1. Gene
  2. Mmp9 - matrix metallopeptidase 9 Gene

Mmp9 - matrix metallopeptidase 9 Gene

Mus musculus

Also known as Clg4b; Gel B; MMP-9; B/MMP9; pro-MMP-9

Gene ID: 17395 | Gene type: protein coding

About Mmp9

Chromosome 2: 164,782,700-164,797,770 forward strand.GRCm39:CM000995.3

This gene has 4 transcripts (splice variants), 216 orthologues, 23 paralogues and is associated with 97 phenotypes. Broad expression in liver E18 (RPKM 9.8), thymus adult (RPKM 8.9) and 21 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]

Mmp9 Products(1)

mRNA Protein Name
NM_013599.5 NP_038627.1 matrix metalloproteinase-9 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
9291580 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
15800063 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
15800063 MGI
acts upstream of or within collagen catabolic process IDA
IDA: Inferred from direct assay
9291580 MGI
acts upstream of or within embryo implantation IDA
IDA: Inferred from direct assay
18556655 MGI
acts upstream of or within extracellular matrix organization IGI
IGI: Inferred from genetic interaction
15800063 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
15800063 MGI
involved in negative regulation of epithelial cell differentiation involved in kidney development IDA
IDA: Inferred from direct assay
24503540 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15800063 MGI
involved in response to amyloid-beta IDA
IDA: Inferred from direct assay
28912710 MGI
acts upstream of or within skeletal system development IGI
IGI: Inferred from genetic interaction
15800063 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
15800063 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp9 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (40 - 94)

Peptidase_M10

Peptidase_M10: pfam00413 (114 - 443)

FN2

FN2: smart00059 (222 - 270)

FN2

FN2: smart00059 (280 - 328)

fn2

fn2: pfam00040 (346 - 387)

PT

PT: pfam04886 (473 - 524)

HX

HX: cd00094 (531 - 728)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-9

92 kDa gelatinase

92 kDa type IV collagenase

92kD gelatinase

92kD type IV collagenase

collagenase type IVB

gelatinase B

Recombinant Mmp9 Proteins

Cat. No. Product Name Accession Purity
HY-P70351 MMP-9 Protein, Mouse (HEK293, His, solution) P41245 (A20-P730) ≥95%
HY-P73807 MMP-9 Protein, Mouse (HEK293) P41245 (P21-P730) ≥95%
HY-P70351A MMP-9 Protein, Mouse (HEK293, C-His) P41245 (A20-P730) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp9 NCBI NCBI:4318