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Alkaline Phosphatase (ALP), Human Placental (ALP, PLAP, Alk Phos) is a biological material or organic compound that can be used in life science research .
Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC50 values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer .
4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .
4-Methylbenzylidene camphor (Standard) is the analytical standard of 4-Methylbenzylidene camphor. This product is intended for research and analytical applications. 4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .
Steroid sulfatase-IN-7 is an irreversible steroid sulfatase (STS) inhibitor with an IC50 value of 0.05 nM against human placental STS and can be used in cancer research .
Anastrozole (Standard) is the analytical standard of Anastrozole. This product is intended for research and analytical applications. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM.
Anastrozole-d12 is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM[1][2].
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.
(S)-Dexfadrostat ((S)-Fadrozole) is an aromatase inhibitor with an IC50 of 4.6 nM in human placental microsomes in vitro. (S)-Dexfadrostat can be used in the study of estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus .
Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation .
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM) .
Nipocalimab (M281) is a fully humanized, recombinant, and non-glycosylated IgG1 monoclonal antibody. Nipocalimab can bind to the IgG-binding site of FcRn with high affinity and inhibit the transplacental transfer of IgG. Nipocalimab can be used in the research of fetal and neonatal hemolytic disease, myasthenia gravis, and various IgG-mediated autoimmune diseases .
Exemestane-d2 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
Exemestane-d3 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
Exemestane (Standard) is the analytical standard of Exemestane. This product is intended for research and analytical applications. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
Exemestane- 13C3 is the 13C-labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
GNQWFI, an anti-Flt1 peptide, is a VEGFR1-specific antagonist. GNQWFI blocks the interaction of VEGFR1 with various VEGFR1 ligands, such as VEGFA, VEGFB, and placental growth factor (PIGF) and inhibits VEGF-induced endothelial cell migration and tube formation. GNQWFI is promising for research of cancer, asthma, and other ocular diseases .
Exemestane- 13C,d2 is 13C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
Triphenyl phosphate is an organic phosphate flame retardant. Triphenyl phosphate can disrupt placental tryptophan metabolism by activating MAOA/ROS/NFκB, leading to abnormal neurological behavior. Triphenyl phosphate promotes oxidative stress by inducing inflammatory factors like nuclear factor kappa B (NFκB), interleukin-6, and tumor necrosis factor α. Triphenyl phosphate can also cause allergic contact dermatitis .
Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research .
Bunitrolol hydrochloride is an orally active β-adrenergic blocker that has a high affinity for β-adrenergic receptors. Bunitrolol hydrochloride exerts significant β-receptor antagonist activity and has weak α1-blocking activity. Bunitrolol hydrochloride is mainly used in the study of cardiovascular diseases such as hypertension and angina pectoris, and is also used in placental transport research .
15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1) is a stereoisomer of PGE1 (HY-B0131) but with less biological activity . 15-epi-PGE1 is a non-competitive inhibitor for human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) with an IC50 of 170 μM .
Oxybenzone-d5 is the deuterium labeled Oxybenzone[1]. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells[2][3][4].
Oxybenzone (Standard) is the analytical standard of Oxybenzone. This product is intended for research and analytical applications. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
2-Ethylhexyl diphenyl phosphate is an organophosphate flame retardants (OPFRs) and a PPARG agonist (EC20: 2.04 µM). 2-Ethylhexyl diphenyl phosphate also inhibits ERRγ transcriptional activity (IC50: 1.3 µM). 2-Ethylhexyl diphenyl phosphate upregulates 3β-HSD1, human chorionic gonadotropin (hCG) and progesterone secretion. 2-Ethylhexyl diphenyl phosphate can be used in studies of female reproduction and fetal development .
Steroid sulfatase-IN-3 (compound 1q) is a potent STS (Steroid sulfatase) inhibitor, with an IC50 of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC50 of 1.04 µM .
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM) .
GNQWFI, an anti-Flt1 peptide, is a VEGFR1-specific antagonist. GNQWFI blocks the interaction of VEGFR1 with various VEGFR1 ligands, such as VEGFA, VEGFB, and placental growth factor (PIGF) and inhibits VEGF-induced endothelial cell migration and tube formation. GNQWFI is promising for research of cancer, asthma, and other ocular diseases .
Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation .
Nipocalimab (M281) is a fully humanized, recombinant, and non-glycosylated IgG1 monoclonal antibody. Nipocalimab can bind to the IgG-binding site of FcRn with high affinity and inhibit the transplacental transfer of IgG. Nipocalimab can be used in the research of fetal and neonatal hemolytic disease, myasthenia gravis, and various IgG-mediated autoimmune diseases .
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM) .
Placental Lactogen/CSH1 Protein, exclusive to pregnancy, orchestrates lactation, fetal growth, and metabolism. Its unique mode of action involves zinc-induced dimerization of the Prolactin Receptor (PRLR), distinct from the Growth Hormone Receptor (GHR). This specificity and structural versatility underline its pivotal role in intricate pregnancy-related processes and maternal physiology. Placental Lactogen/CSH1 Protein, Human (HEK293, His) is the recombinant human-derived Placental Lactogen/CSH1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Placental Lactogen/CSH1 Protein, Human (HEK293, His) is 191 a.a., with molecular weight of ~22-24 kDa.
The GDF-15 Protein, a significant TGF-beta family member, plays a crucial role in cell growth, differentiation, and immune regulation. Its study enhances understanding of signaling pathways associated with the TGF-beta superfamily and provides insights into its unique contributions to cellular homeostasis. GDF-15's classification within the TGF-beta family underscores its specific role among growth factors. Further exploration promises to enhance our knowledge of its contributions to both normal physiology and disease states, offering potential applications in cancer research, inflammation, and metabolic disorders. GDF-15 Protein, Canine (His) is the recombinant canine-derived GDF-15 protein, expressed by E. coli, with N-His labeled tag. The total length of GDF-15 Protein, Canine (His) is 111 a.a., with molecular weight of 15-20 kDa under reduced (R) condition & 23-26 kDa under Non reduced (N) condition., respectively.
GDF-15 Protein regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stresses. Binding to its receptor, GFRAL, activates GFRAL-expressing neurons in the brainstem, triggering a 'stress response circuit.' This involves neurons in the parabrachial nucleus and central amygdala, shaping feeding responses during stress. Additionally, GDF-15 inhibits growth hormone signaling on hepatocytes. Existing as a disulfide-linked homodimer, it acts as a ligand for GFRAL, mediating GDF15 internalization and cellular signaling through RET. GDF-15 Protein, Rat (His) is the recombinant rat-derived GDF-15 protein, expressed by E. coli, with N-His labeled tag. The total length of GDF-15 Protein, Rat (His) is 115 a.a., with molecular weight of 15-17 kDa.
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Human (Biotinylated, HEK293, Fc) has 112 amino acids expressed by HEK293 cells with N-terminal hFc tag.
Galectin-14/LGALS14 protein has the ability to bind β-galactoside and lactose and can serve as an effective inducer of T cell apoptosis, highlighting its key role in the regulation of immune responses. Animal-Free Galectin-14/LGALS14 Protein, Human (His) is the recombinant human-derived animal-FreeGalectin-14/LGALS14 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.
Placental Lactogen/CSH1 Protein, exclusive to pregnancy, orchestrates lactation, fetal growth, and metabolism. Its unique mode of action involves zinc-induced dimerization of the Prolactin Receptor (PRLR), distinct from the Growth Hormone Receptor (GHR). This specificity and structural versatility underline its pivotal role in intricate pregnancy-related processes and maternal physiology. Placental Lactogen/CSH1 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Placental Lactogen/CSH1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Placental Lactogen/CSH1 Protein, Human (Biotinylated, HEK293, His) is 191 a.a., with molecular weight of ~23.7 KDa.
Cadherin-9 Protein, a calcium-dependent cell adhesion molecule, functions within cellular interactions. Exhibiting calcium-dependent adhesion, CDH9 prefers homophilic interactions, connecting cells. This unique feature suggests a potential role in sorting heterogeneous cell types. The calcium-dependent mechanism underscores cadherins' regulatory role in cellular cohesion within intercellular junctions, maintaining tissue integrity and function. Cadherin-3 Protein, Pig (P.pastoris) is the recombinant pig-derived Cadherin-3 protein, expressed by P. pastoris , with tag free.
GDF-15 Protein, a key regulator of food intake and energy balance, binds to its receptor GFRAL, activating neurons in the brainstem and forming an 'emergency circuit' for feeding responses during stress. Additionally, GDF-15 inhibits growth hormone signaling on hepatocytes, existing as a disulfide-linked homodimer. Interacting with GFRAL, it acts as a ligand, mediating GDF15 internalization and cellular signaling through RET. GDF-15 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived GDF-15 protein, expressed by E. coli , with N-His labeled tag. The total length of GDF-15 Protein, Cynomolgus (His) is 116 a.a., with molecular weight of 15-18 kDa.
The GDF-15 protein is critical for regulating food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stress. It binds to its receptor GFRAL and activates GFRAL-expressing neurons in the brainstem. GDF-15 Protein, Human (Biotinylated, His-Avi) is the recombinant human-derived GDF-15 protein, expressed by E. coli , with C-Avi, N-His labeled tag.
Cadherin-3 Protein, Mouse (HEK293, Fc) is a recombinant mouse Cadherin-3 (P-cadherin) produced in HEK293 cells, with an Fc fragment at the C-terminus. Cadherin-3 is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues.
FOLR2 Protein binds folate, enabling the transport of 5-methyltetrahydrofolate into cells with high affinity under neutral pH. Upon endocytosis, exposure to slightly acidic pH induces a conformational change, substantially reducing FOLR2's folate affinity and releasing it from the receptor. FOLR2 Protein, Human (HEK293, His) is the recombinant human-derived FOLR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR2 Protein, Human (HEK293, His) is 212 a.a., with molecular weight of 28-35 KDa.
Cadherin-3 Protein, Human (630a.a, HEK293, His) is a recombinant human Cadherin-3 (P-cadherin) produced in HEK293 cells, with His tag. Cadherin-3 is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues.
PGF Protein, an essential PDGF/VEGF growth factor family member, influences crucial cellular signaling pathways, promoting cell growth, angiogenesis, and vascular development. Its membership underscores significance in orchestrating processes vital for tissue development. Studying PGF provides insights into its functions, potential therapeutic applications, and impact on vascular processes. Further exploration enhances comprehension of PGF's contribution to both normal physiology and pathological conditions. PGF Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PGF protein, expressed by HEK293, with C-His labeled tag. The total length of PGF Protein, Cynomolgus (HEK293, His) is 149 a.a., with molecular weight of 25-35 kDa.
Alkaline Phosphatase/ALPG Proteinas, an enzyme, effectively hydrolyzes various phosphate compounds. Alkaline Phosphatase/ALPG Protein, Mouse (HEK293, His) is the recombinant mouse-derived Alkaline Phosphatase/ALPG protein, expressed by HEK293, with C-His labeled tag. The total length of Alkaline Phosphatase/ALPG Protein, Mouse (HEK293, His) is 484 a.a., with molecular weight of 55-70 kDa.
Various studies have demonstrated that the BCAT2 protein plays a critical role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic processes necessary for energy production and nitrogen balance. BCAT2 Protein, Human is the recombinant human-derived BCAT2 protein, expressed by E. coli , with tag free. The total length of BCAT2 Protein, Human is 365 a.a., .
HAI-2 Protein functions as an inhibitor for various proteases, including HGFAC, plasmin, and plasma kallikrein.It also inhibits TMPRSS13 and ST14/matriptase, regulating their serine protease activity.The interaction with TMPRSS13 promotes its phosphorylation and cell membrane localization.HAI-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HAI-2 protein, expressed by HEK293 , with C-His labeled tag.
The PRL2A1 protein shows specific expression in the placenta, highlighting its unique role in this reproductive organ. Notably, it showed high expression levels in the invasive trophoblast cells that line the central blood vessels of the placenta, suggesting that these key cells have specialized functions. PRL2A1 Protein, Rat (HEK293, His) is the recombinant rat-derived PRL2A1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PRL2A1 Protein, Rat (HEK293, His) is 199 a.a., with molecular weight of ~24 KDa.
Cadherin-3 protein mediates cell-cell interactions by selectively binding to other cadherin molecules in a homophilic manner. This promotes adhesion between cells, aiding in the sorting and organization of different cell types. Cadherin-3 also interacts with CDCP1 and CTNNB1, regulating cellular processes and signaling pathways. Cadherin-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Cadherin-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-3 Protein, Mouse (HEK293, His) is 548 a.a., with molecular weight of 70-80 kDa.
The Alkaline Phosphatase/ALPG protein, an enzyme, hydrolyzes phosphate compounds, breaking down various molecules. It acts as an alkaline phosphatase, cleaving phosphate esters and rendering molecules inactive. This versatile enzyme is vital in processes like bone mineralization, cellular signaling, and metabolism. Alkaline Phosphatase/ALPG Protein, Human (HEK293, His) is the recombinant human-derived Alkaline Phosphatase/ALPG protein, expressed by HEK293 , with C-His labeled tag. The total length of Alkaline Phosphatase/ALPG Protein, Human (HEK293, His) is 484 a.a., with molecular weight of 58-68 kDa.
Various studies have demonstrated that the BCAT2 protein plays a critical role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic processes necessary for energy production and nitrogen balance. BCAT2 Protein, Human (His, Strep) is the recombinant human-derived BCAT2 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of BCAT2 Protein, Human (His, Strep) is 365 a.a., .
The PRL8A4 protein is involved in regulating cells in the basal zone of the placenta, suggesting a potential impact on placental development. Although important, the specific functions and molecular mechanisms of PRL8A4 in these cells require further exploration. PRL8A4 Protein, Rat (HEK293, His) is the recombinant rat-derived PRL8A4 protein, expressed by HEK293 , with C-His labeled tag. The total length of PRL8A4 Protein, Rat (HEK293, His) is 208 a.a., with molecular weight of ~24 KDa.
The critical role of the TFPI2 protein in regulating plasmin-mediated matrix remodeling suggests its involvement in extracellular matrix dynamics. It inhibits trypsin, plasmin, factor VIIa/tissue factor and weak factor Xa, affecting coagulation and fibrinolysis. TFPI2 Protein, Human (HEK293, His) is the recombinant human-derived TFPI2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TFPI2 Protein, Human (HEK293, His) is 191 a.a., with molecular weight of 18-33 kDa.
Cadherin-3 protein, a calcium-dependent adhesion molecule, facilitates cell interactions. It prefers homophilic interaction with other cadherin-3 proteins, aiding cell connection. This interaction helps sort and organize cell types. Cadherin-3 also interacts with CDCP1 and CTNNB1, impacting cellular processes. Cadherin-3 Protein, Human (547a.a, HEK293, His) is the recombinant human-derived Cadherin-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-3 Protein, Human (547a.a, HEK293, His) is 547 a.a., with molecular weight of 70-80 kDa.
The Alkaline Phosphatase/ALPG protein, an enzyme, hydrolyzes phosphate compounds, breaking down various molecules. It acts as an alkaline phosphatase, cleaving phosphate esters and rendering molecules inactive. This versatile enzyme is vital in processes like bone mineralization, cellular signaling, and metabolism. Alkaline Phosphatase/ALPG Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Alkaline Phosphatase/ALPG protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of Alkaline Phosphatase/ALPG Protein, Human (Biotinylated, HEK293, His-Avi) is 484 a.a., with molecular weight of 56-70 kDa.
Cadherin-9 Protein, a calcium-dependent cell adhesion molecule, functions within cellular interactions. Exhibiting calcium-dependent adhesion, CDH9 prefers homophilic interactions, connecting cells. This unique feature suggests a potential role in sorting heterogeneous cell types. The calcium-dependent mechanism underscores cadherins' regulatory role in cellular cohesion within intercellular junctions, maintaining tissue integrity and function. Cadherin-3 Protein, Cynomolgus (547a.a, HEK293, His) is the recombinant cynomolgus-derived Cadherin-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-3 Protein, Cynomolgus (547a.a, HEK293, His) is 547 a.a., with molecular weight of 70-80 kDa.
The HSPB11 protein is an important component of IFT complex B and is indispensable for sonic eager/SHH signaling. It promotes intraflagellar transport in ciliated tissues such as kidney and testis, mediating the transport of SHH components. HSPB11 Protein, Human (His) is the recombinant human-derived HSPB11 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPB11 Protein, Human (His) is 144 a.a., with molecular weight of ~21.0 kDa.
The critical role of the TFPI2 protein in regulating plasmin-mediated matrix remodeling suggests its involvement in extracellular matrix dynamics. It inhibits trypsin, plasmin, factor VIIa/tissue factor and weak factor Xa, affecting coagulation and fibrinolysis. TFPI2 Protein, Human (HEK293, C-His) is the recombinant human-derived TFPI2 protein, expressed by HEK293 , with C-10*His labeled tag.
Thiamin pyrophosphokinase 1 (TPK1) functions as a homodimer and catalyzes the conversion of thiamine (Vitamin B1) to thiamine pyrophosphate (TDP), a cofactor and a transient intermediate carrier of the aldehyde group for some enzymes of the glycolytic and energy production pathways. TPK1 can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. TPK1 Protein, Human (HEK293, His) is the recombinant human-derived TPK1 protein, expressed by HEK293 , with C-6*His labeled tag.
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Cynomolgus (HEK293, Fc) has 112 amino acids expressed by HEK293 cells with N-terminal hFc tag.
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Mouse (HEK293, Fc) has 115 amino acids expressed by HEK293 cells with N-terminal hFc tag and Fc co-transfection.
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Mouse (HEK293, hFc) has 115 amino acids expressed by HEK293 cells with N-terminal hFc tag.
Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (Trx-His) is the recombinant human-derived Serpin B6 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of Serpin B6 Protein, Human (Trx-His) is 376 a.a., with molecular weight of 58-60 kDa.
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Cynomolgus (Biotinylated, HEK293, Fc) has 112 amino acids expressed by HEK293 cells with N-terminal hFc tag.
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Mouse (Biotinylated, HEK293, Fc) has 115 amino acids expressed by HEK293 cells with N-terminal hFc tag.
Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (sf9, His) is the recombinant human-derived Serpin B6 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Serpin B6 Protein, Human (sf9, His) is 375 a.a., with molecular weight of ~43 kDa.
The S100A4 protein is a calcium-binding protein involved in angiogenesis, cell differentiation, apoptosis, and autophagy. S100A4 protein interacts with MYH9 to enhance cell motility and invasion. S100A4 also inhibits the pro-apoptotic function of TP53 by reducing its protein levels. S100A4 Protein, Human (C-His) is the recombinant human-derived S100A4 protein, expressed by E. coli , with C-6*His labeled tag. The total length of S100A4 Protein, Human (C-His) is 101 a.a., with molecular weight of ~13.0 kDa.
PPL13/LGALS14 is a mammalian placenta-specific galectin with placental specificity. Many placental lectins induce apoptosis of activated T cells and other leukocytes, thereby conferring immune tolerance to the recipient. Galectin-14/LGALS14 Protein, Human (HEK293, His) is the recombinant human-derived Galectin-14/LGALS14 protein, expressed by HEK293 , with C-6*His labeled tag.
The S100A4 protein is a calcium-binding protein involved in angiogenesis, cell differentiation, apoptosis, and autophagy. S100A4 protein interacts with MYH9 to enhance cell motility and invasion. S100A4 also inhibits the pro-apoptotic function of TP53 by reducing its protein levels. S100A4 Protein, Human (C/N-His) is the recombinant human-derived S100A4 protein, expressed by E. coli , with N-6*His, C-6*His labeled tag. The total length of S100A4 Protein, Human (C/N-His) is 101 a.a., with molecular weight of ~13 kDa.
Annexin A4 Protein, Human (His-SUMO, Myc) is the recombinant human-derived Annexin A4, expressed by E. coli Cell-free , with C-Myc, N-SUMO, N-10*His labeled tag. The total length of Annexin A4 Protein, Human (His-SUMO, Myc) is 318 a.a.,
HAI-2 protein is a multifunctional inhibitor that regulates multiple cellular processes by potently inhibiting HGFAC and reducing serine protease activity, specifically TMPRSS13 and ST14/matriptase. HAI-2 is good at inhibiting plasmin, plasma and tissue kallikrein, with broad-spectrum inhibitory capabilities. HAI-2 Protein, Human (HEK293, His) is the recombinant human-derived HAI-2 protein, expressed by HEK293 , with C-6*His labeled tag.
The S100A4 protein, a calcium-binding protein, regulates cellular processes including motility, angiogenesis, differentiation, apoptosis, and autophagy.It interacts with MYH9 to enhance cell motility and chemotaxis.It modulates TP53 to reduce protein levels and stimulates cytokine production.S100A4 forms homodimers and interacts with PPFIBP1, ANXA2, TP53, CCR5, CXCR3, and FCGR3A, inhibiting FCGR3A phosphorylation.S100A4 Protein, Mouse (His) is the recombinant mouse-derived S100A4 protein, expressed by E.coli , with C-6*His labeled tag.
SULT1A3 protein, a sulfotransferase utilizing PAPS, catalyzes the sulfate conjugation of phenolic monoamines, including neurotransmitters (dopamine, norepinephrine, serotonin) and drugs. This activity contributes significantly to inactivation and elimination, emphasizing SULT1A3's crucial role in regulating neurotransmitter and drug levels, maintaining homeostasis, and ensuring proper biological system functioning. SULT1A3 Protein, Human (His) is the recombinant human-derived SULT1A3 protein, expressed by E. coli , with N-6*His labeled tag.
SULT1A3 protein, a sulfotransferase utilizing PAPS, catalyzes the sulfate conjugation of phenolic monoamines, including neurotransmitters (dopamine, norepinephrine, serotonin) and drugs. This activity contributes significantly to inactivation and elimination, emphasizing SULT1A3's crucial role in regulating neurotransmitter and drug levels, maintaining homeostasis, and ensuring proper biological system functioning. SULT1A3 Protein, Human (N-His) is the recombinant human-derived SULT1A3, expressed by E. coli , with N-6*His labeled tag. ,
The SLC19A1 protein acts as an antiporter, importing reduced folate and cyclic dinucleotides by exporting organic anions. It acts as a secondary active transporter, exporting intracellular organic anions to facilitate substrate uptake. SLC19A1 Protein, Human (Sf9, His, Strep, FLAG) is the recombinant human-derived SLC19A1 protein, expressed by Sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag. The total length of SLC19A1 Protein, Human (Sf9, His, Strep, FLAG) is 590 a.a., .
Anastrozole-d12 is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM[1][2].
Exemestane-d2 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
Exemestane-d3 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
Exemestane- 13C3 is the 13C-labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
Exemestane- 13C,d2 is 13C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
Oxybenzone-d5 is the deuterium labeled Oxybenzone[1]. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells[2][3][4].
P-Cadherin Antibody (YA1535) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1535), targeting P-Cadherin, with a predicted molecular weight of 97 kDa (observed band size: 130-150 kDa). P-Cadherin Antibody (YA1535) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
GDF15 Antibody (YA2903) is a non-conjugated IgG antibody, targeting GDF15, with a predicted molecular weight of 34 kDa (observed band size: 34 kDa). GDF15 Antibody (YA2903) can be used for WB experiment in human background.
PLGF Antibody (YA1812) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1812), targeting PLGF, with a predicted molecular weight of 25 kDa (observed band size: 23 kDa). PLGF Antibody (YA1812) can be used for WB, ICC/IF, IHC-P experiment in human, mouse, rat background.
Placental Alkaline Phosphatase Antibody (YA1038) is a non-conjugated IgG1 antibody, targeting Placental Alkaline Phosphatase, with a predicted molecular weight of 58 kDa (observed band size: 70 kDa). Placental Alkaline Phosphatase Antibody (YA1038) can be used for WB experiment in human background.
Placental Alkaline Phosphatase Antibody (YA1039) is a non-conjugated IgG antibody, targeting Placental Alkaline Phosphatase, with a predicted molecular weight of 58 kDa (observed band size: 70 kDa). Placental Alkaline Phosphatase Antibody (YA1039) can be used for WB experiment in human background.
Placental lactogen Antibody (YA1191) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1191), targeting Placental lactogen. Placental lactogen Antibody (YA1191) can be used for IHC-P experiment in human background.
P cadherin Antibody (YA1234) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1234), targeting P cadherin. P cadherin Antibody (YA1234) can be used for IHC-P experiment in human background.
Glycodelin Antibody (YA2193) is a non-conjugated IgG antibody, targeting Glycodelin, with a predicted molecular weight of 21 kDa (observed band size: 24 kDa). Glycodelin Antibody (YA2193) can be used for WB experiment in human background.
PGF Antibody (YA1434) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1434), targeting PGF. PGF Antibody (YA1434) can be used for FC, ELISA experiment in human background.
Syntaxin 4 Antibody (YA1849) is a non-conjugated IgG antibody, targeting Syntaxin 4, with a predicted molecular weight of 34 kDa (observed band size: 34 kDa). Syntaxin 4 Antibody (YA1849) can be used for WB experiment in human, mouse, rat background.
IGFBP1; IBP1; Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; placental protein 12; PP12
WB
Human, Mouse, Rat
IGFBP1 Antibody (YA2410) is a non-conjugated IgG antibody, targeting IGFBP1, with a predicted molecular weight of 28 kDa (observed band size: 28 kDa). IGFBP1 Antibody (YA2410) can be used for WB experiment in human, mouse, rat background.
18A2 antibody;
42A antibody;
calcium placental protein antibody;
Calvasculin antibody;
CAPL antibody;
Fibroblast specific protein 1 (FSP1) antibody;
Fibroblast specific protein 1 antibody;
Fibroblast specific protein antibody;
FSP1 antibody;
Leukemia multidrug resistance associated protein antibody;
Malignant transformation suppression 1 (MTS1) antibody;
Malignant transformation suppression 1 antibody;
Metastasin antibody;
MTS1 antibody;
OTTHUMP00000015467 antibody;
OTTHUMP00000015468 antibody;
P9KA antibody;
PEL98 antibody;
placental calcium-binding protein antibody;
Protein Mts1 antibody;
Protein S100 A4 antibody;
Protein S100-A4 antibody;
S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) antibody;
S100 calcium binding protein A4 antibody;
S100 calcium-binding protein A4 antibody;
S100a4 antibody;
S10A4_HUMAN antibody;
WB, ICC/IF, IHC-P, IP, FC
Human, Mouse
S100A4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 12 kDa, targeting to S100A4. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.
ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; placental anticoagulant protein IV; PAP-IV; Protein I; p36
WB, IP
Human
Annexin 2 Antibody (YA2711) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2711), targeting Annexin 2, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Annexin 2 Antibody (YA2711) can be used for WB, IP experiment in human background.
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