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Results for "

FKBP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FKBP (47) Antibiotic (7) Apoptosis (6) AUTACs (2) Autophagy (15) Bacterial (9) Calcium Channel (1) Drug Metabolite (1) E3 Ligase Ligand-Linker Conjugates (2) Endogenous Metabolite (4) Epigenetic Reader Domain (2) Estrogen Receptor/ERR (2) Fungal (2) HSP (2) Isotope-Labeled Compounds (2) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (6) mTOR (7) Parasite (1) Phosphatase (5) Progesterone Receptor (2) PROTACs (15) Small Interfering RNA (siRNA) (14)
By Research Areas:	Cancer (45) Endocrinology (2) Infection (6) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (5)
Oligonucleotides:	Pre-designed siRNA Sets (14) siRNAs (14)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: FKBP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114421

FKBP12 PROTAC dTAG-13 2 Publications Verification dTAG-13	PROTACs FKBP	Cancer
FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 ^F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12 ^F36V and CRBN, thereby selectively degrading FKBP12 ^F36V .

HY-123941

FKBP12 PROTAC dTAG-7 1 Publications Verification dTAG-7	PROTACs FKBP Epigenetic Reader Domain	Cancer
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12 ^F36V with expression of FKBP12 ^F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN .

HY-130835

FKBP12 PROTAC RC32 RC32	PROTACs FKBP	Cancer
FKBP12 PROTAC RC32 (RC32) is a potent *FKBP12* degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984) .

HY-158131

FKBP51-Hsp90-IN-2	FKBP HSP	Neurological Disease Cancer
FKBP51-Hsp90-IN-2 (Compound E08) is a selective *FKBP51-Hsp90* protein-protein interaction inhibitor with IC₅₀ values of 0.4 µM and 5 µM for *FKBP51* and *FKBP52, respectively. FKBP51-Hsp90-IN-2 also effectively stimulates cellular energy metabolism and neurite growth. FKBP*51-Hsp90-IN-2 can be used in research on neurodegenerative diseases and cancer .

HY-158130

FKBP51-Hsp90-IN-1	FKBP HSP	Neurological Disease Metabolic Disease Cancer
FKBP51-Hsp90-IN-1 (Compound D10) is a selective inhibitor of the *FKBP51-Hsp90* protein-protein interaction, with an IC₅₀ value of 0.1 μM against *FKBP51. FKBP*51-Hsp90-IN-1 can be used in the research of stress-related diseases, Alzheimer's disease, and metabolic disorders .

HY-153990

FKBP51F67V-selective antagonist Ligand2	FKBP	Neurological Disease
FKBP51F67V-selective antagonist Ligand2 (example 3-3) is a potent FKBP51 F67V-selective antagonist ligand. FKBP51F67V-selective antagonist Ligand2 reverses the anxiogenic phenotype induced by overexpression of FKBP51 F67V in the amygdala. FKBP51F67V-selective antagonist Ligand2 binds to FKBP51 F67V, but not to wild-type FKBP51 or FKBP52 .

HY-RS04956

FKBP10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP10 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP10 Human Pre-designed siRNA Set A FKBP10 Human Pre-designed siRNA Set A

HY-RS04957

FKBP11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP11 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP11 Human Pre-designed siRNA Set A FKBP11 Human Pre-designed siRNA Set A

HY-RS04958

FKBP14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP14 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP14 Human Pre-designed siRNA Set A FKBP14 Human Pre-designed siRNA Set A

HY-RS04959

FKBP15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP15 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP15 Human Pre-designed siRNA Set A FKBP15 Human Pre-designed siRNA Set A

HY-RS04962

FKBP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP2 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP2 Human Pre-designed siRNA Set A FKBP2 Human Pre-designed siRNA Set A

HY-RS04963

FKBP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP3 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP3 Human Pre-designed siRNA Set A FKBP3 Human Pre-designed siRNA Set A

HY-RS04964

FKBP4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP4 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP4 Human Pre-designed siRNA Set A FKBP4 Human Pre-designed siRNA Set A

HY-RS04965

FKBP5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP5 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP5 Human Pre-designed siRNA Set A FKBP5 Human Pre-designed siRNA Set A

HY-RS04966

FKBP6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP6 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP6 Human Pre-designed siRNA Set A FKBP6 Human Pre-designed siRNA Set A

HY-RS04967

FKBP7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP7 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP7 Human Pre-designed siRNA Set A FKBP7 Human Pre-designed siRNA Set A

HY-RS04968

FKBP8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP8 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP8 Human Pre-designed siRNA Set A FKBP8 Human Pre-designed siRNA Set A

HY-RS04969

FKBP9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP9 Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP9 Human Pre-designed siRNA Set A FKBP9 Human Pre-designed siRNA Set A

HY-RS04960

FKBP1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP1A Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP1A Human Pre-designed siRNA Set A FKBP1A Human Pre-designed siRNA Set A

HY-RS04961

FKBP1B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FKBP1B Human Pre-designed siRNA Set A contains three designed siRNAs for FKBP1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FKBP1B Human Pre-designed siRNA Set A FKBP1B Human Pre-designed siRNA Set A

HY-135345

*PROTAC FKBP* Degrader-3** 1 Publications Verification	PROTACs FKBP	Cancer
PROTAC FKBP Degrader-3 is a PROTAC that comprises a *FKBP* ligand binding group, a linker and an von Hippel-Lindau binding group. PROTAC FKBP Degrader-3 is a potent *FKBP* degrader .

HY-114872

SLF	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for *FKBP51* and an IC₅₀ of 2.6 μM for *FKBP12*. SLF can be used in the synthesis of PROTAC .

HY-114872A

SLF TFA	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for *FKBP51* and an IC₅₀ of 2.6 μM for *FKBP12*. SLF TFA can be used in the synthesis of PROTAC .

HY-107452

SLF-amido-C2-COOH PROTAC FKBP12-binding moiety 1	Ligands for Target Protein for PROTAC FKBP	Cancer
SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for *FKBP* (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs .

HY-113646

Shield-2	FKBP	Others
Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the *FKBP* mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels .

HY-114420

AP1867-2-(carboxymethoxy) 1 Publications Verification PROTAC FKBP12-binding moiety 2	FKBP Ligands for Target Protein for PROTAC	Cancer
AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12 ^F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules .

HY-134184

AUTAC2	AUTACs Autophagy	Inflammation/Immunology Cancer
AUTAC2 is a *FKBP12*-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12 .

HY-102079

SAFit1	FKBP	Neurological Disease Metabolic Disease
SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a K_i of 4±0.3 nM .

HY-112210

Shield-1 4 Publications Verification Shld1	FKBP	Others
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to *mutated FKBP* (mtFKBP)*, allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP*12-derived destabilization domain (DD) .

HY-147098

dTAG-47	PROTACs FKBP	Cancer
dTAG-47, heterobifunctional dTAG molecule, targets mutant FKBP12 (FKBP12 ^F36V). FKBP12 ^F36V serves as a degradation tag (dTAG) and is fused to a protein of interest. dTAG-47 can be used for the research of basal-like breast cancers (BBC) .

HY-103634

dFKBP-1 1 Publications Verification	PROTACs FKBP	Cancer
dFKBP-1 is a potent and PROTAC-based *FKBP12* degrader. dFKBP-1 incorporates the ligand SLF (HY-114872) of *FKBP12, the Thalidomide based Cereblon* ligand and a linker .

HY-106345

ILS-920	FKBP Calcium Channel	Neurological Disease Inflammation/Immunology
ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin *FKBP52* and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for *FKBP52* versus FKBP12 .

HY-150410

TSPO ligand-3	AUTACs	Cancer
TSPO ligand-3 is a ligand of AUTAC2. AUTAC2 contains an p-fluorobenzylguanine (FBnG) and an synthetic ligand of FKBP (SLF) moiety, which can cause significant silencing of FKBP12 in HeLa cells .

HY-129363

AP1867-3-(aminoethoxy)	Ligands for Target Protein for PROTAC FKBP	Cancer
AP1867-3-(aminoethoxy), the AP1867 based moiety, is a synthetic ligand for *FKBP. AP1867-3-(aminoethoxy) can be used in the synthesis of PROTAC FKBP*12 F36V degrader .

HY-145514

dTAGV-1 TFA	PROTACs	Cancer
dTAGV-1 TFA is a potent and selective degrader of mutant FKBP12 ^F36V fusion proteins. dTAGV-1 TFA can induce degradation of FKBP12 ^F36V-Nluc in vivo .

HY-153806

RapaBlock ZZY05-092	FKBP	Cancer
RapaBlock is a potent, non-immunosuppressive and brain-impermeable *FKBP12* ligand .

HY-161794

SP3N	FKBP Ligands for Target Protein for PROTAC	Cancer
SP3N is a specific degrader of the prolyl isomerase *FKBP12. The alkylamine of SP3N is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12* degradation. SP3N may be used in research for cancer .

HY-161157

dTAG-13-NEG	PROTACs	Cancer
dTAG-13-NEG is a negative control of dTAG-13. dTAG-13 (HY-114421), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 ^F36V with expression of FKBP12F36V in-frame with a protein of interest .

HY-114434

AP1867 3 Publications Verification	FKBP	Cancer
AP1867 is a synthetic FKBP12 ^F36V-directed ligand .

HY-145514C

dTAGV-1 hydrochloride	FKBP PROTACs	Cancer
dTAGV-1 hydrochloride is the hydrochloride form of dTAGV-1 that is a small molecule degrader of *FKBP12* .

HY-10218

Everolimus 80+ Cited Publications RAD001; SDZ-RAD	mTOR FKBP Autophagy Apoptosis Bacterial	Cancer
Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to *FKBP-12* to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

HY-10218S

Everolimus-d4 RAD001-d₄; SDZ-RAD-d₄	mTOR FKBP Autophagy Apoptosis	Cancer
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2].

HY-P4581

Suc-Ala-Leu-Pro-Phe-pNA Suc-ALPF-pNA	FKBP	Others
Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a substrate of FK-506 binding protein (FKBP) .

HY-10218R

Everolimus (Standard) RAD001 (Standard); SDZ-RAD (Standard)	mTOR FKBP Autophagy Apoptosis Bacterial	Cancer
Everolimus (Standard) is the analytical standard of Everolimus. This product is intended for research and analytical applications. Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to *FKBP-12* to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .

HY-16046

Rimiducid 30+ Cited Publications AP1903	FKBP Apoptosis	Cancer
Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the *FKBP* domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.

HY-145712

ElteN378	FKBP	Cancer
ElteN378 is an inhibitors of *FKBP12e*. ElteN378 can be used in study Alzheimer disease, Parkinson disease, Amyotrophic Lateral Sclerosis, proliferation disorders and cancer .

HY-129610

KB02-SLF	PROTACs FKBP	Cancer
KB02-SLF is a PROTAC-based nuclear *FKBP12* degrader (molecular glue). KB02-SLF promotes nuclear *FKBP12* degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF .

HY-145514A

dTAGV-1-NEG	PROTACs FKBP	Cancer
dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12 ^F36V-selective degrader .

HY-102080

SAFit2 4 Publications Verification	FKBP	Cancer
SAFit2 is a highly potent, highly selective FK506-binding protein 51 (FKBP51) inhibitor with a K_i of 6 nM and also enhances AKT2-AS160 binding .

HY-131344

mTOR inhibitor-8	mTOR Autophagy	Cancer
mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells .

Cat. No.	Product Name	Target	Research Area

HY-P4581

Suc-Ala-Leu-Pro-Phe-pNA Suc-ALPF-pNA	FKBP	Others
Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a substrate of FK-506 binding protein (FKBP) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13756A

Tacrolimus monohydrate 75+ Cited Publications FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	Phosphatase FKBP Autophagy Bacterial Antibiotic
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-10219

Rapamycin Maximum Cited Publications 875 Publications Verification Sirolimus; AY-22989	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Anti-aging Source classification Disease Research Disease Research Fields Cancer	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial
Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-13756

Tacrolimus 75+ Cited Publications FK506; Fujimycin; FR900506	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Animals Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	Phosphatase FKBP Bacterial Autophagy Antibiotic
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce *FKBP51* mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-10219R

Rapamycin (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Antibiotics Source classification Disease Research Endogenous metabolite	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial
Rapamycin (Standard) is the analytical standard of Rapamycin. This product is intended for research and analytical applications. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-13756AR

Tacrolimus monohydrate (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Antibiotics Source classification Disease Research	Phosphatase FKBP Autophagy Bacterial Antibiotic
Tacrolimus (monohydrate) (Standard) is the analytical standard of Tacrolimus (monohydrate). This product is intended for research and analytical applications. Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-13756R

Tacrolimus (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Animals Antibiotics Source classification Disease Research	Phosphatase FKBP Bacterial Autophagy Antibiotic
Tacrolimus (Standard) is the analytical standard of Tacrolimus. This product is intended for research and analytical applications. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

Species:	Human (8) Mouse (1) E.coli (1)
Tag:	His (8) SUMO (1) Fc (2)
Source:	HEK293 (5) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P76931

	FKBP14 Protein, Human (HEK293, His) Peptidyl-prolyl cis-trans isomerase FKBP14; 22 kDa FKBP; FKBP-22; FKBP-14	Human	HEK293
	The FKBP14 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that uniquely accelerates protein folding, particularly in protein synthesis. FKBP14 particularly favors 4-hydroxyproline-modified substrates, exhibits significant affinity for type III collagen, and has potential effects on type VI and type X collagen. FKBP14 Protein, Human (HEK293, His) is the recombinant human-derived FKBP14 protein, expressed by HEK293 , with C-His labeled tag. The total length of FKBP14 Protein, Human (HEK293, His) is 188 a.a., with molecular weight of ~25 & 27 kDa, respectively.

HY-P76344

	FKBP11 Protein, Human (HEK293, Fc) Peptidyl-prolyl cis-trans isomerase FKBP11; PPIase FKBP11; FKBP-19; Rotamase; FKBP-11	Human	HEK293
	The FKBP11 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that plays a crucial role in accelerating protein folding, especially in complex protein synthesis. FKBP11 uses its enzymatic abilities to promote rapid and precise conformational changes that are critical for correct protein folding and maturation. FKBP11 Protein, Human (HEK293, Fc) is the recombinant human-derived FKBP11 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FKBP11 Protein, Human (HEK293, Fc) is 128 a.a., with molecular weight of ~40.4-45 KDa.

HY-P76345

	FKBP12 Protein, Human (His) Peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP-12; Calstabin-1; FKBP-1A; FKBP1	Human	E. coli
	FKBP12 protein maintains TGFBR1 in an inactive state, inhibits activin signaling by recruiting SMAD7, and modulates RYR1 calcium channel activity. As a PPIase, it speeds up protein folding. FKBP12's multifunctionality underscores its regulatory role in cellular processes, emphasizing its importance in signaling and protein folding. FKBP12 Protein, Human (His) is the recombinant human-derived FKBP12 protein, expressed by E. coli , with C-His labeled tag.

HY-P76346

	FKBP12 Protein, Mouse (His) Peptidyl-prolyl cis-trans isomerase FKBP1A; FKBP-12; Calstabin-1; FKBP-1A; FKBP1	Mouse	E. coli
	The FKBP12 protein is multifunctional and critical in TGF-β signaling by maintaining TGFBR1 in an inactive conformation, thereby preventing receptor activation in the absence of ligand. It recruits SMAD7 to ACVR1B, blocks the binding of SMAD2 and SMAD3 to the activin receptor complex, and thereby inhibits activin signaling. FKBP12 Protein, Mouse (His) is the recombinant mouse-derived FKBP12 protein, expressed by E. coli , with N-His labeled tag. The total length of FKBP12 Protein, Mouse (His) is 107 a.a., with molecular weight of ~13 KDa.

HY-P70949

	FKBP7 Protein, Human (HEK293, His) Peptidyl-Prolyl Cis-Trans Isomerase FKBP7; PPIase FKBP7; 23 kDa FK506-Binding Protein; 23 kDa FKBP; FKBP-23; FK506-Binding Protein 7; FKBP-7; Rotamase; FKBP7; FKBP23	Human	HEK293
	The FKBP7 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that significantly accelerates protein folding, especially in the complexities of protein synthesis. Utilizing its enzymatic abilities, FKBP7 plays a crucial role in coordinating timely conformational changes to achieve correct protein folding and maturation. FKBP7 Protein, Human (HEK293, His) is the recombinant human-derived FKBP7 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70403

	FKBP3 Protein, Human (His) rHuPeptidyl-prolyl cis-trans isomerase FKBP3/FKBP3, His; Peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase; FKBP25	Human	E. coli
	FKBP3 is a member of the FK506 and rapamycin-binding protein (FKBP) family and serves as a receptor for the immunosuppressants FK506 and rapamycin, both of which inhibit two distinct cytoplasmic signaling pathways. T cell proliferation. In addition to serving as a receptor for these immunosuppressants, FKBP3, like other peptidyl prolyl cis-trans isomerases (PPIases), also functions to accelerate protein folding. FKBP3 Protein, Human (His) is the recombinant human-derived FKBP3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FKBP3 Protein, Human (His) is 224 a.a., with molecular weight of ~30.0 kDa.

HY-P70405

	FKBP4 Protein, Human (His) rHuPeptidyl-prolyl cis-trans isomerase FKBP4/FKBP4, His; Peptidyl-prolyl cis-trans isomerase FKBP4; 51kDa FK506-binding protein; 51kDa FK506-binding protein; 59kDa immunophilin; FK506-binding protein 4; FKBP59; HSP-binding immunophilin; immunophilin FKBP52; Rotamase; FKBP4	Human	E. coli
	The FKBP4 protein is an immunophilin with peptidyl prolyl cis-trans isomerase (PPIase) and co-chaperone activity. It plays a key role in the formation of hybrids with steroid receptors, specifically by interacting with heat shock protein 90 (HSP90). FKBP4 Protein, Human (His) is the recombinant human-derived FKBP4 protein, expressed by E. coli , with C-6*His labeled tag. The total length of FKBP4 Protein, Human (His) is 459 a.a., with molecular weight of 50-60 kDa.

HY-P70333

	FKBP2 Protein, Human (HEK293, His) rHuPeptidyl-prolyl cis-trans isomerase FKBP2 Gene/FKBP2, His; Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short); also named 13 kDa FK506-binding protein; FK506-binding protein 2; Immunophilin FKBP13; Rotamase	Human	HEK293
	FKBP2 protein plays a central role in the complex process of protein folding and is an important peptidyl prolyl cis-trans isomerase (PPIase). Its unique ability to catalyze the cis-trans isomerization of proline imide peptide bonds accelerates dynamic conformational changes that are critical for efficient protein folding. FKBP2 Protein, Human (HEK293, His) is the recombinant human-derived FKBP2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FKBP2 Protein, Human (HEK293, His) is 121 a.a., with molecular weight of ~17.0 kDa.

HY-P76932

	FKBP7 Protein, Human (HEK293, Fc) Peptidyl-Prolyl Cis-Trans Isomerase FKBP7; FKBP-23; FK506-Binding Protein 7; Rotamase	Human	HEK293
	The FKBP7 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that significantly accelerates protein folding, especially in the complexities of protein synthesis. Utilizing its enzymatic abilities, FKBP7 plays a crucial role in coordinating timely conformational changes to achieve correct protein folding and maturation. FKBP7 Protein, Human (HEK293, Fc) is the recombinant human-derived FKBP7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71477

	FkpA Protein, E.coli (His-SUMO) fkpA; c4121FKBP-type peptidyl-prolyl cis-trans isomerase FkpA; PPIase; EC 5.2.1.8; Rotamase	E.coli	E. coli
	The FkpA protein plays a central role in cellular processes, acting as a key catalyst in the complex dance of protein folding. Its catalytic efficiency is excellent in promoting the cis-trans isomerization of proline-imine peptide bonds, thus accelerating the overall folding of proteins. FkpA Protein, E.coli (His-SUMO) ) is the recombinant E. coli-derived FkpA protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-10218S

Everolimus-d4
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2].

HY-13756S

Tacrolimus-13C,d2
Tacrolimus- ¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

HY-10219S1

Rapamycin-13C,d3

Rapamycin- ¹³C,d₃ (Sirolimus- ¹³C,d₃; AY-22989- ¹³C,d₃) is the ¹³C and deuterium labeled Rapamycin (HY-10219) . Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-B0652S1

Etonogestrel-d6
Etonogestrel-d₆ is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs[1]. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs)[2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80400

	FKBP12 Antibody	WB, ICC/IF	Human, Mouse
	FKBP12 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 12 kDa, targeting to FKBP12. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse.

HY-P80401

	FKBP51 Antibody	WB, IHC-P, IP, FC	Human, Rat
	FKBP51 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 51 kDa, targeting to FKBP51. It can be used for WB,IHC-P,IP,FC assays with tag free, in the background of Human, Rat.

HY-P80402

	FKBP52 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse
	FKBP52 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to FKBP52. It can be used for WB,ICC,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80759

	mTOR Antibody MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	mTOR Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 289 kDa, targeting to mTOR. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80838

	Phospho-mTOR (Ser2481) Antibody MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar	WB	Human, Mouse, Rat
	Phospho-mTOR (Ser2481) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 289 kDa, targeting to Phospho-mTOR (Ser2481). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80837

	Phospho-mTOR (Ser2448) Antibody (YA171) MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar	WB, IHC-P	Human, Mouse
	Phospho-mTOR (Ser2448) Antibody (YA171) is a non-conjugated and Rabbit origined monoclonal antibody about 289 kDa, targeting to Phospho-mTOR (Ser2448). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P83175

	FKBP6 Antibody (YA2920) FKBP36	WB, IHC-P	Human, Mouse, Rat
	FKBP6 Antibody (YA2920) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2920), targeting FKBP6, with a predicted molecular weight of 37 kDa (observed band size: 37 kDa). FKBP6 Antibody (YA2920) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P83058

	FKBP38 Antibody (YA2803) FKBP 38; FKBP8; FKBPR38; hFKBP38; Rotamase; Sam11	WB, ICC/IF, FC	Human
	FKBP38 Antibody (YA2803) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2803), targeting FKBP38, with a predicted molecular weight of 45 kDa (observed band size: 52 kDa). FKBP38 Antibody (YA2803) can be used for WB, ICC/IF, FC experiment in human background.