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Results for "

Alkylating

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (10) ADC Linker (1) Adenylate Cyclase (2) Antibiotic (6) Apoptosis (32) Autophagy (7) Bacterial (7) Biochemical Assay Reagents (1) Caspase (2) Cathepsin (2) Deubiquitinase (2) DNA Alkylator/Crosslinker (78) DNA-PK (1) DNA/RNA Synthesis (7) Drug Metabolite (1) Drug-Linker Conjugates for ADC (6) Endogenous Metabolite (5) Endonuclease (1) Estrogen Receptor/ERR (1) FLAP (1) Histone Demethylase (2) Isotope-Labeled Compounds (8) MDM-2/p53 (1) NAMPT (1) Necroptosis (1) NF-κB (1) Nucleoside Antimetabolite/Analog (2) Opioid Receptor (2) Ser/Thr Protease (1)
By Research Areas:	Cancer (114) Infection (6) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (4)
Click Chemistry:	Azide (1)

128

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Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-34477

2-Iodoacetamide 2 Publications Verification Iodoacetamide	DNA Alkylator/Crosslinker	Others
2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .

HY-122493

Illudin M	DNA Alkylator/Crosslinker Apoptosis	Cancer
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities .

HY-B0077

Bendamustine hydrochloride 4 Publications Verification SDX-105	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-111397

Bizelesin NSC 615291; U-77779	DNA Alkylator/Crosslinker	Cancer
Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity .

HY-13567

Bendamustine 4 Publications Verification SDX-105 free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-14429

(-)-Irofulven MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863	DNA Alkylator/Crosslinker Apoptosis	Cancer
(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity .

HY-127005

Ritrosulfan	DNA Alkylator/Crosslinker	Cancer
Ritrosulfan is a member of the alkylating sugar alcohol. Ritrosulfan is a hydrolyzing alkylating agent with anti-tumor activity .

HY-120220

Piposulfan A-20968; Ancyte	Others	Cancer
Piposulfan (Ancyte) is a methanesulfonate, alkylating derivative of piperazine. Piposulfan has potential antineoplastic activity. Piposulfan can be used for the research of cancer .

HY-115826

AB-163	Others	Cancer
AB-163 is an alkylating agent with anti-tumor activity. AB-163 exerts LD₅₀s of 198 (p.o.) and 159 (i.p.) mg/kg in ICR/Ha male mice and can be utilized in cancer research .

HY-19412

DMS-612 NSC-281612	Others	Cancer
DMS-612 (NSC-281612) is an alkylating agent with anti-renal cell carcinoma activity. DMS-612 can be used in cancer research .

HY-N10281

Asperglaucin B	Bacterial	Infection
Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and *Bacillus cereus*, with an MIC value of 6.25 μM .

HY-B0077R

Bendamustine hydrochloride (Standard)	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (hydrochloride) (Standard) is the analytical standard of Bendamustine (hydrochloride). This product is intended for research and analytical applications. Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-19577

Ambamustine PTT119	DNA Alkylator/Crosslinker	Infection Cancer
Ambamustine (PTT119) is a new bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities .

HY-105815

Chlornaphazine	DNA Alkylator/Crosslinker	Cancer
Chlornaphazine, a nitrogen mustard derivative, is a bifunctional alkylating agent. Chlornaphazine is an antineoplastic agent, which can be used for the study of polycythemia vera and Hodgkin’s disease .

HY-119970

Helenalin 5 Publications Verification	NF-κB	Inflammation/Immunology Cancer
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-13703

Nimustine	Apoptosis	Cancer
Nimustine is a nitrosourea alkylating agent. Nimustine induces cell apoptosis, and activates DNA damage response and MAPK signaling. Nimustine shows anti-cancer effects, it can be used for the research of cancer .

HY-34758

N-Nitroso-N-methylurea 10+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane .

HY-B0245

Busulfan 10+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent *alkylating* antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-B0078A

Dacarbazine citrate Imidazole Carboxamide citrate	Apoptosis Antibiotic	Cancer
Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC₅₀ values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma .

HY-B0181

Altretamine 2 Publications Verification ENT-50852; RB-1515; WR-95704	DNA Alkylator/Crosslinker	Cancer
Altretamine is an *alkylating* antineoplastic agent.

HY-B0181A

Altretamine hydrochloride ENT-50852 hydrochloride; RB-1515 hydrochloride; WR-95704 hydrochloride	DNA Alkylator/Crosslinker	Cancer
Altretamine hydrochloride is an *alkylating* antineoplastic agent.

HY-17576

Satraplatin BMS182751; BMY45594; JM216	DNA Alkylator/Crosslinker	Cancer
Satraplatin is an *alkylating* agent, with potent antitumor effect.

HY-B0733

Fotemustine S10036	DNA Alkylator/Crosslinker	Cancer
Fotemustine is a *DNA-alkylating* agent, with antitumor activity.

HY-17574

Thio-TEPA 1 Publications Verification	DNA Alkylator/Crosslinker Bacterial Antibiotic	Infection Cancer
Thio-TEPA is a DNA alkylating agent, with antitumor activity.

HY-N0780

Isoalantolactone 4 Publications Verification (+)-Isoalantolactone; Isohelenin	Apoptosis Autophagy Bacterial Endogenous Metabolite	Cancer
Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.

HY-17419

Ifosfamide 5+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Ifosfamide is an *alkylating* chemotherapeutic agent with activity against a wide range of tumors.

HY-13669

Lomustine 5 Publications Verification CCNU; NSC 79037	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.

HY-114577

Palifosfamide tromethamine Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine	DNA Alkylator/Crosslinker	Cancer
Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

HY-17420

Cyclophosphamide 25+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide is a synthetic *alkylating* agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-16325

Miriplatin (hydrate) SM-11355 (hydrate)	DNA Alkylator/Crosslinker	Cancer
Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of *alkylating* agents.

HY-16325A

Miriplatin 3 Publications Verification SM-11355	DNA Alkylator/Crosslinker	Cancer
Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of *alkylating* agents.

HY-17420A

Cyclophosphamide hydrate 25+ Cited Publications Cyclophosphamide monohydrate	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide hydrate is a synthetic *alkylating* agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

HY-16513

VAL-083 1 Publications Verification Dianhydrodulcitol; Dianhydrogalactitol	DNA Alkylator/Crosslinker	Cancer
VAL-083 is an *alkylating* agent that creates N7 methylation on DNA, with antitumor activity.

HY-69014

2-O-Methylcytosine	DNA/RNA Synthesis Endogenous Metabolite	Cancer
2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase .

HY-16117A

Brostallicin PNU-166196	Others	Cancer
Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity .

HY-16503

Treosulfan 3 Publications Verification NSC 39069; Treosulphan	DNA Alkylator/Crosslinker	Cancer
Treosulfan (NSC 39069) is a bifunctional *alkylating* agent with activity in ovarian cancer and other solid tumor types.

HY-16173

Mipicoledine DM-CHOC-PEN	DNA Alkylator/Crosslinker	Neurological Disease Cancer
Mipicoledine is a potential neuro-alkylating agent for study of glioblastoma and metastatic cancers involving the central nervous system .

HY-B0181R

Altretamine (Standard)	DNA Alkylator/Crosslinker	Cancer
Altretamine (Standard) is the analytical standard of Altretamine. This product is intended for research and analytical applications. Altretamine is an alkylating antineoplastic agent.

HY-13733

Procarbazine Hydrochloride 3 Publications Verification	DNA Alkylator/Crosslinker	Cancer
Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research .

HY-U00155

NCI172112 NSC172112; NSC268497	DNA Alkylator/Crosslinker	Cancer
NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.

HY-16232

GLUFOSFAMIDE D 19575; Glucosylifosfamide mustard	Others	Cancer
Glufosfamide is a novel alkylating agent in which the active metabolite of isophosphoramide mustard is glycosidically linked to β-D-glucose.

HY-13733A

Procarbazine	DNA Alkylator/Crosslinker	Cancer
Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research .

HY-119696

MTIC	Drug Metabolite	Neurological Disease Cancer
MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity .

HY-13739

Ranimustine MCNU	DNA Alkylator/Crosslinker	Cancer
Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera .

HY-Y0643

Pivaloyloxymethyl chloride Pivaloyloxymethyl chloride	Biochemical Assay Reagents	Others
Pivaloyloxymethyl chloride can be used as electrolyte solvent for lithium batteries, or used as alkylating agent to improve the biomembrane transport of an agent .

HY-Y0694

2',4'-Dihydroxyacetophenone Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone	Endogenous Metabolite	Others
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO₃-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite .

HY-13567S

Bendamustine-d4 SDX-105-d₄ free base	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-136327

Phenylacetic acid mustard	DNA Alkylator/Crosslinker	Cancer
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating* agent* with antitumor activity .

HY-17420S1

Cyclophosphamide-d8	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

Cat. No.	Product Name

HY-L112

Chemotherapy Drug Library

100 compounds

Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs.

Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 100 chemotherapy drugs, which is a useful tool for cancer treatment research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122493

Illudin M	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	DNA Alkylator/Crosslinker Apoptosis
Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities .

HY-119970

Helenalin 5 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Inflammation/Immunology Disease Research Fields	NF-κB
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-N0780

Isoalantolactone 4 Publications Verification (+)-Isoalantolactone; Isohelenin	Structural Classification Classification of Application Fields Terpenoids Dalbergia velutina Benth. Sesquiterpenes Source classification Plants Compositae Endogenous metabolite Disease Research Fields Cancer	Apoptosis Autophagy Bacterial Endogenous Metabolite
Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.

HY-69014

2-O-Methylcytosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	DNA/RNA Synthesis Endogenous Metabolite
2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase .

HY-Y0694

2',4'-Dihydroxyacetophenone Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone	Structural Classification Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO₃-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite .

HY-125098

Illudin S 1 Publications Verification	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	DNA Alkylator/Crosslinker Apoptosis
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-N10281

Asperglaucin B	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Bacterial
Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and *Bacillus cereus*, with an MIC value of 6.25 μM .

HY-N0780R

Isoalantolactone (Standard)	Structural Classification Terpenoids Dalbergia velutina Benth. Sesquiterpenes Source classification Plants Compositae Endogenous metabolite	Apoptosis Autophagy Bacterial Endogenous Metabolite
Isoalantolactone (Standard) is the analytical standard of Isoalantolactone. This product is intended for research and analytical applications. Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.

HY-N9460

Sibiromycin	Structural Classification Monophenols Microorganisms Classification of Application Fields Antibiotics Source classification Phenols Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	DNA Alkylator/Crosslinker Antibiotic
Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine .

HY-12457

Rachelmycin CC-1065; NSC 298223	Structural Classification Classification of Application Fields Source classification Disease Research Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Anticancer Disease Research Fields Cancer	Antibiotic DNA/RNA Synthesis
Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .

HY-D0843

N-Ethylmaleimide Maximum Cited Publications 14 Publications Verification NEM	Microorganisms Source classification	Cathepsin Deubiquitinase Apoptosis
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC₅₀ value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-34477S1

2-Iodoacetamide-d4
2-Iodoacetamide-d₄ is the deuterium labeled 2-Iodoacetamide[1]. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[2][3].

HY-13567S

Bendamustine-d4
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-17420S1

Cyclophosphamide-d8
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-17419S1

Ifosfamide-d4
Ifosfamide-d₄ is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].

HY-17420S

Cyclophosphamide-d4
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].

HY-17420AS

Cyclophosphamide-d8 hydrate
Cyclophosphamide-d₈ (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

HY-B0077S1

Bendamustine-d8 hydrochloride
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

HY-113081S

1-Methyladenosine-d3
1-Methyl Adenosine-d3 is the deuterium labeled 1-Methyladenosine. 1-Methyladenosine is an RNA modification originating essentially from two different reaction types, one catalyzed by enzymes and the other the result of the reaction of RNA with certain alkylating agents.

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine[1]. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[2].

HY-D0843S

N-Ethylmaleimide-d5
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-13593S1

Chlorambucil-d8-1
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-17364S

Temozolomide-d3

Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].

Cat. No.	Product Name		Classification

HY-151738

Fmoc-Aeg(N3)-OH		Azide
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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