Search Result
Results for "
dimer
" in MedChemExpress (MCE) Product Catalog:
9
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-148424
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ADC Cytotoxin
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Cancer
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PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer .
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- HY-141514
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STING
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Inflammation/Immunology
Cancer
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MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .
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- HY-138291
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Others
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Inflammation/Immunology
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Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10?mg/kg shows hepatotoxicity in mice .
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- HY-136113
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Btk
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Cancer
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Ibrutinib dimer is a Dimer of Ibrutinib. Ibrutinib dimer is an impurity of Ibrutinib . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
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- HY-139673
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Fluorescent Dye
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Others
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BG dimer is a molecular dimer organic luminogen with aggregation-induced emission.
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-
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- HY-141736S
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-
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- HY-N10638
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Reactive Oxygen Species
NF-κB
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Inflammation/Immunology
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N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .
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- HY-N10637
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Others
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Others
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N-Acetyldopamine dimer-1 is a 2-(3',4'-dihydroxyphenyl)-1,4-benzodioxane derivative. N-Acetyldopamine dimer-1 is optically active, can be isolated from crude agent "Zentai," a cast-off shell of the cicada of Cryptotympana sp. (Cicadidae) .
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-
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- HY-N10646
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Others
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Metabolic Disease
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N-Acetyldopamine dimer-3 (compound 11) is a natural product that can be found in Aspongopus chinensis .
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- HY-131449
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Adrenergic Receptor
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Others
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Terazosin dimer impurity dihydrochloride, a dimer of Terazosin, is an impurity of Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist .
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-
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- HY-P5213
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-
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- HY-142217S
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-
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- HY-P5214
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Vasopressin Receptor
Oxytocin Receptor
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Endocrinology
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Vasopressin Dimer (anti-parallel) TFA is an anti-parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (anti-parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR .
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- HY-W033466
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Benzeneruthenium(II) chloride dimer
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Biochemical Assay Reagents
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Others
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Benzeneruthenium(II) Chloride Dimer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W012515
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Biochemical Assay Reagents
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Others
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1,3-Dihydroxyacetone dimer can be used as an aldose, serving as a model compound for studying the structure and function of carbohydrates. 1,3-Dihydroxyacetone dimer is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-143859S
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-
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- HY-126678
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Dimethyl-PBD dimer
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ADC Cytotoxin
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Cancer
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Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication .
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- HY-141410
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Drug Metabolite
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Others
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Fluticasone dimer impurity is a dimeric impurity of Fluticasone Propionate . Fluticasone propionate is a corticosteroid with comparatively high receptor affinity and topical activity .
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- HY-101127
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PBD dimer
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ADC Cytotoxin
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Cancer
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SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
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- HY-W033577
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CORM-2
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Others
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Inflammation/Immunology
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Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level .
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- HY-W033831
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Rh2(TPA)4
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Others
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Rhodium(II) triphenylacetate dimer (Rh2(TPA)4) is an important catalyst with high C–H activation reaction activity. Rhodium(II) triphenylacetate dimer is widely used in organic synthesis to achieve the construction of complex molecules. Rhodium(II) triphenylacetate dimer can also be used to catalyze the synthesis of certain biologically active molecules and improve the preparation efficiency of compounds. Rhodium(II) triphenylacetate dimer exhibits excellent selectivity and reaction rate in catalytic reactions.
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- HY-153804
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NCD
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Molecular Glues
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Others
Cancer
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Naphthyridine caebamate dimer (NCD) is a DNA molecular glue that induces designed structural changes in target functional DNA to modulate function .
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- HY-123350
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Antibiotic
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Infection
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Saroaspidin B, a dimer of a phloroglucinol moiety, is an antibiotic compound .
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- HY-N9150
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Others
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Others
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Shizukaol A is an sesquiterpene dimer that can be isolated from Chloranthus japonicas .
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- HY-133022
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(E)-2-Undecenoic acid; (E)-Undec-2-enoic acid
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Others
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Metabolic Disease
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trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O .
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- HY-W025817
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Fluorescent Dye
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Others
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Citrazinic acid is a weakly fluorescent compound whose optical properties are dependent on aggregation states and chemical environment. Citrazinic acid strongly tends to form dimers at high concentrations .
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- HY-N10766
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Others
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Others
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Ampelopsins F is a bridged plant oligostilbene that can be isolated from Ampelopsis brevipedunculata var. hancei roots. Ampelopsins F is a resveratrol dimer .
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- HY-139718
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NF-κB
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Inflammation/Immunology
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IMD-biphenylB is a potent imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.
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- HY-W441004
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Liposome
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Others
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DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .
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- HY-W020887
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Chlorobis(cyclooctene)iridium(I)dimer
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Others
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[IrCl(COE)2]2 (Chlorobis(cyclooctene)iridium(I)dimer) is a transition metal catalyst with remarkable catalytic activity. It is widely used in catalyzing a variety of organic reactions, especially in the synthesis of unsaturated compounds. In addition, [IrCl(COE)2]2 has shown potential anti-tumor properties in biochemical research.
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- HY-B2224
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HIV
Endogenous Metabolite
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Infection
Metabolic Disease
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Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .
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- HY-101161
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SG3199
2 Publications Verification
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DNA Alkylator/Crosslinker
ADC Cytotoxin
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Cancer
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SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
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- HY-N8404
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Potassium Channel
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Inflammation/Immunology
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Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC50 of 3.6 μM .
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- HY-101160
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DRG16
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DNA Alkylator/Crosslinker
ADC Cytotoxin
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Cancer
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SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .
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- HY-128952
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SG3249
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Drug-Linker Conjugates for ADC
DNA Alkylator/Crosslinker
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Cancer
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Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
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- HY-120397
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PROTAC Linkers
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Infection
Cancer
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Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-77490A
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- HY-B2224R
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HIV
Endogenous Metabolite
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Infection
Metabolic Disease
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Thiamine disulfide (Standard) is the analytical standard of Thiamine disulfide. This product is intended for research and analytical applications. Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .
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- HY-N6310
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Bacterial
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Infection
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Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC50 of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC50 of 7.49 μM .
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- HY-164492
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Raf
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Cancer
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LSN3074753, an analog of LY3009120 (HY-12558), is a pan-RAF and Raf dimer inhibitor. LSN3074753 demonstrates activity against tumor cells with MAPK pathway activation driven by BRAF monomer or RAF dimers including BRAF- or KRAS-mutant colorectal cancer. LSN3074753 combined with Cetuximab (HY-P9905) shows additive and synergistic effects for colorectal cancer PDX models, particularly those with KRAS or BRAF mutation .
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- HY-D1660
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NSC 219743
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DNA Stain
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Others
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Acridine homodimer (NSC 219743), acridine dimer, is a fluorescence dye. Acridine homodimer emits a blue-green fluorescence when bound to DNA. Acridine homodimer has extremely high affinity for AT-rich regions of nucleic acids, can be used for chromosome banding .
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- HY-114348
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DiNAC; (Ac-Cys-OH)2
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Others
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Cardiovascular Disease
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N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .
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- HY-112636
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Amyloid-β
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Others
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Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice .
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- HY-16182A
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Biochemical Assay Reagents
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Others
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Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .
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- HY-77490AR
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Endogenous Metabolite
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Cardiovascular Disease
Neurological Disease
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1,3-Butanediol (Standard) is the analytical standard of 1,3-Butanediol. This product is intended for research and analytical applications. 1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .
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- HY-D0916
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YOYO 1; YOYO1
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Fluorescent Dye
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Thiazole orange dimer YOYO 1 is a green fluorescent dye used for DNA staining. It belongs to the monomethine cyanine dye family and is a tetracationic homodimer of oxazole yellow (abbreviated as YO, hence the name YOYO), usually provided as a tetraiodide salt. In aqueous buffer, the free YOYO-1 dye (λmax 458 nm; λmax 564 nm) has a very low fluorescence quantum yield, but after binding to double-stranded DNA through diintercalation, the fluorescence intensity is increased by 3200 times (λmax 489 nm; λmax 509 nm).
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- HY-E70377
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Cu/Zn SOD
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SOD
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Inflammation/Immunology
Cancer
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Cu/Zn Superoxide dismutase (Cu/Zn SOD; SOD1) is a cytosolic copper-zinc dimer form of superoxide dismutase enzyme. Cu/Zn Superoxide dismutase has oxygen radical enzymatic dismutation .
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- HY-N7980
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NF-κB
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Cancer
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Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .
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- HY-114348R
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Others
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Cardiovascular Disease
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N,N'-Diacetyl-L-cystine (Standard) is the analytical standard of N,N'-Diacetyl-L-cystine. This product is intended for research and analytical applications. N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .
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- HY-16182
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Biochemical Assay Reagents
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Others
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Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
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- HY-N10577
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TGF-beta/Smad
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Cancer
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Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity .
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- HY-111009
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Fungal
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Infection
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Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .
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- HY-16182R
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Biochemical Assay Reagents
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Others
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Ecamsule (Standard) is the analytical standard of Ecamsule. This product is intended for research and analytical applications. Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
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- HY-N12704
-
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Others
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Others
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N-Acetyldopamine dimers B is the dimer form of N-Acetyldopamine (HY-N7493) .
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- HY-125772
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Acetylpodocarpic dimer; APD
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LXR
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Cardiovascular Disease
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Acetyl podocarpic acid anhydride is a potent, semisynthetic liver X receptor(LXR) agonist derived from extracts of the mayapple. Acetyl podocarpic acid anhydride has the potential to be useful for the prevention and research of atherosclerosis, especially in the context of low HDL levels .
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- HY-139714
-
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NF-κB
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Cancer
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IMD-vanillin is a novel imidazoquinolinone-NF-κB immunomodulator dimers.
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-
- HY-126649
-
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Others
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Infection
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Bacillosporin C is an oxaphenalenone dimer originally isolated from T. bacillosporus. Bacillosporin C, an anhydride, is formed from the lactone bacillosporin D in the mangrove endophytic fungus SBE-14. Similar oxaphenalenone dimers have antibiotic activity and inhibit acetylcholinesterase.
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- HY-150265
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TMP-NVOC linker-Halo
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Others
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Others
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TNH is a dimer that can enter living cells and recruit proteins into cellular structures .
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- HY-145736A
-
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Drug-Linker Conjugates for ADC
Apoptosis
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Cancer
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β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity .
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- HY-145736
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Drug-Linker Conjugates for ADC
Apoptosis
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Cancer
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β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity .
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- HY-W019734
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Pentamethylcyclopentadienylrhodium(III) chloride dimer
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Biochemical Assay Reagents
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Others
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[Rh(Cp*)Cl2]2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-139717
-
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NF-κB
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Cancer
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IMD-biphenylA is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves the adjuvanticity of small molecule immune potentiators.
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- HY-N3393
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- HY-N1350
-
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Others
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Others
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Riligustilide (compound 2) is a kind of phthalide dimer. Riligustilide can be isolated from the radix of Angelica sinensis .
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- HY-W008033
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C-61; SYKINH-61
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Others
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Others
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(DHQD)2PHAL is a dimer that can be used as a ligand for the Sharpless asymmetric dihydroxylation reaction .
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- HY-N7697B
-
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Others
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Others
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Chitobiose dihydrochloride, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units .
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- HY-N3671
-
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Others
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Others
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Cycloshizukaol A is a symmetrical cyclic lindenane dimer with C2 symmetry. Cycloshizukaol A can be isolated from the root of Chloranthus serratus .
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- HY-W018845
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Pentamethylcyclopentadienyliridium(III) chloride,dimer
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Biochemical Assay Reagents
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Others
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[Ir(Cp-)Cl2]2 is used as a precursor for the asymmetric transfer hydrogenation catalyst of ketones. It is a catalyst for greener amine synthesis .
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- HY-W001951
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Tetrakis(acetato)dirhodium(II); Rhodium(II) acetate dimer
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Biochemical Assay Reagents
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Others
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Dirhodium tetraacetate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-102001
-
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ADC Cytotoxin
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Cancer
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Tomaymycin DM, a DNA alkylator, is a derivative of Tomaymycin, it is a PBD dimer, which is attached to tumor targeting antibodies to create antibody-drug conjugates (ADCs).
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- HY-139719
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NF-κB
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Inflammation/Immunology
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IMD-biphenylC is a novel imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.
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- HY-P10436
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Raf
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Cancer
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Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF G469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence .
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- HY-108045
-
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Phosphodiesterase (PDE)
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Endocrinology
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Lodenafil carbonate, a dimer that acts as a proagent delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED) .
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- HY-N2083
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NF-κB
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Inflammation/Immunology
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Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production .
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- HY-P2931
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TPI
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Endogenous Metabolite
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Others
Cancer
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Triosephosphate isomerase (TPI) is a glycolytic enzyme. Triosephosphate isomerase fast interconverts dihydroxyacetone phosphate and D: -glyceraldehyde-3-phosphate, its catalytic site is at the dimer interface .
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- HY-164730
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ADCT-602; hLL2-Cys-PBD
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Antibody-Drug Conjugates (ADCs)
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Cancer
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Epratuzumab Tesirine (ADCT-602) is a novel CD22-targeted ADC. Epratuzumab Tesirine contains a PBD dimer and a payload SG3249 .
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- HY-W008260
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Chloro-1,5-cyclooctadiene iridium(I) dimer
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Biochemical Assay Reagents
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Others
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[Ir(cod)Cl]2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-128685
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Ac12Az9
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P-glycoprotein
BCRP
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Cancer
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FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity .
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- HY-139716
-
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NF-κB
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Inflammation/Immunology
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IMD-catechol is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves efficacy in a CT26 mouse colon carcinoma tumor model while eliciting minimal adjuvant toxicity.
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- HY-N7697F
-
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Others
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Others
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Chitobiose, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units . Chitobiose has orally activity and high antioxidant activity .
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- HY-N3574
-
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Fungal
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Infection
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Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candida albicans and C.parapsilosis with a MIC value of 0.068 μM .
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-
- HY-161100
-
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Apoptosis
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Cancer
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BDM19 binds and activates cytosolic BAX dimers, and prompts cell apoptosis either alone or in combination with BCL-2/BCL-XL inhibitor Navitoclax (HY-10087) .
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- HY-163607
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Apoptosis
NF-κB
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Cancer
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SpiD3 is a novel spirocyclic dimer. SpiD3 shows antitumor effect and induces cell apoptosis in malignant B cells. SpiD3 can be used for study of chronic lymphocytic leukemia .
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- HY-13036A
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Btk
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Cancer
|
IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
|
-
- HY-13036B
-
|
Btk
|
Cancer
|
IBT6A hydrochloride is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
|
-
- HY-161252
-
|
ADC Cytotoxin
|
Cancer
|
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC). PBD-monoamide has DNA-binding activity and reduces cell viability .
|
-
- HY-12324
-
|
Dopamine Receptor
|
Neurological Disease
|
SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.
|
-
- HY-136297
-
|
Drug-Linker Conjugates for ADC
|
Cancer
|
DGN549-C consists a cleavable ADC linker valine-alanine (va) and PBD dimer. DGN549 is a novel DNA-alkylating cytotoxic payload and can be used in the synthesis of antibody-agent conjugates (ADCs) .
|
-
- HY-130778
-
|
Endogenous Metabolite
|
Others
|
N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli .
|
-
- HY-158615
-
Stimulator of interferon genes 18
|
Others
|
Others
|
STING18 (Stimulator of interferon genes 18) is a compound that inhibits STING protein by utilizing a small molecule active site dimer, with good oral exposure, slow binding kinetics, and functional inhibitory activity on STING-mediated cytokine release.
|
-
- HY-N4299
-
|
Others
|
Metabolic Disease
|
Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration .
|
-
- HY-162161
-
|
Fluorescent Dye
|
Cancer
|
Flutax-2 is an active fluorescent derivative of Paclitaxel, binds to αβ-tubulin dimer polymerized. Flutax-2 can be used for imaging microtubules in live cells, isolated cytoskeletons and parasite (Ex/Em=496/526 nm) .
|
-
- HY-N2941
-
|
TRP Channel
|
Metabolic Disease
Inflammation/Immunology
|
Bisandrographolide C is an unusual dimer of ent-labdane diterpenoid isolated and identified from Andrographis paniculata. Bisandrographolide C activates TRPV1 and TRPV3 channels with Kd values of 289 and 341 μM respectively, and protects cardiomyocytes from hypoxia-reoxygenation injury .
|
-
- HY-108523
-
UVI 2112
|
RAR/RXR
|
Metabolic Disease
|
LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR .
|
-
- HY-23999
-
|
LOX-1
|
Cardiovascular Disease
|
BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 µM) that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain .
|
-
- HY-13036
-
|
Btk
|
Cancer
|
(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
|
-
- HY-N2344
-
Proanthocyanidin A1
|
PKC
|
Inflammation/Immunology
|
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca 2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .
|
-
- HY-13036C
-
|
Btk
|
Cancer
|
(Rac)-IBT6A hydrochloride is a racemate of IBT6A hydrochloride. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
|
-
- HY-125636
-
|
Others
|
Cancer
|
Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .
|
-
- HY-126979
-
|
Others
|
Cancer
|
Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .
|
-
- HY-108045R
-
|
Phosphodiesterase (PDE)
|
Endocrinology
|
Lodenafil carbonate (Standard) is the analytical standard of Lodenafil carbonate. This product is intended for research and analytical applications. Lodenafil carbonate, a dimer that acts as a proagent delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED) .
|
-
- HY-P99734
-
ADCT-601
|
TAM Receptor
|
Cancer
|
Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers .
|
-
- HY-N0282
-
|
Microtubule/Tubulin
Apoptosis
|
Inflammation/Immunology
Cancer
|
Demecolcine is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .
|
-
- HY-121432
-
|
Others
|
Others
|
Kitol is peptide used for after-sun repair cosmetics. The dominant degradation reaction for vitamin A derivatives is heat-induced formation of kitols, i.e., dimers or higher oligomers. Vitamin A esters are used as a model system to evaluate microcalorimetry as a tool for monitoring the stability of heat-sensitive substances .
|
-
- HY-112575
-
|
Others
|
Infection
Cardiovascular Disease
Inflammation/Immunology
|
Tiazotic acid is a metabolic agent that has immunomodulatory, anti-inflammatory, antioxidant, anti-ischemic, cardio- and endothelioprotective, antiplatelet, hepatoprotective activities. Tiazotic acid increases the levels of eNOS. Tiazotic acid also reduces the level of D-dimer in the blood, which reduces the risks of heart attacks and strokes in post-COVID syndrome .
|
-
- HY-E70371
-
|
Biochemical Assay Reagents
|
Others
|
Cre recombinase is a resolvase derived from the P1 bacteriophage. Cre recombinase catalyzes site-specific recombination between two loxP DNA sequences, converts dimers of P1 chromosome into monomers before cell division. Cre recombinase is utilized in genetic engineering and molecular biology applications .
|
-
- HY-P990757
-
|
TNF Receptor
PD-1/PD-L1
|
Inflammation/Immunology
|
Ragistomig is an anti-TNFRSF9/CD274 IgG1 monoclonal antibody composed of a κ light chain and a variable region with a λ light chain and an IgG1 heavy chain. The overall structure is a dimer composed of two identical IgG1 heavy chains .
|
-
- HY-P2797A
-
AMCase, Streptomyces griseus
|
Endogenous Metabolite
|
Others
|
Chitinase, Streptomyces griseus is a chitinase mainly found in Bacillus species and uses colloidal chitin as a substrate. The Km and Vmax of Chitinase are 4.28 mg/mL and 14.29 μg/(Min·mL) respectively. The final enzymatic hydrolysis product is N-acetylglucosamine, and the monomer and dimer contents are 14.33% and 85.67% respectively .
|
-
- HY-N3841
-
epsilon-Viniferin
|
Cytochrome P450
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity .
|
-
- HY-145010
-
SN-011
3 Publications Verification
|
STING
|
Inflammation/Immunology
|
SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease .
|
-
- HY-D1815
-
APC Dye
|
Fluorescent Dye
|
Others
|
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .
|
-
- HY-131010
-
|
Fluorescent Dye
Microtubule/Tubulin
|
Cancer
|
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .
|
-
- HY-145889
-
|
Others
|
Others
|
LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL * and WIL-FL * T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .
|
-
- HY-24144
-
|
DNA Alkylator/Crosslinker
|
Cancer
|
Tesirine intermediate-2 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
|
-
- HY-47820
-
|
DNA Alkylator/Crosslinker
|
Cancer
|
Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
|
-
- HY-133191
-
|
PROTAC Linkers
|
Infection
Cancer
|
Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N3841A
-
|
Cytochrome P450
|
Metabolic Disease
|
δ-Viniferin is a resveratrol dehydrodimer, an isomer of ε-Viniferin (HY-N3841) . ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity.
|
-
- HY-N0282R
-
|
Microtubule/Tubulin
Apoptosis
|
Inflammation/Immunology
Cancer
|
Colcemid (Standard) is the analytical standard of Colcemid. This product is intended for research and analytical applications. Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .
|
-
- HY-E70364
-
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .
|
-
- HY-N2344R
-
|
PKC
|
Inflammation/Immunology
|
Procyanidin A1 (Standard) is the analytical standard of Procyanidin A1. This product is intended for research and analytical applications. Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .
|
-
- HY-167935
-
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. LCC-12 formic reduces inflammation in mouse models of bacterial and viral infections. LCC-12 formic also serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
|
-
- HY-N12235
-
|
Caspase
|
Inflammation/Immunology
|
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .
|
-
- HY-106586A
-
P-286 sodium
|
Biochemical Assay Reagents
|
Cardiovascular Disease
Cancer
|
Ioxaglate sodium (P-286 sodium) is an ionic, dimeric diagnostic contrast agent whose activity is mainly reflected in its ability to provide sufficient X-ray absorption to enhance visualization of blood vessels and other structures during imaging. Ioxaglate sodium is used to study the anatomical structure and functional status of cardiac vessels, especially in the diagnosis of coronary artery disease .
|
-
- HY-P99668
-
|
PD-1/PD-L1
|
Cancer
|
Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research .
|
-
- HY-156483
-
|
Others
|
Cancer
|
TT-012 specifically binds to dynamic MITF and destroys the latter's dimer formation and DNA-binding ability. TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells. TT-012 inhibits the growth of high-MITF melanoma cells, and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models .
|
-
- HY-D2353
-
|
DNA/RNA Synthesis
|
Cancer
|
Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .
|
-
- HY-P10438
-
|
Raf
|
Cancer
|
Tat-braftide is a peptide inhibitor designed to block the dimerization of BRAF, thereby inhibiting its kinase activity. The destruction of BRAF dimer by Tat-braftide makes BRAF protein more susceptible to proteasome degradation, directly inhibits the activity of BRAF kinase, and reduces the activation of MAPK signaling pathway. Tat-braftide can be used for the role of RAF kinase in MAPK signaling pathway and for the study of BRAF mutant cancers .
|
-
- HY-162152
-
|
Keap1-Nrf2
|
Inflammation/Immunology
|
biKEAP1 (compound 3) is an inhibitor targeting the dimerKEAP1. biKEAP1 binds to cellular KEAP1 dimers and releases the NRF2 protein sequestered by KEAP1, resulting in immediate activation of NRF2. biKEAP1 also promotes nuclear translocation of NRF2 and directly inhibits proinflammatory cytokine transcription. biKEAP1 can reduce acute inflammation and reduce inflammatory damage in acute inflammation models .
|
-
- HY-N11894
-
|
Others
|
Others
|
1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside ( Compound 20) is a quinone compound that can be isolated from the roots and rhizomes of Madder .
|
-
- HY-126640
-
|
Parasite
|
Infection
Cancer
|
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC50 is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC50 is 0.99, 0.51 and 1.4 µg/mL, respectively .
|
-
- HY-N3841R
-
|
Cytochrome P450
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
ε-Viniferin (Standard) is the analytical standard of ε-Viniferin. This product is intended for research and analytical applications. ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity .
|
-
- HY-136927
-
MSA-2
Maximum Cited Publications
14 Publications Verification
|
STING
|
Inflammation/Immunology
Cancer
|
MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models .
|
-
- HY-157214
-
|
STING
|
Cancer
|
NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models .
|
-
- HY-124653
-
J2
|
HSP
|
Cancer
|
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .
|
-
- HY-160962
-
|
Caspase
Apoptosis
|
Cancer
|
SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC50 < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model .
|
-
- HY-108795A
-
GLP-1-Gly8 TFA; GLP-1 (7-36) analog TFA
|
GLP Receptor
|
Metabolic Disease
|
Albiglutide fragment (GLP-1 (7-36) analog) TFA is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment TFA significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies .
|
-
- HY-108795
-
GLP-1-Gly8; GLP-1 (7-36) analog
|
GLP Receptor
|
Metabolic Disease
|
Albiglutide fragment (GLP-1 (7-36) analog) is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies .
|
-
- HY-P99238
-
|
ADC Antibody
|
Inflammation/Immunology
Cancer
|
Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
|
-
- HY-P99463
-
AVB-S6-500
|
TAM Receptor
|
Cancer
|
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .
|
-
- HY-P1441A
-
|
Sodium Channel
|
Neurological Disease
|
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
|
-
- HY-155101
-
|
PD-1/PD-L1
|
Cancer
|
PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research .
|
-
- HY-P3801
-
DiMe-C7
|
Neurokinin Receptor
|
Others
Neurological Disease
Metabolic Disease
|
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D0916
-
YOYO 1; YOYO1
|
Dyes
|
Thiazole orange dimer YOYO 1 is a green fluorescent dye used for DNA staining. It belongs to the monomethine cyanine dye family and is a tetracationic homodimer of oxazole yellow (abbreviated as YO, hence the name YOYO), usually provided as a tetraiodide salt. In aqueous buffer, the free YOYO-1 dye (λmax 458 nm; λmax 564 nm) has a very low fluorescence quantum yield, but after binding to double-stranded DNA through diintercalation, the fluorescence intensity is increased by 3200 times (λmax 489 nm; λmax 509 nm).
|
-
- HY-D1815
-
APC Dye
|
Dyes
|
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .
|
-
- HY-131010
-
|
Dyes
|
Flutax-2 (5/6-mixture) is an active fluorescent derivative of paclitaxel. Flutax-2 (5/6-mixture) binds to a polymerized α,β tubulin dimer. Excitation/emission wavelength: 496/524 nm. Paclitaxel, a diterpenoid secondary metabolite produced by Taxus species, can be used for the research of a variety of cancers .
|
-
- HY-D2353
-
|
Dyes
|
Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .
|
Cat. No. |
Product Name |
Type |
-
- HY-W019734
-
Pentamethylcyclopentadienylrhodium(III) chloride dimer
|
Biochemical Assay Reagents
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[Rh(Cp*)Cl2]2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W018845
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Pentamethylcyclopentadienyliridium(III) chloride,dimer
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Biochemical Assay Reagents
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[Ir(Cp-)Cl2]2 is used as a precursor for the asymmetric transfer hydrogenation catalyst of ketones. It is a catalyst for greener amine synthesis .
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- HY-W001951
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Tetrakis(acetato)dirhodium(II); Rhodium(II) acetate dimer
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Biochemical Assay Reagents
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Dirhodium tetraacetate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W008260
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Chloro-1,5-cyclooctadiene iridium(I) dimer
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Biochemical Assay Reagents
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[Ir(cod)Cl]2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-NP021
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D dimer protein; D dimer antigen; Human D-dimer protein
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Native Proteins
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Human D-dimer protein is a good surrogate biomarker of thrombosis. Human D-dimer protein is the end product of fibrinolysis .
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- HY-W033466
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Benzeneruthenium(II) chloride dimer
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Biochemical Assay Reagents
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Benzeneruthenium(II) Chloride Dimer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W012515
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Carbohydrates
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1,3-Dihydroxyacetone dimer can be used as an aldose, serving as a model compound for studying the structure and function of carbohydrates. 1,3-Dihydroxyacetone dimer is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-154920
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Biochemical Assay Reagents
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Dehydro-L-(+)-ascorbic acid dimer is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W441004
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Drug Delivery
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DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P3222
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Peptides
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Endocrinology
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Oxytocin antiparallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .
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- HY-P3215
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Peptides
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Endocrinology
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Oxytocin parallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .
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- HY-P3215A
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Peptides
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Endocrinology
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Oxytocin parallel dimer TFA is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .
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- HY-P5213
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- HY-P3432
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Peptides
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Others
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DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection .
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- HY-P10436
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Raf
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Cancer
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Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF G469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence .
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- HY-P10332
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Peptides
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Others
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WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1 function .
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- HY-P3222A
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Peptides
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Endocrinology
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Oxytocin antiparallel dimer TFA is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .
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- HY-P4957
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Peptides
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Others
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Octreotide dimer parallel is a dimer parallel of Octreotide. Octreotide (HY-P0036) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue .
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- HY-P5214
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Vasopressin Receptor
Oxytocin Receptor
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Endocrinology
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Vasopressin Dimer (anti-parallel) TFA is an anti-parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (anti-parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR .
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- HY-P10722
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Peptides
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Inflammation/Immunology
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Efpegerglucagon is an Fc fragment of human immunoglobulin G4 (IgG4), formed as a disulfide-bonded dimer. One of the Fc chains is linked via a bifunctional maleimide-polyethylene glycol-aldehyde linker to a glucagon peptide analogue .
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- HY-P5340
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Peptides
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Others
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Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)
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- HY-P10438
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Raf
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Cancer
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Tat-braftide is a peptide inhibitor designed to block the dimerization of BRAF, thereby inhibiting its kinase activity. The destruction of BRAF dimer by Tat-braftide makes BRAF protein more susceptible to proteasome degradation, directly inhibits the activity of BRAF kinase, and reduces the activation of MAPK signaling pathway. Tat-braftide can be used for the role of RAF kinase in MAPK signaling pathway and for the study of BRAF mutant cancers .
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- HY-108795A
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GLP-1-Gly8 TFA; GLP-1 (7-36) analog TFA
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GLP Receptor
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Metabolic Disease
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Albiglutide fragment (GLP-1 (7-36) analog) TFA is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment TFA significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies .
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- HY-108795
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GLP-1-Gly8; GLP-1 (7-36) analog
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GLP Receptor
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Metabolic Disease
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Albiglutide fragment (GLP-1 (7-36) analog) is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies .
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- HY-P1441A
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Sodium Channel
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Neurological Disease
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Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.
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- HY-P3801
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DiMe-C7
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Neurokinin Receptor
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Others
Neurological Disease
Metabolic Disease
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[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P9991
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TST001
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Inhibitory Antibodies
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Cancer
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Osemitamab is an IgG1 antibody targeting to human claudin-18.2. Osemitamab consists of human-Mus musculus monoclonal TST001 γ1-chain, disulfide with human-Mus musculus monoclonal TST001 κ-chain, dimer (ACI). Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .
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- HY-P99238
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ADC Antibody
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Inflammation/Immunology
Cancer
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Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
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- HY-P99463
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AVB-S6-500
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TAM Receptor
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Cancer
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Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .
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- HY-P99734
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ADCT-601
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TAM Receptor
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Cancer
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Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers .
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- HY-P990757
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TNF Receptor
PD-1/PD-L1
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Inflammation/Immunology
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Ragistomig is an anti-TNFRSF9/CD274 IgG1 monoclonal antibody composed of a κ light chain and a variable region with a λ light chain and an IgG1 heavy chain. The overall structure is a dimer composed of two identical IgG1 heavy chains .
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- HY-P99668
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PD-1/PD-L1
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Cancer
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Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-141736S
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Acetaminophen dimer-d6 is the deuterium labeled Acetaminophen dimer[1].
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- HY-142217S
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Quetiapine dimer impurity-d8 is the deuterium labeled Quetiapine dimer impurity[1].
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- HY-143859S
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Metoprolol dimer-d10 is the deuterium labeled Nitrosotetracaine[1].
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Cat. No. |
Product Name |
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Classification |
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- HY-120397
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PROTAC Synthesis
Alkynes
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Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-133191
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Alkynes
PROTAC Synthesis
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Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cat. No. |
Product Name |
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Classification |
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- HY-W441004
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Phospholipids
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DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .
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