mAChR

Muscarinic acetylcholine receptor

mAChR

mAChR Isoform Specific Products:

mAChR Isoform Comparison

mAChR Related Products (577)
Antibodies (2)
mAChR Isoform Comparison

By Effects:	Controls (6) Inhibitors (97) Ligand (1) Agonists (115) Antagonists (277) Activators (10) Modulators (35) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-155819

M3/PDE4 modulator-1	Antagonist
M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PDE4 modulator-1 (10-1000 nM/kg; iv) reduces cysteine eosinophil influx in the OVA rat model.

HY-N0214A

Peimisine hydrochloride	Antagonist
Peimisine (Ebeiensine) hydrochloride is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine hydrochloride shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research.

HY-22437S1

(±)-Darifenacin-d₄ hydrobromide	Antagonist
(±)-Darifenacin-d₄ (hydrobromide) is deuterium labeled (±)-Darifenacin. (±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist[1].

HY-W014208

NGX-267	Agonist
NGX-267 is a selective agonist of the actin M1 receptor, which has high selectivity among the five actin receptor subtypes, especially for the M1 receptor rather than the M3 receptor. NGX-267 also has significant differences in affinity for dopamine D2 and 5-HT2B receptors.

HY-W743804

Aclidinium-d₅ bromide	Antagonist
Aclidinium-d₅ (LAS 34273-d₅; LAS-W 330-d₅) bromide is deuterium-labeled Aclidinium Bromide (HY-14144).

HY-90010R

Tolterodine (tartrate) (Standard)	Antagonist
Tolterodine (tartrate) (Standard) is the analytical standard of Tolterodine (tartrate). This product is intended for research and analytical applications. Tolterodine Tartrate (Kabi-2234; PNU-200583E) is a potent muscarinic receptor antagonist and shows selectivity for the urinary bladder over salivary glands in vivo.

HY-129826

J-104129	Antagonist
J-104129 is a selective and orally active muscarinic M3 receptor antagonist (K_i = 4.2 nM). J-104129 is effective in promoting bronchodilation.

HY-B0267AR

Oxybutynin chloride (Standard)	Antagonist
Oxybutynin (chloride) (Standard) is the analytical standard of Oxybutynin (chloride). This product is intended for research and analytical applications. Oxybutynin chloride is an oral active and competitive mAChR antagonist with K_is of 14.3 and 5.55 nM for specific [³H]NMS binding in the mouse bladder and cerebral cortex, respectively. Oxybutynin chloride inhibits vascular Kv channels in a manner independent of anticholinergic effect, with an IC₅₀ value of 11.51 μM. Oxybutynin chloride reduces muscle spasm in the bladder and urinary tract, can be used in study of overactive bladder syndrome (OAB). Oxybutynin (chloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0083C

Methacholine iodide	Agonist
Methacholine iodide is a potent muscarinic-3 (M3) agonist. Methacholine iodide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine iodide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine iodide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.

HY-120576

ML169	Modulator
ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M₁ mAChR, with an EC₅₀ of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease.

HY-148527

LAS190792	Antagonist
LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC₅₀ 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilator.

HY-136634

BTM-1042	Inhibitor
BTM-1042 is a newly synthesized compound with antispasmodic effects. It can inhibit the twitch reaction of the guinea pig ileum under electrical stimulation and is not affected by naloxone. It has similar effects to atropine and can block muscarinic receptors, but has less effect on other types of receptors. BTM-1042 also has an inhibitory effect on the ileal reaction caused by nicotine and 5-hydroxytryptamine. BTM-1042 showed a dose-dependent inhibitory effect on the spontaneous movement of the rabbit stomach. In general, BTM-1042 is a agent with a strong antispasmodic effect.

HY-A0030S

Fesoterodine-d₇ fumarate
Fesoterodine-d₇ (fumarate) is the deuterium labeled Fesoterodine fumarate[1]. Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB)[2][3].

HY-B1487R

Procyclidine (hydrochloride) (Standard)	Antagonist
Procyclidine (hydrochloride) (Standard) is the analytical standard of Procyclidine (hydrochloride). This product is intended for research and analytical applications. Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy.

HY-13204R

Biperiden (hydrochloride) (Standard)	Inhibitor
Biperiden (hydrochloride) (Standard) is the analytical standard of Biperiden (hydrochloride). This product is intended for research and analytical applications. Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders.

HY-149733

M1/M2/M4 muscarinic agonist 3	Agonist
M1/M2/M4 muscarinic agonist 3 (compound 45) is a muscarinic mAChR M1/M2/M4 agonist with EC₅₀s of 3.2 nM, 32 nM and 1.7 nM, respectively.

HY-17360R

Tiotropium (Bromide) (Standard)	Antagonist
Tiotropium (Bromide) (Standard) is the analytical standard of Tiotropium (Bromide). This product is intended for research and analytical applications. Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-113616

VU0364572	Agonist
VU0364572 is a selective allosteric agonist of the M1 muscarinic receptor with an EC₅₀ of 0.11 μM. VU0364572 has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer’s Disease. VU0364572 is orally active and is CNS penetrant.

HY-17360S1

Tiotropium-d₆ bromide	Antagonist
Tiotropium-d₆ (bromide) is deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-107652

AF-DX 384	Antagonist	98.0%
AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (K_is=6.03 and 10 nM, respectively). AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine.

Clozapine N-oxide			mAChR3	mAChR4		99.98%
Deschloroclozapine			mAChR3	mAChR4		99.83%
Pilocarpine Hydrochloride			mAChR3			99.98%
Atropine				mAChR4		99.85%
Clozapine N-oxide dihydrochloride			mAChR3	mAChR4		99.74%
p-F-HHSiD hydrochloride			mAChR3
Pilocarpine			mAChR3			99.89%
Clozapine	mAChR1, Ki: 9.5 nM (Antagonist)			mAChR4, EC₅₀: 11 nM (Agonist)		99.84%
Xanomeline	mAChR1			mAChR4		99.52%
Methacholine chloride			mAChR3			≥98.0%
Darifenacin hydrobromide			mAChR3			99.97%
(S)-(+)-Dimethindene maleate	mAChR1, pKi: 7.08	mAChR2, pKi: 7.78	mAChR3, pKi: 6.70	mAChR4, pKi: 7.00		99.80%
Atropine sulfate				mAChR4		99.63%
Iperoxo	mAChR1, pEC₅₀: 9.87	mAChR2, pEC₅₀: 10.1	mAChR3, pEC₅₀: 9.78			99.48%
DREADD agonist 21			mAChR3			99.46%
Oxotremorine sesquifumarate		mAChR2				≥98.0%
4-DAMP			mAChR3		mAChR5	99.99%
Trospium chloride	mAChR1	mAChR2	mAChR3			99.88%
Bethanechol chloride	mAChR1		mAChR3	mAChR4	mAChR5	98.15%
Pirenzepine dihydrochloride	mAChR1					99.84%
Atropine sulfate monohydrate				mAChR4		99.68%
DREADD agonist 21 dihydrochloride			mAChR3			98.94%
Fesoterodine fumarate	mAChR1		mAChR3	mAChR4	mAChR5	99.73%
Pilocarpine nitrate			mAChR3			99.83%
Diphenidol hydrochloride	mAChR1	mAChR2	mAChR3	mAChR4		99.95%
VU 0255035	mAChR1					99.76%
Ipratropium bromide	mAChR1	mAChR2	mAChR3			99.92%
VU0467154				mAChR4		99.56%
Tropicamide				mAChR4		99.22%
Darifenacin			mAChR3			99.81%
Cevimeline hydrochloride hemihydrate	mAChR1		mAChR3			99.52%
Cevimeline hydrochloride	mAChR1		mAChR3			98.74%
(Rac)-5-Hydroxymethyl Tolterodine	mAChR1		mAChR3	mAChR4	mAChR5	99.59%
N-Desmethylclozapine	mAChR1					98.99%
Telenzepine dihydrochloride	mAChR1					99.08%
Otenzepad		mAChR2				99.93%
VU0357017 hydrochloride	mAChR1					99.91%
Dicyclomine hydrochloride	mAChR1	mAChR2				≥98.0%
Aceclidine	mAChR1		mAChR3			99.23%
Imidafenacin			mAChR3			99.32%
Fesoterodine L-mandelate	mAChR1		mAChR3	mAChR4	mAChR5	99.00%
Smilagenin	mAChR1					≥98.0%
Trihexyphenidyl hydrochloride	mAChR1					99.93%
VU6028418				mAChR4		99.52%
Biperiden hydrochloride	mAChR1					99.90%
VU0152100				mAChR4		98.98%
McN-A-343	mAChR1					99.81%
VU 0238429					mAChR5	99.96%
VU6019650					mAChR5, IC₅₀: 36 nM	98.61%
JHU37160			mAChR3	mAChR4		99.98%
VU0364572 TFA	mAChR1, EC₅₀: 0.11 μM					99.27%
Batefenterol		mAChR2	mAChR3			98.30%
Penehyclidine hydrochloride	mAChR1		mAChR3			99.2%
Sofpironium bromide			mAChR3	mAChR4	mAChR5	98.26%
Solifenacin	mAChR1	mAChR2	mAChR3			99.83%
Clozapine (Standard)	mAChR1			mAChR4		99.98%
PD 102807				mAChR4		98.52%
TBPB	mAChR1, EC₅₀: 289 nM					99.74%
Umeclidinium bromide	mAChR1				mAChR5	99.72%
VU 6008667					mAChR5	99.53%
Talsaclidine		mAChR2	mAChR3			≥98.0%
ML375					mAChR5	99.70%
ASP8302			mAChR3			98.95%
Ipratropium bromide hydrate	mAChR1, IC₅₀: 2.9 nM	mAChR2, IC₅₀: 2 nM	mAChR3, IC₅₀: 1.7 nM			99.90%
Olanzapine-d₃	mAChR1					99.09%
LY2119620		mAChR2		mAChR4		99.74%
VU 0365114					mAChR5	99.41%
PCS1055 dihydrochloride				mAChR4		98.88%
VU0467485				mAChR4		≥99.0%
JHU37152			mAChR3	mAChR4		99.45%
HY-078020			mAChR3			98.87%
Fesoterodine	mAChR1		mAChR3	mAChR4	mAChR5	99.02%
Tarafenacin D-tartrate			mAChR3			99.86%
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride	mAChR1		mAChR3	mAChR4	mAChR5
AC260584	mAChR1					99.60%
VU6004256	mAChR1, EC₅₀: 155 nM					99.61%
Solifenacin hydrochloride	mAChR1	mAChR2	mAChR3			99.71%
PCS1055				mAChR4, IC₅₀: 18.1 nM mAChR4, Kd: 5.72 nM		98.02%
VU10010				mAChR4		98.70%
mAChR antagonist 1	mAChR1, Ki: 255 nM	mAChR2, Ki: >1000 nM	mAChR3, Ki: 121 nM	mAChR4, Ki: 158 nM	mAChR5, Ki: 255 nM	99.59%
PDE4-IN-4			mAChR3
VLVNTFCDSCIPKTYWNLGY TFA			mAChR3
VU0448088				mAChR4, EC₅₀: 56 nM		98.67%
Bethanechol	mAChR1		mAChR3	mAChR4	mAChR5
Tarafenacin			mAChR3
YM-58790	mAChR1, Ki: 28 nM	mAChR2, Ki: 260 nM	mAChR3, Ki: 15 nM			98.21%
Cevimeline	mAChR1		mAChR3
(Rac)-VU 6008667					mAChR5	99.85%
Penehyclidine	mAChR1		mAChR3
rel-Biperiden EP impurity A-d₅	mAChR1
Solifenacin D5 hydrochloride	mAChR1	mAChR2	mAChR3
VU0467319	mAChR1, EC₅₀: 492 nM
M1/M4 muscarinic agonist 1	mAChR1, EC₅₀: 55 nM			mAChR4, EC₅₀: 14 nM
N-Desmethylclozapine-d₈	mAChR1
Pilocarpine-d₃ hydrochloride			mAChR3
Solifenacin-d₅ succinate	mAChR1	mAChR2	mAChR3
YM-58790 free base	mAChR1, Ki: 28 nM	mAChR2, Ki: 260 nM	mAChR3, Ki: 15 nM
Pirenzepine-d₈	mAChR1
PTAC oxalate	mAChR1, Ki: 0.6 nM	mAChR2, Ki: 2.8 nM	mAChR3, Ki: 0.2 nM	mAChR4, Ki: 0.2 nM	mAChR5, Ki: 0.8 nM
(±)-Darifenacin-d₄ hydrobromide			mAChR3
LAS190792	mAChR1, pIC₅₀: 8.9	mAChR2, pIC₅₀: 8.8	mAChR3, pIC₅₀: 8.8	mAChR4, pIC₅₀: 9.2	mAChR5, pIC₅₀: 8.2
DIBA-Cy5	mAChR1, Kd: 104.5 nM	mAChR2, Kd: 1.80 nM
Atropine hydrobromide				mAChR4
M4 mAChR Modulator-1				mAChR4
Lu 26-046	mAChR1, Ki: 0.51 nM	mAChR2, Ki: 26 nM	mAChR3, Ki: 5 nM
5-Hydroxymethyl Tolterodine-d₁₄ formate	mAChR1		mAChR3	mAChR4	mAChR5
M1 ligand 1	mAChR1
J 104129 fumarate		mAChR2, Ki: 490 nM	mAChR3, Ki: 4.2 nM
Umeclidinium-d₅ bromide	mAChR1				mAChR5
rel-Biperiden EP impurity B-d₅	mAChR1
Hexocyclium methylsulfate	mAChR1, pKi: 8.9	mAChR2, pKi: 7.7	mAChR3, pKi: 8.4	mAChR4, pKi: 8.8
Diphenidol	mAChR1	mAChR2	mAChR3	mAChR4
Dicyclomine	mAChR1	mAChR2
Solifenacin-d₇ hydrochloride	mAChR1	mAChR2	mAChR3
Biperiden-d₅ hydrochloride	mAChR1
Clozapine dihydrochloride	mAChR1, Ki: 9.5 nM			mAChR4, EC₅₀: 11 nM
(±)-Darifenacin-d₄			mAChR3
Umeclidinium-d₁₀ bromide	mAChR1				mAChR5
MHP 133	mAChR1	mAChR2
Navafenterol			mAChR3
M1/M2/M4 muscarinic agonist 1	mAChR1, EC₅₀: 26 nM	mAChR2, EC₅₀: 210 nM		mAChR4, EC₅₀: 6.5 nM
Aceclidine hydrochloride	mAChR1		mAChR3			≥98.0%
CHF-6550			mAChR3, pKi: 9.3
Darifenacin (hydrobromide) (Standard)			mAChR3
TAAR1 agonist 2		mAChR2, pEC₅₀: 5
Navafenterol saccharinate			mAChR3
rel-Biperiden-d₅	mAChR1
Direclidine				mAChR4
Sofpironium tosylate	mAChR1	mAChR2	mAChR3	mAChR4	mAChR5
Trihexyphenidyl-d₅ hydrochloride	mAChR1
PF-3635659			mAChR3
AE9C90CB	mAChR1, pKi: 9.7	mAChR2, pKi: 8.6	mAChR3, pKi: 9.9	mAChR4, pKi: 9.5	mAChR5, pKi: 9.5
Alvameline			mAChR3
Revatropate	mAChR1	mAChR2	mAChR3
Atropine oxide hydrochloride	mAChR1	mAChR2	mAChR3	mAChR4	mAChR5
Rispenzepine	mAChR1		mAChR3
(1R,3S-)Solifenacin-d₅ hydrochloride	mAChR1	mAChR2	mAChR3
Clozapine hydrochloride	mAChR1, Ki: 9.5 nM			mAChR4, EC₅₀: 11 nM

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mAChR

mAChR

mAChR Isoform Specific Products:

mAChR Isoform Specific Products:

mAChR Related Products (577)

Antibodies (2)

mAChR Isoform Comparison

mAChR Related Products (577):