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Pathways Recommended:	Cell Cycle/DNA Damage

Results for "

DNA topoisomerase II

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (16) Topoisomerase (114) ADC Cytotoxin (13) AMPK (3) Antibiotic (25) Apoptosis (31) Autophagy (22) Bacterial (34) c-Myc (3) Caspase (1) Cathepsin (1) Cuproptosis (1) Drug-Linker Conjugates for ADC (5) Endogenous Metabolite (3) Fungal (3) HBV (3) HIV (3) Isotope-Labeled Compounds (5) Microtubule/Tubulin (3) Mitochondrial Metabolism (1) Mitophagy (7) Parasite (5) Phosphatase (3) Reverse Transcriptase (3) SARS-CoV (3) Sirtuin (3) Virus Protease (1)
By Research Areas:	Cancer (112) Cardiovascular Disease (3) Infection (37) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (7)

By Targets:

DNA/RNA Synthesis (16)

Topoisomerase (114)

ADC Cytotoxin (13)

AMPK (3)

Antibiotic (25)

Apoptosis (31)

Autophagy (22)

Bacterial (34)

c-Myc (3)

Caspase (1)

Cathepsin (1)

Cuproptosis (1)

Drug-Linker Conjugates for ADC (5)

Endogenous Metabolite (3)

Fungal (3)

HBV (3)

HIV (3)

Isotope-Labeled Compounds (5)

Microtubule/Tubulin (3)

Mitochondrial Metabolism (1)

Mitophagy (7)

Parasite (5)

Phosphatase (3)

Reverse Transcriptase (3)

SARS-CoV (3)

Sirtuin (3)

Virus Protease (1)

By Research Areas:

Cancer (112)

Cardiovascular Disease (3)

Infection (37)

Inflammation/Immunology (4)

Metabolic Disease (1)

Neurological Disease (7)

133

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Topoisomerase Photosystem II DNA-PK DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19024

Merbarone NSC 336628	Topoisomerase	Cancer
Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent .

HY-160774

Val-Cit-PABC-DOX	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Cit-PABC-DOX (compound 10109), an epsilon-poly-L-lysine-based drug conjugate, is an agent-linker conjugate for ADC by using a DNA topoisomerase I and topoisomerase II inhibitor, Doxorubicin (HY-15142), linked via the linker, Val-Cit-PABC .

HY-100777

DACA	Topoisomerase	Cancer
DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells .

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-124552

Epolactaene	DNA/RNA Synthesis Topoisomerase	Others
Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC₅₀ values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively .

HY-162381

Topoisomerase II inhibitor 19	Topoisomerase	Cancer
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and topoisomerase II inhibitor (IC₅₀ value of 0.34 μM). Topoisomerase II inhibitor 19 would induce detectable potent damage in ctDNA .

HY-113642

CP-67804	Topoisomerase	Cancer
CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent .

HY-120747

A-65282	Bacterial DNA/RNA Synthesis	Infection
A-65282 is an antibacterial agent. A-65282 inhibits P4 DNA unknotting with an IC₅₀ value of 8 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II .

HY-146316

Topoisomerase II inhibitor 6	Topoisomerase	Cancer
Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .

HY-134290

8-Chloro-ATP	Topoisomerase	Cancer
8-Chloro-ATP, an ATP (HY-B2176) analog, is a **topoisomerase II (Topo II)** inhibitor. 8-Chloro-ATP inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP inhibits Topo II-catalyzed ATP hydrolysis .

HY-134290A

8-Chloro-ATP tetrasodium	Topoisomerase	Cancer
8-Chloro-ATP tetrasodium, an ATP (HY-B2176) analog, is a **topoisomerase II (Topo II)** inhibitor. 8-Chloro-ATP tetrasodium inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP tetrasodium inhibits Topo II-catalyzed ATP hydrolysis .

HY-121782

A 65281	Bacterial DNA/RNA Synthesis	Infection
A 65281 is a potent DNA gyrase inhibitor with an IC₅₀ value of 0.1 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II. A 65281 inhibits P4 DNA unknotting with an IC₅₀ value of 8 µg/mL .

HY-149410

MSN8C	Topoisomerase	Cancer
MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell apoptosis. MSN8C shows significant anti-tumor cell proliferation activity in vitro .

HY-122594

BNS-22	Topoisomerase	Cancer
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC₅₀ values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .

HY-152187

Topoisomerase IIα-IN-5	Topoisomerase Apoptosis	Others
Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629) .

HY-147877

Topoisomerase II inhibitor 12	Topoisomerase	Cancer
Topoisomerase II inhibitor 12 (Compound 8c) is a **topoisomerase II (topo II)** inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity .

HY-143281

Topoisomerase II inhibitor 5	Topoisomerase	Cancer
Topoisomerase II inhibitor 5 (Compound E24) is a DNA topoisomerase II inhibitor with anticancer activities .

HY-B0879

Suramin	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor .Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-106307

Retelliptine BD84	Topoisomerase	Cancer
Retelliptine (BD84), a derivative of ellipticine, is an inhibitor of Topoisomerase II with anticancer activity. Retelliptine can bind to DNA and inhibit Topoisomerase II during DNA replication .

HY-B0879A

Suramin sodium salt 15+ Cited Publications Suramin hexasodium salt	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-170557

Topoisomerase IIα-IN-10	Topoisomerase Apoptosis Mitochondrial Metabolism	Cancer
Topoisomerase IIα-IN-10 (Compound 13r) is an inhibitor of Topoisomerase IIα. It binds to the active site of DNA when complexed with Topoisomerase IIα, and this binding is stabilized through interactions with DNA base pairs and amino acid residues. Topoisomerase IIα-IN-10 can induce Apoptosis by intercalating DNA and inhibiting Topoisomerase IIα, thereby disrupting the mitochondrial membrane potential and inhibiting the growth of HCT116 cell lines, with an IC₅₀ of 4.37 μM against HCT116 cells. Topoisomerase IIα-IN-10 can be used for research in the field of cancer treatment .

HY-10982

Amonafide 3 Publications Verification AS1413	Topoisomerase	Cancer
Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

HY-152473

Topoisomerase IIα-IN-6	Topoisomerase	Cancer
Topoisomerase IIα-IN-6 (Compound 47d) is an inhibitor of DNA topoisomerase IIα/β. Topoisomerase IIα-IN-6 inhibits human topoisomerase IIα and human topoisomerase IIβ with IC₅₀ values of 0.67 µM and 0.55 µM, respectively. Topoisomerase IIα-IN-6 has stable metabolism .

HY-B0879AR

Suramin (sodium salt) (Standard)	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin (sodium salt) (Standard) is the analytical standard of Suramin (sodium salt). This product is intended for research and analytical applications. Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-146021

Topoisomerase IIα-IN-2	Topoisomerase	Cancer
Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase .

HY-119892

Batracylin NSC 320846; BAY-H 2049	Topoisomerase	Cancer
Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks .

HY-146020

Topoisomerase IIα-IN-1	Topoisomerase	Cancer
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines .

HY-155693

Topoisomerase II inhibitor 16	Topoisomerase Parasite	Infection
Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible *trypanosomal topoisomerase* II** inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research .

HY-147801

Topoisomerase IIα-IN-3	Topoisomerase Apoptosis	Cancer
Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis .

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Microtubule/Tubulin	Cancer
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-152479

Topoisomerase IIα-IN-7	Topoisomerase	Cancer
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC₅₀ value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability .

HY-16742B

Gepotidacin mesylate hydrate 5+ Cited Publications	Antibiotic Bacterial Topoisomerase	Infection
Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase .

HY-143279

Topoisomerase II inhibitor 3	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 3 (Compound 6 h ) is a acridone derivatives, as well as a Type II DNA topoisomerase (topo II) inhibitor , as a topo IIα/β inhibitor with the value of IC₅₀ is 0.17 μM for topo IIα and the value of IC₅₀ is 0.23 μM for topo IIβ subtypes, caused obvious DNA damage, and induced apoptosis by triggering the loss of mitochondrial membrane potential .

HY-143402

Topoisomerase I/II inhibitor 2	Topoisomerase	Cancer
Topoisomerase I/II inhibitor 2 (compound 1a) is a potent *Topoisomerase* inhibitor (IC₅₀= 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells). Topoisomerase I/II inhibitor 2 has dual inhibition on DNA topoisomerase I/II, also can obviously reduce the growth of xenograft tumor in mice model. Topoisomerase I/II inhibitor 2 has the potential value in researching liver cancer .

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Topoisomerase	Cancer
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Topoisomerase	Cancer
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-B0067

Amrubicin SM-5887	Topoisomerase Bacterial	Cancer
Amrubicin (SM-5887) is a DNA topoisomerase II inhibitor, used for the research of cancer.

HY-B0067A

Amrubicin hydrochloride SM-5887 hydrochloride	Topoisomerase Bacterial	Cancer
Amrubicin (SM-5887) hydrochloride is a DNA topoisomerase II inhibitor, used for the research of cancer.

HY-150044

*Type II topoisomerase* inhibitor 1**	DNA/RNA Synthesis Topoisomerase Bacterial	Infection
Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC₅₀: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC₅₀: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area .

HY-W178011

Topoisomerase IIα-IN-9 4,4'-Sulfonylbis(2-methylphenol)	Topoisomerase	Cancer
Topoisomerase IIα-IN-9 (NSC85582) is a bisphenol compound that has a moderate inhibitory effect on DNA topoisomerase Topoisomerase II (IC₅₀: 571 μM). Topoisomerase IIα-IN-9 also exhibits a certain cell growth inhibitory effect, with IC₅₀s of 117 μM and 218 μM for K562 and CHO, respectively .

HY-120185

Saintopin UCT-1003	Topoisomerase	Infection Cancer
Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage .

HY-146189

Topoisomerase II inhibitor 9	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC₅₀ of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC₅₀ of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells .

HY-13758A

TAS-103 dihydrochloride 1 Publications Verification BMS-247615 dihydrochloride	Topoisomerase	Cancer
TAS-103 dihydrochloride is a dual inhibitor of DNA **topoisomerase I/II**, used for cancer research.

HY-13758

TAS-103 BMS-247615	Topoisomerase	Cancer
TAS-103 is a dual inhibitor of DNA **topoisomerase I/II**, used for cancer research.

HY-13727A

Pixantrone 3 Publications Verification BBR 2778	Topoisomerase	Cancer
Pixantrone (BBR 2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.

HY-16518

Voreloxin Hydrochloride 2 Publications Verification SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride	Topoisomerase Apoptosis	Cancer
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

HY-15552S

Podofilox-d6	Microtubule/Tubulin	Cancer
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].

HY-W031307

Topoisomerase IIα-IN-8	Topoisomerase	Cancer
Topoisomerase IIα-IN-8 (compound 15) is a weak *human DNA* topoisomerase IIa (htIIa) inhibitor, with an IC₅₀** of 462 ± 38.0 μM .

HY-13550

Ametantrone NSC 196473; NSC 290813	DNA/RNA Synthesis	Cancer
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break .

HY-19825

Rebeccamycin	Topoisomerase ADC Cytotoxin Antibiotic	Cancer
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .

Cat. No.	Product Name	Type

HY-16700G

PNU-159682 (GMP)	Fluorescent Dye
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Cat. No.	Product Name	Type

HY-16700G

PNU-159682 (GMP)	Biochemical Assay Reagents
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-124552

Epolactaene	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis Topoisomerase
Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC₅₀ values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively .

HY-19825

Rebeccamycin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Topoisomerase ADC Cytotoxin Antibiotic
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .

HY-N10367

Corydamine	Alkaloids Corydalis bulleyana Diels Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Topoisomerase
Corydamine, 3-arylisoquinoline alkaloid, is a potent **DNA topoisomerase I/II** inhibitor. Corydamine has anti-cancer activity .

HY-15552R

Podofilox (Standard)	Structural Classification Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae	Microtubule/Tubulin
Podofilox (Standard) is the analytical standard of Podofilox. This product is intended for research and analytical applications. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-121309

Doxorubicinone Adriamycin aglycone; Adriamycinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-N12129

6,6′-Dihydroxythiobinupharidine	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Plants Nuphar pumila (Timm) de Candolle Nymphaeaceae	Cathepsin
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .

HY-121309R

Doxorubicinone (Standard)	Quinones Structural Classification Anthraquinones Source classification Endogenous metabolite	Endogenous Metabolite
Doxorubicinone (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-13629

Etoposide 100+ Cited Publications VP-16; VP-16-213	Infection Structural Classification Monophenols Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Source classification Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy . Doxorubicin inhibits human DNA topoisomerase I with an IC₅₀ of 0.8 μM .

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 437 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-N11536

erythro-Austrobailignan-6	Structural Classification Saururaceae Saururus chinensis (Lour.) Baill. Source classification Lignans Phenylpropanoids Plants	Topoisomerase Apoptosis
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA *topoisomerase* I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .

HY-13629R

Etoposide (Standard)	Structural Classification Monophenols Sinopodophyllum hexandrum (Royle) Ying Source classification Lignans Phenols Phenylpropanoids Plants Berberidaceae	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-15142R

Doxorubicin (hydrochloride) (Standard) 1 Publications Verification	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-N0354

Anthraquinone	Seeds of Cassia tora Linn. Quinones Structural Classification other families Classification of Application Fields Leguminosae Anthraquinones Source classification Other Diseases Plants Disease Research Fields	Virus Protease Topoisomerase Apoptosis
Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis .

HY-13062

Daunorubicin hydrochloride 20+ Cited Publications Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13062A

Daunorubicin Daunomycin; RP 13057; Rubidomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Autophagy Bacterial Antibiotic Apoptosis
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13062R

Daunorubicin (hydrochloride) (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Source classification Phenols Polyphenols	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (hydrochloride) (Standard) is the analytical standard of Daunorubicin (hydrochloride). This product is intended for research and analytical applications. Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

Cat. No.	Product Name	Chemical Structure

HY-13562AS

Banoxantrone-d12 dihydrochloride
Banoxantrone-d₁₂ (dihydrochloride) is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-15552S

Podofilox-d6
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].

HY-13562S

Banoxantrone-d12
Banoxantrone-d₁₂ is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-121309S

Doxorubicinone-d3
Doxorubicinone-d₃ is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-13629S1

Etoposide-13C,d3
Etoposide- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].

HY-13629S

Etoposide-d3
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80980

	TOP2A Antibody DNA topoisomerase II; DNA topoisomerase II-alpha; TOP2; TP2A; alpha isozyme, topoisomerase II alpha	WB, IHC-P, IP	Human, Mouse, Rat
	TOP2A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 174 kDa, targeting to TOP2A. It can be used for WB, IHC-P, IP assays with tag free, in the background of Human, Mouse, Rat.

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