Search Result
Results for "
Poly(I:C)
" in MedChemExpress (MCE) Product Catalog:
113
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-107202
-
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Poly(I:C)
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Toll-like Receptor (TLR)
PKD
HSP
Bcl-2 Family
Interleukin Related
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Infection
Inflammation/Immunology
Cancer
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Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .
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- HY-135748
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Poly(I:C) sodium
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Toll-like Receptor (TLR)
Apoptosis
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Inflammation/Immunology
Cancer
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Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis .
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- HY-107202A
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Toll-like Receptor (TLR)
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Infection
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Poly (I:C):Kanamycin (1:1) is a mixture of poly (I:C) and kanamycin. Poly(I:C) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Kanamycin is positively charged (poly-NH3) and can thus neutralize the negative charge of Poly I:C and thereby stabilized the molecule.
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- HY-135748A
-
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Toll-like Receptor (TLR)
Apoptosis
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Infection
Cancer
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Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and b>MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .
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- HY-23497
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- HY-W243303E
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Biochemical Assay Reagents
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Others
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Poly(acrylic acid) (MW 450000) is a polyacrylic acid with a molecular weight of 450000. Poly(acrylic acid) (MW 450000) is an anionic polymer. Poly(acrylic acid) (MW 450000) can be as a corrosion-mitigating and surface-stabilizing agent .
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- HY-134958
-
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Poly(I:C) potassium
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Toll-like Receptor (TLR)
Apoptosis
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Inflammation/Immunology
Cancer
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Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid potassium can directly trigger cancer cells to undergoApoptosis .
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- HY-135164
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- HY-172148
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Interleukin Related
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Inflammation/Immunology
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Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid (HY-Y0520) that efficiently delivers the active ingredient Itaconic acid to skin tissue following oral administration. Itaconic acid prodrug-1 possesses immunomodulatory properties, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 can be utilized for the research of alopecia areata and other inflammatory skin diseases .
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- HY-138830A
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Histone Demethylase
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Neurological Disease
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(S,S)-TAK-418 is a potent inhibitor of lysine-specific demethylase 1 (LSD1), demonstrating significant normalization of aberrant gene expression in neurodevelopmental disorders. (S,S)-TAK-418 also ameliorates ASD-like behaviors in rodent models affected by maternal exposure to valproate or poly I:C. (S,S)-TAK-418 modulates gene expression differently across various models and ages, indicating its potential as a therapeutic agent for conditions like autism spectrum disorder and schizophrenia.
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- HY-B2247
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poly(lactic-co-glycolic acid) (50:50)
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Biochemical Assay Reagents
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Others
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PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
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- HY-112531
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Biochemical Assay Reagents
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Others
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Poly(2-hydroxyethyl methacrylate) (MW 20000) is one of the most important hydrogels in the biomaterials world. Poly(2-hydroxyethyl methacrylate) is the basic component of contact lenses, and is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agent and etc .
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- HY-112531A
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Biochemical Assay Reagents
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Others
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Poly(2-hydroxyethyl methacrylate) (MW 1000000) is one of the most important hydrogels in the biomaterials world. Poly(2-hydroxyethyl methacrylate) is the basic component of contact lenses, and is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of agent and etc .
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- HY-401383
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Biochemical Assay Reagents
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Others
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Poly(acrylic acid) (MW 10000-60000) is a polyacrylic acid with a molecular weight of 10000-60000. Poly(acrylic acid) (MW 10000-60000) is an anionic polymer. Poly(acrylic acid) (MW 10000-60000) can be used as a corrosion-mitigating and surface-stabilizing agent .
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- HY-W440408
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Polyester short-cut fiber
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Biochemical Assay Reagents
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Others
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Poly(oxyethyleneoxyterephthaloyl) is a commonly used waterproof polymer material. Poly(oxyethyleneoxyterephthaloyl) can be used in textile, electrical and other fields .
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- HY-112111
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Biochemical Assay Reagents
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Cancer
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Poly-L-Glutamic acid (MW 700000) is biochemical reagent.Poly-L-Glutamic acid can be used as the drug carrier for targeted delivery of anticancer agents .
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- HY-W243303C
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Biochemical Assay Reagents
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Others
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Poly(acrylic acid) (Mv 4000000) is a polyacrylic acid (and an anionic polymer) with a molecular weight of 4000000. Poly(acrylic acid) (Mv 4000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 4000000) is a biomaterial or organic compound that can be used in life science research .
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- HY-126437C
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Biochemical Assay Reagents
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Cancer
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Poly-L-lysine hydrobromide (MW 150000-300000) is a lysine polymer. Poly-L-lysine hydrobromide is a nonspecific attachment factor for cells, promoting cell adhesion to solid substrates. Poly-L-lysine hydrobromide can be used as a coating substrate for culture dishes, slides, etc. Poly-L-lysine hydrobromide (MW 150000-300000) exhibits anticancer activity against melanoma and lymphoma. Poly-L-lysine hydrobromide (MW 150000-300000) can be used for combined hyperthermia, magnetic resonance imaging, and cancer cell detection .
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- HY-126437
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Apoptosis
Bcl-2 Family
MDM-2/p53
VEGFR
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Cardiovascular Disease
Cancer
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Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material .
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- HY-158759
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Biochemical Assay Reagents
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Others
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Poly(vinyl acetate) is a widely available adhesive used for porous materials like wood, paper, and cloth. Poly(vinyl acetate) is prepared by polymerization of vinyl acetate (VAM) .
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- HY-172378
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Biochemical Assay Reagents
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Others
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Poly(styrene)-block-poly(acrylic acid) (PS:PAA 30000:2000) is a diblock copolymer used to prepare polymer micelles or vesicles and other encapsulation applications .
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- HY-W243303D
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Biochemical Assay Reagents
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Others
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Poly(acrylic acid) (Mv 1250000) is a polyacrylic acid (an anionic polymer) with a molecular weight of 1250000. Poly(acrylic acid) (Mv 1250000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 1250000) is a biomaterial or organic compound that can be used as a life science research related biomaterial or organic compound .
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- HY-W243303B
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Biochemical Assay Reagents
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Others
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Poly(acrylic acid) (Mv 3000000) is a polyacrylic acid (an anionic polymer) with a molecular weight of 3000000. Poly(acrylic acid) (Mv 3000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 3000000) is a biomaterial or organic compound that can be used as a life science research related biomaterial or organic compound .
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- HY-138646
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Poly(dA:dT) sodium
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Cyclic GMP-AMP Synthase
AIM2
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Infection
Cancer
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Polydeoxyadenylic-thymidylic acid (Poly(dA:dT)) sodium is a synthetic DNA polymer. Poly(dA:dT) sodium can be used to determine the activity of bound and free ribonucleic acid polymerase. Poly(dA:dT) sodium is recognized by multiple PRRs (cytosolic DNA sensors (CDS), including cGAS, AIM2, DAI, DDX41, IFI16, and LRRFIP1), and triggers the production of type I interferons. Poly(dA:dT) sodium can be used for the research of cancer and virus infection .
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- HY-172381
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Biochemical Assay Reagents
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Others
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Poly(guluronate), low endotoxin is the portion of the Alginate molecule that is responsible for its gelling behaviour. Poly(guluronate), low endotoxin has ionic cross-linking effects .
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- HY-W723152
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Drug Intermediate
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Others
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Poly(D,L-lactide-co-glycolide) is a synthetic polymer material with good biocompatibility. Poly(D,L-lactide-co-glycolide) can be used in the research of drug delivery systems .
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- HY-149449
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- HY-167566
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- HY-W416291
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- HY-112531B
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Endogenous Metabolite
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Others
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Poly(2-hydroxyethyl methacrylate) (Mv 300000) is an acrylic polymer utilized in dental applications, primarily for its ability to prevent cell adhesion on growth surfaces within culture vessels.
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- HY-150502
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pSAT
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Biochemical Assay Reagents
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Others
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Poly(styrenyl acetal trehalose) (pSAT) is composed of trehalose side chains linked to a polystyrene backbone via acetals. Poly(styrenyl acetal trehalose) stabilizes a variety of proteins and enzymes against fluctuations in temperature, and does not trigger the innate immune response. Poly(styrenyl acetal trehalose) can be used in synthesis of protein-polymer conjugates for reduced renal clearance of the biomolecule .
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- HY-W110542D
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 1000) (PEGDA (MW 1000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 1000) can be used in the formation of a cross-linked polymers .
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- HY-W110542L
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PEGDA (MW 3500)
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 3500) (PEGDA (MW 3500)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 3500) can be used in the formation of a cross-linked polymers .
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- HY-W110542H
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PEGDA (MW 10000)
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 10000) (PEGDA (MW 10000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 10000) can be used in the formation of a cross-linked polymers .
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- HY-172378A
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Biochemical Assay Reagents
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Others
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Poly(styrene)-block-poly(acrylic acid) (PS:PAA 3,000:5,000,DDMAT terminated) is a diblock copolymer used to prepare polymer micelles or vesicles and other encapsulation applications .
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- HY-W110542G
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PEGDA (MW 6000)
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 6000) (PEGDA (MW 6000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 6000) can be used in the formation of a cross-linked polymers .
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- HY-W110542M
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PEGDA (MW 20000)
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 20000) (PEGDA (MW 20000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 20000) can be used in the formation of a cross-linked polymers .
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- HY-W110542J
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PEGDA (MW 700)
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 700) (PEGDA (MW 700)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 700) can be used in the formation of a cross-linked polymers .
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- HY-W110542K
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PEGDA (MW 1500)
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 1500) (PEGDA (MW 1500)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 700) can be used in the formation of a cross-linked polymers .
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- HY-W243303A
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- HY-W763557B
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) methacrylate (MW 500) is a monomethacrylate functionalized PEG, which is used to prepare composite materials, such as Poly(ethylene glycol) methacrylate-chitosan, and can be used as an ocular drug delivery carrier .
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- HY-W763557A
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) methacrylate (MW 360) is a monomethacrylate functionalized PEG, which is used to prepare composite materials, such as Poly(ethylene glycol) methacrylate-chitosan, and can be used as an ocular drug delivery carrier .
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- HY-139201B
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PDLHB (MW 84000)
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CaSR
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Neurological Disease
Cancer
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Poly-D-lysine hydrobromide (MW 84000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .
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- HY-126437D
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Biochemical Assay Reagents
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Others
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Poly-L-lysine hydrobromide (MW 150000-300000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine hydrobromide (MW 150000-300000) has good biocompatibility. Poly-L-lysine hydrobromide (MW 150000-300000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface .
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- HY-126437B
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Biochemical Assay Reagents
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Others
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Poly-L-lysine (hydrobromide) (MW 70000-150000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine (hydrobromide) (MW 70000-150000) has good biocompatibility. Poly-L-lysine (hydrobromide) (MW 70000-150000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface .
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- HY-158799
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Poly(ADP-ribose) Glycohydrolase (PARG)
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Others
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Poly(ADP-ribose) Polymer/pADPr is a complex polymer of repeating ADP-ribose units, which is synthesized using poly(ADP-ribose) polymerase (PARP) in the presence of NAD +, cleaved from PARP, and subsequently purified .
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- HY-139201A
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PDLHB (MW 70000-150000)
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Biochemical Assay Reagents
CaSR
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Neurological Disease
Cancer
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Poly-D-lysine hydrobromide (MW 70000-150000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .
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- HY-139201
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PDLHB (MW 30000-70000)
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CaSR
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Neurological Disease
Metabolic Disease
Cancer
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Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide is a CaSR agonist peptide .
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- HY-W596474I
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- HY-W596474H
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- HY-W243303M
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- HY-W243303K
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- HY-W243303N
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- HY-W596474A
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- HY-W596474E
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- HY-W596474D
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- HY-W243303J
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- HY-W596474C
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- HY-W596474B
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- HY-W243303L
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- HY-141475
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Endogenous Metabolite
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Others
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Acetoacetyl coenzyme A sodium is a central endogenous metabolite. The Km at pH 7.5 for Acetoacetyl coenzyme A sodium is 1.10 mM. Acetoacetyl coenzyme A sodium can be used for the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB) .
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- HY-163990D
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- HY-163990B
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- HY-163990C
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- HY-163990
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- HY-163990E
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- HY-163990A
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- HY-126437E
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Biochemical Assay Reagents
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Others
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Poly-L-lysine (hydrobromide) (MW 15000-30000) can promote cell adhesion to solid-phase substrates. Poly-L-lysine (hydrobromide) (MW 15000-30000) is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-126437I
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Biochemical Assay Reagents
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Others
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Poly-L-lysine (hydrobromide) (MW 1000-5000) can promote cell adhesion to solid-phase substrates. Poly-L-lysine (hydrobromide) (MW 1000-5000) is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-126437H
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Biochemical Assay Reagents
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Others
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Poly-L-lysine (hydrobromide) (MW 4000-15000) can promote cell adhesion to solid-phase substrates. Poly-L-lysine (hydrobromide) (MW 4000-15000) is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-W110542P
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PEGDA (MW 4000), MEHQ as inhibitor
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor (PEGDA (MW 4000), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .
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- HY-W110542N
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PEGDA (MW 250),MEHQ as inhibitor
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 250), MEHQ as inhibitor (PEGDA (MW 250), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 250), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .
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- HY-W110542O
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PEGDA (MW 575),MEHQ as inhibitor
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor (PEGDA (MW 575), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .
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- HY-149448
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- HY-D1005A24
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PEG-PPG-PEG, 5000 (Averag)
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Biochemical Assay Reagents
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Others
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Poloxamer 402 L122 (PEG-PPG-PEG, 5000 Averag) is a synthetic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO). Poloxamer 402 L122 forms thermoreversible gel, which remains fluid at room temperature but becomes more viscous gel at body temperature. Poloxamer 402 L122 is utilized in drug delivery, tissue regeneration and generation of micellar system .
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- HY-134354
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ADP-ribose-pNP
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Poly(ADP-ribose) Glycohydrolase (PARG)
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Others
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pNP-ADPr is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes .
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- HY-W749617
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- HY-172353
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- HY-134354A
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ADP-ribose-pNP disodium
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Poly(ADP-ribose) Glycohydrolase (PARG)
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Others
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pNP-ADPr disodium is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr disodium can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes .
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- HY-168938
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Biochemical Assay Reagents
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Others
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Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing Maleimide (HY-W007324). Due to the Maleimide functional group, Poly(ethylene glycol) methyl ether maleimide (Mn 2000) can be used to conjugate biomolecules containing thiol groups.
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- HY-W739372A
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- HY-W739372B
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- HY-W391506
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- HY-W739372
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Biochemical Assay Reagents
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Poly (sodium 4-styrenesulfonate) is a cation exchange polyelectrolyte used to prepare highly mechanically stable and highly reproducible coatings. During the reduction of graphene oxide, Poly (sodium 4-styrenesulfonate) is used to synthesize polymer-coated graphite nanosheets. Furthermore, the interactions between Poly (sodium 4-styrenesulfonate) and metal ions have been studied, and it has been combined with Nafion for mixed coatings in bismuth film electrodes, showcasing its broad application potential in functional materials and electrochemical research .
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- HY-126437K
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PLL solution 0.01%, sterile-filtered, hydrobromide, MW 70000-150000, for cell culture
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Biochemical Assay Reagents
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Others
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Poly-L-lysine solution (0.01%, sterile-filtered, MW 70000-150000) is a biochemical reagent.
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- HY-126437J
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PLL solution 0.01%, sterile-filtered, hydrobromide, MW 150000-300000, for cell culture
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Biochemical Assay Reagents
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Others
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Poly-L-lysine solution (0.01%, sterile-filtered, MW 150000-300000) is a biochemical reagent.
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- HY-134031
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DNA/RNA Synthesis
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Others
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Ara-ATP, a structural analog of ATP, inhibits poly(A) polymerase activity by competing with ATP .
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- HY-158228
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PLMA
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Biochemical Assay Reagents
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Others
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Poly-L-lysine Methacryloyl (PLMA) is methacrylated polylysine. When Poly-L-lysine Methacryloyl is cross-linked on polyetheretherketone (PEEK) through UV-induced cross-linking, it can improve the hydrophilicity of PEEK and retain its own degradation bioinertness . Poly-L-lysine Methacryloyl needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.
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- HY-W093254A
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- HY-135846
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- HY-W093254B
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- HY-W763597
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- HY-139480
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- HY-W017766
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PHMB
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Bacterial
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Infection
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|
Poly(hexamethylenebiguanide) hydrochloride is an antimicrobial agent, which can be used in medical, apparel, and household textile sectors .
|
-
- HY-148154
-
|
|
Drug Derivative
|
Others
|
|
Poly(oxy-1,2-ethanediyl)-propoxy-amide-C6 (n=450) is an active compound. Poly(oxy-1,2-ethanediyl)-propoxy-amide-C6 is a small molecule moiety for pegylation modification in Avacincaptad pegol (HY-147080) .
|
-
- HY-D1545
-
|
Acid Violet 9
|
Fluorescent Dye
|
Others
|
|
Violamine R (Acid Violet 9) is a potent fluorophore. Violamine R shows environment and temperature-dependent photoluminescence (PL) intermittency in poly(vinyl alcohol) (PVOH) and potassium acid phthalate (KAP). Violamine R can be used to measure the temperatures spanning the glass-transition temperature (Tg) of the polymer host by the fluorescence intermittency or blinking in poly(vinyl alcohol) (PVA) .
|
-
- HY-123786
-
|
|
Apoptosis
Caspase
|
Cancer
|
|
NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage .
|
-
- HY-108360
-
-
- HY-U00223
-
|
|
PARP
|
Cancer
|
|
WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.
|
-
- HY-126437A
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide. .
|
-
- HY-G0023
-
|
Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib
|
Drug Metabolite
|
Others
|
|
Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
|
-
- HY-D0502
-
|
|
Fluorescent Dye
|
Others
|
|
C.I.Pigment red 88 is a red pigment that can be used in plasticised Poly(viny1 chloride) (PVC) .
|
-
- HY-142657
-
|
|
PARP
|
Cancer
|
|
PARP1-IN-7 is an inhibitor of poly(ADP-ribose) polymerase-1 (PARP1) as an anticancer agent.
|
-
- HY-W110540D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 2000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-W110540H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 3400) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-W110540K
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 10000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-W110540L
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 20000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-121719
-
|
|
PARP
|
Cardiovascular Disease
Cancer
|
|
TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent .
|
-
- HY-118090A
-
|
|
Endogenous Metabolite
|
Others
|
|
D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain .
|
-
- HY-W110540I
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 4000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-W110540J
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 6000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-101020
-
|
2-Picolinamide
|
PARP
|
Metabolic Disease
|
|
Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells .
|
-
- HY-W110540C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 1000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-E70238
-
|
Nicotinamide 2-azidoadenine dinucleotide
|
Glutamate Dehydrogenase (GLDH)
|
Others
|
|
2-Azido-NAD is a NAD + analog that can be used for visualization of intracellular Poly(ADP ribos)ylation (PARylation) processes .
|
-
- HY-W110540A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 750) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-W110540
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dimethacrylate (MW 550) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-B2247A
-
|
poly(lactic-co-glycolic acid) (75:25)
|
Biochemical Assay Reagents
|
Others
|
|
PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides .
|
-
- HY-W763546A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) diglycidyl ether (MW 500) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-170542
-
|
|
PARP
|
Cancer
|
|
ZINC20906412 is a poly(ADP-ribose) polymerase-10 (PARP10) inhibitor. ZINC20906412 can be used for the research of cancer .
|
-
- HY-Z0283S
-
|
Benzenecarboxamide-15N; Phenylamide-15N
|
Endogenous Metabolite
PARP
|
Others
|
|
Benzamide- 15N is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP)[1][2].
|
-
- HY-W763546D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) diglycidyl ether (MW 1000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-W763546C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) diglycidyl ether (MW 6000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-W763546B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) diglycidyl ether (MW 2000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
-
- HY-W110548B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 950) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
-
- HY-D1107
-
|
|
PARP
|
Others
|
|
NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors (extracted from patent US20190331688A1) .
|
-
- HY-147245
-
|
STP1002
|
PARP
|
Cancer
|
|
Basroparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 5.8 nM for TNKS1, exhibiting antitumor activity .
|
-
- HY-140649
-
|
Poly(ethylene glycol)-bis-amine (MW 20000)
|
PROTAC Linkers
|
Cancer
|
|
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W763598B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) distearate (Mn 930) is a derivative of polyethylene glycol, which can be used as a cross-linking agent and click chemistry reaction .
|
-
- HY-W110548D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 4000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
-
- HY-115666
-
-
- HY-140646
-
|
Poly(ethylene glycol)-bis-amine (MW 2000)
|
PROTAC Linkers
|
Cancer
|
|
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W110548A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 300) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
-
- HY-W110548C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 1500) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
-
- HY-133530
-
-
- HY-172357
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) is a biodegradable polymer that can be used to construct nanoparticles for drug delivery .
|
-
- HY-W110548
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 500) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
-
- HY-140647
-
|
Poly(ethylene glycol)-bis-amine (MW 3400)
|
PROTAC Linkers
|
Cancer
|
|
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-168490A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol)methyl ether thiol (MW 2000) is a thiol-modified PEG that can be used to modify the surface of materials to enhance their hydrophilicity and functionality .
|
-
- HY-168490B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol)methyl ether thiol (MW 6000) is a thiol-modified PEG that can be used to modify the surface of materials to enhance their hydrophilicity and functionality .
|
-
- HY-139480B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dithiol (Mn 1500) is a thiol-modified PEG that can be used to synthesize dithiol-terminated amphiphilic diblock copolymers for drug delivery .
|
-
- HY-168490
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol)methyl ether thiol (MW 800) is a thiol-modified PEG that can be used to modify the surface of materials to enhance their hydrophilicity and functionality .
|
-
- HY-139480A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) dithiol (Mn 1000) is a thiol-modified PEG that can be used to synthesize dithiol-terminated amphiphilic diblock copolymers for drug delivery .
|
-
- HY-167927
-
|
CVL218
|
PARP
|
Cancer
|
|
Mefuparib (CVL218) is a poly ADP-ribose polymerase (PARP) inhibitor used in cancer research that exhibits potent brain penetration due to its high protein binding.
|
-
- HY-129563
-
|
|
HIV
HIV Protease
|
Infection
|
|
CGP 57813 is a peptidomimetic inhibitor of HIV protease that can be encapsulated by nanoparticles composed of poly(D,L-lactic acid) (PLA) and pH-sensitive methacrylic acid copolymers and delivered into the body .
|
-
- HY-136649
-
|
AfTP (tetralithium), 2′-Fluoro-2′-deoxy-ATP (tetralithium）
|
DNA/RNA Synthesis
|
Others
|
|
2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium is an ATP analog, it exerted a strong but mixed-type inhibition on poly(AU) synthesis.
|
-
- HY-Y0479
-
-
- HY-W250166
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) (12) tridecyl ether is a nonionic surfactant belonging to the family of ethoxylated fatty alcohols. It is commonly used as an emulsifier, solubilizer, and wetting agent in a variety of industrial and personal care products. Poly(ethylene glycol)(12) tridecyl ether has various properties that make it suitable for these applications, including its low toxicity, high solubility in water and organic solvents, and ability to stabilize emulsions. In addition, it can be used as a raw material for the production of other surfactants and specialty chemicals.
|
-
- HY-139039
-
|
|
PROTACs
CDK
|
Cancer
|
|
BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162) .
|
-
- HY-172377A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(L-lactide) (MW 10000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
|
-
- HY-133531
-
-
- HY-172377
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(L-lactide) (MW 5000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
|
-
- HY-W040233B
-
|
(S)-2-Hydroxypropanoic acid (sodium) (purity≥90%)
|
Drug Intermediate
|
Others
|
|
Sodium (S)-2-hydroxypropanoate (Sodium L-lactate) (purity≥90%) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid .
|
-
- HY-172377C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(L-lactide) (MW 40000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
|
-
- HY-W440548
-
|
Ethylene diacrylate
|
Biochemical Assay Reagents
|
Others
|
|
Ethylene glycol diacrylate (Ethylene diacrylate) is a cross-linking homobifunctional reagent. Ethylene glycol diacrylate can be polymerized to form poly(ethylene glycol) diacrylate for drug delivery .
|
-
- HY-122041
-
|
|
Apoptosis
Poly(ADP-ribose) Glycohydrolase (PARG)
|
Cancer
|
|
Ethacridine is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor and an activator of the transcriptional coactivator. Ethacridine induces thyroid cancer cells apoptosis and promotes differentiation in thyroid follicular cells .
|
-
- HY-W145493
-
|
Tetraglycol; Poly(ethylene glycol) tetrahydrofurfuryl ether
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) tetrahydrofurfuryl ether is liquid glycogen can be easily transformed into a gel system with excellent elasticity, so it can be used as a medium for dissolving water-insoluble agents.
|
-
- HY-172377B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(L-lactide) (MW 20000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
|
-
- HY-172382B
-
|
PGCL, 65:35
|
Biochemical Assay Reagents
|
Others
|
|
Poly(D,L-lactide-co-glycolide), 65:35 (PGCL, 65:35) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .
|
-
- HY-172382A
-
|
PGCL,75:25
|
Biochemical Assay Reagents
|
Others
|
|
Poly(D,L-lactide-co-glycolide), 75:25 (PGCL, 75:25) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .
|
-
- HY-112111A
-
|
|
Biochemical Assay Reagents
|
|
|
Poly-L-Glutamic acid (MW 100000) is a biopolymer composed of L-glutamic acid units. It has the activity of forming stable water-soluble complexes with metal ions and is widely used in the manufacture of biodegradable materials.
|
-
- HY-172382
-
|
PGCL, 50:50
|
Biochemical Assay Reagents
|
Others
|
|
Poly(D,L-lactide-co-glycolide), 50:50 (PGCL, 50:50) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .
|
-
- HY-126436D
-
|
L-Ornithine homopolymer (hydrochloride) (MW 15000-30000)
|
Biochemical Assay Reagents
|
Others
|
|
Poly-L-ornithine (hydrochloride) (MW 15000-30000) (L-Ornithine homopolymer (hydrochloride) (MW 15000-30000)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-113432
-
|
2PY
|
Endogenous Metabolite
PARP
|
Metabolic Disease
|
|
Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
|
-
- HY-168939A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 2000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
|
-
- HY-168939
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 1000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
|
-
- HY-125924
-
|
DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium
|
Liposome
|
Others
|
|
DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents .
|
-
- HY-168939C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 5000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
|
-
- HY-168939B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 3400) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
|
-
- HY-148775B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) has a molecular weight of 60kDA to 3.4kDA and contains a 75:25 ratio of lactic acid (LA) to glycolic acid (GA) molecules .
|
-
- HY-148775
-
|
|
Biochemical Assay Reagents
|
Others
|
|
PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) has a molecular weight of 60kDA to 3.4kDA and contains a 75:25 ratio of lactic acid (LA) to glycolic acid (GA) molecules .
|
-
- HY-128720
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Diethyl oxalpropionate is an intermediate for poly((R,S)-3,3-dimethylmalic acid) (PDMMLA) derivative synthesis. PDMMLA derivative can be used in synthesis of nanoparticles and study of warfarin encapsulation and controlled release .
|
-
- HY-148775A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
mPEG-PLGA (21500-26500) is a biodegradable polymer composed of methyl polyethylene glycol (mPEG) and poly(lactic-co-glycolic acid) (PLGA). mPEG-PLGA (21500-26500) can be used in drug delivery systems .
|
-
- HY-126436B
-
|
L-Ornithine homopolymer (hydrobromide) (MW>100000)
|
Biochemical Assay Reagents
|
Others
|
|
Poly-L-ornithine (hydrobromide) (MW>100000) (L-Ornithine homopolymer (hydrobromide) (MW>100000)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-126436A
-
|
L-Ornithine homopolymer (hydrobromide) (MW 30000-70000)
|
Biochemical Assay Reagents
|
Others
|
|
Poly-L-ornithine (hydrobromide) (MW 30000-70000) (L-Ornithine homopolymer (hydrobromide) (MW 30000-70000)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-158255A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
mPEG-PLGA (22500-26500) is a biodegradable polymer composed of methyl polyethylene glycol (mPEG) and poly(lactic-co-glycolic acid) (PLGA). mPEG-PLGA (22500-26500) can be used in drug delivery systems .
|
-
- HY-126436C
-
|
L-Ornithine homopolymer (hydrobromide) (MW 5000-15000)
|
Biochemical Assay Reagents
|
Others
|
|
Poly-L-ornithine (hydrobromide) (MW 5000-15000) (L-Ornithine homopolymer (hydrobromide) (MW 5000-15000)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-164757
-
-
- HY-W040233
-
-
- HY-W010854
-
|
dADP disodium
|
DNA/RNA Synthesis
|
Others
|
|
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .
|
-
- HY-101020R
-
|
2-Picolinamide (Standard)
|
PARP
|
Metabolic Disease
|
|
Picolinamide (Standard) is the analytical standard of Picolinamide. This product is intended for research and analytical applications. Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells .
|
-
- HY-W243303O
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Poly(acrylic acid) (Mv 1250000) (viscous liquid) is an anionic polymer with a molecular weight of 1,250,000. It can be used as a corrosion inhibitor and surface stabilizer, as well as a biomaterial or organic compound relevant to life sciences research .
|
-
- HY-B2174
-
|
Acrinol
|
Bacterial
|
Infection
|
|
Ethacridine lactate (Acrinol) is a widely used antiseptic and abortifacient. Ethacridine lactate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .
|
-
- HY-B0889
-
|
Acrinol monohydrate
|
Bacterial
|
Infection
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|
Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .
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-
- HY-157243
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|
|
Biochemical Assay Reagents
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Others
|
|
CEX Cation-exchange resin 2 is a CEX strong cation exchange resin, ADC purification resin. CEX Cation-exchange resin 2 contains cross-linked poly(styrene-divinylbenzene), which has good hydrophobicity .
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-
- HY-13962
-
|
|
DNA Methyltransferase
Apoptosis
|
Cancer
|
|
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.
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-
- HY-N7765
-
|
|
HCV
Bacterial
Apoptosis
Fungal
|
Infection
Inflammation/Immunology
Cancer
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|
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase .
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-
- HY-E70136
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|
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Others
|
Metabolic Disease
|
|
Endo-β-Galactosidase catalyzes the hydrolysis of internal β1-4 galactose linkages in unbranched, repeating poly-N-acetyllactosamine ([GlcNAc- (1-3)Gal- (1-4)]n) structures .
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-
- HY-W440895
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|
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Biochemical Assay Reagents
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Others
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|
DSPE-PEG-SH (MW 1000) is an amphiphilic poly-PEG that can form lipid bilayers in water. This amphiphilic polymer can form lipid bilayers in aqueous solution and can be used to embed active molecules for drug delivery systems such as mRNA vaccines.
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-
- HY-164478
-
|
|
PARP
|
Cancer
|
|
G-631 is a selective inhibitor for tankyrase. G-631 inhibits tankyrase auto-PARsylation (poly ADP ribosylation) with an IC50 of 7 nM, and inhibits Wnt signaling pathway. G-631 exhibits good pharmacokinetic characteristics in mice .
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-
- HY-E70141
-
|
EC:2.4.1.149; B3GNT4
|
Glycosyltransferase
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Others
|
|
β-1,3-N-Acetylglucosaminyltransferase 4 (EC:2.4.1.149, B3GNT4) is involved in the synthesis of poly-N-acetyllactosamine and has activity for type 2 oligosaccharides .
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- HY-137924
-
|
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Poly(ADP-ribose) Glycohydrolase (PARG)
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Cancer
|
|
JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death .
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-
- HY-113058
-
|
|
Biochemical Assay Reagents
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Others
|
|
3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.
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-
- HY-15048
-
|
|
PARP
|
Inflammation/Immunology
|
|
GPI 15427 is a potent inhibitor of the enzyme poly (ADP-ribose) polymerase-1 (PARP-1), which plays a harmful role during inflammation. In a rat model of gut injury and inflammation, including splanchnic artery occlusion (SAO) shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis, GPI 15427 demonstrated strong anti-inflammatory effects. It reduced inflammatory cell infiltration, histological injury, and delayed clinical signs of inflammation. GPI 15427 also diminished the accumulation of poly (ADP-ribose) in the ileum and colon of treated rats. These results suggest GPI 15427 could be useful for treating intestinal ischemia and inflammation .
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-
- HY-148776
-
|
|
Biochemical Assay Reagents
|
Others
|
|
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) has a molecular weight of 20kDA to 5.0kDA and contains a 50:50 ratio of lactic acid (LA) to glycolic acid (GA) molecules. The molecular ratio of LA to GA determines the rate of matrix degradation and protein re-release .
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-
- HY-Y0479S3
-
-
- HY-N2374
-
|
|
Apoptosis
|
Cancer
|
|
Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .
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-
- HY-141867
-
|
Z-Phe-Phe-FMK
|
Cathepsin
|
Neurological Disease
|
|
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .
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-
- HY-158970
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
Caf1-IN-1 (Compound 8j) is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM .
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-
- HY-W051513
-
|
|
PARP
|
Others
|
|
2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM .
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-
- HY-118090
-
|
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Others
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Others
|
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L-γ-Glutamyl-L-glutamic acid is the isomer of D-γ-Glutamyl-D-glutamic acid (HY-118090A), and can be used as an experimental control. D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain .
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-
- HY-128760
-
COH34
1 Publications Verification
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Poly(ADP-ribose) Glycohydrolase (PARG)
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Cancer
|
|
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors .
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- HY-113432R
-
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2PY (Standard)
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Endogenous Metabolite
PARP
|
Metabolic Disease
|
|
Nudifloramide (Standard) is the analytical standard of Nudifloramide. This product is intended for research and analytical applications. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
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- HY-107856
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-
- HY-160774
-
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Drug-Linker Conjugates for ADC
Topoisomerase
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Cancer
|
|
Val-Cit-PABC-DOX (compound 10109), an epsilon-poly-L-lysine-based drug conjugate, is an agent-linker conjugate for ADC by using a DNA topoisomerase I and topoisomerase II inhibitor, Doxorubicin (HY-15142), linked via the linker, Val-Cit-PABC .
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- HY-115768
-
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Poly-p-methoxyphenethylmethylamine
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Phospholipase
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Neurological Disease
Cancer
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Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways .
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- HY-14830
-
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Albitiazolium bromide
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Parasite
|
Infection
|
|
SAR 97276 (Albitiazolium bromide) is an antimalarial agent. SAR 97276 interfers with the phospholipid metabolism of malarial parasites, especially the biosynthesis of phosphatidylcholine (PC). SAR 97276 enters erythrocytes through the new permeability pathways (NPP) of infected erythrocytes, and is transported into the malarial parasite by a poly-specific cation carrier .
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- HY-134313A
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-
- HY-W391671
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|
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Endogenous Metabolite
Biochemical Assay Reagents
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Others
|
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Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] is a poly(triarylamine) that is an organic p-type semiconductor with hole mobilities ranging from 10 3 to 10 2 cm 2/V/s, which significantly improves carrier mobility. This stable, glassy polymer has an ionization potential suitable for thick film diodes. Committed to providing green alternatives that meet one or more of the 12 principles of green chemistry, this material falls into the enabling category of green alternatives, in line with the principle of "energy efficient design". In addition, while hole transport organic materials like these ensure optimal energy level alignment with the absorber layer for efficient charge collection, they can be susceptible to degradation under ambient conditions.
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![Poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine]](//file.medchemexpress.eu/product_pic/hy-w391671.gif)
- HY-134355
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Others
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Others
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ADPRP is an intranuclear enzyme whose main activity is to use NAD+ (nicotinamide adenine dinucleotide) as a substrate to add ADP-ribose units to chromatin-bound proteins, including the ADPRP enzyme itself. This process, called poly(ADP-ribosylation), is a post-translational modification that regulates the interaction between DNA and nuclear proteins .
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-
- HY-113432S
-
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Endogenous Metabolite
PARP
|
Metabolic Disease
|
|
Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].
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- HY-134313
-
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8-Aminoadenosine-5'-O-triphosphate
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DNA/RNA Synthesis
Endogenous Metabolite
|
Metabolic Disease
|
|
8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase .
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-
- HY-N8481
-
|
3,6-DHF
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Apoptosis
|
Cancer
|
|
3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation .
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-
- HY-B0889R
-
|
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Bacterial
|
Infection
|
|
Ethacridine (lactate monohydrate) (Standard) is the analytical standard of Ethacridine (lactate monohydrate). This product is intended for research and analytical applications. Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .
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-
- HY-15045A
-
|
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PARP
|
Cancer
|
|
INO-1001 mesylate is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 mesylate is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death . INO-1001 mesylate has anti-tumor effects .
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-
- HY-155348
-
|
|
PARP
|
Cancer
|
|
Ru3 is a poly(ADP-ribose) polymerase 1 inhibitor. Ru3 induces apoptosisin MCF-7 cells by multiple modes, inclusive of inducing DNA damage, suppressing DNA damage repair, disturbing cell cycle distribution, decreasing the mitochondrial membrane potential, and increasing the intracellular reactive oxygen species levels .
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-
- HY-125140
-
|
|
Endogenous Metabolite
|
Others
|
|
ω-3 Arachidonic acid is a poly fatty acid that is essential for growth and development in infants. ω-3 Arachidonic acid inhibits arachidenol-CoA synthetase with Ki values of 14 µM. It also inhibited arachidenol-CoA synthetase of calf brain extract with IC50 values of about 5 µM .
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-
- HY-15045
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|
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PARP
|
Cancer
|
|
INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death . INO-1001 has anti-tumor effects .
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-
- HY-124099
-
|
|
Leukotriene Receptor
|
Inflammation/Immunology
|
|
SCH 40120 is a potent leukotriene inhibitor with antiinflammatory effects. SCH 40120 suppresses T cell proliferative responses, antigen-specific and poly-clonally-induced in vitro antibody responses. SCH 40120 suppresses an edematous response and inhibits the recruitment of circulating neutrophils into sites of inflammation. SCH 40120 is proming for rasearch of anti-psoriatic agents .
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-
- HY-105692
-
|
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PARP
|
Neurological Disease
|
|
DR2313 is a potent, selective, competitive and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively. DR2313 exhibits neuroprotective effects on ischemic injuries in vitro and in vivo .
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-
- HY-112175R
-
|
|
Histamine Receptor
Endogenous Metabolite
|
Inflammation/Immunology
Endocrinology
|
|
Ethacridine (lactate monohydrate) (Standard) is the analytical standard of Ethacridine (lactate monohydrate). This product is intended for research and analytical applications. Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor .
|
-
- HY-W783623
-
|
DG(22:6/0:0/22:6); 1,3-Didocosahexaenoin
|
Biochemical Assay Reagents
|
Cardiovascular Disease
|
|
1,3-Didocosahexaenoyl glycerol (DG(22:6/0:0/22:6); 1,3-Didocosahexaenoin) is an ω-3 polyunsaturated fatty acid, which exhibits cardioprotective effects in rat myocardial ischemia/reperfusion (I/R) injury model through conjugation with Poly-l-glutamic acid (PGA) .
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-
- HY-N2374R
-
|
|
Apoptosis
|
Cancer
|
|
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .
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-
- HY-137817
-
|
|
DNA/RNA Synthesis
|
Metabolic Disease
|
|
BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging .
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-
- HY-108708
-
|
|
PARP
|
Cancer
|
|
GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2 (MD2), with a Kd value of 2.1 μM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage .
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-
- HY-Z0283
-
|
Benzenecarboxamide; Phenylamide
|
Endogenous Metabolite
PARP
|
Others
|
|
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .
|
-
- HY-W040233R
-
|
(S)-2-Hydroxypropanoic acid (sodium) (Standard)
|
Bacterial
|
Infection
Cancer
|
|
Sodium (S)-2-hydroxypropanoate (Standard) is the analytical standard of Sodium (S)-2-hydroxypropanoate. This product is intended for research and analytical applications. L-lactate Sodium (Sodium (S)-2-hydroxypropanoate) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .
|
-
- HY-10885
-
|
ABT-472
|
PARP
|
Cancer
|
|
A-620223 succinate (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 succinate (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research .
|
-
- HY-118988
-
|
|
PPAR
Apoptosis
|
Cancer
|
|
CAY10506 is a PPARγ ligand that can induce cell death and ROS production in a PPARγ-dependent manner in vitro. CAY10506 exhibits radiosensitizing effects, enhancing γ-radiations-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage. CAY10506 can be used in cancer research .
|
-
- HY-146248
-
|
|
Poly(ADP-ribose) Glycohydrolase (PARG)
|
Others
|
|
TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .
|
-
- HY-155807
-
|
|
STAT
JAK
Apoptosis
|
Cancer
|
|
DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand. DPP inhibit the JAK2-STAT3 pathway in breast cancer (BC) cells with antiproliferative activity, and activates caspase-3 and cleaved poly ADP-ribose polymerase to induces apoptosis. DPP promotes the maturation and antigen presentation of dendritic cells, and exhibits in vivo safety .
|
-
- HY-Y0850U1
-
|
Polyvinyl alcohol (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization); Poly(Ethenol) (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization)
|
Biochemical Assay Reagents
|
Others
|
|
PVA (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization) (Polyvinyl alcohol (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization); Poly(Ethenol) (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization)) is a biodegradable of polymer. PVA (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization) can be used to produce bio-composite films .
|
-
- HY-107856R
-
|
|
Drug Metabolite
DNA/RNA Synthesis
Apoptosis
|
Cancer
|
|
5-Fluorouridine (Standard) is the analytical standard of 5-Fluorouridine. This product is intended for research and analytical applications. 5-Fluorouridine, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis .
|
-
- HY-D0153
-
|
|
Fluorescent Dye
|
Cancer
|
|
Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles .
|
-
- HY-Y0850U2
-
|
Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization)
|
Biochemical Assay Reagents
|
Others
|
|
PVA (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization) (Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization)) is a biodegradable of polymer. PVA (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization) can be used to blend with various biopolymers and hydrophilic synthetic polymers to improve mechanical properties of films .
|
-
- HY-Y0850U
-
|
Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ～630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)
|
Biochemical Assay Reagents
|
Others
|
|
PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) (Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ～630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)) is a biocompatible, biodegradable, nontoxic and hydrophilic synthetic polymer. PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) can be used to produce bone tissue engineering scaffold [1]
|
-
- HY-B0097
-
|
5-Fluorouracil 2'-deoxyriboside
|
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Bacterial
CMV
HSV
Apoptosis
|
Infection
Cancer
|
|
Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .
|
-
- HY-N0155
-
|
|
ROR
Reactive Oxygen Species
Apoptosis
Autophagy
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .
|
-
- HY-135218
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .
|
-
- HY-146248A
-
|
|
Poly(ADP-ribose) Glycohydrolase (PARG)
|
Others
|
|
TFMU-ADPr triethylamine is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr triethylamine can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr triethylamine has excellent reactivity, generality, stability, and usability. TFMU-ADPr triethylamine is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .
|
-
- HY-148710
-
|
|
PARP
|
Inflammation/Immunology
|
|
ARTD10/PARP10-IN-2 (compound 19) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1 with IC50s of 2.0 μM, and 9.7 μM, respectively .
|
-
- HY-P10285
-
|
D-(KLAKLAK)2
|
Mitochondrial Metabolism
PARP
Caspase
|
Cancer
|
|
d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects .
|
-
- HY-152696
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
|
-
- HY-Z0283R
-
|
|
Endogenous Metabolite
PARP
|
Others
|
|
Benzamide (Standard) is the analytical standard of Benzamide. This product is intended for research and analytical applications. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .
|
-
- HY-W039271
-
|
2-Chloro-6-O-methyl-inosine
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
|
-
- HY-154017
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
|
-
- HY-135218A
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .
|
-
- HY-154393
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
|
-
- HY-144433
-
|
|
DNA Methyltransferase
|
Infection
|
|
DNMT3A-IN-1 (compound 1) is an effective and selective DNMT3A inhibitor. DNMT3A-IN-1 exhibits inhibitory activity against DNMT3A, with KI values ranging from 9.16 to 18.85 μM (AdoMet) and 11.37 to 23.34 μM (poly dI-dC). DNMT3A-IN-1 can induce apoptosis in acute myeloid leukemia (AML) cell lines (Apoptosis) .
|
-
- HY-B0097R
-
|
5-Fluorouracil 2'-deoxyriboside (Standard)
|
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Bacterial
CMV
HSV
Apoptosis
|
Infection
Cancer
|
|
Floxuridine (Standard) is the analytical standard of Floxuridine. This product is intended for research and analytical applications. Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .
|
-
- HY-145533
-
|
KDN
|
Endogenous Metabolite
|
Others
|
|
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish . 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is abundant in fetal cord red blood cells and malignant human ovarian cancer cells .
|
-
- HY-125629
-
|
|
Others
|
Others
|
|
Primordazine B is a small molecule compound identified by chemical screening in zebrafish embryos with the activity of selectively destroying Primordial Germ Cells (PGCs). Primordazine B inhibits a process called Poly(A)-tail Independent Non-canonical Translation (PAINT) without inhibition of polyadenylate tail dependent typical translation (PAT). Primordazine B can be used to study translational control of cells in specific physiological or pathological states, such as gene expression regulation during cell dormancy, viral infection, or stress conditions .
|
-
- HY-N0155R
-
|
|
ROR
Reactive Oxygen Species
Apoptosis
Autophagy
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Nobiletin (Standard) is the analytical standard of Nobiletin. This product is intended for research and analytical applications. Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .
|
-
- HY-W141392
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
|
-
- HY-156153
-
|
|
Histone Methyltransferase
|
Cancer
|
|
PROTAC CARM1 degrader-2 (compound 3e) is a degrader (DC50=8.8 nM) of co-activator associated argininemethyltransferase (CARM1). PROTAC CARM1 degrader-2 degrades CARM1 in a VHL- and proteasome-dependent manner. Thus, PROTAC CARM1 degrader-2 inhibits methylation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155 and inhibits breast cancer cell migration .
|
-
- HY-N6969A
-
|
|
Adrenergic Receptor
|
Cancer
|
|
Dicentrine hydrochloride is a drug with anti-inflammatory and anti-cancer activity. Dicentrine hydrochloride exerts its effects by enhancing TNF-α-induced apoptosis in A549 lung adenocarcinoma cells. Dicentrine hydrochloride increases caspase-8, -9, -3 and poly(ADP-ribose) polymerase (PARP) activities. Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells. Dicentrine hydrochloride significantly inhibited the TNF-α-activated TAK1, p38, JNK and Akt signaling pathways, and reduced the transcriptional activities of NF-κB and AP-1 .
|
-
- HY-115862
-
|
|
Adenosine Receptor
PARP
Aurora Kinase
|
Cardiovascular Disease
Cancer
|
|
Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM .
|
-
![Benzo[c][1,8]naphthyridin-6(5H)-one](//file.medchemexpress.eu/product_pic/hy-115862.gif)
- HY-W392836
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
|
-
- HY-156152
-
|
|
Histone Methyltransferase
|
Cancer
|
|
PROTAC CARM1 degrader-1 (compound 3b) is a degrader (DC50=8.1 nM) of co-activator associated argininemethyltransferase (CARM1). PROTAC CARM1 degrader-1 degrades CARM1 in a VHL- and proteasome-dependent manner. Thus, PROTAC CARM1 degrader-1 inhibits methylation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155 and inhibits breast cancer cell migration .
|
-
- HY-152678
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
|
-
- HY-148709
-
|
|
PARP
|
Inflammation/Immunology
|
|
ARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC50s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively .
|
-
- HY-P5327
-
|
|
Bcl-2 Family
|
Others
|
|
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)
|
-
- HY-100847
-
|
|
PARP
|
Cancer
|
|
AZ0108 is an inhibitor for poly ADP-ribose polymerase (PARP), which inhibits PARP1, PARP2, PARP3, PARP6, TNKS1, TNKS2, with IC50s of <0.03, <0.03, 2.8, 0.083, 3.2, >3 μM, respectively. AZ0108 prevents centrosome clustering with an EC50 of 0.053 μM, and exhibits cytotoxicity in cell OCI-LY-19 with GI50 of 0.017 μM. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models .
|
-
- HY-156152A
-
|
|
Histone Methyltransferase
PROTACs
|
Cancer
|
|
CARM1 degrader-1 hydrochloride is the hydrochloride salt form of CARM1 degrader-1 (HY-156152). CARM1 degrader-1 hydrochloride is a PROTAC degrader for co-activator associated argininemethyltransferase 1 (CARM1), which degrades CARM1 in a VHL- and proteasome-dependent manner with a DC50 of 8.1 nM. CARM1 degrader-1 hydrochloride inhibits methylation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, and thus inhibits breast cancer cell migration .
|
-
- HY-W250308A
-
|
Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
|
Bacterial
|
Infection
|
|
ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
|
-
- HY-P1925A
-
|
|
PI3K
Reactive Oxygen Species
Apoptosis
|
Cancer
|
|
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .
|
-
- HY-164059
-
|
|
Nucleoside Antimetabolite/Analog
Fluorescent Dye
|
Others
|
|
mCherry is a red fluorescent protein the derived from Discosoma sp.. mCherry has excitation/emission wavelengths of 587 nm/610 nm. LZCap AG(3'Acm) mCherry mRNA is synthesized and purified in a one-step transcription process using T7 RNA polymerase and LZCap AG(3'Acm) cap analog from a linear template. LZCap AG(3'Acm) generates a Cap1 structure mRNA post-transcription, providing more efficient and stable expression compared to Cap0 and other commercially available Cap1 structures. LZCap AG(3'Acm) mCherry mRNA contains poly A, optimized 5'UTR, and 3'UTR structures to improve mRNA stability and promote translation efficiency, resulting in enhanced expression. Upon entering cells, LZCap AG(3'Acm) mCherry mRNA expresses red fluorescence, suitable for experiments related to mRNA delivery, translation efficiency, transfection efficiency, and in vivo imaging.
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D1545
-
|
Acid Violet 9
|
Dyes
|
|
Violamine R (Acid Violet 9) is a potent fluorophore. Violamine R shows environment and temperature-dependent photoluminescence (PL) intermittency in poly(vinyl alcohol) (PVOH) and potassium acid phthalate (KAP). Violamine R can be used to measure the temperatures spanning the glass-transition temperature (Tg) of the polymer host by the fluorescence intermittency or blinking in poly(vinyl alcohol) (PVA) .
|
-
- HY-146248
-
|
|
Chromogenic Substrates
|
|
TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .
|
-
- HY-D0153
-
|
|
Fluorescent Dyes/Probes
|
|
Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles .
|
| Cat. No. |
Product Name |
Type |
-
- HY-W243303E
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (MW 450000) is a polyacrylic acid with a molecular weight of 450000. Poly(acrylic acid) (MW 450000) is an anionic polymer. Poly(acrylic acid) (MW 450000) can be as a corrosion-mitigating and surface-stabilizing agent .
|
-
- HY-B2247
-
PLGA (50:50)
Maximum Cited Publications
18 Publications Verification
poly(lactic-co-glycolic acid) (50:50)
|
Drug Delivery
|
|
PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
|
-
- HY-126437
-
|
|
Drug Delivery
|
|
Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material .
|
-
- HY-W243303B
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (Mv 3000000) is a polyacrylic acid (an anionic polymer) with a molecular weight of 3000000. Poly(acrylic acid) (Mv 3000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 3000000) is a biomaterial or organic compound that can be used as a life science research related biomaterial or organic compound .
|
-
- HY-149449
-
-
- HY-W243303C
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (Mv 4000000) is a polyacrylic acid (and an anionic polymer) with a molecular weight of 4000000. Poly(acrylic acid) (Mv 4000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 4000000) is a biomaterial or organic compound that can be used in life science research .
|
-
- HY-172378
-
|
|
Drug Delivery
|
|
Poly(styrene)-block-poly(acrylic acid) (PS:PAA 30000:2000) is a diblock copolymer used to prepare polymer micelles or vesicles and other encapsulation applications .
|
-
- HY-172381
-
|
|
3D Bioprinting
|
|
Poly(guluronate), low endotoxin is the portion of the Alginate molecule that is responsible for its gelling behaviour. Poly(guluronate), low endotoxin has ionic cross-linking effects .
|
-
- HY-167566
-
-
- HY-W110542D
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 1000) (PEGDA (MW 1000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 1000) can be used in the formation of a cross-linked polymers .
|
-
- HY-W110542L
-
|
PEGDA (MW 3500)
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 3500) (PEGDA (MW 3500)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 3500) can be used in the formation of a cross-linked polymers .
|
-
- HY-W110542H
-
|
PEGDA (MW 10000)
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 10000) (PEGDA (MW 10000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 10000) can be used in the formation of a cross-linked polymers .
|
-
- HY-172378A
-
|
|
Drug Delivery
|
|
Poly(styrene)-block-poly(acrylic acid) (PS:PAA 3,000:5,000,DDMAT terminated) is a diblock copolymer used to prepare polymer micelles or vesicles and other encapsulation applications .
|
-
- HY-W110542G
-
|
PEGDA (MW 6000)
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 6000) (PEGDA (MW 6000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 6000) can be used in the formation of a cross-linked polymers .
|
-
- HY-W110542M
-
|
PEGDA (MW 20000)
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 20000) (PEGDA (MW 20000)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 20000) can be used in the formation of a cross-linked polymers .
|
-
- HY-W110542J
-
|
PEGDA (MW 700)
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 700) (PEGDA (MW 700)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 700) can be used in the formation of a cross-linked polymers .
|
-
- HY-W110542K
-
|
PEGDA (MW 1500)
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 1500) (PEGDA (MW 1500)) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 700) can be used in the formation of a cross-linked polymers .
|
-
- HY-W243303A
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) is a polyacrylic acid with a molecular weight of 2000.
|
-
- HY-W763557B
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methacrylate (MW 500) is a monomethacrylate functionalized PEG, which is used to prepare composite materials, such as Poly(ethylene glycol) methacrylate-chitosan, and can be used as an ocular drug delivery carrier .
|
-
- HY-W763557A
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methacrylate (MW 360) is a monomethacrylate functionalized PEG, which is used to prepare composite materials, such as Poly(ethylene glycol) methacrylate-chitosan, and can be used as an ocular drug delivery carrier .
|
-
- HY-W596474I
-
|
|
Drug Delivery
|
|
Poly-L-glutamic acid sodium salt (MW 120000) is a kind of biochemical reagent.
|
-
- HY-W596474H
-
|
|
Drug Delivery
|
|
Poly-L-glutamic acid sodium salt (MW 60000) is a kind of biochemical reagent.
|
-
- HY-W243303M
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (Mv 100000) is a kind of biochemical reagent.
|
-
- HY-W243303K
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (MW 1000000) is a kind of biochemical reagent.
|
-
- HY-W243303N
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (Mv 500000) is a kind of biochemical reagent.
|
-
- HY-W596474A
-
|
|
Drug Delivery
|
|
Poly-L-glutamic acid sodium salt (MW 3000) is a kind of biochemical reagent.
|
-
- HY-W596474E
-
|
|
Drug Delivery
|
|
Poly-L-glutamic acid sodium salt (MW 45000) is a kind of biochemical reagent.
|
-
- HY-W596474D
-
|
|
Drug Delivery
|
|
Poly-L-glutamic acid sodium salt (MW 30000) is a kind of biochemical reagent.
|
-
- HY-W243303J
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (MW 250000) is a kind of biochemical reagent.
|
-
- HY-W596474C
-
|
|
Drug Delivery
|
|
Poly-L-glutamic acid sodium salt (MW 15000) is a kind of biochemical reagent.
|
-
- HY-W596474B
-
|
|
Drug Delivery
|
|
Poly-L-glutamic acid sodium salt (MW 7500) is a kind of biochemical reagent.
|
-
- HY-W243303L
-
|
|
Drug Delivery
|
|
Poly(acrylic acid) (Mv 8000000) is a kind of biochemical reagent.
|
-
- HY-163990D
-
-
- HY-163990B
-
-
- HY-163990C
-
-
- HY-163990
-
-
- HY-163990E
-
-
- HY-163990A
-
-
- HY-126437E
-
|
|
Cell Assay Reagents
|
|
Poly-L-lysine (hydrobromide) (MW 15000-30000) can promote cell adhesion to solid-phase substrates. Poly-L-lysine (hydrobromide) (MW 15000-30000) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-126437I
-
|
|
Cell Assay Reagents
|
|
Poly-L-lysine (hydrobromide) (MW 1000-5000) can promote cell adhesion to solid-phase substrates. Poly-L-lysine (hydrobromide) (MW 1000-5000) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-126437H
-
|
|
Cell Assay Reagents
|
|
Poly-L-lysine (hydrobromide) (MW 4000-15000) can promote cell adhesion to solid-phase substrates. Poly-L-lysine (hydrobromide) (MW 4000-15000) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-W110542P
-
|
PEGDA (MW 4000), MEHQ as inhibitor
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor (PEGDA (MW 4000), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .
|
-
- HY-W110542N
-
|
PEGDA (MW 250),MEHQ as inhibitor
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 250), MEHQ as inhibitor (PEGDA (MW 250), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 250), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .
|
-
- HY-W110542O
-
|
PEGDA (MW 575),MEHQ as inhibitor
|
3D Bioprinting
|
|
Poly(ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor (PEGDA (MW 575), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .
|
-
- HY-149448
-
-
- HY-D1005A24
-
|
PEG-PPG-PEG, 5000 (Averag)
|
Co-solvents
|
|
Poloxamer 402 L122 (PEG-PPG-PEG, 5000 Averag) is a synthetic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO). Poloxamer 402 L122 forms thermoreversible gel, which remains fluid at room temperature but becomes more viscous gel at body temperature. Poloxamer 402 L122 is utilized in drug delivery, tissue regeneration and generation of micellar system .
|
-
- HY-W749617
-
|
|
Surfactants
|
|
Poly(ethylene glycol) Monooleate (MW=860) is a plasticizer and surfactant .
|
-
- HY-172353
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) dibenzoate (MW 410)) is a derivative of polyethylene glycol (PEG).
|
-
- HY-168938
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing Maleimide (HY-W007324). Due to the Maleimide functional group, Poly(ethylene glycol) methyl ether maleimide (Mn 2000) can be used to conjugate biomolecules containing thiol groups.
|
-
- HY-W739372A
-
|
|
Filter Medium
|
|
Poly(sodium 4-styrenesulfonate) (MW 70000) is an ion exchange exchange polyelectrolyte .
|
- HY-W739372B
-
|
|
Filter Medium
|
|
Poly(sodium 4-styrenesulfonate) (MW 1000000) is an ion exchange exchange polyelectrolyte .
|
- HY-126437K
-
|
PLL solution 0.01%, sterile-filtered, hydrobromide, MW 70000-150000, for cell culture
|
Cell Assay Reagents
|
|
Poly-L-lysine solution (0.01%, sterile-filtered, MW 70000-150000) is a biochemical reagent.
|
- HY-126437J
-
|
PLL solution 0.01%, sterile-filtered, hydrobromide, MW 150000-300000, for cell culture
|
Cell Assay Reagents
|
|
Poly-L-lysine solution (0.01%, sterile-filtered, MW 150000-300000) is a biochemical reagent.
|
- HY-158228
-
|
PLMA
|
3D Bioprinting
|
Poly-L-lysine Methacryloyl (PLMA) is methacrylated polylysine. When Poly-L-lysine Methacryloyl is cross-linked on polyetheretherketone (PEEK) through UV-induced cross-linking, it can improve the hydrophilicity of PEEK and retain its own degradation bioinertness . Poly-L-lysine Methacryloyl needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.
|
- HY-W093254A
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) bis(carboxymethyl) ether (Mn 250) is an amine-reactive crosslinking agent .
|
- HY-W093254B
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) bis(carboxymethyl) ether (Mn 600) is an amine-reactive crosslinking agent .
|
- HY-W763597
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) phenyl ether acrylate (MW 320) is a difunctional cross-linking agent .
|
- HY-126437A
-
|
|
Drug Delivery
|
|
Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide. .
|
- HY-W110540D
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 2000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110540H
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 3400) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110540K
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 10000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110540L
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 20000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110540I
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 4000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110540J
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 6000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110540C
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 1000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110540A
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 750) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110540
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dimethacrylate (MW 550) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W763546A
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) diglycidyl ether (MW 500) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W763546D
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) diglycidyl ether (MW 1000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W763546C
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) diglycidyl ether (MW 6000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W763546B
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) diglycidyl ether (MW 2000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used as a cross-linking agent .
|
- HY-W110548B
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 950) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
- HY-140649
-
|
Poly(ethylene glycol)-bis-amine (MW 20000)
|
Drug Delivery
|
|
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
- HY-W763598B
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) distearate (Mn 930) is a derivative of polyethylene glycol, which can be used as a cross-linking agent and click chemistry reaction .
|
- HY-W110548D
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 4000) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
- HY-140646
-
|
Poly(ethylene glycol)-bis-amine (MW 2000)
|
Drug Delivery
|
|
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
- HY-W110548A
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 300) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
- HY-W110548C
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 1500) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
- HY-172357
-
|
|
Drug Delivery
|
|
Poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) is a biodegradable polymer that can be used to construct nanoparticles for drug delivery .
|
- HY-W110548
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methyl ether methacrylate (MW 500) is a nonlinear analogue of polyethylene glycol (PEG) and can be used for PEG surface modification .
|
- HY-140647
-
|
Poly(ethylene glycol)-bis-amine (MW 3400)
|
Drug Delivery
|
|
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
- HY-168490A
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol)methyl ether thiol (MW 2000) is a thiol-modified PEG that can be used to modify the surface of materials to enhance their hydrophilicity and functionality .
|
- HY-168490B
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol)methyl ether thiol (MW 6000) is a thiol-modified PEG that can be used to modify the surface of materials to enhance their hydrophilicity and functionality .
|
- HY-139480B
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dithiol (Mn 1500) is a thiol-modified PEG that can be used to synthesize dithiol-terminated amphiphilic diblock copolymers for drug delivery .
|
- HY-168490
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol)methyl ether thiol (MW 800) is a thiol-modified PEG that can be used to modify the surface of materials to enhance their hydrophilicity and functionality .
|
- HY-139480A
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) dithiol (Mn 1000) is a thiol-modified PEG that can be used to synthesize dithiol-terminated amphiphilic diblock copolymers for drug delivery .
|
- HY-W250166
-
|
|
Biochemical Assay Reagents
|
|
Poly(ethylene glycol) (12) tridecyl ether is a nonionic surfactant belonging to the family of ethoxylated fatty alcohols. It is commonly used as an emulsifier, solubilizer, and wetting agent in a variety of industrial and personal care products. Poly(ethylene glycol)(12) tridecyl ether has various properties that make it suitable for these applications, including its low toxicity, high solubility in water and organic solvents, and ability to stabilize emulsions. In addition, it can be used as a raw material for the production of other surfactants and specialty chemicals.
|
- HY-172377A
-
|
|
Drug Delivery
|
|
Poly(L-lactide) (MW 10000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
|
- HY-172377
-
|
|
Drug Delivery
|
|
Poly(L-lactide) (MW 5000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
|
- HY-172377C
-
|
|
Drug Delivery
|
|
Poly(L-lactide) (MW 40000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
|
- HY-W145493
-
|
Tetraglycol; Poly(ethylene glycol) tetrahydrofurfuryl ether
|
Carbohydrates
|
|
Poly(ethylene glycol) tetrahydrofurfuryl ether is liquid glycogen can be easily transformed into a gel system with excellent elasticity, so it can be used as a medium for dissolving water-insoluble agents.
|
- HY-172377B
-
|
|
Drug Delivery
|
|
Poly(L-lactide) (MW 20000) is a polymer that can be used for orthopedic devices, dental applications, scaffolds for autologous transplanted new skin, wound coverings, vascular systems and stents .
|
- HY-172382B
-
|
PGCL, 65:35
|
Drug Delivery
|
|
Poly(D,L-lactide-co-glycolide), 65:35 (PGCL, 65:35) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .
|
- HY-172382A
-
|
PGCL,75:25
|
Drug Delivery
|
|
Poly(D,L-lactide-co-glycolide), 75:25 (PGCL, 75:25) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .
|
- HY-112111A
-
|
|
Biochemical Assay Reagents
|
|
Poly-L-Glutamic acid (MW 100000) is a biopolymer composed of L-glutamic acid units. It has the activity of forming stable water-soluble complexes with metal ions and is widely used in the manufacture of biodegradable materials.
|
- HY-172382
-
|
PGCL, 50:50
|
Drug Delivery
|
|
Poly(D,L-lactide-co-glycolide), 50:50 (PGCL, 50:50) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .
|
- HY-126436D
-
|
L-Ornithine homopolymer (hydrochloride) (MW 15000-30000)
|
Drug Delivery
|
|
Poly-L-ornithine (hydrochloride) (MW 15000-30000) (L-Ornithine homopolymer (hydrochloride) (MW 15000-30000)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
- HY-168939A
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 2000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
|
- HY-168939
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 1000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
|
- HY-125924
-
|
DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium
|
Drug Delivery
|
|
DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents .
|
- HY-168939C
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 5000) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
|
- HY-168939B
-
|
|
3D Bioprinting
|
|
Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 3400) is a derivative of polyethylene glycol, which can be used for bioconjugation, drug delivery, PEG hydrogel, crosslinker and surface functionalization .
|
- HY-126436B
-
|
L-Ornithine homopolymer (hydrobromide) (MW>100000)
|
Drug Delivery
|
|
Poly-L-ornithine (hydrobromide) (MW>100000) (L-Ornithine homopolymer (hydrobromide) (MW>100000)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
- HY-126436A
-
|
L-Ornithine homopolymer (hydrobromide) (MW 30000-70000)
|
Drug Delivery
|
|
Poly-L-ornithine (hydrobromide) (MW 30000-70000) (L-Ornithine homopolymer (hydrobromide) (MW 30000-70000)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
- HY-126436C
-
|
L-Ornithine homopolymer (hydrobromide) (MW 5000-15000)
|
Drug Delivery
|
|
Poly-L-ornithine (hydrobromide) (MW 5000-15000) (L-Ornithine homopolymer (hydrobromide) (MW 5000-15000)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
- HY-W010854
-
|
dADP disodium
|
Gene Sequencing and Synthesis
|
|
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .
|
- HY-W440895
-
|
|
Drug Delivery
|
|
DSPE-PEG-SH (MW 1000) is an amphiphilic poly-PEG that can form lipid bilayers in water. This amphiphilic polymer can form lipid bilayers in aqueous solution and can be used to embed active molecules for drug delivery systems such as mRNA vaccines.
|
- HY-E70141
-
|
EC:2.4.1.149; B3GNT4
|
Enzyme Substrates
|
|
β-1,3-N-Acetylglucosaminyltransferase 4 (EC:2.4.1.149, B3GNT4) is involved in the synthesis of poly-N-acetyllactosamine and has activity for type 2 oligosaccharides .
|
- HY-113058
-
|
|
Biochemical Assay Reagents
|
|
3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.
|
- HY-Y0850U1
-
|
Polyvinyl alcohol (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization); Poly(Ethenol) (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization)
|
Drug Delivery
|
|
PVA (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization) (Polyvinyl alcohol (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization); Poly(Ethenol) (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization)) is a biodegradable of polymer. PVA (Mw 61000, 98-99% hydrolyzed, ～1400 polymerization) can be used to produce bio-composite films .
|
- HY-Y0850U2
-
|
Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization)
|
Drug Delivery
|
|
PVA (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization) (Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization)) is a biodegradable of polymer. PVA (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization) can be used to blend with various biopolymers and hydrophilic synthetic polymers to improve mechanical properties of films .
|
- HY-Y0850U
-
|
Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ～630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)
|
Drug Delivery
|
|
PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) (Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ～630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)) is a biocompatible, biodegradable, nontoxic and hydrophilic synthetic polymer. PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) can be used to produce bone tissue engineering scaffold [1]
|
- HY-W250308A
-
|
Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
|
Cell Assay Reagents
|
|
ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-126437D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly-L-lysine hydrobromide (MW 150000-300000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine hydrobromide (MW 150000-300000) has good biocompatibility. Poly-L-lysine hydrobromide (MW 150000-300000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface .
|
-
- HY-126437B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly-L-lysine (hydrobromide) (MW 70000-150000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine (hydrobromide) (MW 70000-150000) has good biocompatibility. Poly-L-lysine (hydrobromide) (MW 70000-150000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface .
|
-
- HY-W250166
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) (12) tridecyl ether is a nonionic surfactant belonging to the family of ethoxylated fatty alcohols. It is commonly used as an emulsifier, solubilizer, and wetting agent in a variety of industrial and personal care products. Poly(ethylene glycol)(12) tridecyl ether has various properties that make it suitable for these applications, including its low toxicity, high solubility in water and organic solvents, and ability to stabilize emulsions. In addition, it can be used as a raw material for the production of other surfactants and specialty chemicals.
|
-
- HY-141867
-
|
Z-Phe-Phe-FMK
|
Cathepsin
|
Neurological Disease
|
|
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .
|
-
- HY-P10285
-
|
D-(KLAKLAK)2
|
Mitochondrial Metabolism
PARP
Caspase
|
Cancer
|
|
d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects .
|
-
- HY-P1925A
-
|
|
PI3K
Reactive Oxygen Species
Apoptosis
|
Cancer
|
|
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .
|
-
- HY-118090A
-
|
|
Endogenous Metabolite
|
Others
|
|
D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain .
|
-
- HY-P4525
-
|
|
Peptides
|
Others
|
|
Ala-Ala-Ala-Ala is a poly-L-alanine (PLA) sequences. PLA is a kind of key element of the crystalline domains of spider dragline and wild silkworm silks .
|
-
- HY-P5327
-
|
|
Bcl-2 Family
|
Others
|
|
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)
|
-
- HY-K0512
-
|
|
|
MCE microRNA RT Master Mix for qPCR Ⅲ (poly A) uses poly(A)-tailing method to perform reverse transcription from miRNA first-strand to cDNA.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-Z0283S
-
|
|
|
Benzamide- 15N is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP)[1][2].
|
-
-
- HY-113432S
-
|
|
|
Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].
|
-
-
- HY-Y0479S3
-
|
|
|
L-Lactic acid-2- 13C1 is the 13C-labeled L-Lactic acid (HY-Y0479). L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W243303E
-
|
|
|
Polymers
|
|
Poly(acrylic acid) (MW 450000) is a polyacrylic acid with a molecular weight of 450000. Poly(acrylic acid) (MW 450000) is an anionic polymer. Poly(acrylic acid) (MW 450000) can be as a corrosion-mitigating and surface-stabilizing agent .
|
-
- HY-B2247
-
PLGA (50:50)
Maximum Cited Publications
18 Publications Verification
poly(lactic-co-glycolic acid) (50:50)
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Polymers
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PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
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- HY-126437
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Polymers
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Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material .
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- HY-W243303A
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Polymers
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Poly(acrylic acid) is a polyacrylic acid with a molecular weight of 2000.
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- HY-126437A
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Polymers
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Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide. .
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- HY-B2247A
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poly(lactic-co-glycolic acid) (75:25)
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Polymers
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PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides .
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- HY-125924
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DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium
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Pegylated Lipids
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DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents .
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- HY-148775
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Polymers
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PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (60kDA-3.4kDA, LA:GA ratio 75:25) has a molecular weight of 60kDA to 3.4kDA and contains a 75:25 ratio of lactic acid (LA) to glycolic acid (GA) molecules .
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- HY-136649
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AfTP (tetralithium), 2′-Fluoro-2′-deoxy-ATP (tetralithium）
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Nucleotides and their Analogs
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2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium is an ATP analog, it exerted a strong but mixed-type inhibition on poly(AU) synthesis.
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- HY-148776
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Polymers
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PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) is a kind of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) has a molecular weight of 20kDA to 5.0kDA and contains a 50:50 ratio of lactic acid (LA) to glycolic acid (GA) molecules. The molecular ratio of LA to GA determines the rate of matrix degradation and protein re-release .
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- HY-152696
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Nucleosides and their Analogs
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6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
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- HY-154017
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Nucleosides and their Analogs
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2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
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- HY-154393
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Nucleosides and their Analogs
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2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
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- HY-W141392
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Nucleoside Phosphoramidites
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2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
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- HY-W392836
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Nucleoside Phosphoramidites
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2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
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- HY-152678
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Nucleosides and their Analogs
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6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .
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- HY-164059
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mRNA
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mCherry is a red fluorescent protein the derived from Discosoma sp.. mCherry has excitation/emission wavelengths of 587 nm/610 nm. LZCap AG(3'Acm) mCherry mRNA is synthesized and purified in a one-step transcription process using T7 RNA polymerase and LZCap AG(3'Acm) cap analog from a linear template. LZCap AG(3'Acm) generates a Cap1 structure mRNA post-transcription, providing more efficient and stable expression compared to Cap0 and other commercially available Cap1 structures. LZCap AG(3'Acm) mCherry mRNA contains poly A, optimized 5'UTR, and 3'UTR structures to improve mRNA stability and promote translation efficiency, resulting in enhanced expression. Upon entering cells, LZCap AG(3'Acm) mCherry mRNA expresses red fluorescence, suitable for experiments related to mRNA delivery, translation efficiency, transfection efficiency, and in vivo imaging.
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