Search Result

Results for "

antimalarial agents

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) Antibiotic (16) Antifolate (3) Apoptosis (12) Autophagy (23) Bacterial (9) CaMK (2) CD47 (1) Cytochrome P450 (4) Dihydrofolate reductase (DHFR) (3) Dihydroorotate Dehydrogenase (2) DNA Stain (1) Drug Isomer (1) Drug Metabolite (6) Ephrin Receptor (1) Ferroptosis (5) Fungal (1) GLUT (1) HCV (4) Histone Methyltransferase (6) HIV (8) Isotope-Labeled Compounds (12) MDM-2/p53 (2) Mitochondrial Metabolism (1) Mitophagy (4) Na+/K+ ATPase (1) Nuclear Hormone Receptor 4A/NR4A (5) Nucleoside Antimetabolite/Analog (1) Parasite (162) PI4K (2) Potassium Channel (4) Reactive Oxygen Species (1) ROS Kinase (3) SARS-CoV (20) Sodium Channel (1) Toll-like Receptor (TLR) (17) Wnt (1)
By Research Areas:	Cancer (41) Cardiovascular Disease (4) Infection (161) Inflammation/Immunology (28) Metabolic Disease (4) Neurological Disease (11)
Oligonucleotides:	Nucleosides and their Analogs (1)

172

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W112166

(E/Z)-4,4'-Dicyanostilbene	Parasite Drug Isomer	Infection
(E/Z)-4,4'-Dicyanostilbene is the isomer of 4,4'-Dicyanostilbene (HY-W112166A), and can be used as an experimental control. 4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC₅₀ of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA) .

HY-W009109

Antimalarial agent 1	Parasite	Infection
Antimalarial agent 1 is a potent antimalarial agent .

HY-114197

Antimalarial agent 14	Mitochondrial Metabolism Parasite	Infection
Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent .

HY-W131282

Antimalarial agent 39	Parasite	Infection
Antimalarial agent 39 (compound 1) is an intermediate in the synthesis of antimalarial agents .

HY-159900

Antimalarial agent 46	Parasite	Infection
Antimalarial agent 46 (Compound 42a) is an antimalarial agent with antimalarial activity. Antimalarial agent 46 shows inhibitory activity against P. falciparum lines .

HY-116552

KAR425	Parasite	Infection
KAR425 is a potent and orally active antimalarial agent. KAR425 shows antimalarial activity against the Chloroquine-sensitive (CQS) D6, the Chloroquine-resistant (CQR) Dd2, and 7G8 strains of Plasmodium falciparum, with IC₅₀ values of 62 nM, 55 nM, and 60 nM, respectively .

HY-W112166A

4,4'-Dicyanostilbene	Bacterial	Infection
4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC₅₀ of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA) .

HY-149938

Antimalarial agent 25	Parasite	Infection
Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo .

HY-148429

Antimalarial agent 17	Parasite	Others
Antimalarial agent 17 is an antimalarial agent, also acts as a herbicide. Antimalarial agent 17 is photosystem II inhibitor, shows post-emergence herbicidal activity equal to commercial herbicides .

HY-168208

Antimalarial agent 45	Parasite	Infection
Antimalarial agent 45 (compound 8I) is a antimalarial agent and shows antiplasmodial activity the IC₅₀ of 0.21 μM. Antimalarial agent 45 can be used for study of malaria .

HY-149937

Antimalarial agent 24	Parasite	Infection
Antimalarial agent 24 (Compound 7) is an antimalarial agent in vitro. Antimalarial agent 24 inhibits P. falciparum W2 strain with an IC₅₀ of 0.81 μM. Antimalarial agent 24 displays a CC₅₀ higher than 200 μM against HepG2 cells .

HY-152614

Antimalarial agent 19	Parasite	Infection
Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC₅₀ values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine .

HY-115905

Antimalarial agent 9	Parasite	Infection
Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive (IC₅₀-0.14 μM) and MDR strain (IC₅₀-0.41 μM) with minimal cytotoxicity and high selectivity .

HY-161170

Antimalarial agent 36	Parasite	Infection
Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC₅₀s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2 .

HY-149939

Antimalarial agent 26	Parasite	Infection
Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo .

HY-147198

Antimalarial agent 13	Parasite	Infection
Antimalarial agent 13 (Compound 1) is a potent *antimalarial* agent. Antimalarial agent 13 shows inhibition with EC₅₀ values of 124 nM and 2.5 μM against P. falciparum parasite and HepG2, respectively .

HY-169194

Antimalarial agent 44	Parasite	Infection
Antimalarial agent 44 (Compound 3) is an antimalarial agent against parasite. Antimalarial agent 44 has a good permeability across MDCK-MDR1 cell monolayers and a high clearance by mouse liver microsomes .

HY-149919

Antimalarial agent 23	Parasite	Infection
Antimalarial agent 23 is an *antimalarial* benzimidazole with IC₅₀s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin .

HY-151965

Antimalarial agent 18	Parasite	Infection
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC₅₀=50 nM) and A. baumanii (IC₅₀=390 nM) .

HY-163070

Antimalarial agent 35	Parasite	Infection
Antimalarial agent 35 (compound QP11) is a selective inhibitor FP2. Antimalarial agent 35 has antimalarial activity and shows synergistic effects when combined with chloroquine(HY-17589A) .

HY-150066

Antimalarial agent 16	Parasite	Infection Inflammation/Immunology
Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC₅₀=2.0 nM) .

HY-143487

Antimalarial agent 12	Parasite	Infection
Antimalarial agent 12 (compound R-3b) is a potent *antimalarial* agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC₅₀=155 nM), 3D7 strain (EC₅₀=136 nM). Antimalarial agent 12 has CC₅₀ values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli .

HY-170848

Antimalarial agent 48	Parasite	Infection
Antimalarial agent 48 (Compound 15a) is a triazine-class compound with antimalarial activity, showing inhibitory concentrations of 280 nM against Plasmodium falciparum K1 and 290 nM against Plasmodium falciparum FCR3. Antimalarial agent 48 is expected to be useful for research in the field of antimalarial infections .

HY-146769

Antimalarial agent 11	Parasite	Infection
Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent *antimalarial* agent. Antimalarial agent 11 exhibits excellent potency with an EC₅₀ of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC₅₀s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively .

HY-145704

Antimalarial agent 8	Parasite	Infection
Antimalarial agent 8 (Compound 7e) is a novel orally active class of antimalarials. Antimalarial agent 8 is potent in vitro against P. falciparum and is orally efficacious (40 mg/kg) in an in vivo mouse model of malaria .

HY-150065

Antimalarial agent 15	Parasite	Infection Inflammation/Immunology
Antimalarial agent 15 (Compound 4e) is a parasite inhibitor. Antimalarial agent 15 shows antimalarial activity, and can inhibit P. falciparum 3D7 parasite growth (IC₅₀=20 nM) .

HY-155688

Antimalarial agent 29	Parasite	Infection
Antimalarial agent 29 (compound 16) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

HY-155689

Antimalarial agent 30	Parasite	Infection
Antimalarial agent 30 (compound 11) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

HY-115721

Antimalarial agent 2	Parasite	Infection
Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.

HY-163765

Antimalarial agent 41	PI4K Potassium Channel	Infection
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC₅₀ of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC₅₀ of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC₅₀ of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models .

HY-143409

Antimalarial agent 10	Parasite	Infection
Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC₅₀ values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is .

HY-B1896

Piperaquine	Parasite	Infection
Piperaquine is a bisquinoline *antimalarial* agent. Piperaquine can be used in antimalarial research in combination with Artemisinin .

HY-B1896A

Piperaquine phosphate	Parasite	Infection
Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin .

HY-123915

Antimalarial agent 20	Parasite	Infection
Antimalarial agent 20 (Compound 49c) is an antimalarial agent with an IC₅₀ of 0.6 nM against P. falciparum NF54 parasite strain in the NF54 albumax assay .

HY-149882

Antimalarial agent 27	Parasite	Infection
Antimalarial agent 27 (compound 11a) is an antimalarial agent, potently targeting to P.falciparum (IC₅₀=0.37 μM). Antimalarial agent 27 acts function via P.falciparum DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibition (IC₅₀=0.11 μM) .

HY-170840

Antimalarial agent 47	Parasite	Infection
Antimalarial agent 47 (compound F14) is an antimalarial compound, with an IC₅₀ of 235 nM for the Plasmodium falciparum W2 strain .

HY-163997

Antimalarial agent 42	Parasite	Infection
Antimalarial agent 42 (Compound 2) is an antimalarial agent, that inhibits Plasmodium falciparum in the phase of asexual blood stages (IC₅₀ <0.5μM) and gametocytes (IC₅₀ is 0.14 μM) .

HY-B1896B

Piperaquine tetraphosphate tetrahydrate	Parasite	Infection
Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin .

HY-145327

Antimalarial agent 7	Na+/K+ ATPase Parasite	Infection
Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum .

HY-155354

Antimalarial agent 33	Parasite	Infection
Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC₅₀ of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T_1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .

HY-161171

Antimalarial agent 37	Parasite Ephrin Receptor	Cancer
Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7 .

HY-162905

Antimalarial agent 43	Parasite	Infection
Antimalarial agent 43 (compound 16c) is an antimalarial compound, with an IC₅₀ value of 0.0151 μM against 3D7 strain .

HY-155536

Antimalarial agent 28	Parasite	Infection
Antimalarial agent 28 (Compound 2i) is an antiplasmodial agent. Antimalarial agent 28 inhibits P. berghei, with IC₅₀s of 0.561 μM, 0.14 μM, 4.34 μM for Liver stage, early gametocytes and ring stages of P. falciparum .

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Parasite Ferroptosis	Infection
Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin .

HY-B1896S

Piperaquine-d6	Parasite	Infection
Piperaquine-d₆ is the deuterium labeled Piperaquine[1]. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[2][3].

HY-B0803S

Lumefantrine-d18 Benflumetol-d₁₈	Isotope-Labeled Compounds Parasite	Infection
Lumefantrine-d₁₈ is the deuterium labeled Lumefantrine, which is an antimalarial agent.

HY-122385

Dabequin phosphate	Parasite	Infection
Dabequin phosphate is an antimalarial agent, that exhibits inhibitory activity against Plasmodium falciparum .

HY-A0130

Sulfalene Sulfametopyrazine; AS-18908	Parasite Bacterial Antibiotic	Infection
Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial.

HY-N3957

1-(26-Hydroxyhexacosanoyl)-glycerol	Parasite	Infection
1-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC₅₀ value of 9.48 µM for Plasmodium falciparum .

HY-118865S

Piperaquine-d6 tetraphosphate	Isotope-Labeled Compounds Parasite	Infection
Piperaquine-d₆ (tetraphosphate) is the deuterium labeled Piperaquine tetraphosphate. Piperaquine tetraphosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Infection other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields	Parasite Ferroptosis
Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin .

HY-N0352

Tuberostemonine	Infection Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields	Parasite
Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP ⁺ reductases (pfFNR) .

HY-W585869

Amorphadiene	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Parasite
Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast .

HY-100711A

Prodigiosin hydrochloride 2 Publications Verification Prodigiosine hydrochloride	Infection Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Pigments Inflammation/Immunology Disease Research Fields Food Research	Bacterial Apoptosis Fungal Wnt Parasite
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-N7926

Pentadecane	Structural Classification Natural Products Kaempferia galanga L. Source classification Plants Zingiberaceae	Parasite
Pentadecane is a floral volatile antimalarial agent that can inhibit the growth of parasites such as Leishmania and avoid infection of macrophages. The IC₅₀s of Pentadecane against promastigotes and amastigotes are 65.3 μM and 60.5 μM, respectively. Pentadecane also has anti-inflammatory, analgesic, and antipyretic activities .

HY-N3957

1-(26-Hydroxyhexacosanoyl)-glycerol	Structural Classification Natural Products Source classification Rourea minor (Gaerth.) Leenh. Plants Connaraceae	Parasite
1-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC₅₀ value of 9.48 µM for Plasmodium falciparum .

HY-N0176A

α-Dihydroartemisinin α-Dihydroqinghaosu; α-Artenimol	Structural Classification Terpenoids Sesquiterpenes Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae	Drug Metabolite Parasite
α-Dihydroartemisinin (α-Dihydroqinghaosu; α-Artenimol) is a antimalarial agent that can be found in Artemisia annua L .

HY-N9438

Lactucin	Iridoids Genista quadriflora Munby Source classification Plants Compositae	Apoptosis Parasite
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities .

HY-N0352R

Tuberostemonine (Standard)	Alkaloids Structural Classification other families Pyrrole Alkaloids Source classification Plants	Parasite
Tuberostemonine (Standard) is the analytical standard of Tuberostemonine. This product is intended for research and analytical applications. Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP+ reductases (pfFNR) .

HY-N9438R

Lactucin (Standard)	Iridoids Genista quadriflora Munby Source classification Plants Compositae	Apoptosis Parasite
Lactucin (Standard) is the analytical standard of Lactucin. This product is intended for research and analytical applications. Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities [4].

HY-B0094

Artemisinin Maximum Cited Publications 17 Publications Verification Qinghaosu; NSC 369397	Infection Structural Classification Piscidia erythrina L. Neurological Disease Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields	HCV Parasite Akt Ferroptosis
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an *anti-malarial* agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-Y0152A

Cinchonine monohydrochloride hydrate (8R,9S)-Cinchonine monohydrochloride hydrate; LA40221 monohydrochloride hydrate	Cardiovascular Disease Infection Cinchona succirubra Pav. ex Klotzsch Alkaloids Classification of Application Fields Source classification Rubiaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields	Parasite Apoptosis
Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as *antimalarial* agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis .

HY-N7926R

Pentadecane (Standard)	Structural Classification Natural Products Kaempferia galanga L. Source classification Plants Zingiberaceae	Parasite
Pentadecane (Standard) is the analytical standard of Pentadecane. This product is intended for research and analytical applications. Pentadecane is a floral volatile antimalarial agent that can inhibit the growth of parasites such as Leishmania and avoid infection of macrophages. The IC50s of Pentadecane against promastigotes and amastigotes are 65.3 μM and 60.5 μM, respectively. Pentadecane also has anti-inflammatory, analgesic, and antipyretic activities .

HY-B0094R

Artemisinin (Standard)	Structural Classification Piscidia erythrina L. Terpenoids Sesquiterpenes Source classification Plants Compositae	HCV Parasite Akt Ferroptosis
Artemisinin (Standard) is the analytical standard of Artemisinin. This product is intended for research and analytical applications. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

Cat. No.	Product Name	Chemical Structure

HY-B0806S

Proguanil-d6
Proguanil-d₆ is the deuterium labeled Proguanil, which is a prophylactic antimalarial agent.

HY-A0130S

Sulfalene-13C6
Sulfalene- ¹³C₆ is the ¹³C₆ labeled Sulfalene. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial .

HY-100662S

Didesethyl chloroquine-d4
Didesethyl chloroquine-d₄ is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

HY-14749AS

Pyronaridine-d4 tetraphosphate
Pyronaridine-d₄ (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].

HY-W031727S

Hydroxychloroquine-d4-1 sulfate
Hydroxychloroquine-d₄-1 (sulfate) is the deuterium labeled Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-B1896S

Piperaquine-d6
Piperaquine-d₆ is the deuterium labeled Piperaquine[1]. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[2][3].

HY-B0803S

Lumefantrine-d18
Lumefantrine-d₁₈ is the deuterium labeled Lumefantrine, which is an antimalarial agent.

HY-118865S

Piperaquine-d6 tetraphosphate
Piperaquine-d₆ (tetraphosphate) is the deuterium labeled Piperaquine tetraphosphate. Piperaquine tetraphosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].

HY-W031727S1

Hydroxychloroquine-d5
Hydroxychloroquine-d₅ is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

HY-B1370S

Hydroxychloroquine-d4 sulfate
Hydroxychloroquine-d₄ (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-B0094S

Artemisinin-d3

Artemisinin-d₃ is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

HY-B1322AS

Amodiaquine-d10
Amodiaquine-d₁₀ is the deuterium labeled Amodiaquine. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-B1322AS1

Amodiaquine-d10 hydrochloride
Amodiaquine-d₁₀ hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine (HY-17589A). Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-13832S3

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-B0094S3

Artemisinin-13C,d4

Artemisinin- ¹³C,d₄ is ¹³C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-13832S2

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

Cat. No.	Product Name		Classification

HY-152313

2-Bromoadenosine		Nucleosides and their Analogs
2-Bromoadenosine, antimalarial agent is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks