Search Result

Isoforms Recommended:	IL-10

Results for "

IL10

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (6) AMPK (3) Apoptosis (13) Caspase (2) CD28 (1) CDK (4) COX (3) Endogenous Metabolite (6) FLT3 (6) HDAC (6) IFNAR (3) Interleukin Related (39) IRAK (6) Isotope-Labeled Compounds (1) JAK (1) Leukotriene Receptor (2) MALT1 (3) MMP (1) MyD88 (6) nAChR (1) Neurokinin Receptor (2) NF-κB (9) NO Synthase (3) NOD-like Receptor (NLR) (3) Orphan Receptor (1) p38 MAPK (2) Parasite (1) Phosphodiesterase (PDE) (6) Reactive Oxygen Species (2) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (5) SOD (1) STING (1) Syk (1) TNF Receptor (17) Toll-like Receptor (TLR) (6)
By Research Areas:	Cancer (27) Infection (1) Inflammation/Immunology (51) Metabolic Disease (3) Neurological Disease (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (3) Antisense Oligonucleotides (2) siRNAs (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990001

*Anti-Mouse IL-10* Antibody (JES5-2A5)**	Interleukin Related	Inflammation/Immunology
Anti-Mouse IL-10 Antibody (JES5-2A5) is an IgG1 antibody inhibitor against mouse IL-10. Derived from rat.

HY-101757

NO-prednisolone NCX-1015	Interleukin Related	Inflammation/Immunology
NO-prednisolone is a nitric oxide (NO)-releasing derivative of Prednisolone. NO-prednisolone potently stimulates *IL-10* production in vivo.

HY-RS06672

Il10 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il10 Rat Pre-designed siRNA Set A Il10 Rat Pre-designed siRNA Set A

HY-RS06671

Il10 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il10 Mouse Pre-designed siRNA Set A Il10 Mouse Pre-designed siRNA Set A

HY-RS06670

IL10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL10 Human Pre-designed siRNA Set A contains three designed siRNAs for IL10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL10 Human Pre-designed siRNA Set A IL10 Human Pre-designed siRNA Set A

HY-RS06674

IL10RB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL10RB Human Pre-designed siRNA Set A contains three designed siRNAs for IL10RB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL10RB Human Pre-designed siRNA Set A IL10RB Human Pre-designed siRNA Set A

HY-RS06673

IL10RA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL10RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL10RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL10RA Human Pre-designed siRNA Set A IL10RA Human Pre-designed siRNA Set A

HY-143422A

(R)-MALT1-IN-3	MALT1	Cancer
(R)-MALT1-IN-3 (compound 121) is a potent MALT1 protease inhibitor with an IC₅₀ of 20 nM. (R)-MALT1-IN-3 has IC₅₀ of 60 nM, 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively .

HY-P990776

Vimekofusp	Interleukin Related	Inflammation/Immunology
Vimekofusp is a recombinant IL-10 fusion protein that targets IL10RA and IL10RB .

HY-150232

MALT1-IN-11	MALT1	Inflammation/Immunology Cancer
MALT1-IN-11 (Example 151 in reference Patent) is a MALT1 protease inhibitor (IC₅₀ < 10 nM). MALT1-IN-11 inhibits IL10 secretion with an IC₅₀ of 10-100 nM. MALT1-IN-11 can be used for the research of cancer, autoimmune and inflammatory disorders .

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Interleukin Related Reactive Oxygen Species	Inflammation/Immunology
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine *IL-10* levels. Sodium thiocyanate also significantly reduces of ROS formation .

HY-N14039

Pinus pinaster bark extract	Toll-like Receptor (TLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases toll-like receptor (TLR) activity, inducing production of *IL-10* .

HY-160040A

Cobitolimod sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Cobitolimod sodium is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod sodium inhibits Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway .

HY-160040

Cobitolimod	Toll-like Receptor (TLR)	Inflammation/Immunology
Cobitolimod is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod suppresses Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway .

HY-122586

BRD6989	CDK Interleukin Related	Inflammation/Immunology
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates *IL-10. BRD6989 selectively binds a complex of CDK8 with an IC₅₀* of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes .

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR	Inflammation/Immunology
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

HY-123625

R-348 choline R-932348 choline	Interleukin Related JAK Syk	Inflammation/Immunology
R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection .

HY-101019

Ossirene 2 Publications Verification AS101	Interleukin Related Caspase	Inflammation/Immunology Cancer
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor . Ossirene abolishes phosphorylation of STAT3 by inhibiting *IL-10. Ossirene potently inhibits Caspase-1* and is used for the autoimmune diseases and certain malignancies .

HY-147527

CDK8-IN-5	CDK	Inflammation/Immunology
CDK8-IN-5 is a potent CDK8 inhibitor with an IC₅₀ of 72 nM. CDK8-IN-5 shows anti-inflammatory activities with 43% IL-10 enhancement rate. CDK8-IN-5 has the potential for the research of inflammatory bowel disease .

HY-168846

CDK8/19-IN-3	CDK	Inflammation/Immunology
CDK8/19-IN-3 (compound 3-7) is a potent and selective CDK8 and CDK19 inhibitor. CDK8/19-IN-3 upregulates IL-10 levels. CDK8/19-IN-3 has the potential for the research of inflammatory bowel disease (IBD) .

HY-N8249

Cynandione A	nAChR Interleukin Related	Inflammation/Immunology
Cynandione A is an acetophenone that can be isolated from Cynanchum Wilfordii Radix. Cynandione A protects hepatocytes and cortical neurons from toxicity and improves neurological deficits in a rat model of cerebral ischemia. On the other hand, cynandione A has significant anti-inflammatory effects and inhibits inflammation by activating macrophage α7 nAChR and IL-10 expression .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-143422

MALT1-IN-3	MALT1	Cancer
MALT1-IN-3 (compound 122) is a potent MALT1 protease inhibitor, with an IC₅₀ of 0.06 μM. MALT1-IN-3 has IC₅₀ of 0.14 and 0.13 μM for human IL6/IL10 in OCI-LY3 cells, respectively .

HY-124344

Avenanthramide C	Interleukin Related	Neurological Disease
Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-15507

VGX-1027 1 Publications Verification GIT 27	Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events .

HY-N6607

Tryptanthrin 5+ Cited Publications	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-147506

NOD2 antagonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC₅₀ of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs .

HY-168091

YM-I-26	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
YM-I-26 is a selective NLRP3 inflammasome inhibitor. YM-I-26 enhances the phagocytosis of β-amyloid protein by mouse microglial BV2 cells and inhibits the production of IL-1β and *IL-10*. YM-I-26 can be used to study the immunomodulatory activity associated with inflammation .

HY-P990561

BT-063	Interleukin Related	Inflammation/Immunology
BT-063 is a humanized antibody expressed in CHO cells, targeting *IL-10*. BT-063 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for BT-063 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-135317

Emavusertib 3 Publications Verification CA-4948	IRAK Apoptosis FLT3 NF-κB MyD88	Inflammation/Immunology Cancer
Emavusertib is an orally active inhibitor for IRAK4 (IC₅₀=57 nM) and FLT3. Emavusertib inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib exhibits antitumor activity in mouse model

HY-N0405

Orientin 3 Publications Verification	TNF Receptor Interleukin Related	Neurological Disease Cancer
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases *IL-10* level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-161440

SIK-IN-1	AMPK	Inflammation/Immunology
SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SIK1, SIK2 and SIK3 with IC₅₀s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC₅₀ of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC₅₀ of 4 nM in human macrophages .

HY-161441

SIK-IN-2	AMPK	Inflammation/Immunology
SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC₅₀s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC₅₀ of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC₅₀ of 2 nM in human macrophages .

HY-161442

SIK-IN-3	AMPK	Inflammation/Immunology
SIK-IN-3 (Compound 6B) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC₅₀s of 0.1, 0.3 and 0.8 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC₅₀ of 0.6 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC₅₀ of 3 nM in human macrophages .

HY-147105

LRH-1 modulator-1	Orphan Receptor	Inflammation/Immunology
LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa .

HY-107390A

AX-024 hydrochloride 1 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, *IL-10* and IL-17A.

HY-N6607R

Tryptanthrin (Standard)	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
Tryptanthrin (Standard) is the analytical standard of Tryptanthrin. This product is intended for research and analytical applications. Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-107390

AX-024 1 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, *IL-10* and IL-17A.

HY-107909

Theophylline sodium glycinate 1,3-Dimethylxanthine sodium glycinate; Theo-24 sodium glycinate	Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor	Cancer
Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-135317F

Emavusertib phosphate CA-4948 phosphate	IRAK FLT3 NF-κB MyD88 Apoptosis	Inflammation/Immunology Cancer
Emavusertib phosphate (CA-4948 phosphate) is the phosphate salt form of Emavusertib (HY-135317). Emavusertib phosphate is an orally active inhibitor for IRAK4 (IC₅₀=57 nM) and FLT3. Emavusertib phosphate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib phosphate exhibits antitumor activity in mouse model .

HY-135317E

Emavusertib maleate CA-4948 maleate	IRAK FLT3 NF-κB MyD88 Apoptosis	Inflammation/Immunology Cancer
Emavusertib maleate (CA-4948 maleate) is the maleate salt form of Emavusertib (HY-135317). Emavusertib maleate is an orally active inhibitor for IRAK4 (IC₅₀=57 nM) and FLT3. Emavusertib maleate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib maleate exhibits antitumor activity in mouse model .

HY-111164

CBS-3595	p38 MAPK Phosphodiesterase (PDE)	Inflammation/Immunology
CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases .

HY-135317C

Emavusertib tosylate CA-4948 tosylate	IRAK FLT3 NF-κB MyD88 Apoptosis	Inflammation/Immunology Cancer
Emavusertib tosylate (CA-4948 tosylate) is the tosylate salt form of Emavusertib (HY-135317). Emavusertib tosylate is an orally active inhibitor for IRAK4 (IC₅₀=57 nM) and FLT3. Emavusertib tosylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib tosylate exhibits antitumor activity in mouse model .

HY-N0405R

Orientin (Standard)	TNF Receptor Interleukin Related	Neurological Disease Cancer
Orientin (Standard) is the analytical standard of Orientin. This product is intended for research and analytical applications. Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-162600

CDK8-IN-15	CDK	Inflammation/Immunology
CDK8-IN-15 (Compound 46) is a potent CDK8 inhibitors with an IC₅₀ value of 57 nM. It can enhance the thermal stability of CDK8 along with inhibition against NF-κB and have favourable selectivity across the CDK family and tyrosine kinase. Additionally, it also demostrates a positive effect in vitro psoriasis model induced by TNF-α and alleviats the inflammatory response enhancing the expression of Foxp3 and IL-10, which is promising for research of psoriasis diseases .

HY-135317B

Emavusertib hydrochloride CA-4948 hydrochloride	IRAK FLT3 Apoptosis NF-κB MyD88	Inflammation/Immunology Cancer
Emavusertib hydrochloride (CA-4948 tosylate) is the hydrochloride salt form of Emavusertib (HY-135317). Emavusertib hydrochloride is an orally active inhibitor for IRAK4 (IC₅₀=57 nM) and FLT3. Emavusertib hydrochloride inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib hydrochloride exhibits antitumor activity in mouse model .

HY-N15347

Talaromyketide B	NF-κB p38 MAPK Interleukin Related TNF Receptor NO Synthase COX	Inflammation/Immunology
Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases .

HY-135317D

Emavusertib mesylate CA-4948 mesylate	IRAK FLT3 NF-κB MyD88 Apoptosis	Inflammation/Immunology Cancer
Emavusertib mesylate (CA-4948 mesylate) is the mesylate salt form of Emavusertib (HY-135317). Emavusertib mesylate is an orally active inhibitor for IRAK4 (IC₅₀=57 nM) and FLT3. Emavusertib mesylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib mesylate exhibits antitumor activity in mouse model .

HY-149365

SIKs-IN-1	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .

Cat. No.	Product Name	Type

HY-D1056C1

Lipopolysaccharides, from S. enterica serotype enteritidis

LPS, from Salmonella enterica (Serotype enteritidis)

Carbohydrates

Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis are lipopolysaccharide endotoxins and TLR-4 activators derived from the enteritidis serotype of S. enterica, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. enterica serotype enteritidis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype enteritidis can induce systemic inflammatory responses, increasing levels of TNF-α, IFN-γ, IL-6, IL-10, and nitrate in plasma .

Cat. No.	Product Name	Target	Research Area

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P2114

IT9302	Peptides	Cancer
IT9302 is a synthetic IL-10 agonist with the activity of inducing tolerogenic dendritic cells. IT9302 is able to mimic multiple effects of IL-10, including downregulating the antigen presentation machinery and increasing the sensitivity of tumor cells to natural killer cell-mediated lysis. IT9302 can also hinder the response of human monocytes to differentiation factors and reduce the antigen presentation and co-stimulatory capacity of dendritic cells. Dendritic cells treated with IT9302 showed a weakened ability to stimulate T cell proliferation and interferon-γ production. IT9302 exerts its effects through mechanisms that are partially different from IL-10, involving STAT3 inactivation and regulation of the NF-κB intracellular pathway. IT9302-treated dendritic cells showed enhanced expression of membrane-bound TGF-β, associated with the effective induction of foxp3+ regulatory T cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Structural Classification Natural Products Classification of Application Fields Animals Source classification Inflammation/Immunology Disease Research Fields	Interleukin Related Reactive Oxygen Species
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine *IL-10* levels. Sodium thiocyanate also significantly reduces of ROS formation .

HY-N0600

Ginsenoside F3	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related IFNAR
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

HY-124344

Avenanthramide C	Structural Classification Simple Phenylpropanols Avena sativa Linn. Gramineae Source classification Phenylpropanoids Plants	Interleukin Related
Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .

HY-N6607

Tryptanthrin 5+ Cited Publications	Alkaloids Structural Classification Classification of Application Fields Polygonaceae Source classification Plants Polygonum tinctorium Ait. Inflammation/Immunology Disease Research Fields Indole Alkaloids	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-N0405

Orientin 3 Publications Verification	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases *IL-10* level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N14039

Pinus pinaster bark extract	Structural Classification Natural Products Pinaceae Pinus pinaster. Source classification Plants	Toll-like Receptor (TLR) Interleukin Related
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases toll-like receptor (TLR) activity, inducing production of *IL-10* .

HY-N8249

Cynandione A	Apocynaceae Structural Classification Source classification Phenols Polyphenols Plants Cynanchum boudieri H. Lév. & Vaniot	nAChR Interleukin Related
Cynandione A is an acetophenone that can be isolated from Cynanchum Wilfordii Radix. Cynandione A protects hepatocytes and cortical neurons from toxicity and improves neurological deficits in a rat model of cerebral ischemia. On the other hand, cynandione A has significant anti-inflammatory effects and inhibits inflammation by activating macrophage α7 nAChR and IL-10 expression .

HY-N6607R

Tryptanthrin (Standard)	Alkaloids Structural Classification Polygonaceae Source classification Plants Polygonum tinctorium Ait. Indole Alkaloids	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related
Tryptanthrin (Standard) is the analytical standard of Tryptanthrin. This product is intended for research and analytical applications. Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-N0405R

Orientin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Orientin (Standard) is the analytical standard of Orientin. This product is intended for research and analytical applications. Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N15347

Talaromyketide B	Structural Classification Natural Products Microorganisms Source classification	NF-κB p38 MAPK Interleukin Related TNF Receptor NO Synthase COX
Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases .

HY-113402A

Gamma-glutamylcysteine TFA 2 Publications Verification γ-Glutamylcysteine TFA	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Interleukin Related TNF Receptor Endogenous Metabolite
Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine *IL-10* and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes .

HY-N1940

β-Anhydroicaritin 1 Publications Verification Cycloicaritin	Flavonols Structural Classification Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-B0809A

Theophylline monohydrate 1,3-Dimethylxanthine monohydrate; Theo-24 monohydrate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite
Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809

Theophylline Maximum Cited Publications 9 Publications Verification 1,3-Dimethylxanthine; Theo-24	Structural Classification Classification of Application Fields Source classification Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Alkaloids Immune System Disorder Microorganisms Other Alkaloids Disease markers Disease Research Fields Theaceae Cancer	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809B

Theophylline sodium acetate 1,3-Dimethylxanthine sodium acetate; Theo-24 sodium acetate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor
Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809R

Theophylline (Standard) Maximum Cited Publications 9 Publications Verification 1,3-Dimethylxanthine(Standard); Theo-24 (Standard)	Structural Classification Alkaloids Immune System Disorder Classification of Application Fields Source classification Disease markers Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Disease Research Fields Theaceae Cancer	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite
Theophylline (Standard) is the analytical standard of Theophylline. This product is intended for research and analytical applications. Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-W013579

(S)-(+)-Carvone D-Carvone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Gymnaster koraiensis Source classification Other Diseases Umbelliferae Plants Disease Research Fields	SOD Reactive Oxygen Species Interleukin Related NOD-like Receptor (NLR) Caspase Apoptosis
(S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, *IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic* death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis ^[10] .

HY-N0976

1,11b-Dihydro-11b-hydroxymedicarpin 11b-Hydroxy-11b,1-dihydromedicarpin	Structural Classification Natural Products Classification of Application Fields Leguminosae Source classification Derris robusta Plants Inflammation/Immunology Disease Research Fields	Interleukin Related
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative . Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways . Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice .

HY-W013579R

(S)-(+)-Carvone (Standard)	Structural Classification Ketones, Aldehydes, Acids Gymnaster koraiensis Source classification Umbelliferae Plants	Others
(S)-(+)-Carvone (Standard) is the analytical standard of (S)-(+)-Carvone. This product is intended for research and analytical applications. (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, *IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic* death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis ^[10] .

Recombinant Proteins Recommended:

IL-10

Species:	Human (14) Virus (1) Rhesus Macaque (2) Mouse (9) Rat (4) Cat (1) Cynomolgus (2) Canine (1) Pig (2)
Tag:	His (16) Tag Free (13) Avi (5) Fc (8)
Source:	HEK293 (21) CHO (3) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P70517

	IL-10 Protein, Mouse 3 Publications Verification Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF;	Mouse	E. coli
	IL-10 protein is a key immunomodulator that, by binding to its heterotetrameric receptors (IL10RA and IL10RB), activates JAK1 and STAT2 (the latter phosphorylates STAT3), thereby triggering potent anti-inflammatory effects. Phosphorylated STAT3 translocates to the nucleus and promotes the expression of anti-inflammatory mediators. IL-10 Protein, Mouse is the recombinant mouse-derived IL-10 protein, expressed by E. coli , with tag free. The total length of IL-10 Protein, Mouse is 160 a.a..

HY-P70751

	IL-10 Protein, Human (HEK293) Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10; RP11-262N9.1; IL10A; MGC126450; MGC126451; TGIF	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with tag free. The total length of IL-10 Protein, Human (HEK293) is 160 a.a., with molecular weight of 16-20 kDa.

HY-P7030

	IL-10 Protein, Human 2 Publications Verification rHuIL-10; CSIF	Human	E. coli
	IL-10 Protein, Human is an anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation.

HY-P7098

	IL-10 Protein, Rat 1 Publications Verification rRtIL-10; CSIF	Rat	E. coli
	IL-10 Protein, Rat is an immunosuppressive cytokine produced by a variety of mammalian cell types including macophages, monocytes, B-cells, T-cells and keratinocytes.

HY-P7030A

	IL-10 Protein, Human (CHO) 4 Publications Verification rHuIL-10; CSIF	Human	CHO
	IL-10 Protein, Human (CHO) is a CHO cell derived anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation.

HY-P7098A

	IL-10 Protein, Rat (CHO) 1 Publications Verification rRtIL-10; CSIF	Rat	CHO
	IL-10 Protein, Rat (CHO) is a CHO cell derived immunosuppressive cytokine produced by a variety of mammalian cell types including macophages, monocytes, B-cells, T-cells and keratinocytes.

HY-P7074A

	IL-10 Protein, Mouse (CHO) rMuIL-10; CSIF	Mouse	CHO
	IL-10 Protein, Mouse (CHO) is a potent CHO cell derived anti-inflammatory cytokine results in increased immune-mediated demyelination in mice infected with a neurotropic coronavirus.

HY-P79268

	IL-10 Protein, Canine IL10; CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; IL10A; IL-10MGC126451; interleukin-10; TGIF; Interleukin 10	Canine	E. coli
	IL-10 is the most important cytokine that inhibits pro-inflammatory responses and limits excessive immune responses in various autoimmune diseases. It belongs to the type 2 cytokine superfamily. IL-10 plays an important role in transmitting information, activating and regulating immune cells, mediating T and B cell activation, proliferation and differentiation, and in inflammatory responses. IL-10 can promote the proliferation and activation of CD8T⁺ cells, enhancing anti-tumor capabilities. IL-10 Protein, Canine is the recombinant canine-derived IL-10 protein, expressed by E. coli , with tag free. The total length of IL-10 Protein, Canine is 160 a.a..

HY-P73154

	IL-10 Protein, Pig 1 Publications Verification Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Pig	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. IL-10 Protein, Pig is the recombinant pig-derived IL-10 protein, expressed by E. coli , with tag free. The total length of IL-10 Protein, Pig is 157 a.a., with molecular weight of ~18.0 kDa.

HY-P73152

	IL-10 Protein, Feline Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Cat	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. IL-10 Protein, Feline is the recombinant IL-10 protein, expressed by E. coli , with tag free.

HY-P73153

	IL-10 Protein, Human (HEK293, His) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293, His) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His labeled tag.

HY-P700740

	IL-10 Protein, Cynomolgus (HEK293, His) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Cynomolgus	HEK293
	IL-10 Protein, a key immune regulatory cytokine, centrally modulates immune responses. IL-10 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-10 protein, expressed by HEK293 , with N-His labeled tag. The total length of IL-10 Protein, Cynomolgus (HEK293, His) is 160 a.a., with molecular weight of 20-22 kDa.

HY-P78460

	IL-10 Protein, Human (HEK293, His-Avi) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-10 Protein, Human (HEK293, His-Avi) is 160 a.a., with molecular weight of 23-25 kDa.

HY-P78144

	IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) is 160 a.a., with molecular weight of 23-25 kDa.

HY-P700741

	IL-10R alpha Protein, Cynomolgus (HEK293, His) IL-10RA; IL10RA; IL10R; IL-10R1; IL-10R subunit 1; CDw210a; HIL-10R; IBD28; IL-10 R alpha	Cynomolgus	HEK293

HY-P78464

	IL-10R alpha Protein, Human (HEK293, His-Avi) IL-10RA; IL10RA; IL10R; IL-10R1; IL-10R subunit 1; CDw210a; HIL-10R; IBD28; IL-10 R alpha	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His-Avi) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a His and Avi tag at the C-terminus.

HY-P70692

	IL-10R alpha Protein, Human (HEK293, His) Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a 6*His tag at the C-terminus.

HY-P700639

	IL-10R alpha Protein, Human (HEK293) Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a 6*His tag at the C-terminus.

HY-P79362

	IL-10 Protein, Virus Viral interleukin-10 homolog; BCRF1; vIL-10; 20 kDa protein; Protein BCRF1; Interleukin 10	Virus	E. coli
	IL-10 Protein critically masks infected cells for immune evasion by down-regulating the host TAP1 gene, hindering peptide transport into the endoplasmic reticulum and loading onto MHC class I molecules. IL-10 also inhibits IFN-gamma synthesis and exists as a homodimer. IL-10 Protein, Virus is the recombinant Virus-derived IL-10 protein, expressed by E. coli , with tag free.

HY-P75825

	IL-10R alpha Protein, Mouse (HEK293, Fc) Interleukin-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R1; CD210; IL10RA	Mouse	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Mouse (HEK293, Fc) is expressed by HEK 293cells with a hFc tag at the C-terminus.

HY-P72599

	IL-10R beta Protein, Human (HEK293, His) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses.IL-10R beta Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (W221-F242) with a 6*His tag at the C-terminus.

HY-P74837

	IL-10R beta Protein, Mouse (HEK293, His) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Mouse	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (W223-Y251) with a His tag at the C-terminus.

HY-P74838

	IL-10R beta Protein, Mouse (HEK293, hFc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Mouse	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Mouse (HEK293, hFc) is expressed by HEK 293 cells and has a transmembrane region (W223-Y251) with a hFc tag at the C-terminus.

HY-P76414

	IL-10R beta Protein, Rat (HEK293, Fc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Rat	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses.IL-10R beta Protein, Rat (HEK293, Fc) is expressed by HEK 293 cells and consists of 351 amino acids (M1-V351) with a Fc tag at the C-terminus.

HY-P76987

	IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc) Interleukin-10 receptor subunit alpha; IL-10RA; CDw210a; IL-10R1; CD210	Rhesus Macaque	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines.IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc) is expressed in HEK 293 cells and consists of 590 amino acids (M1-S590) with a -hFc tag at the C-terminus.

HY-P76988

	IL-10R alpha Protein, Rhesus Macaque (HEK293, His) Interleukin-10 receptor subunit alpha; IL-10RA; CDw210a; IL-10R1; CD210	Rhesus Macaque	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Rhesus Macaque (HEK293, His) is expressed in HEK 293 cells and consists of 590 amino acids (M1-S590) with a His tag at the C-terminus.

HY-P74839

	IL-10R beta Protein, Human (HEK293, His-hFc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Human (HEK293, His-hFc) is expressed by HEK293 cells and with a His and -hFc tag at the C-terminus.

HY-P700188AF

	*Animal-Free IL-10* Protein, Mouse (His)** Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF	Mouse	E. coli
	IL-10 protein is a key immunomodulator that, by binding to its heterotetrameric receptors (IL10RA and IL10RB), activates JAK1 and STAT2 (the latter phosphorylates STAT3), thereby triggering potent anti-inflammatory effects. Phosphorylated STAT3 translocates to the nucleus and promotes the expression of anti-inflammatory mediators. Animal-Free IL-10 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-10 Protein, Mouse (His) is 160 a.a., with molecular weight of ~19.69 kDa.This product is for cell culture use only.

HY-P700244AF

	*Animal-Free IL-10* Protein, Pig (His)** Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF	Pig	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. Animal-Free IL-10 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-10 Protein, Pig (His) is 157 a.a., with molecular weight of ~19.1 kDa.This product is for cell culture use only.

HY-P700097AF

	*Animal-Free IL-10* Protein, Human (His)** B-TCGF; CSIF; TGIF	Human	E. coli
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. Animal-Free IL-10 Protein, Human (His) is the recombinant human-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-10 Protein, Human (His) is 160 a.a., with molecular weight of ~19.6 kDa.This product is for cell culture use only.

HY-P701062

	*IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi)* IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ	Human	HEK293
	Interleukin 10 receptor beta (IL-10Rβ) is an important component of the interleukin 10 (IL-10), IL-22 and IL-24 receptor complex and plays a central role in mediating multiple signaling pathways effect. As part of the IL-10 receptor, IL-10Rβ forms a functional heterodimer with IL-10Rα and initiates IL-10 signaling through the JAK/STAT pathway. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

HY-P700872

	*IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi)* IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ	Human	HEK293
	Interleukin 10 receptor beta (IL-10Rβ) is an important component of the interleukin 10 (IL-10), IL-22 and IL-24 receptor complex and plays a central role in mediating multiple signaling pathways effect. As part of the IL-10 receptor, IL-10Rβ forms a functional heterodimer with IL-10Rα and initiates IL-10 signaling through the JAK/STAT pathway. IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

HY-P73892

	IL-20 Protein, Rat Cytokine Zcyto10; IL10D; IL20; Interleukin-20	Rat	E. coli
	IL-20 Protein, a pivotal immune regulatory cytokine, critically modulates immune responses. IL-20 Protein, Rat is the recombinant rat-derived IL-20 protein, expressed by E. coli , with tag free. The total length of IL-20 Protein, Rat is 152 a.a., with molecular weight of ~17 kDa.

HY-P77963

	IL-20 Protein, Mouse (HEK293, Fc) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	HEK293
	IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P77964

	IL-20 Protein, Mouse (HEK293, His) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	HEK293
	IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-His labeled tag.

HY-P700198AF

	Animal-Free IL-20 Protein, Mouse (His) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	E. coli
	IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. Animal-Free IL-20 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-20 protein, expressed by E. coli , with C-His labeled tag.This product is for cell culture use only.

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HY-B0809S1

Theophylline-d3

Theophylline-d₃ is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81113

	IL-10 Antibody Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. 白介素10	WB, ICC/IF, FC	Human
	IL-10 Antibody is an unconjugated, approximately 18 kDa, rabbit-derived, anti-IL-10 monoclonal antibody. IL-10 Antibody can be used for: WB, ICC, FC expriments in human background without labeling.

HY-P81240

	IL-19 Antibody IL-19; MDA1; NG.1; ZMDA1; IL-10C	WB, IHC-P	Human
	IL-19 Antibody is a non-conjugated IgG antibody, targeting IL-19, with a predicted molecular weight of 20 kDa. IL-19 Antibody can be used for WB, IHC-P experiment in human background.