Search Result

Results for "

suppression

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (1) Adenosine Receptor (2) Adrenergic Receptor (4) Akt (3) AMPK (1) Amyloid-β (3) Angiotensin Receptor (1) Antibiotic (6) Antifolate (1) Apoptosis (32) Autophagy (10) Bacterial (12) Bcl-2 Family (3) Bcr-Abl (2) c-Kit (2) c-Met/HGFR (3) Calcium Channel (1) CCR (1) CDK (2) Complement System (1) COX (3) CXCR (1) Cytochrome P450 (1) DGK (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (6) Dopamine Receptor (4) DYRK (1) E1/E2/E3 Enzyme (1) EGFR (3) Endogenous Metabolite (9) Epigenetic Reader Domain (3) ERK (5) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (1) FAK (2) Ferroptosis (2) FGFR (1) FLT3 (2) Fungal (2) G Protein-coupled Receptor Kinase (GRK) (1) Glucocorticoid Receptor (2) Glutathione Peroxidase (1) GnRH Receptor (1) Guanylate Cyclase (1) HBV (4) HCV (1) HDAC (3) Histamine Receptor (1) Histone Methyltransferase (1) HIV (2) HSP (2) HSV (1) IAP (2) IGF-1R (2) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (4) Liposome (1) LXR (2) MALT1 (1) MAP4K (1) MAPKAPK2 (MK2) (2) MDM-2/p53 (3) Melanocortin Receptor (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) mTOR (4) Myosin (2) NF-κB (18) NO Synthase (2) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (1) Organoid (2) Orphan Receptor (1) Oxidative Phosphorylation (1) P-glycoprotein (2) Parasite (4) PD-1/PD-L1 (1) PDGFR (3) PERK (1) Phosphatase (3) PI3K (5) PKC (2) Potassium Channel (1) PPAR (2) Progesterone Receptor (5) PROTACs (1) Proteasome (1) PSMA (1) RAD51 (2) Raf (3) RAR/RXR (1) Ras (3) Reactive Oxygen Species (4) RET (2) Sirtuin (1) STAT (3) TGF-beta/Smad (2) TGF-β Receptor (2) Thymidylate Synthase (1) TNF Receptor (3) Toll-like Receptor (TLR) (2) Trk Receptor (1) Tyrosinase (1) VD/VDR (1) VEGFR (3)
By Research Areas:	Cancer (105) Cardiovascular Disease (23) Endocrinology (10) Infection (30) Inflammation/Immunology (47) Metabolic Disease (19) Neurological Disease (18)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Nucleosides and their Analogs (1) Aptamers (1) Cationic Lipids (1) Antisense Oligonucleotides (4)

198

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3465

Bulevirtide 2 Publications Verification Myrcludex B	HBV	Infection
Bulevirtide (Myrcludex B) is a NTCP inhibitor, a linear lipopeptide of 47 amino acids. Bulevirtide inhibits HBV and HDV entry into liver cells, blocks HBV infection in hepatocytes, and participates in HBV transcriptional suppression. Bulevirtide can be used in HDV infection and compensated cirrhosis research .

HY-14530

Pelitrexol 1 Publications Verification AG 2037	Antifolate	Cancer
Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice .

HY-10431

SB-431542 Maximum Cited Publications 194 Publications Verification	Organoid TGF-β Receptor Apoptosis	Cancer
SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC₅₀ values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways .

HY-10431R

SB-431542 (Standard)	Apoptosis TGF-β Receptor Organoid	Cancer
SB-431542 (Standard) is the analytical standard of SB-431542. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC₅₀ values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways .

HY-126428

ZL0580	HIV Epigenetic Reader Domain	Infection Inflammation/Immunology
ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter .

HY-N0113

Hordenine 1 Publications Verification Ordenina; Peyocactine	Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-160449

p53 Activator 10	MDM-2/p53	Cancer
p53 Activator 10 (Example C-2) is a compound that targets the y220c mutant of p53. p53 Activator 10 activation is involved in the downstream effects of tumor suppression .

HY-147783

Anticancer agent 68	MDM-2/p53	Cancer
Anticancer agent 68 is (Compound 12) is an anti-cancer agent. Anticancer agent 68 arrests the cells at the G2/M phase and induces programmed cell death. Anticancer agent 68 induces upregulation of tumor suppression via activation of p53 & PTEN .

HY-B0689C

(threo)-Indinavir (threo)-MK-639; (threo)-L735524	Others	Infection
(Threo)-Indinavir is a protease inhibitor that plays an important role in HIV/AIDS suppression. (Threo)-Indinavir is used as a component of highly active antiretroviral suppression. By inhibiting the viral protease, (threo)-Indinavir ((threo)-MK-639) is able to effectively block the replication of the HIV virus .

HY-78726A

Fosamprenavir sodium Amprenavir phosphate sodium; GW 433908 sodium	HIV Endogenous Metabolite	Infection
Fosamprenavir sodium (Amprenavir phosphate sodium) is an anti-HIV drug with antiviral activity. Fosamprenavir sodium is a water-soluble prodrug of amprenavir. Fosamprenavir sodium can help achieve and maintain viral suppression during antiretroviral suppression, thereby reducing the risk of HIV transmission through breast milk. Fosamprenavir sodium is not recommended for use during breastfeeding .

HY-N0113B

Hordenine hydrochloride 1 Publications Verification Ordenina hydrochloride; Peyocactine hydrochloride	Antibiotic	Infection
Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-B1214

Prednisolone acetate Prednisolone 21-acetate	Glucocorticoid Receptor	Inflammation/Immunology Cancer
Prednisolone acetate (Prednisolone 21-acetate) is an adrenocortical hormone active molecule with various pharmacological effects such as anti-inflammatory, anti-allergic, and immune suppression.

HY-N10114

Hyperectumine	Others	Inflammation/Immunology
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-14742

Faxeladol	Others	Others
Faxeladol is a compound with analgesic activity that reduced mean pain intensity compared with placebo in a suppression trial for painful polyneuropathy with a favorable safety profile.

HY-N0644

Carnosic acid 5 Publications Verification	Apoptosis Bacterial	Inflammation/Immunology Cancer
Carnosic acid is an orally active lipid absorption inhibitor. Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity.

HY-113261

Oleoylcarnitine	Endogenous Metabolite	Metabolic Disease Cancer
Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-119720

Neocryptotanshinone	NF-κB NO Synthase	Inflammation/Immunology
Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways .

HY-N0671

Rhapontin 1 Publications Verification Rhaponiticin	Apoptosis	Cancer
Rhapontin (Rhaponiticin), a component of rhubarb (Rheum officinale Baill), induces apoptosis resulting in suppression of proliferation of human stomach cancer KATO III cells .

HY-161248

E7130	Microtubule/Tubulin	Cancer
E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling .

HY-162004

NF-κB-IN-14	NF-κB Toll-like Receptor (TLR)	Inflammation/Immunology
NF-κB-IN-14 (compound 5e) significantly inhibits nitric oxide production in LPS-induced macrophages (IC₅₀: 6.4 μM). NF-κB-IN-14 disrupts the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway suppression. NF-κB-IN-14 reduces ear edema and inflammation in an atopic dermatitis mouse model .

HY-156602

Bocodepsin OKI-179	HDAC	Cancer
Bocodepsin (OKI-179) is an orally active and selective HDAC inhibitor, with antitumor activity. Bocodepsin can be used for suppression on solid tumor and hematologic malignancies .

HY-156602A

Bocodepsin hydrochloride OKI-179 hydrochloride	HDAC	Cancer
Bocodepsin hydrochloride (OKI-179) is an orally active and selective HDAC inhibitor, with antitumor activity. Bocodepsin hydrochloride can be used for suppression on solid tumor and hematologic malignancies .

HY-W747648

(+)-Norgestrel	Others	Others
(+)-Norgestrel is a progestin used in birth control pills that has reproductive hormone-regulating activity. (+)-Norgestrel also plays an important role in menopausal hormone suppression .

HY-P6176

JLB2-110c	Melanocortin Receptor	Metabolic Disease Endocrinology
JLB2-110c activates MCRs receptor (mMC4R EC₅₀ = 0.34 nM) and has a strong in vivo appetite suppressant effect .

HY-126287

JND4135	Trk Receptor Apoptosis	Cancer
JND4135 is a Type II TRK inhibitor with IC₅₀ values of 2.79, 3.19, and 3.01 nM against TRKA, TRKB, TRKC, respectively. JND4135 can overcome resistance from TRK xDFG and other mutant forms in the BaF3 stable model, inhibiting phosphorylation of both WT and xDFG mutant TRKs, along with their downstream signaling molecules. JND4135 can induce G0/G1 phase arrest and apoptosis in BaF3–CD74-TRKA-G667C cells. JND4135 shows tumor growth inhibition activity in the BaF3-CD74-TRKA-G667C mouse xenograft model .

HY-B0795

MHY1485 125+ Cited Publications	mTOR Autophagy	Cancer
MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes .

HY-136448

SJ000025081	Parasite	Infection
SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii .

HY-B1318

Foscarnet sodium 2 Publications Verification Trisodium phosphonoformate; Phosphonoformic acid trisodium salt	DNA/RNA Synthesis	Infection
Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis .

HY-156394

Laxiflorin B-4	ERK	Cancer
Laxiflorin B-4 is modificative compound of Laxiflorin B (HY-156393), exhibited higher affinity for ERK1/2 and stronger tumor suppression .

HY-162069

Antiviral agent 47	HSV	Infection
Antiviral agent 47 (Compound 26) is an antiviral agent, which inhibits HSV-1 with ID₅₀ of 16 μM, through suppression of herpes virus replication .

HY-121850

Rolicyprine EX-4883	HBV	Neurological Disease
Rolicyprine (EX-4883) is an antidepressant with neuroprotective activity. Rolicyprine can improve depressive symptoms and promote neuroregeneration. Rolicyprine also shows potential effectiveness for anxiety suppression .

HY-N15152

Isoaesculioside D	Others	Metabolic Disease
Isoaesculioside D (compound 3) is an agent for preventing or ameliorating skin aging. Isoaesculioside D exhibits an excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin .

HY-145306

DX3-234	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-234 shows significant tumor suppression in the Pan02 syngeneic model of pancreatic cancer .

HY-P99554

Topsalysin PRX-302	PSMA	Cancer
Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle .

HY-N0113R

Hordenine (Standard) Ordenina (Standard); Peyocactine (Standard)	Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine (Standard) is the analytical standard of Hordenine. This product is intended for research and analytical applications. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0644R

Carnosic acid (Standard)	Apoptosis Bacterial	Cancer
Carnosic acid (Standard) is the analytical standard of Carnosic acid. This product is intended for research and analytical applications. Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity .

HY-123662

AGN-201904Z	Others	Others
AGN-201904Z is a compound that inhibits gastric acid secretion and is a new type of proton pump inhibitor that can produce more significant and lasting acid suppression effects than esomeprazole.

HY-N0113S

Hordenine-d6 Ordenina-d₆; Peyocactine-d₆	Isotope-Labeled Compounds Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-126730

Rubratoxin A	Phosphatase	Cancer
Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A) with an IC₅₀ of 170 nM. Rubratoxin A causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts .

HY-122949

Momordicine I	DGK	Metabolic Disease
Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ .

HY-153670

IPG7236	CCR	Cancer
IPG7236 is a selective CCR8 antagonist. IPG7236 exhibits significant tumor suppression in a mouse xenograft model of human breast cancer. IPG7236 can be used in cancer research .

HY-122200

Phenamacril JS399-19	Myosin Fungal	Infection
Phenamacril (JS399-19) inhibits activity of myosin I non-competitively with an IC₅₀ of 360 nM through suppression of the ATPase activity, exhibits therefore an antifungal efficacy towards Fusarium species .

HY-162457

Mn007	Others	Infection
Mn007 is a potent inhibitor of bovine pancreatic DNase I, with the IC₅₀ of 45 μM, by forming molecular aggregation. Mn007 shows suppression of S. pyogenes growth in human whole blood .

HY-121423

Dimethachlor	Apoptosis Reactive Oxygen Species	Metabolic Disease
Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .

HY-14915

Bedoradrine	Adrenergic Receptor	Endocrinology
Bedoradrine is a highly selective β2-adrenergic agonist with activity in suppressing asthma and chronic obstructive pulmonary disease (COPD). Bedoradrine is administered by intravenous infusion and is specifically indicated for the suppression of acute asthma attacks. Bedoradrine has shown good safety and preliminary efficacy in clinical trials, especially in patients with stable moderate to severe asthma. The results of Bedoradrine studies have shown that it can provide clinical benefits without increasing clinical risks, especially for patients who are unable to use inhalation or nebulization suppression .

HY-101021

Ascochlorin Ilicicolin D	STAT Apoptosis Antibiotic	Inflammation/Immunology Cancer
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity .

HY-122720

SEC inhibitor KL-1 1 Publications Verification KL-1	Apoptosis	Cancer
SEC inhibitor KL-1 (KL-1) is a peptide-like lead compound that is an effective selective SEC inhibitor. SEC inhibitor KL-1 promotes apoptosis and has anti-tumor activity. SEC inhibitor KL-1 doses dependently inhibits the AFF4-CCNT1 interaction, with a Ki value of 3.48 μM .

HY-145414

DYSP-C34	Reactive Oxygen Species	Cancer
DYSP-C34 is a potent, biocompatible, and ultrasound (US)-triggered multifunctional molecular machine. DYSP-C34 has multiple favorable properties, such as improved lipophilic/hydrophilic balance, intensified US-induced ROS production capacity, and better cellular permeability, resulting in the excellent tumor target efficiency and notable sonodynamic therapy (SDT)-mediated tumor regression. DYSP-C34 exhibits mild immunogenicity by stimulating APCs directly .

HY-W013256

Foscarnet trisodium hexahydrate 2 Publications Verification Trisodium phosphonoformate hexahydrate; Phosphonoformic acid trisodium salt hexahydrate	DNA/RNA Synthesis	Infection
Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis .

HY-101633

GSK-1004723	Others	Others
GSK-1004723 is a novel H1/H3 receptor antagonist with limited activity for the suppression of seasonal allergic rhinitis. GSK-1004723 is available as a suspension or solution for intranasal administration.

Cat. No.	Product Name	Type

HY-147087

YSK 05	Drug Delivery
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .

Cat. No.	Product Name	Target	Research Area

HY-P3465

Bulevirtide 2 Publications Verification Myrcludex B	HBV	Infection
Bulevirtide (Myrcludex B) is a NTCP inhibitor, a linear lipopeptide of 47 amino acids. Bulevirtide inhibits HBV and HDV entry into liver cells, blocks HBV infection in hepatocytes, and participates in HBV transcriptional suppression. Bulevirtide can be used in HDV infection and compensated cirrhosis research .

HY-P1401

Protein Kinase C (19-36)	PKC	Metabolic Disease
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC₅₀ of 0.18 μM. Protein Kinase C (19-36) markedly attenuated vascular hyperproliferation and hypertrophy as well as glucose-induced suppression of natriuretic peptide receptor response .

HY-P4190

Fsh receptor-binding inhibitor fragment(bi-10)	GnRH Receptor	Endocrinology
FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries .

HY-P6176

JLB2-110c	Melanocortin Receptor	Metabolic Disease Endocrinology
JLB2-110c activates MCRs receptor (mMC4R EC₅₀ = 0.34 nM) and has a strong in vivo appetite suppressant effect .

HY-P3472

Cyclo(IP) Cyclo(L-Pro-L-Ile)	Peptides	Inflammation/Immunology
Cyclo(IP) (Cyclo-(L-Pro-L-Ile)), a Diketopiperazine can be derived From Bacillus thuringiensis JCK-1233, results in suppression of PWD severity and increased the expression of defense-related genes similarly to Bacillus thuringiensis JCK-1233 treatment .

Cat. No.	Product Name	Target	Research Area

HY-P99203

Cemiplimab	PD-1/PD-L1	Cancer
Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research .

HY-108810

Canakinumab Ilaris; ACZ 885	Interleukin Related	Inflammation/Immunology Cancer
Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC₅₀ values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin .

HY-P99554

Topsalysin PRX-302	PSMA	Cancer
Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0113

Hordenine 1 Publications Verification Ordenina; Peyocactine	Cardiovascular Disease Alkaloids Structural Classification Monophenols other families Classification of Application Fields Other Alkaloids Source classification Phenols Plants Disease Research Fields	Bacterial Antibiotic
Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0113B

Hordenine hydrochloride 1 Publications Verification Ordenina hydrochloride; Peyocactine hydrochloride	Coryphantha vivipara var arizonica Structural Classification Alkaloids Monophenols Cactaceae Other Alkaloids Source classification Phenols Plants	Antibiotic
Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0644

Carnosic acid 5 Publications Verification	Structural Classification Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Labiatae Phenols Polyphenols Diterpenoids Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bacterial
Carnosic acid is an orally active lipid absorption inhibitor. Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity.

HY-113261

Oleoylcarnitine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-119720

Neocryptotanshinone	Quinones Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants Naphthalene Quinones Inflammation/Immunology Disease Research Fields	NF-κB NO Synthase
Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways .

HY-N0671

Rhapontin 1 Publications Verification Rhaponiticin	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Rhapontin (Rhaponiticin), a component of rhubarb (Rheum officinale Baill), induces apoptosis resulting in suppression of proliferation of human stomach cancer KATO III cells .

HY-N10114

Hyperectumine	Alkaloids Classification of Application Fields Source classification Hypecoum erectum L. Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Papaveraceae	Others
Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.

HY-N15152

Isoaesculioside D	Triterpenes Structural Classification Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants	Others
Isoaesculioside D (compound 3) is an agent for preventing or ameliorating skin aging. Isoaesculioside D exhibits an excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin .

HY-N0113R

Hordenine (Standard) Ordenina (Standard); Peyocactine (Standard)	Cardiovascular Disease Structural Classification Alkaloids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	Bacterial Antibiotic
Hordenine (Standard) is the analytical standard of Hordenine. This product is intended for research and analytical applications. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0644R

Carnosic acid (Standard)	Structural Classification Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Labiatae Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bacterial
Carnosic acid (Standard) is the analytical standard of Carnosic acid. This product is intended for research and analytical applications. Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity .

HY-122949

Momordicine I	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	DGK
Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ .

HY-101021

Ascochlorin Ilicicolin D	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Disease Research Plants Other Antibiotics Microorganisms other families Antibiotics Phenols Polyphenols Anticancer Inflammation/Immunology Disease Research Fields	STAT Apoptosis Antibiotic
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity .

HY-N0587

Demethylzeylasteral 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants Inflammation/Immunology Disease Research Fields	Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK
Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation ^[1][2].

HY-113261R

Oleoylcarnitine (Standard)	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Oleoylcarnitine (Standard) is the analytical standard of Oleoylcarnitine. This product is intended for research and analytical applications. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-N8087

Epimedin K Korepimedoside B	Cardiovascular Disease Flavonols Flavonoids Monophenols Classification of Application Fields Epimedium koreanum Nakai Source classification Phenols Plants Berberidaceae Disease Research Fields Inflammation/Immunology	Others
Epimedin K (Korepimedoside B), a flavonol glycoside, is isolated from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a famous Chinese herbal medicine for the research of impotence, osteoporosis, immune suppression and cardiovascular diseases .

HY-N8086

Korepimedoside C Epimedin I	Cardiovascular Disease Flavonols Flavonoids Monophenols Classification of Application Fields Epimedium koreanum Nakai Source classification Phenols Plants Berberidaceae Disease Research Fields Inflammation/Immunology	Others
Korepimedoside C (Epimedin I), a flavonol glycoside, is isolated from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a famous Chinese herbal medicine for the research of impotence, osteoporosis, immune suppression and cardiovascular diseases .

HY-N0671R

Rhapontin (Standard) Rhaponiticin (Standard)	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Plants Disease Research Fields Cancer	Apoptosis
Rhapontin (Standard) is the analytical standard of Rhapontin. This product is intended for research and analytical applications. Rhapontin (Rhaponiticin), a component of rhubarb (Rheum officinale Baill), induces apoptosis resulting in suppression of proliferation of human stomach cancer KATO III cells .

HY-129482

Detoxin D1	Structural Classification Natural Products Microorganisms Source classification	Others
Detoxin D1 is a compound with antihistamine activity and a new type of H1 antagonist. In the suppression of seasonal allergic rhinitis, a daily dose of 10-30 mg has an equivalent and highly effective inhibitory effect compared with placebo and has good safety.

HY-13906

Largazole (+)-Largazole	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
Largazole ((+)-Largazole) is a potent and selective histone deacetylase (HDAC) inhibitor with antiproliferative activity. Largazole is able to modulate gene expression and affect cell growth and differentiation. Largazole has also shown potential application value in anti-tumor suppression .

HY-N2078

Yamogenin Neodiosgenin	Structural Classification other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Steroids	LXR
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-N1231

Sophoraflavanone G 1 Publications Verification Kushenol F	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Sophora flavescens Aiton Plants Disease Research Fields Cancer	Apoptosis
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .

HY-N2602

Sanggenol L	Structural Classification Flavonoids Classification of Application Fields Morus mongolica (Bur.) Schneid. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	MDM-2/p53
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

HY-N0613

Sauchinone 1 Publications Verification	Structural Classification Saururaceae Classification of Application Fields Saururus chinensis (Lour.) Baill. Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-N7119

Cimicifugoside	Triterpenes Classification of Application Fields Terpenoids Source classification Ranunculaceae Plants Cimicifuga foetida Linn. Disease Research Fields Inflammation/Immunology	Others
Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity . Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function .

HY-126601

Malonganenone A	Infection Structural Classification Alkaloids Classification of Application Fields Animals Other Alkaloids Source classification Disease Research Fields	Parasite HSP
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x .

HY-N0587R

Demethylzeylasteral (Standard)	Triterpenes Structural Classification Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants	Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK
Demethylzeylasteral (Standard) is the analytical standard of Demethylzeylasteral. This product is intended for research and analytical applications. Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation .

HY-N2078R

Yamogenin (Standard)	Structural Classification other families Source classification Plants Steroids	LXR
Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-N6246

Asperulosidic Acid	Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields	NF-κB ERK
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities . ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .

HY-N0478

Neoline 1 Publications Verification Bullatine B	Alkaloids Piperidine Alkaloids Structural Classification other families Source classification Plants	Others
Neoline (Bullatine B)) is the active ingredient of the active ingredient (PA), which can be used to cure the disease. Neoline Flow Suppression Nav1.7 Electrical Flow Control (VGSC)，Improve diabetes mechanical pain sensitivity. Neoline has a list of compounds that can be used, research on its use, and the quality of its processing during processing in pain.

HY-N2329

Piperlongumine 5+ Cited Publications Piplartine	Piper longum Linn. Infection Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Piperaceae Plants Disease Research Fields	ERK Reactive Oxygen Species Autophagy Apoptosis Bacterial Ferroptosis
Piperlongumine is a alkaloid , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities . Piperlongumine induces ROS, and induces apoptosis in cancer cell lines . Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome .

HY-107818

4-Hydroxychalcone	Cardiovascular Disease Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	NF-κB
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .

HY-N0148A

Rutin hydrate Maximum Cited Publications 11 Publications Verification Rutoside hydrate; Quercetin 3-O-rutinoside hydrate	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N3289A

(E)-Methyl 3,4,5-trimethoxycinnamate	Simple Phenylpropanols Piper tuberculatum jacq. Source classification Piperaceae Phenylpropanoids Plants	Others
(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes .

HY-122552

Chrysotobibenzyl	Structural Classification Natural Products Orchidaceae Source classification Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl.	Integrin
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394) .

HY-N1231R

Sophoraflavanone G (Standard)	Structural Classification Flavonoids Leguminosae Flavonones Source classification Phenols Polyphenols Sophora flavescens Aiton Plants	Apoptosis
Sophoraflavanone G (Standard) is the analytical standard of Sophoraflavanone G. This product is intended for research and analytical applications. Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .

HY-N0613R

Sauchinone (Standard)	Structural Classification Saururaceae Saururus chinensis (Lour.) Baill. Terpenoids Source classification Diterpenoids Plants	NF-κB
Sauchinone (Standard) is the analytical standard of Sauchinone. This product is intended for research and analytical applications. Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-N0107

Cyclovirobuxine D	Cardiovascular Disease Structural Classification Alkaloids Buxaceae Classification of Application Fields Other Alkaloids Plants Disease Research Fields Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.	Apoptosis Autophagy mTOR Akt
Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR . Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis . Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction .

HY-N0074

Byakangelicol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Inflammation/Immunology Disease Research Fields	COX
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory agent on airway inflammation .

HY-N2453

Convallatoxin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Adonis amurensis Regel et Radde Plants Inflammation/Immunology Disease Research Fields	PPAR NF-κB P-glycoprotein
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-N0148

Rutin Maximum Cited Publications 11 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Leguminosae Sunscreen Phenols Polyphenols Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N6246R

Asperulosidic Acid (Standard)	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Morinda officinalis How	NF-κB ERK
Asperulosidic Acid (Standard) is the analytical standard of Asperulosidic Acid. This product is intended for research and analytical applications. Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities . ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .

HY-17473

Embelin 4 Publications Verification Embelic acid; Emberine; NSC 91874	Quinones Structural Classification Classification of Application Fields Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae Disease Research Fields Cancer	IAP NF-κB Apoptosis Autophagy
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC₅₀=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-N0084

Betulinaldehyde 4 Publications Verification Betulinic aldehyde; Betunal	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Bacterial
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca ²⁺/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research .

HY-N0908

Ginsenoside Rg5 2 Publications Verification	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae Endocrinology	IGF-1R NF-κB COX
Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-N2453R

Convallatoxin (Standard)	Triterpenes Structural Classification Terpenoids Ranunculaceae Adonis amurensis Regel et Radde Plants	PPAR NF-κB P-glycoprotein
Convallatoxin (Standard) is the analytical standard of Convallatoxin. This product is intended for research and analytical applications. Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-N0107R

Cyclovirobuxine D (Standard)	Structural Classification Alkaloids Buxaceae Other Alkaloids Plants Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.	Apoptosis Autophagy mTOR Akt
Cyclovirobuxine D (Standard) is the analytical standard of Cyclovirobuxine D. This product is intended for research and analytical applications. Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR . Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis . Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction .

HY-N0617

Sanggenon C 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Moraceae Flavanonols Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Morus alba Linn.	Phosphatase ERK NF-κB Apoptosis
Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .

HY-N0148R

Rutin (Standard)	Flavonols Structural Classification Flavonoids other families Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants Convolvulaceae Inflammation/Immunology Disease Research Fields Ipomoea batatas (Linn.) Lamarck	Akt NF-κB
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases .

HY-N10503

Norartocarpetin	Structural Classification Flavonoids Flavones Plants Moraceae	Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis
Norartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC₅₀ value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC₅₀ value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells .

Cat. No.	Compare	Product Name	Species	Source

HY-P70076

	DAND1 Protein, Mouse (HEK293, His) rMuNeuroblastoma suppressor of tumorigenicity 1/DAND1, His; DAND1; NBL1; DAN domain family member 1; neuroblastoma suppressor of tumorigenicity 1; Protein N03; suppression of tumorigenicity 1	Mouse	HEK293
	DAND1 protein, identified as a potential tumor suppressor gene in neuroblastoma, plays a pivotal role in inhibiting cells from progressing into the crucial G1/S stage of the transformation process.As a homodimer, DAND1 underscores its involvement in regulatory mechanisms governing cellular transformation and contributing to the maintenance of normal cellular growth control.DAND1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DAND1 protein, expressed by HEK293 , with C-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-N0113S

Hordenine-d6
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-111614S2

Melengestrol acetate-d3

Melengestrol acetate-d₃ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-B0439S1

Sulfadoxine D3

Sulfadoxine-d₃ is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

HY-113261S

Oleoylcarnitine-d9
Oleoylcarnitine-d₉ is deuterium labeled Oleoylcarnitine. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .

HY-111614S

Melengestrol acetate-d6

Melengestrol acetate-d₆ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-111614S1

Melengestrol acetate-d2

Melengestrol acetate-d₂ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-B1901S

Eperisone-d10 hydrochloride

Eperisone-d₁₀ (hydrochloride) is the deuterium labeled Eperisone hydrochloride. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[1][2 [3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80317

	S100A4 Antibody 18A2 antibody; 42A antibody; calcium Placental protein antibody; Calvasculin antibody; CAPL antibody; Fibroblast specific protein 1 (FSP1) antibody; Fibroblast specific protein 1 antibody; Fibroblast specific protein antibody; FSP1 antibody; Leukemia multidrug resistance associated protein antibody; Malignant transformation suppression 1 (MTS1) antibody; Malignant transformation suppression 1 antibody; Metastasin antibody; MTS1 antibody; OTTHUMP00000015467 antibody; OTTHUMP00000015468 antibody; P9KA antibody; PEL98 antibody; Placental calcium-binding protein antibody; Protein Mts1 antibody; Protein S100 A4 antibody; Protein S100-A4 antibody; S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) antibody; S100 calcium binding protein A4 antibody; S100 calcium-binding protein A4 antibody; S100a4 antibody; S10A4_HUMAN antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	S100A4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 12 kDa, targeting to S100A4. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-129510

4-Methyl erlotinib		Alkynes
4-Methyl erlotinib, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. 4-Methyl erlotinib potently inhibits EGF-mediated tumor cell mitosis by reducing EGFr-specific tyrosine phosphorylation. Using a mouse model of human tumor transplantation, 4-Methyl erlotinib demonstrated significant and sustained suppression of EGFr phosphotyrosine levels, resulting in significant growth inhibition of EGFr-dependent human cancers .

Cat. No.	Product Name		Classification

HY-145729A

Danvatirsen sodium AZD9150 sodium		Antisense Oligonucleotides
Danvatirsen sodium is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen sodium binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

HY-147087

YSK 05		Cationic Lipids
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .

HY-154508

FdUMP triethylammonium 2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium		Nucleosides and their Analogs
FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

HY-153494

Rosomidnar PNT100		Antisense Oligonucleotides
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-153494A

Rosomidnar sodium PNT100 sodium		Antisense Oligonucleotides
PNT100 sodium is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-145729

Danvatirsen AZD9150		Antisense Oligonucleotides
Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

HY-147081

AS 1411 AGRO-100		Aptamers
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks