabolite	Others
Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis .

DAG peptide	Biochemical Assay Reagents	Neurological Disease
DAG peptide is a cyclic peptide. DAG peptide selectively recognizes a subset of astrocytes that are activated in Alzheimer's disease (AD) starting at an early stage of the disease. DAG peptide can be used as a tool to enhance the delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation .

Motuporin	Others	Others
Motuporin is a **cyclic peptide*. Motuporin was initially isolated from T. swinhoei* .

Fmoc-Tyr(3-F,tBu)-OH	Amino Acid Derivatives	Others
Fmoc-Tyr(3-F,tBu)-OH is a cyclic peptide compound with high membrane permeability and can specifically binds to a target molecule (extracted from patent WO2018225864A1) .

ε-Amanitin	DNA/RNA Synthesis ADC Cytotoxin	Cancer
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II .

N-Fmoc-O-ethyl-L-homoserine	Amino Acid Derivatives	Others
N-Fmoc-O-ethyl-L-homoserine is an homoserine derivative, can be used in cyclic peptide compounds synthesis, as a reducing reagent .

Cyclic L27-11	Bacterial	Infection
Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as Pseudomonas sp. Cyclic L27-11 shows nanomolar antibacterial activity against Pseudomonas sp., especially Pseudomonas aeruginosa. Cyclic L27-11 interferes with the function of bacterial outer membrane protein LptD, preventing the normal transport of lipopolysaccharide (LPS), leading to the accumulation of membrane-like substances in bacterial cells, which in turn affects the survival of bacteria. Cyclic L27-11 can be used in the development of antibacterial agents .

VH4127	LDLR	Metabolic Disease
VH4127 is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a K_D of 18 nM for hLDLR. VH4127, bearing non-natural amino acid residues, specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR .

CXJ-2	PI3K ERK	Inflammation/Immunology
CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy .

Certepetide CEND-1; iRGD; LSTA1	Integrin Complement System	Cancer
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors .

β-Amanitin	DNA/RNA Synthesis ADC Cytotoxin	Cancer
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

187-1, N-WASP inhibitor 1 Publications Verification	Arp2/3 Complex	Others
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein .

Jasplakinolide 5 Publications Verification	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

187-1, N-WASP inhibitor TFA	Arp2/3 Complex	Others
187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein .

Murepavadin TFA 2 Publications Verification POL7080 TFA	Bacterial Antibiotic	Infection
Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC₅₀ and MIC₉₀ values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .

Murepavadin POL7080	Bacterial Antibiotic	Infection
Murepavadin (POL7080), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with both MIC₅₀ and MIC₉₀ values of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .

Aspercolorin	Endogenous Metabolite	Others
Aspercolorin, a secondary metabolite, is a cyclic peptide .

K-13	Drug Intermediate	Others
K-13 is a cyclic peptide compound synthesized by a specific organozinc reagent. Its synthesis process involves intermolecular and intramolecular Negishi cross-coupling reactions and is one of the shortest routes reported for the synthesis of such cyclic peptides.

Argyrin G	Others	Others
Argyrin G is a natural cyclic, non-ribosomal peptide .

Argyrin H	Others	Others
Argyrin H is a natural cyclic, non-ribosomal peptide .

Argyrin E	Others	Others
Argyrin E is a natural cyclic, non-ribosomal peptide .

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM .

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM .

Peptide R	CXCR	Cancer
Peptide R, a cyclic peptide, is a specific CXCR4 antagonist. Peptide R shows outstanding capacities to profoundly remodel the tumor stroma. Peptide R has the potential for tumor research .

Aselacin C	Fungal	Infection
Aselacin C is a cyclic peptide that can be isolated from the fungus Acremonium spp. .

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins .

Cyclic MKEY	CXCR	Cardiovascular Disease Cancer
Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice .

Grb2 SH2 domain inhibitor 1	EGFR	Others
Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

Grb2 SH2 domain inhibitor 1 TFA	Src	Others
Grb2 SH2 domain inhibitor 1 TFA is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

Cyclic MKEY TFA	CXCR	Cardiovascular Disease Cancer
Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice .

β-Bag cell peptide	Potassium Channel	Neurological Disease
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .

Cyclic nona-L-arginine hydrochloride	Biochemical Assay Reagents	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

Eurocidin D	Antibiotic	Infection Inflammation/Immunology
Eurocidin D is a cyclic peptide antibiotic. Eurocidin D can inhibit the degranulation of rat mast cells .

Argyrin C	Bacterial	Infection
Argyrin C is a natural cyclic, non-ribosomal peptide that displays a promising antimicrobial activity against Pseudomonas aeruginosa .

Cat. No.	Product Name

HY-L110

Cyclic Peptide Library

92 compounds

Cyclic peptides are polypeptide chains taking cyclic ring structure, which exhibit diverse biological activities, such as antibacterial activity, immunosuppressive activity and anti-tumor activity. Cyclic peptides, with the features of good binding affinity, target selectivity and low toxicity, show great success as therapeutics. Multiple cyclic peptides are currently in clinical use, for examples, gramicidin and tyrocidine with bactericidal activity, cyclosporin A with immunosuppressive activity, and vancomycin with antibacterial activity. Furthermore, cyclic peptides usually have the sufficient size and a balanced conformational flexibility/rigidity for binding to flat protein-protein interaction (PPI) interfaces, which have potential to develop PPI drugs.

MCE offers a unique collection of 92 cyclic peptides, all of which have good bioactivities. MCE Cyclic Peptide Library is a powerful tool for drug discovery and PPI inhibitor screening.

Cat. No.	Product Name	Type

HY-104086

Cucurbit[7]uril

1 Publications Verification

CB7; Carrier CB7

Drug Delivery

Cucurbit[7]uril is a cyclic organic molecule consisting of seven glycoluril units linked by methylene bridges. It has a rigid barrel-like structure with two identical inlets at both ends to selectively encapsulate guest molecules of appropriate size, shape, and polarity. Cucurbit[7]uril is known for its high binding affinity for a variety of organic and inorganic guests, including drugs, amino acids, peptides, and metal ions. This property makes them promising candidates for various applications in areas such as drug delivery, catalysis, and sensing.

Cat. No.	Product Name	Target	Research Area

HY-P4102

**Cyclic PSAP peptide**	Peptides	Cancer
Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo .

HY-P10383

*SPSB2-iNOS inhibitory cyclic* peptide-1**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P5217

CSTSMLKAC (disulfide)	Peptides	Others
CSTSMLKAC (peptide 2) is a *cyclic* 9 amino acid sequence that mimics endogenous peptide sequences. CSTSMLKAC homes to cardiomyocytes in the ischemic myocardium .

HY-P10383A

*SPSB2-iNOS inhibitory cyclic* peptide-1 TFA**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-1(HY-P10383). SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P10384A

*SPSB2-iNOS inhibitory cyclic* peptide-2 TFA**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-2 (HY-P10384). SPSB2-iNOS inhibitory cyclic peptide-2 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 TFA is reduction-resistant and oxidatively stable .

HY-P10835

*LAG-3 cyclic* peptide inhibitor C25**	LAG-3	Cancer
LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a K_d value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8 ⁺ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer .

HY-P10385A

*SPSB2-iNOS inhibitory cyclic* peptide-3 TFA**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-3 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-3 (HY-P10385). SPSB2-iNOS inhibitory cyclic peptide-3 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM .

HY-P10837

*LAG-3 cyclic* peptide inhibitor 12**	LAG-3	Inflammation/Immunology Cancer
LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC₅₀ value of 4.45 μM and a K_i value of 2.66 µM .

HY-P10384

*SPSB2-iNOS inhibitory cyclic* peptide-2**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 (Compound CP2) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 is reduction-resistant and oxidatively stable .

HY-P10385

*SPSB2-iNOS inhibitory cyclic* peptide-3**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-3 (Compound CP3) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM .

HY-P5957

Omphalotin A	Parasite	Infection
Omphalotin A is a cyclic peptide, and shows nematicidal activity .

HY-133801

Unguisin A	Peptides	Others
Unguisin A s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .

HY-125488

Unguisin B	Peptides	Others
Unguisin B s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .

HY-35028

Boc-Glu-Ofm	Amino Acid Derivatives	Others
Boc-Glu-Ofm is a peptide. Boc-Glu-Ofm has been used for the synthesis of ester insulin and cyclic peptide mixtures .

HY-P3557

Mibenratide	Adrenergic Receptor	Cardiovascular Disease
Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research .

HY-P3557A

Mibenratide TFA	Adrenergic Receptor	Cardiovascular Disease
Mibenratide TFA, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide TFA can be used for heart failure research .

HY-P10557

DAG peptide	Biochemical Assay Reagents	Neurological Disease
DAG peptide is a cyclic peptide. DAG peptide selectively recognizes a subset of astrocytes that are activated in Alzheimer's disease (AD) starting at an early stage of the disease. DAG peptide can be used as a tool to enhance the delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation .

HY-W036160

N-Fmoc-O-ethyl-L-homoserine	Amino Acid Derivatives	Others
N-Fmoc-O-ethyl-L-homoserine is an homoserine derivative, can be used in cyclic peptide compounds synthesis, as a reducing reagent .

HY-P10812

CP61	Peptides	Cancer
CP61, a cyclic peptide, is a dual CtBP1/CtBP2 inhibitor. CP61 binds CtBP1 with 3 μM affinity. CP61 inhibits the heterodimerization and homodimerization of CtBP2 with an IC₅₀ value of 19 μM. CP61 is promising for research of cancers .

HY-P10548

Cyclic L27-11	Bacterial	Infection
Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as Pseudomonas sp. Cyclic L27-11 shows nanomolar antibacterial activity against Pseudomonas sp., especially Pseudomonas aeruginosa. Cyclic L27-11 interferes with the function of bacterial outer membrane protein LptD, preventing the normal transport of lipopolysaccharide (LPS), leading to the accumulation of membrane-like substances in bacterial cells, which in turn affects the survival of bacteria. Cyclic L27-11 can be used in the development of antibacterial agents .

HY-P10697

VH4127	LDLR	Metabolic Disease
VH4127 is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a K_D of 18 nM for hLDLR. VH4127, bearing non-natural amino acid residues, specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR .

HY-149205

CXJ-2	PI3K ERK	Inflammation/Immunology
CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy .

HY-P3448

Certepetide CEND-1; iRGD; LSTA1	Integrin Complement System	Cancer
Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors .

HY-P1045

187-1, N-WASP inhibitor 1 Publications Verification	Arp2/3 Complex	Others
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein .

HY-P0027

Jasplakinolide 5 Publications Verification	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

HY-P1045A

187-1, N-WASP inhibitor TFA	Arp2/3 Complex	Others
187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein .

HY-P1674A

Murepavadin TFA 2 Publications Verification POL7080 TFA	Bacterial Antibiotic	Infection
Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC₅₀ and MIC₉₀ values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .

HY-P1674

Murepavadin POL7080	Bacterial Antibiotic	Infection
Murepavadin (POL7080), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with both MIC₅₀ and MIC₉₀ values of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .

HY-P4615

Cyclo(-Glu-Glu)	Peptides	Others
Cyclo(-Glu-Glu) is a cyclic peptide, a cyclic structure formed by linking two glutamic acid residues through a peptide bond .

HY-P4520

(Trp4)-Kemptide	Peptides	Others
(Trp4)-Kemptide is a peptide substrate for adenosine 3',5'-cyclic monophosphate-dependent protein kinase .

HY-P4617

Cyclo(-Leu-Phe)	Peptides	Others
Cyclo(-Leu-Phe) is a cyclic peptide composed of leucine and phenylalanine, forming a ring structure through peptide bonds .

HY-N9526

Lyciumin B	Peptides	Cardiovascular Disease
Lyciumin B is a cyclic peptide isolated from Lysium chinense .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM .

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM .

HY-P4111

Peptide R	CXCR	Cancer
Peptide R, a cyclic peptide, is a specific CXCR4 antagonist. Peptide R shows outstanding capacities to profoundly remodel the tumor stroma. Peptide R has the potential for tumor research .

HY-P2202

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins .

HY-N13127

Segetalin C	Peptides	Endocrinology
Segetalin C is a cyclic peptide that increases uterine weight in ovariectomized rats (2.5 mg/kg).

HY-P1949

Cyclic MKEY	CXCR	Cardiovascular Disease Cancer
Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice .

HY-146127

Grb2 SH2 domain inhibitor 1	EGFR	Others
Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P4909

Autoinducing Peptide I	Peptides	Infection
Autoinducing Peptide I is a cyclic octapeptide secreted by Staphylococcus aureus and can be used in vaccine research .

HY-146127A

Grb2 SH2 domain inhibitor 1 TFA	Src	Others
Grb2 SH2 domain inhibitor 1 TFA is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P1949A

Cyclic MKEY TFA	CXCR	Cardiovascular Disease Cancer
Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice .

HY-P3777

β-Bag cell peptide	Potassium Channel	Neurological Disease
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .

HY-P3193A

Cyclic nona-L-arginine hydrochloride	Biochemical Assay Reagents	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P2171

CCP peptide	Peptides	Inflammation/Immunology
CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .

HY-P3193

Cyclic nona-L-arginine TFA	Peptides	Others
Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P2171A

CCP peptide TFA	Peptides	Inflammation/Immunology
CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .

HY-P3957

Urotensin II, teleost fish	Urotensin Receptor	Others
Urotensin II, teleost fish is a cyclic peptide. It can be isolated from the caudal neurosecretory system of teleost fish .

HY-P6372

SDZ 280-446	Peptides
SDZ 280-446 is an orally active semisynthetic cyclic peptide lactone. SDZ 280-446 can be used in anticancer research .

HY-P10033

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide trypsin inhibitor comprising 14 amino acid residues. SFTI-1 is a potent Bowman-Birk inhibitor.

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