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Results for "

GPx

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (8) Autophagy (1) Bcl-2 Family (2) CDK (1) COX (2) Endogenous Metabolite (7) Ferroptosis (49) Glutathione Peroxidase (36) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (2) Keap1-Nrf2 (2) Ligands for E3 Ligase (1) MDM-2/p53 (3) Mitochondrial Metabolism (1) mTOR (1) p62 (1) PI3K (1) Prostaglandin Receptor (2) PROTAC Linkers (1) PROTACs (7) Reactive Oxygen Species (8) Small Interfering RNA (siRNA) (8) STAT (1) STING (1) TNF Receptor (1) VD/VDR (2) YAP (3)
By Research Areas:	Cancer (51) Cardiovascular Disease (1) Endocrinology (2) Infection (1) Inflammation/Immunology (12) Metabolic Disease (6) Neurological Disease (5)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Pre-designed siRNA Sets (8) siRNAs (8)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138556

GPX4-IN-2	Glutathione Peroxidase	Cancer
GPX4-IN-2 is a potent *GPX4* inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer .

HY-141809

GPX4-IN-3 1 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM .

HY-155663

GPX4-IN-5	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-5 (Compound C18) is a *GPX4* covalent inhibitor with an IC₅₀ value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

HY-149923

GPX4-IN-4	Glutathione Peroxidase	Cancer
GPX4-IN-4 (Compound 24) is a potent *GPX4* inhibitor. GPX4-IN-4 can be used for the research of cancer .

HY-149455

GPX4-IN-8	Glutathione Peroxidase	Cancer
GPX4-IN-8 (compound A80) is a potent *GPX4* inhibitor. GPX4-IN-8 shows antiproliferative activity .

HY-162717

GPX4-IN-11	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-11 (compound I14) is a potent inhibitor of *GPX4, with the K_D* of 45.7 μM. GPX4-IN-11 plays an important role in ferroptosis research .

HY-162718

GPX4-IN-12	Ferroptosis	Cancer
GPX4-IN-12 (compound I22) is a non-covalent *GPX4* inhibitor. GPX4-IN-12 induces ferroptosis and inhibits cell growth of HT1080 cells .

HY-162716

GPX4-IN-10	Ferroptosis	Cancer
GPX4-IN-10 (compound I20) is a non-covalent *GPX4* inhibitor. GPX4-IN-10 induces ferroptosis and inhibits cell growth of HT1080 cells .

HY-156286

GPX4-IN-7	Ferroptosis	Cancer
GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC₅₀ value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis .

HY-157762

GPX4-IN-9	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets *GPX4* under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research .

HY-155664

GPX4-IN-6	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-6 (Compound C25) is a *GPX4* covalent inhibitor with an IC₅₀ value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

HY-159990

GPX4-IN-15	Glutathione Peroxidase	Cancer
GPX4-IN-15 (Compound C1) is an inhibitor for *GPX4, that inhibits 19.8% GPX4 at 1 μM. GPX4-IN-15 inhibits the proliferation of cancer cell MDA-MB-468, BT-549 and MDA-MB-231 with IC₅₀* of 0.86, 0.96 and 0.48 μM .

HY-163995

GPX4-IN-13	Ferroptosis Glutathione Peroxidase	Cancer
GPX4-IN-13 (compound 16) is a *GPX4* inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of *GPX4. GPX*4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC₅₀=8.39 μM), MDA-T32 (IC₅₀=10.28 μM) and MDA-T41 (IC₅₀=8.18 μM) .

HY-168011

GPX4-IN-14	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
GPX4-IN-14 (compound 2c) is an inhibitor of *GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4* protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects .

HY-163272

GPX4/CDK-IN-1	Glutathione Peroxidase CDK	Cancer
GPX4/CDK-IN-1 (Compound B9) is a dual inhibitor of *GPX4* and CDK, with IC₅₀ values of 542.5 nM, 191.2 nM and 68.1 nM for GPX4, CDK4 and CDK6, reapectively. GPX4/CDK-IN-1 shows strong cancer cell growth inhibition in vivo .

HY-161929

GPX4 activator 2	Glutathione Peroxidase Ferroptosis	Cardiovascular Disease
GPX4 activator 2 (Compound C3) is an activator of *GPX4. GPX4 activator 2 exhibits cardioprotective effects and can inhibit cellular ferroptosis* (EC₅₀ = 7.8 μM)。GPX4 activator 2 can be used in the research of myocardial injury .

HY-161928

GPX4 activator 1	Glutathione Peroxidase Ferroptosis	Cancer
GPX4 activator 1 (Compound A9) is a allosteric activator of *GPX4* (K_d = 5.86 μM, EC₅₀ = 19.19 μM). GPX4 activator 1 can selectively act on ferroptosis and prevent the accumulation of intracellular lipid peroxides caused by ferroptosis inducers .

HY-RS05765

GPX2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX2 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX2 Human Pre-designed siRNA Set A GPX2 Human Pre-designed siRNA Set A

HY-RS05766

GPX3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX3 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX3 Human Pre-designed siRNA Set A GPX3 Human Pre-designed siRNA Set A

HY-RS05767

GPX4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX4 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX4 Human Pre-designed siRNA Set A GPX4 Human Pre-designed siRNA Set A

HY-RS05768

GPX5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX5 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX5 Human Pre-designed siRNA Set A GPX5 Human Pre-designed siRNA Set A

HY-RS05769

GPX6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX6 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX6 Human Pre-designed siRNA Set A GPX6 Human Pre-designed siRNA Set A

HY-RS05770

GPX7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX7 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX7 Human Pre-designed siRNA Set A GPX7 Human Pre-designed siRNA Set A

HY-RS05771

GPX8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX8 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX8 Human Pre-designed siRNA Set A GPX8 Human Pre-designed siRNA Set A

HY-RS05764

GPX1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX1 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX1 Human Pre-designed siRNA Set A GPX1 Human Pre-designed siRNA Set A

HY-115627

PKUMDL-LC-101-D04 2 Publications Verification GPx4-Activator-1d4	Glutathione Peroxidase	Inflammation/Immunology
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 *(GPX4)* allosteric activator (pEC₅₀=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation .

HY-162106

*PROTAC GPX4 degrader-2*	Ferroptosis PROTACs Glutathione Peroxidase	Cancer
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC_{50, 48h} value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect .

HY-149236

*PROTAC GPX4 degrader-1*	PROTACs Glutathione Peroxidase Ferroptosis	Cancer
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based *GPX4* degrader, with a DC₅₀ of 0.03 μM in HT1080 cells .

HY-161930

*PROTAC GPX4 degrader-3*	PROTACs Ferroptosis	Cancer
PROTAC GPX4 degrader-3 is a potent PROTAC *GPX4* degrader with a DC₅₀ (24h) of 0.019 μM and an IC₅₀ of 0.024 μM in HT1080 cell .

HY-113402

Gamma-glutamylcysteine 2 Publications Verification γ-Glu-Cys	Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

HY-113402R

Gamma-glutamylcysteine (Standard)	Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (Standard) is the analytical standard of Gamma-glutamylcysteine. This product is intended for research and analytical applications. Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

HY-139001

JKE-1716	Glutathione Peroxidase Ferroptosis	Others
JKE-1716 is a potent and selective nitrolic acid-containing *GPX4* inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent *GPX4* inhibition .

HY-155852

Lepadin H	Ferroptosis	Others
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-100003

ML-210 10+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity .

HY-120912

Gingerenone A	Keap1-Nrf2 Glutathione Peroxidase Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice .

HY-155851

Lepadin E	Ferroptosis MDM-2/p53 Glutathione Peroxidase	Cancer
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-153748

ML162-yne	Glutathione Peroxidase	Cancer
ML162-yne is a potent GPX4-inhibitor affinity probe . ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-169133

GDCNF-11	PROTACs Glutathione Peroxidase Ferroptosis	Cancer
GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of *GPX4* through the HSP 90 chaperone complex, reduces endogenous *GPX4* expression to induce ferroptosis in HT-1080 cells, and the DC₅₀ value is 0.08 μM (Pink: Target protein ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: Linker (HY-W169526)) .

HY-A0020

Eldecalcitol 2 Publications Verification ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	VD/VDR Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .

HY-A0020R

Eldecalcitol (Standard)	VD/VDR Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Eldecalcitol (Standard) is the analytical standard of Eldecalcitol. This product is intended for research and analytical applications. Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .

HY-100218A

RSL3 Maximum Cited Publications 248 Publications Verification (1S,3R)-RSL3	p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species	Cancer
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-151428

Antitumor agent-78	Ferroptosis Apoptosis Bcl-2 Family COX	Cancer
Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .

HY-151429

Antitumor agent-77	Apoptosis Ferroptosis Bcl-2 Family COX	Cancer
Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .

HY-103087

FIN56 10+ Cited Publications	Ferroptosis	Others
FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

HY-136057

iFSP1 15+ Cited Publications	Ferroptosis	Cancer
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

HY-100002

ML162 5+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

HY-138153

JKE-1674 2 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of *GPX4* inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors .

HY-100218C

(1R,3R)-RSL3	Ferroptosis	Cancer
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-161933

1-Adamantane-amide-C7-NH2	PROTAC Linkers	Cancer
1-Adamantane-amide-C7-NH2 is the linker, which can be used for syntheisis of PROTAC GPX4 degrader-3 (HY-161930) .

HY-139008

RC363	Others	Others
RC363 is a novel probucol analog with the activity to protect mouse hippocampal cells and primary cortical neurons from glutamate-induced oxidative cell death (ferroptosis) and increase glutathione peroxidase (GPx) 1 levels and activity.

Cat. No.	Product Name	Type

HY-Y0669

Pipecolic acid 2 Publications Verification	Cell Assay Reagents
Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the *YAP-GPX4* signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .

HY-Y0669R

Pipecolic acid (Standard)

Cell Assay Reagents

Pipecolic acid (Standard) is the analytical standard of Pipecolic acid. This product is intended for research and analytical applications. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113402

Gamma-glutamylcysteine 2 Publications Verification γ-Glu-Cys	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

HY-120912

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase Ferroptosis
Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice .

HY-N0070

Solasonine 2 Publications Verification	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Solanum nigrum Linn. Solanaceae Plants Disease Research Fields Cancer	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-113402A

Gamma-glutamylcysteine TFA 2 Publications Verification γ-Glutamylcysteine TFA	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Interleukin Related TNF Receptor Endogenous Metabolite
Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes .

HY-113402R

Gamma-glutamylcysteine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Gamma-glutamylcysteine (Standard) is the analytical standard of Gamma-glutamylcysteine. This product is intended for research and analytical applications. Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .

HY-155852

Lepadin H	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-155851

Lepadin E	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis MDM-2/p53 Glutathione Peroxidase
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-N0070R

Solasonine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Solanum nigrum Linn. Solanaceae Plants	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-W008820R

Glutaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I . In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .

Species:	Human (2) Pig (2)
Tag:	His (3) Myc (2) Fc (1)
Source:	HEK293 (1) P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75798

	GPX7 Protein, Human (HEK293, Fc) Glutathione peroxidase 7; GPx-7; GSHPx-7; CL683; GPx6	Human	HEK293
	GPX7, a protein with catalase activity, is predicted to respond to oxidative stress. It is located in the endoplasmic reticulum and is expressed in various tissues, including placenta (RPKM 15.6) and thyroid (RPKM 9.2). This highlights the potential importance of GPX7 in antioxidative processes throughout the body. GPX7 Protein, Human (HEK293, Fc) is the recombinant human-derived GPX7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71739

	*EGLP/GPX5 Protein, Pig (P.pastoris, Myc, His)* GPx5; Epididymal secretory glutathione peroxidase; EGLP; Glutathione peroxidase 5; GPx-5; GSHPx-5	Pig	P. pastoris
	EGLP/GPX5 may constitute a protective system similar to glutathione peroxidase, protecting sperm membrane lipids from peroxidative damage. Despite the limited enzyme activity, the protective effect suggests an effect beyond enzyme function. EGLP/GPX5 Protein, Pig (P.pastoris, Myc, His) is the recombinant pig-derived EGLP/GPX5 protein, expressed by P. pastoris , with N-His, C-Myc labeled tag.

HY-P702646

	GPX4 Protein, Human (U73S, His) PHGPx; Glutathione peroxidase 4; GPx-4; GSHPx-4	Human	E. coli
	GPX4 Protein, Human (U73S, His) is the recombinant human-derived GPX4, expressed by E. coli , with N-6*His labeled tag. ,

HY-P72211

	*EGLP/GPX5 Protein, Pig (His-Myc)* GPx5Epididymal secretory glutathione peroxidase; EC 1.11.1.9; Epididymis-specific glutathione peroxidase-like protein; EGLP; Glutathione peroxidase 5; GPx-5; GSHPx-5	Pig	E. coli
	EGLP/GPX5 may constitute a protective system similar to glutathione peroxidase, protecting sperm membrane lipids from peroxidative damage. Despite the limited enzyme activity, the protective effect suggests an effect beyond enzyme function. EGLP/GPX5 Protein, Pig (His-Myc) is the recombinant pig-derived EGLP/GPX5 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of EGLP/GPX5 Protein, Pig (His-Myc) is 198 a.a., with molecular weight of ~27.6 kDa.

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HY-Y0669S

Pipecolic acid-d9
Pipecolic acid-d₉ is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the *YAP-GPX4* signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80146

	GPX1 Antibody	WB, IHC-P, FC	Human
	GPX1 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 22 kDa, targeting to GPX1. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human.

HY-P80450

	GPX4 Antibody 1 Publications Verification	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	GPX4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 22 kDa, targeting to GPX4. It can be used for WB,IHC-P,ICC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80692

	Glutathione Peroxidase 4 Antibody Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; Glutathione peroxidase 4; GPx-4; GSHPx-4	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Glutathione Peroxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 22 kDa, targeting to Glutathione Peroxidase 4. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P82408

	Glutathione Peroxidase 2 Antibody (YA2153) GI GPx; GPRP; GPRP-2; GPx-GI; GPx2; GSHPx 2; GSHPx GI; GSHPx-2; GSHPx-GI	WB, IHC-P	Human
	Glutathione Peroxidase 2 Antibody (YA2153) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2153), targeting Glutathione Peroxidase 2, with a predicted molecular weight of 22 kDa (observed band size: 22 kDa). Glutathione Peroxidase 2 Antibody (YA2153) can be used for WB, IHC-P experiment in human background.