GABARAPL1 - GABA type A receptor associated protein like 1 Gene

Homo sapiens

Also known as ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE

Gene ID: 23710 | Gene type: protein coding

About GABARAPL1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,212,877-10,223,128 (from NCBI)

This gene has 19 transcripts (splice variants), 202 orthologues and 6 paralogues. Broad expression in brain (RPKM 136.2), kidney (RPKM 101.2) and 23 other tissues.

Summary

Enables Tat protein binding activity and ubiquitin protein Ligase binding activity. Predicted to be involved in autophagosome assembly; Autophagy of mitochondrion; and cellular response to nitrogen starvation. Located in autophagosome. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

GABARAPL1 Products(2)

mRNA	Protein	Name
NM_001363598.2	NP_001350527.1	gamma-aminobutyric acid receptor-associated protein-like 1 isoform 1
NM_031412.4	NP_113600.1	gamma-aminobutyric acid receptor-associated protein-like 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Tat protein binding	IPI IPI: Inferred from physical interaction	22354992	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	20404487	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9892355	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25127057	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	15292400	GOA
colocalizes with mitochondrion	IGI IGI: Inferred from genetic interaction	20200478	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABARAPL1 Protein Structure

Atg8

0
100
117 a.a.

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor-associated protein-like 1

GABA(A) receptor-associated protein-like 1

GABARAPL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GABARAPL1	Q9H0R8	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	GABARAPL1	Q9H0R8	RETREG3	Homo sapiens	Q86VR2	Y2H Array	25416956
Intra	GABARAPL1	Q9H0R8	RETREG3	Homo sapiens	Q86VR2	Y2H Array	29892012
Intra	GABARAPL1	Q9H0R8	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	25416956
Intra	GABARAPL1	Q9H0R8	TBC1D5	Homo sapiens	B9A6K1	Validated Y2H	25416956
Intra	GABARAPL1	Q9H0R8	AHNAK2	Homo sapiens	Q8IVF2-2	Validated Y2H	25416956
Intra	GABARAPL1	Q9H0R8	NEK9	Homo sapiens	Q8TD19	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	TBC1D15	Homo sapiens	Q8TC07	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	OSBPL3	Homo sapiens	Q9H4L5	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	OSBPL3	Homo sapiens	Q9H4L5	Validated Y2H	32296183
Intra	GABARAPL1	Q9H0R8	OSBPL3	Homo sapiens	Q9H4L5	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	STRN3	Homo sapiens	Q13033-2	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	STRN3	Homo sapiens	Q13033-2	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	STRN3	Homo sapiens	Q13033-2	BioID	34524948
Intra	GABARAPL1	Q9H0R8	RABGAP1	Homo sapiens	Q9Y3P9	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	RABGAP1	Homo sapiens	Q9Y3P9	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	UMAD1	Homo sapiens	C9J7I0	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	UMAD1	Homo sapiens	C9J7I0	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	CLINT1	Homo sapiens	Q14677	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	TBC1D25	Homo sapiens	Q3MII6	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	TBC1D25	Homo sapiens	Q3MII6	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	SCYL3	Homo sapiens	Q8IZE3-2	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	SCYL3	Homo sapiens	Q8IZE3-2	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	SCYL3	Homo sapiens	Q8IZE3-2	BioID	34524948
Intra	GABARAPL1	Q9H0R8	NEDD4	Homo sapiens	P46934-3	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	NEDD4	Homo sapiens	P46934-3	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	GABARAPL1	Q9H0R8	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	NFIA	Homo sapiens	Q12857-2	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	NFIA	Homo sapiens	Q12857-2	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	TMEM131	Homo sapiens	Q0P631	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	TMEM131	Homo sapiens	Q0P631	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	PTPRR	Homo sapiens	Q15256-5	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	PTPRR	Homo sapiens	Q15256-5	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	ATG2A	Homo sapiens	Q2TAZ0	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	ATG2A	Homo sapiens	Q2TAZ0	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	KBTBD6	Homo sapiens	Q86V97	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	KBTBD6	Homo sapiens	Q86V97	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	KBTBD6	Homo sapiens	Q86V97	Pull Down	25684205
Intra	GABARAPL1	Q9H0R8	KBTBD6	Homo sapiens	Q86V97	Confocal	25684205
Intra	GABARAPL1	Q9H0R8	ATG101	Homo sapiens	Q9BSB4	BioID	34524948
Intra	GABARAPL1	Q9H0R8	DNAAF4	Homo sapiens	Q8WXU2	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	FNIP1	Homo sapiens	Q8TF40	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	TECPR2	Homo sapiens	O15040	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	NSMAF	Homo sapiens	Q92636	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	STBD1	Homo sapiens	O95210	BioID	34524948
Intra	GABARAPL1	Q9H0R8	STBD1	Homo sapiens	O95210	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	TBC1D2B	Homo sapiens	Q9UPU7	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	ATG4A	Homo sapiens	Q8WYN0	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	ATG4A	Homo sapiens	Q8WYN0	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	ATG4A	Homo sapiens	Q8WYN0	Validated Y2H	25416956
Intra	GABARAPL1	Q9H0R8	ATG4A	Homo sapiens	Q8WYN0	Validated Y2H	32296183
Intra	GABARAPL1	Q9H0R8	ATG4A	Homo sapiens	Q8WYN0	Y2H Array	25416956
Intra	GABARAPL1	Q9H0R8	SQSTM1	Homo sapiens	Q13501	Phage Display	39009827
Intra	GABARAPL1	Q9H0R8	SQSTM1	Homo sapiens	Q13501	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	SQSTM1	Homo sapiens	Q13501	FPS	39009827
Intra	GABARAPL1	Q9H0R8	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	SQSTM1	Homo sapiens	Q13501	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	SQSTM1	Homo sapiens	Q13501	Phage Display	37219487
Intra	GABARAPL1	Q9H0R8	NIPSNAP2	Homo sapiens	O75323	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	NIPSNAP2	Homo sapiens	O75323	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	DYNLL1	Homo sapiens	P63167	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	DYNLL1	Homo sapiens	P63167	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	SAFB2	Homo sapiens	Q14151	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	SAFB2	Homo sapiens	Q14151	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	IPO5	Homo sapiens	O00410	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	HADHB	Homo sapiens	P55084	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	RCN2	Homo sapiens	Q14257	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	RCN2	Homo sapiens	Q14257	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	RCN2	Homo sapiens	Q14257	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	HADHA	Homo sapiens	P40939	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	TNIP1	Homo sapiens	Q15025	Y2H Array	25416956
Intra	GABARAPL1	Q9H0R8	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	TNIP1	Homo sapiens	Q15025	Y2H Array	31515488
Intra	GABARAPL1	Q9H0R8	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	GABARAPL1	Q9H0R8	KBTBD7	Homo sapiens	Q8WVZ9	Y2H Prey Pooling	25416956
Intra	GABARAPL1	Q9H0R8	KBTBD7	Homo sapiens	Q8WVZ9	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	KBTBD7	Homo sapiens	Q8WVZ9	Y2H Array	25416956
Intra	GABARAPL1	Q9H0R8	KBTBD7	Homo sapiens	Q8WVZ9	Pull Down	25684205
Intra	GABARAPL1	Q9H0R8	PRKAR1A	Homo sapiens	P10644	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	PSMB4	Homo sapiens	P28070	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	PSMB4	Homo sapiens	P28070	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	ATG4B	Homo sapiens	Q9Y4P1	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	ATG4B	Homo sapiens	Q9Y4P1	Validated Y2H	32296183
Intra	GABARAPL1	Q9H0R8	ATG4B	Homo sapiens	Q9Y4P1	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	ATG4B	Homo sapiens	Q9Y4P1	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	BSDC1	Homo sapiens	Q9NW68	Validated Y2H	32296183
Intra	GABARAPL1	Q9H0R8	BSDC1	Homo sapiens	Q9NW68	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	BSDC1	Homo sapiens	Q9NW68	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	ZBTB22	Homo sapiens	O15209	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	ZBTB22	Homo sapiens	O15209	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	NEDD4	Homo sapiens	P46934	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	GABARAPL1	Q9H0R8	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	GABARAPL1	Q9H0R8	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	KXD1	Homo sapiens	Q9BQD3	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	KXD1	Homo sapiens	Q9BQD3	Y2H	21516116
Intra	GABARAPL1	Q9H0R8	KXD1	Homo sapiens	Q9BQD3	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	PBXIP1	Homo sapiens	Q96AQ6	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	PBXIP1	Homo sapiens	Q96AQ6	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	THAP7	Homo sapiens	Q9BT49	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	THAP7	Homo sapiens	Q9BT49	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	TBC1D5	Homo sapiens	Q92609	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	TBC1D5	Homo sapiens	Q92609	BioID	34524948
Intra	GABARAPL1	Q9H0R8	TBC1D5	Homo sapiens	Q92609	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	NBR1	Homo sapiens	Q14596	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	NBR1	Homo sapiens	Q14596	Pull Down	19250911
Intra	GABARAPL1	Q9H0R8	UBA5	Homo sapiens	Q9GZZ9	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	CALCOCO1	Homo sapiens	Q9P1Z2	Validated Y2H	32296183
Intra	GABARAPL1	Q9H0R8	CALCOCO1	Homo sapiens	Q9P1Z2	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	CALCOCO1	Homo sapiens	Q9P1Z2	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	NCOA7	Homo sapiens	Q8NI08	BioID	34524948
Intra	GABARAPL1	Q9H0R8	NCOA7	Homo sapiens	Q8NI08	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	BNIP3L	Homo sapiens	O60238	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	BNIP3L	Homo sapiens	O60238	Y2H Array	32296183
Intra	GABARAPL1	Q9H0R8	MLX	Homo sapiens	Q9UH92-3	Validated Y2H	32296183
Intra	GABARAPL1	Q9H0R8	ULK1	Homo sapiens	O75385	BioID	34524948
Intra	GABARAPL1	Q9H0R8	OPRK1	Homo sapiens	P41145	Y2H	16431922
Intra	GABARAPL1	Q9H0R8	OPRK1	Homo sapiens	P41145	Pull Down	16431922
Intra	GABARAPL1	Q9H0R8	ATG7	Homo sapiens	O95352	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	20562859
Intra	GABARAPL1	Q9H0R8	STK3	Homo sapiens	Q13188	Pull Down	20562859
Intra	GABARAPL1	Q9H0R8	TP53INP1	Homo sapiens	Q96A56	Y2H Prey Pooling	32296183
Intra	GABARAPL1	Q9H0R8	TP53INP1	Homo sapiens	Q96A56	MAPPIT	32296183
Intra	GABARAPL1	Q9H0R8	TP53INP1	Homo sapiens	Q96A56	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GABARAPL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70913	GABARAPL1/GEC-1 Protein, Human (His)	Q9H0R8 (M1-K117)	≥95%

Related Diseases

Diseases

Alias

Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis	Acanthamoeba Encephalitis
Acanthamoeba Granulomatous Encephalitis	Granulomatous Amebic Encephalitis Due To Acanthamoeba

Primary Amebic Meningoencephalitis

Pam	Naegleria Fowleri Infection
Meningoencephalitis Caused By Naegleria Fowleri	Primary Amoebic Meningoencephalitis

Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3

Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05202	GABARAPL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GABARAPL1	VGNC	VGNC:99929
Mus musculus	GABARAPL1	MGD	MGI:1914980
Canis familiaris	GABARAPL1	VGNC	VGNC:57447
Rattus norvegicus	GABARAPL1	RGD	RGD:1596143
Felis catus	GABARAPL1	VGNC	VGNC:84022
Bos taurus	GABARAPL1	VGNC	VGNC:56201
Others	GABARAPL1	NCBI

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