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Pathways Recommended:	PROTAC

Results for "

PROTAC SMARCA2 degrader

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ligands for Target Protein for PROTAC (7) PROTAC Linkers (11) Apoptosis (2) E3 Ligase Ligand-Linker Conjugates (17) Epigenetic Reader Domain (36) Ligands for E3 Ligase (6) PROTACs (67) Target Protein Ligand-Linker Conjugates (1)
By Research Areas:	Cancer (107) Inflammation/Immunology (1)
Click Chemistry:	Azide (15)

109

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Click Chemistry

Targets Recommended: PROTAC Linkers PROTAC-Linker Conjugates for PAC Ligands for Target Protein for PROTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-168257

PROTAC SMARCA2 degrader-30	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-30 (example 85) is a **PROTAC SMARCA2** degrader with a DC₅₀ less than 100 nM in H1299 cells .

HY-161882

PROTAC SMARCA2 degrader-8	PROTACs	Cancer
PROTAC SMARCA2 degrader-8 (compound 1) is a potent *SMARCA2* degrader with a DC₅₀ of 28nM in A375 cells .

HY-169278

PROTAC SMARCA2 degrader-26	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-26 (compound 45) is a potent *SMARCA2* PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity .

HY-169271

PROTAC SMARCA2 degrader-20	PROTACs	Cancer
PROTAC SMARCA2 degrader-20 (Compound I-40) is a **PROTAC SMARCA2** degrader. PROTAC SMARCA2 degrader-20 has the potential for the research of cancer .

HY-169270

PROTAC SMARCA2 degrader-19	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for *SMARCA2, that degrades* *SMARCA2* in cell A549 and MV411 with a DC₅₀ < 100 nM. PROTAC SMARCA2 degrader-19 degrades *SMARCA4* in cell MV411 with a DC₅₀ > 1000 nM .

HY-169269

PROTAC SMARCA2 degrader-18	PROTACs	Cancer
PROTAC SMARCA2 degrader-18 (Example144) is a **PROTAC SMARCA2** degrader. PROTAC SMARCA2 degrader-18 has the potential for the research of non-small cell lung cancer (NSCLC) .

HY-169274

PROTAC SMARCA2 degrader-23	PROTACs	Cancer
PROTAC SMARCA2 degrader-23 (Example 1) is a potent and selective **PROTAC SMARCA2** degrader, with a DC₅₀ of <100 nM. PROTAC SMARCA2 degrader-23 has the potential for the research of cancer .

HY-162245

PROTAC SMARCA2 degrader-3	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-3 is a *PROTAC* degrader of the SWI/SNF ATPase subunits, *SMARCA2. PROTAC* SMARCA2 degrader-3 has anticancer effects (WO2023244764A1; Compound 153) .

HY-169273

PROTAC SMARCA2 degrader-22	PROTACs	Cancer
PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for *SMARCA2* with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC₅₀ < 250 nM .

HY-168229

PROTAC SMARCA2 degrader-27	PROTACs	Cancer
PROTAC SMARCA2 degrader-27 (compound 4) is a **PROTAC SMARCA2** degrader. PROTAC SMARCA2 degrader-27 has the potential to be used in cancer research (blue: SMARCA2 ligand, (HY-168232); black: linker, (HY-168231); pink: VHL ligand, (HY-168230)) .

HY-169275

PROTAC SMARCA2 degrader-24	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for *SMARCA2* with a DC₅₀ < 0.1 µM in HeLa. PROTAC SMARCA2 degrader-24 degrades *SMARCA4* with a DC₅₀ > 10 μM in HeLa .

HY-153424

PROTAC SMARCA2 degrader-1	Target Protein Ligand-Linker Conjugates	Cancer
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC₅₀<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate .

HY-169276

PROTAC SMARCA2 degrader-25	PROTACs	Cancer
PROTAC SMARCA2 degrader-25 (example 86) is a potent **PROTAC SMARCA2** degrader with the DC₅₀ of ＜0.01 μM .

HY-159450

PROTAC SMARCA2 degrader-6	PROTACs	Cancer
PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159462

PROTAC SMARCA2 degrader-10	PROTACs	Cancer
PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162746

PROTAC SMARCA2 degrader-9	PROTACs	Cancer
PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162747

PROTAC SMARCA2 degrader-17	PROTACs	Cancer
PROTAC SMARCA2 degrader-17 (compound I-290) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162742

PROTAC SMARCA2 degrader-16	PROTACs	Cancer
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-169272

PROTAC SMARCA2 degrader-21	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for *SMARCA, that degrades* *SMARCA2* with a DC₅₀ of 10-50 nM in A549 cell, and degrades *SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <1 nM and >100 nM, respectively .

HY-163865

PROTAC SMARCA2 degrader-13	PROTACs	Cancer
SMARCA2 degrader-2 (compound I-322) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163866

PROTAC SMARCA2 degrader-14	PROTACs	Cancer
SMARCA2 degrader-3 (compound I-323) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163867

PROTAC SMARCA2 degrader-15	PROTACs	Cancer
SMARCA2 degrader-4 (compound I-332) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163874

PROTAC SMARCA2 degrader-12	PROTACs	Cancer
SMARCA2 degrader-13 (compound I-406) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-153425

PROTAC SMARCA2 degrader-2	PROTACs	Cancer
PROTAC SMARCA2 degrader-2 is a potent and selective **SMARCA2/4 PROTAC** degrader with an IC₅₀ of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research .

HY-159449

PROTAC SMARCA2 degrader-5	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC* SMARCA2 degrader-5 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

PROTAC SMARCA2 degrader-7	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) *SMARCA2. PROTAC* SMARCA2 degrader-7 degrades *SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159457

PROTAC SMARCA2/4-degrader-6	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-6 (compound I-438) is a *SMARCA2/4* degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Blue:SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Pink:VHL ligand (HY-112078)) .

HY-159459

PROTAC SMARCA2/4-degrader-32	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163869

PROTAC SMARCA2/4-degrader-16	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-16 (compound I-337) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162741

PROTAC SMARCA2/4-degrader-33	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163872

PROTAC SMARCA2/4-degrader-10	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent *SMARCA2* degrader with an DC₅₀ value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer (Blue:SMARCA2/4 ligand, (HY-159542); Black: linker (HY-W088435); Pink:VHL ligand (HY-125845)) .

HY-163875

PROTAC SMARCA2/4-degrader-22	PROTACs	Cancer
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163876

PROTAC SMARCA2/4-degrader-23	PROTACs	Cancer
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163871

PROTAC SMARCA2/4-degrader-18	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-18 degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159531); Black: Linker (HY-76547); Blue: Ligand for E3 Ligase (HY-125845))

HY-163868

PROTAC SMARCA2/4-degrader-15	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-15 degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-N3024); Blue: Ligand for E3 Ligase (HY-125845))

HY-163870

PROTAC SMARCA2/4-degrader-17	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-17 degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W053507); Blue: Ligand for E3 Ligase (HY-125845))

HY-162743

PROTAC SMARCA2/4-degrader-29	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-29 degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159682); Blue: ligand for E3 ligase (HY-W382038)) .

HY-169279

PROTAC SMARCA2/4-degrader-34	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent *SMARCA2* and *SMARCA4* PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC₅₀ value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280); Black: Linker (HY-43048); Blue: Ligand for E3 ligase (HY-125845) .

HY-159458

PROTAC SMARCA2/4-degrader-7	PROTACs	Cancer
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

PROTAC SMARCA2/4-degrader-1	PROTACs	Cancer
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

PROTAC SMARCA2/4-degrader-2	PROTACs	Cancer
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159461

PROTAC SMARCA2/4-degrader-9	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2 degrader-9 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-163877

PROTAC SMARCA2/4-degrader-19	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-19 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-163949); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-125845))

HY-163873

PROTAC SMARCA2/4-degrader-20	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC* SMARCA2/4-degrader-20 degrades *SMARCA2* in A549 and MV411 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-163932))

HY-162748

PROTAC SMARCA2/4-degrader-30	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-30 degrades *SMARCA2* in A549 and in MV411 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159684); Blue: ligand for E3 ligase (HY-W382038)) .

HY-162744

PROTAC SMARCA2/4-degrader-31	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-31 degrades *SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038)) .

HY-159460

PROTAC SMARCA2/4-degrader-8	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC* SMARCA2/4-degrader-8 degrades *SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

PROTAC SMARCA2/4-degrader-4	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-4 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

PROTAC SMARCA2/4-degrader-5	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-5 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159454

PROTAC SMARCA2/4-degrader-3	PROTACs	Cancer
SMARCA2/4-degrader-3 (compound I-433) is a PROTAC *SMARCA2/4*-degrader based on VH032-NH2, with a degradation potency (DC₅₀) <100 nM in MV4-11 cells .

Cat. No.	Product Name		Classification

HY-159450

PROTAC SMARCA2 degrader-6		Azide
PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159462

PROTAC SMARCA2 degrader-10		Azide
PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting *SMARCA2; it degrades* SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159449

PROTAC SMARCA2 degrader-5		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC* SMARCA2 degrader-5 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

PROTAC SMARCA2 degrader-7		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) *SMARCA2. PROTAC* SMARCA2 degrader-7 degrades *SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159457

PROTAC SMARCA2/4-degrader-6		Azide
PROTAC SMARCA2/4-degrader-6 (compound I-438) is a *SMARCA2/4* degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Blue:SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Pink:VHL ligand (HY-112078)) .

HY-159459

PROTAC SMARCA2/4-degrader-32		Azide
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159458

PROTAC SMARCA2/4-degrader-7		Azide
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

PROTAC SMARCA2/4-degrader-1		Azide
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

PROTAC SMARCA2/4-degrader-2		Azide
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades* SMARCA2/4 proteins in A549 cells with the DC₅₀s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159461

PROTAC SMARCA2/4-degrader-9		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2 degrader-9 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

PROTAC SMARCA2/4-degrader-8		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC* SMARCA2/4-degrader-8 degrades *SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

PROTAC SMARCA2/4-degrader-4		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-4 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

PROTAC SMARCA2/4-degrader-5		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC* SMARCA2/4-degrader-5 degrades *SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159454

PROTAC SMARCA2/4-degrader-3		Azide
SMARCA2/4-degrader-3 (compound I-433) is a PROTAC *SMARCA2/4*-degrader based on VH032-NH2, with a degradation potency (DC₅₀) <100 nM in MV4-11 cells .

HY-163926

SMARCA2/4-IN-2		Azide
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

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PROTAC SMARCA2 degrader

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