2. Gene
  3. CYS1 - cystin 1 Gene

CYS1 - cystin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 192668 | Gene type: protein coding

About CYS1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,056,473-10,080,411 (from NCBI)

This gene has 2 transcripts (splice variants) and 45 orthologues. Biased expression in kidney (RPKM 77.2), ovary (RPKM 7.7) and 4 other tissues.

Summary

Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to act upstream of or within animal organ development and regulation of transcription, DNA-templated. Predicted to be located in cytoskeleton; membrane raft; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CYS1 Products(1)

mRNA Protein Name
NM_001037160.3 NP_001032237.1 cystin-1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22085962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystin-1

cilia-associated protein

Related Diseases

Diseases Alias
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease

Arpkd

Polycystic Kidney Disease, Autosomal Recessive

Polycystic Kidney And Hepatic Disease 1

Pkhd1

PKD4

Polycystic Kidney Disease 4 With Or Without Hepatic Disease

Polycystic Kidney Disease, Infantile, Type I

Polycystic Kidney Disease, Infantile Type

Polycystic Kidney, Autosomal Recessive

Pkd3, Formerly

Polycystic Kidney Disease 4, With Or Without Hepatic Disease

Arpkd/Chf

Ar-Pkd

Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease

Infantile Polycystic Kidney Disease Type I

Pkd3

Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease

Polycystic Kidney Disease 3, Autosomal Dominant
Spinocerebellar Ataxia 14

Spinocerebellar Ataxia Type 14

SCA14

Ataxia, Spinocerebellar, Type 14
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Cystic Kidney Disease

Renal Cyst

Simple Renal Cyst

Kidney Cysts

Kidney Diseases, Cystic

Renal Cysts

Kidney Cyst

Cystic Kidney

Congenital Cystic Kidney Disease

Cystic Kidney Diseases

Bosniak 1 Cyst
Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0090 Calcitonin (salmon) Agonist 99.95% Unkown
HY-B1811 Vasopressin 99.83% Yes
HY-P0049 Argipressin Agonist 99.82% Unkown
HY-P1955A Etelcalcetide hydrochloride Activator 99.61% Unkown
HY-P0004 Lysipressin Activator 98.02% Unkown
HY-A0182 Felypressin Agonist 99.62% Unkown
HY-P1955 Etelcalcetide Activator / Unkown
HY-17584A Linaclotide acetate Agonist / Unkown
HY-P0049A Argipressin diacetate / Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-A0182A Felypressin acetate Agonist 98.31% Phase 4
HY-P3448 Certepetide Activator 99.40% Phase 2
HY-106302 Duramycin 99.46% Phase 2
Pre-clinical Phase
Bioactive Molecules (41)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0202 Endothelin 1 (swine, human) Activator 99.12% Unkown
HY-P0256 Apamin Inhibitor 99.85% Unkown
HY-P0202A Endothelin 1 (swine, human) (TFA) 99.95% Unkown
HY-P0204A Endothelin-3, human, mouse, rabbit, rat TFA 99.51% Unkown
HY-P4860 Adropin (34-76) (human, mouse, rat) Activator 99.87% Unkown
HY-P1408A Obtustatin triacetate Inhibitor 99.66% Unkown
HY-P0256A Apamin TFA Inhibitor 98.35% Unkown
HY-P1206 CH 275 Agonist 99.71% Unkown
HY-P3561A Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA) Inhibitor 96.96% Unkown
HY-102029 Sarafotoxin S6c Agonist 98.19% Unkown
HY-P10235 Cyclic AC253 Antagonist 99.87% Unkown
HY-P1408 Obtustatin Inhibitor 99.51% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.91% Unkown
HY-P2538 Big Endothelin-1 (1-38), human Agonist 81.54% Unkown
HY-P0090A Calcitonin (salmon) (acetate) Agonist / Unkown
HY-P10328 Vasoactive intestinal contractor Inhibitor / Unkown
HY-P10388 TAX2 peptide / Unkown
HY-P1372 PKC ζ pseudosubstrate Inhibitor / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2496 Endothelin 1 (swine, human), Alexa Fluor 488-labeled Activator / Unkown
HY-P2539 Big Endothelin-1 (1-39), porcine Agonist / Unkown
HY-P3433 Sarafotoxin S6b Agonist / Unkown
HY-P3561 Agouti-related Protein (AGRP) (83-132) Amide (human) Antagonist / Unkown
HY-P3563 [Lys4] Sarafotoxin S6c Agonist / Unkown
HY-P3571 [Ala2] Endothelin-3, human / Unkown
HY-P4205 Aminopeptidase N Ligand (CD13) NGR peptide Inhibitor / Unkown
HY-P4320 Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10) / Unkown
HY-P4605 (Ile8)-Oxytocin / Unkown
HY-P4678 (Phe2,Orn8)-Oxytocin Agonist / Unkown
HY-P4678A (Phe2,Orn8)-Oxytocin acetate Agonist / Unkown
HY-P4990 Pro8-Oxytocin Activator / Unkown
HY-P4990A Pro8-Oxytocin TFA Activator / Unkown
HY-P4994 Val9-Oxytocin Antagonist / Unkown
HY-P5010 (D-Arg8)-Inotocin Antagonist / Unkown
HY-P5017 (Val3,Pro8)-Oxytocin Agonist / Unkown
HY-P5140 ω-Tbo-IT1 Inhibitor / Unkown
HY-P5738 Palicourein Inhibitor / Unkown
HY-P5907 Helianorphin-19 Activator / Unkown
HY-RS03493 CYS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W539944 Argipressin acetate / Unkown
HY-P4605A (Ile8)-Oxytocin acetate / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CYS1 RGD RGD:1596023
Mus musculus CYS1 MGD MGI:2177632