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Results for "

SPP

" in MedChemExpress (MCE) Product Catalog:

130

Inhibitors & Agonists

8

Peptides

2

Inhibitory Antibodies

32

Natural
Products

7

Recombinant Proteins

9

Isotope-Labeled Compounds

2

Antibodies

7

Click Chemistry

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128926

    N-succinimidyl 4-(2-pyridyldithio) pentanoate

    ADC Linker Cancer
    SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate .
    SPP
  • HY-163548

    Sialyltransferase Cancer
    SPP-002 is a sulfate analogue that acts as a potential Sialyltransferase (ST) inhibitor. SPP-002 selectively inhibits n-glycosialylation with inhibition at least an order of magnitude greater than that of unmodified parental cholic acid (LCA). SPP-002 reduces tumor cell migration and invasion by inhibiting the integrin /FAK/Paxillin signaling pathway. SPP-002 can be used in the study of tumor metastasis .
    SPP-002
  • HY-110193
    SPP-86
    2 Publications Verification

    RET Cancer
    SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells . SPP-86 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    SPP-86
  • HY-126491

    Drug-Linker Conjugates for ADC Cancer
    SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP .
    SPP-DM1
  • HY-15195

    Ro 67-0565; SPP-301

    Endothelin Receptor Cardiovascular Disease Endocrinology
    Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.
    Avosentan
  • HY-RS16219

    Small Interfering RNA (siRNA) Others

    SPP1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for SPP1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SPP1 Mouse Pre-designed siRNA Set A
    SPP1 Mouse Pre-designed siRNA Set A
  • HY-RS13702

    Small Interfering RNA (siRNA) Others

    SPP1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SPP1 Human Pre-designed siRNA Set A
    SPP1 Human Pre-designed siRNA Set A
  • HY-12177
    Aliskiren hemifumarate
    5+ Cited Publications

    CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate

    Renin Autophagy Cardiovascular Disease Cancer
    Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .
    Aliskiren hemifumarate
  • HY-RS13703

    Small Interfering RNA (siRNA) Others

    SPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for SPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SPP2 Human Pre-designed siRNA Set A
    SPP2 Human Pre-designed siRNA Set A
  • HY-12176A

    CGP 60536 hydrochloride; CGP60536B hydrochloride; SPP 100 hydrochloride

    Renin Autophagy Cardiovascular Disease Cancer
    Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hydrochloride can be used for the research of hypertension, cardiovascular diseases and cancer cachexia - .
    Aliskiren hydrochloride
  • HY-12176B

    CGP 60536 fumarate; CGP60536B fumarate; SPP 100 fumarate

    Renin Autophagy Cardiovascular Disease Cancer
    Aliskiren fumarate is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren fumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .
    Aliskiren fumarate
  • HY-12176
    Aliskiren
    5+ Cited Publications

    CGP 60536; CGP60536B; SPP 100

    Renin Autophagy Cardiovascular Disease Cancer
    Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .
    Aliskiren
  • HY-12177S

    CGP 60536 d6 hemifumarate; CGP60536B d6 hemifumarate; SPP 100 d6 hemifumarate

    Isotope-Labeled Compounds Renin Autophagy Cardiovascular Disease Cancer
    Aliskiren-d6 (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM[1][2].
    Aliskiren-d6 hemifumarate
  • HY-12176AS

    CGP 60536-d6 Hydrochloride; CGP60536Bd6 Hydrochloride; SPP 100d6(Hydrochloride)

    Isotope-Labeled Compounds Renin Cardiovascular Disease Cancer
    Aliskiren-d6 (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.
    Aliskiren-d6 hydrochloride
  • HY-129367

    ADC Linker Cancer
    NO2-SPP is a cleavable linker that is used for making antibody-drug conjugate (ADC).
    NO2-SPP
  • HY-129377

    ADC Linker Cancer
    Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-SPP
  • HY-129377A

    ADC Linker Cancer
    Sulfo-SPP sodium a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-SPP sodium
  • HY-130111

    ADC Linker Cancer
    DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    DMAC-SPP
  • HY-130110

    ADC Linker Cancer
    Sulfo-DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Sulfo-DMAC-SPP
  • HY-133547

    ADC Linker Cancer
    NO2-SPP-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    NO2-SPP-sulfo
  • HY-129378

    ADC Linker Cancer
    NO2-SPP-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC) .
    NO2-SPP-sulfo-Me
  • HY-P990116

    Integrin Others
    Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived IgG2c, κ type antibody inhibitor, targeting to mouse osteopontin/SPP1.
    Anti-Mouse osteopontin/SPP1 Antibody (103D6)
  • HY-116479

    Bacterial Others
    Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .
    Citromycetin
  • HY-164207

    Biochemical Assay Reagents Infection
    VLPA-GlcNAc is a chromogenic glucosaminide substrate. VLPA-GlcNAc can be used to prepare agar media for the identification of Candida spp .
    VLPA-GlcNAc
  • HY-16246

    Fungal Infection
    Haloprogin is a potent antifungal agent. Haloprogin has activity against dermatophytes, Candida spp and a limited number of Gram-positive bacteria .
    Haloprogin
  • HY-105282

    MM 45289; A 82846A

    Antibiotic Bacterial Infection
    Eremomycin (MM 45289) is a potent glycopeptide antibiotic closely related to Vancomycin (HY-B0671). Eremomycin shows antibacterial activity in Staphylococcus spp. and Bacillus subtilis ATCC6633, with the MIC values of 0.03-1.6 μg/mL .
    Eremomycin
  • HY-Y1636

    Amino Acid Derivatives Biochemical Assay Reagents Metabolic Disease
    Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
    Fmoc-Arg(Pbf)-OH
  • HY-N12178

    A 83094A; Omomycin

    Antibiotic Bacterial Parasite Infection
    16-Deethylindanomycin (A 83094A) is an antibiotic, which can be produced by Streptomyces setonii. 16-Deethylindanomycin exhibits antimicrobial activities against gram-positive bacteria Staphylococcus spp. and Streptococcus with MIC of 2-4 µg/mL. 16-Deethylindanomycin exhibits anticoccidial activity against Eimeria tenella .
    16-Deethylindanomycin
  • HY-151671

    ADC Linker Others
    Fmoc-L-MeLys(N3)-OH is a click chemistry reagent containing an azide. Fmoc-L-MeLys(N3)-OH is a SPPS building-block for the introduction of N-Me-Lys that can be modified at the N3-group using Click-chemistry . Fmoc-L-MeLys(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fmoc-L-MeLys(N3)-OH
  • HY-120729

    Curamil

    Fungal Infection
    Pyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp. .
    Pyrazophos
  • HY-125388

    Antibiotic Bacterial Infection
    Martinomycin is an antibiotic, which inhibits Staphylococcus spp., Streptococcus spp. and Enterococcus spp., with MICs ranging from 0.06 to 0.5 μg/mL .
    Martinomycin
  • HY-W020785

    Cholinesterase (ChE) Others
    Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase .
    Fosthiazate
  • HY-151786

    ADC Linker Others
    Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Fmoc-L-Lys(Pentynoyl-DIM)-OH
  • HY-108009

    Biafungin; CD101; SP-3025

    Fungal Infection
    Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
    Rezafungin
  • HY-108009A
    Rezafungin acetate
    1 Publications Verification

    Biafungin acetate; CD101 acetate; SP-3025 acetate

    Fungal Infection
    Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
    Rezafungin acetate
  • HY-120729R

    Fungal Infection
    Pyrazophos (Standard) is the analytical standard of Pyrazophos. This product is intended for research and analytical applications. Pyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp. .
    Pyrazophos (Standard)
  • HY-W286805

    Phenalenone

    Fungal Infection
    Perinaphthenone has antifungal activity, with IC50s of 36.2 μM (at day 3), 13.3 μM (at day 3), and 39.0 μM (at 60 h) for Botrytis spp., Fusarium spp. and Botryodiplodia spp., respectively .
    Perinaphthenone
  • HY-W020785R

    Cholinesterase (ChE) Others
    Fosthiazate (Standard) is the analytical standard of Fosthiazate. This product is intended for research and analytical applications. Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase .
    Fosthiazate (Standard)
  • HY-111360
    SPL-707
    1 Publications Verification

    γ-secretase Inflammation/Immunology
    SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells .
    SPL-707
  • HY-P2148

    Bacterial Antibiotic Infection Inflammation/Immunology
    P-113 is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5. P-113 is active against clinically important microorganisms such as Pseudomonas spp., Staphylococcus spp., and C. albicans .
    P-113
  • HY-151679

    ADC Linker Others
    Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition . Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fmoc-L-Lys(4-N3-Z)-OH
  • HY-N11995

    Others Others
    allo-Aloeresin D is a chromone glycoside isolated from Aloe spp. .
    allo-Aloeresin D
  • HY-N15183

    Fungal Infection
    Aselacin C is a cyclic peptide that can be isolated from the fungus Acremonium spp. .
    Aselacin C
  • HY-N9142

    Ergosterol 3-O-β-D-glucopyranoside

    Others Others
    Ergosterol glucoside is a phenolic compound that can be isolated from Tuber spp. truffles .
    Ergosterol glucoside
  • HY-W250315

    pectate sodium

    Glycosidase Bacterial Endogenous Metabolite Others
    Polypectate sodium is a major component of cell wall polysaccharides (pectins) and is used as a carbon source and inducer of polygalacturonase. Polypectate sodium can also be used to evaluate alkaline active and alkaline stable pectate lyases from Streptomyces spp. and to study the optimization of polygalacturonase production from Xanthophyllum spp. and reaction conditions .
    Polypectate sodium
  • HY-N2728

    Others Others
    6-O-Syringoylajugol (compound 65) is a natural product that can be found in Verbacum spp .
    6-O-Syringoylajugol
  • HY-N1136

    Bacterial Infection
    (+)-Totarol is a diterpenoid compound isolated from Podocarpus spp.. (+)-Totarol is a potent antioxidant and antibacterial agent .
    (+)-Totarol
  • HY-N2340

    (+)-Melezitose; D-Melezitose

    Bacterial Infection
    D-(+)-Melezitose can be used to identify clinical isolates of indole-positive and indole-negative Klebsiella spp.
    D-(+)-Melezitose
  • HY-N2340A

    (+)-Melezitose hydrate; D-Melezitose hydrate

    Bacterial Infection
    D-(+)-Melezitose hydrate ((+)-Melezitose hydrate) can be used to identify clinical isolates of indole-positive and indole-negative Klebsiella spp .
    D-(+)-Melezitose hydrate
  • HY-129034

    Bacterial Antibiotic Infection
    Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria .
    Ramoplanin

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