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Results for "

P21

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Adrenergic Receptor (1) Androgen Receptor (1) Antibiotic (4) Apoptosis (35) Aurora Kinase (1) Autophagy (6) Bacterial (7) Bcl-2 Family (3) BRK (1) c-Myc (2) Caspase (3) CDK (6) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) Deubiquitinase (4) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (1) DNA/RNA Synthesis (7) E1/E2/E3 Enzyme (4) Endogenous Metabolite (13) Epigenetic Reader Domain (1) Farnesyl Transferase (1) Flavivirus (2) Fluorescent Dye (1) Fungal (4) HDAC (11) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) Histone Methyltransferase (3) HIV (3) HSP (2) HSV (2) Influenza Virus (2) Isotope-Labeled Compounds (6) Keap1-Nrf2 (1) MDM-2/p53 (19) MicroRNA (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) MMP (2) NAMPT (1) NF-κB (10) NO Synthase (1) Notch (1) PAK (13) Parasite (1) PARP (2) PDGFR (1) PKC (1) Potassium Channel (3) PPAR (9) PROTACs (2) Proteasome (1) RAR/RXR (1) Reactive Oxygen Species (7) Sirtuin (2) STAT (1) Topoisomerase (2) Tyrosinase (1) VD/VDR (2) VEGFR (1) Virus Protease (2) Wnt (1) β-catenin (2)
By Research Areas:	Cancer (92) Cardiovascular Disease (4) Endocrinology (2) Infection (15) Inflammation/Immunology (17) Metabolic Disease (5) Neurological Disease (6)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	saRNAs (2)

107

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UC2288 4 Publications Verification	MDM-2/p53	Cancer
UC2288 is a novel, cell-permeable, and orally active *p21* attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM .

Senexin A 5+ Cited Publications	CDK	Cancer
Senexin A is an inhibitor of CDK8/19 (IC₅₀: 280 nM, CDK8) and an inhibitor downstream of *p21* transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .

G-5555 hydrochloride 5+ Cited Publications	PAK	Cancer
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a K_i of 3.7 nM.

EN219	E1/E2/E3 Enzyme	Cancer
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination .

FRAX597 5+ Cited Publications	PAK	Cancer
FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC₅₀ of 8, 13 and 19 nM for PAK1, 2 and 3.

FRAX486 5+ Cited Publications	PAK	Cancer
FRAX486 is a p21-activated kinase (PAK) inhibitor with IC₅₀s of 14, 33 and 39 nM for PAK1, PAK2 and PAK3, respectively.

G-5555 5+ Cited Publications	PAK	Cancer
G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with K_is of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.

Senexin A hydrochloride	CDK	Cancer
Senexin A hydrochloride is an inhibitor of CDK8/19 (IC₅₀: 280 nM, CDK8) and an inhibitor downstream of *p21* transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A hydrochloride inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .

Fmoc-1,6-diaminohexane hydrochloride	Others	Cancer
Fmoc-1,6-diaminohexane hydrochloride is the hydrochloride form of Fmoc-1,6-diaminohexane (HY-103664). Fmoc-1,6-diaminohexane hydrochloride conjugates with monoclonal antibody, and exhibits anticancer activity against p21-deficient cancer .

USP7-IN-2	Deubiquitinase MDM-2/p53	Cancer
USP7-IN-2 (compound 4) is a non-competitive USP7 inhibitor with an IC₅₀ of 6 nM. USP7-IN-2 causes degradation of MDM2, stabilization of p53 and induction of *p21* in multiple cell lines, and can be utilized in cancer research .

Ischemin sodium	Apoptosis MDM-2/p53 Epigenetic Reader Domain	Cardiovascular Disease
Ischemin sodium is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin sodium salt inhibits p53-induced *p21* activation with an IC₅₀ value of 5 µM. Ischemin sodium salt also prevents apoptosis in ischemic cardiomyocytes. Ischemin sodium salt can be used in the study of cardiovascular diseases (such as myocardial ischemia) .

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone	Apoptosis	Neurological Disease Cancer
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

MIR002	HDAC DNA/RNA Synthesis Apoptosis	Cancer
MIR002 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo .

Tenovin-D3 hydrochloride	Sirtuin	Cancer
Tenovin-D3 hydrochloride is a sirtuin SirT2 inhibitor that increases p21 (CDKN1A) expression in a p53 independent manner .

5-Aminosalicylic Acid 15+ Cited Publications Mesalamine; 5-ASA; Mesalazine	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

Anticancer agent 70	Mitochondrial Metabolism	Cancer
Anticancer agent 70 (Compound 21), an anticancer agent, exhibits remarkable cytotoxic activity against numerous human cancer cell lines. Anticancer agent 70 results in the G0/G1-cell cycle arrest with a concomitant increase in p53 and p21 protein levels. Anticancer agent 70 leads to ATP depletion and disruption of the mitochondrial membrane potential .

Hygrolidin	Antibiotic Fungal ADC Cytotoxin	Infection Cancer
Hygrolidin is a 16-membered macrolide antibiotic produced by Streptomyces hygroscopicus D-1166. Hygrolidin has anti-fungus activity against Valsa ceratosperma. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity .

Mesalamine impurity P	PPAR PAK NF-κB	Inflammation/Immunology Cancer
Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

Aaptamine	Adrenergic Receptor	Endocrinology Cancer
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner .

CEP1612	Proteasome Apoptosis	Cancer
CEP1612 is a dipeptidyl proteasome inhibitor with the IC₅₀ of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo .

Sterigmatocystine	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite	Infection Cancer
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

5-Aminosalicylic Acid (Standard)	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic Acid (Standard) is the analytical standard of 5-Aminosalicylic Acid. This product is intended for research and analytical applications. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

Deoxynybomycin	Antibiotic Bacterial DNA/RNA Synthesis Topoisomerase Apoptosis	Infection Cancer
Deoxynybomycin is an antibiotic, that can be isolated from Streptomyces, and antibacterial activity against Staphylococcus aureus. Deoxynybomycin is the inhibitor for DNA gyrase and Topoisomerase I. Deoxynybomycin induces expression of p21/WAF1, exhibits cytotoxicity and induces apoptosis in cancer cells Saos-2, TMK-1, and THP-1 .

USP7-IN-9	Deubiquitinase Apoptosis	Cancer
USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC₅₀ value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and DNMT1 and increases the protein levels of tumor suppressors p53 and p21 .

FUBP1-IN-2	c-Myc	Cancer
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases *p21* mRNA and protein expression, and depletes intracellular polyamines .

WS-383	E1/E2/E3 Enzyme	Cancer
WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC₅₀ of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2 .

YM-1	HSP NO Synthase	Cancer
YM-1 is a stable and soluble MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and *p21* proteins .

Eugenol acetate Acetyleugenol	Fungal Bacterial Endogenous Metabolite	Infection Inflammation/Immunology Cancer
Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HNHA	HDAC MMP HIF/HIF Prolyl-Hydroxylase	Cancer
HNHA is a potent histone deacetylase (HDAC) inhibitor. HNHA arrests the cell cycle at the G1/S phase via p21 induction. HNHA inhibits tumor growth and tumor neovascularization. HNHA may be a potent anti-cancer agent against breast cancer .

EN219-alkyne	Fluorescent Dye	Cancer
EN219-alkyne is an alkyne-functionalized EN219 probe. EN219 (HY-P0287A) is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination . EN219-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

(S)-(-)-Perillic acid	Apoptosis Bacterial	Infection Cancer
(S)-(-)-Perillic acid is a terpenoid plant extract with antimicrobial and anticancer activities. (S)-(-)-Perillic acid induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, *p21* and caspase-3 proteins. (S)-(-)-Perillic acid can be used for cancer and infection research .

KCC-07	DNA Alkylator/Crosslinker	Cancer
KCC-07 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity .

Trilexium TRX-E-009-1	Microtubule/Tubulin Apoptosis PARP Caspase	Cancer
Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1 (HY-114250). Trilexium increases *p21* protein expression and induces apoptosis. Trilexium depolymerizes microtubules. Trilexium shows broad anti-cancer activity .

TRAP-1 XJZ-06-462	MDM-2/p53 Autophagy Apoptosis	Cancer
TRAP-1 (XJZ-06-462) is ap53 transcriptional activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. TRAP-1 rapidly upregulates *p21* and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 inhibits cell proliferation, with IC₅₀ values of 3.94 and 0.531 μM in BxPC-3 and A549 cells, respectively. TRAP-1 regulates autophagy in lung cancer cells and offers protective effects against oxidative stress and cell apoptosis .

AD4 1 Publications Verification	PROTACs	Cancer
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC₅₀: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .

Wnt/β-catenin-IN-3	Wnt β-catenin MDM-2/p53	Cancer
Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI₅₀s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of *p53-p21* pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells .

VDR agonist 1	VD/VDR Apoptosis	Cancer
VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC₅₀ of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2 .

2′-Deoxy-4′-thiocytidine	DNA Methyltransferase	Cancer
2′-Deoxy-4′-thiocytidine (T-dCyd) is a novel epigenetic agent. 2′-Deoxy-4′-thiocytidine administrations led to a significant *p21* increase. 2′-Deoxy-4′-thiocytidine can eradicate of tumor cells in the double-mutant xenografts .

XR 3054	Farnesyl Transferase	Cancer
XR 3054 is an inhibitor for Farnesyl Transferase, that inhibits farnesylation of CAAX recognition peptide with IC₅₀ of 50 μM. XR 3054 suppresses the farnesylation of p21 ras and activation of MAP kinase. XR 3054 inhibits the proliferation of prostate cancer cell and colon cancer cell, with IC₅₀ of 8.8-21.4 μM .

WS-383 free base	E1/E2/E3 Enzyme	Cancer
WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC₅₀ of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2 .

Sterigmatocystine (Standard)	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite	Infection Cancer
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

Cat. No.	Product Name	Target	Research Area

HY-131923

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

Species:	Human (14)
Tag:	His (6) SUMO (2) Tag Free (4) GST (5)
Source:	Sf9 insect cells (5) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P702747

	PAK4 Protein, Human (His) PAK4; P21 protein (Cdc42/Rac)-activated kinase 4; P21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; P21-activated kinase 4; P21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs	Human	E. coli

HY-P77099

	NCKIPSD Protein, Human (His) NCK-interacting protein with SH3 domain; VIP54; WISH; AF3P21; SPIN90	Human	E. coli
	NCKIPSD Protein, vital for stress fiber formation induced by active DRF1, stimulates N-WASP-induced ARP2/3 complex activation, independent of CDC42. Implicated in sarcomere maintenance, myofibril assembly, actin polymerization, and angiogenesis. Associates with vimentin, desmin, NCK, GRB2, and interacts with Helicobacter pylori toxin vacA, FHOD1, FASLG, and TMIGD2, showcasing its diverse cellular interactions. NCKIPSD Protein, Human (His) is the recombinant human-derived NCKIPSD protein, expressed by E. coli, with N-His labeled tag. The total length of NCKIPSD Protein, Human (His) is 244 a.a., with molecular weight of ~33-45 kDa.

HY-P700570

	CDKN1A Protein, Human (GST) CDK-interacting protein 1Melanoma differentiation-associated protein 6 ; MDA-6P21	Human	E. coli
	The CDKN1A protein critically controls cell cycle progression and mediates DNA damage-induced G2 arrest through p53/TP53-dependent and CREB3L1-mediated p53-independent pathways. It inhibits cyclin-dependent kinase activity, blocking cell cycle progression by preventing phosphorylation of key substrates. CDKN1A Protein, Human (GST) is the recombinant human-derived CDKN1A protein, expressed by E. coli , with N-GST labeled tag. The total length of CDKN1A Protein, Human (GST) is 163 a.a., with molecular weight of 45 kDa.

HY-P74607

	RAC2 Protein, Human (His) Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; P21-Rac2	Human	E. coli
	The RAC2 protein is a plasma membrane-associated small GTPase that dynamically regulates cellular responses by cycling between an active GTP-bound state and an inactive GDP-bound state. In its active state, RAC2 regulates secretory function, phagocytosis, and epithelial cell polarization. RAC2 Protein, Human (His) is the recombinant human-derived RAC2 protein, expressed by E. coli , with N-His labeled tag. The total length of RAC2 Protein, Human (His) is 189 a.a., with molecular weight of ~25 kDa.

HY-P702748

	PAK5 Protein, Human PAK5; P21 (RAC1) activated kinase 5; PAK7	Human	E. coli
	PAK5 Protein, Human is the recombinant human-derived PAK5, expressed by E. coli , with tag Free labeled tag. ,

HY-P702745

	PAK2 Protein, Human (sf9, GST) PAK2; P21 (RAC1) activated kinase 2; KNO2; PAK65; PAKgamma	Human	Sf9 insect cells
	PAK2 Protein, Human (sf9, GST) is the recombinant human-derived PAK2, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P702746

	PAK3 Protein, Human (sf9) PAK3; P21 protein (Cdc42/Rac)-activated kinase 3; bPAK; MRX30; MRX47; OPHN3; hPAK3; CDKN1A; PAK3beta; P21-activated kinase 3; beta-PAK; oligophrenin-3; OTTHUMP00000023856; P21 (CDKN1A)-activated kinase 3; serine/threonine-protein kinase PAK 3; EC 2.7.11.1	Human	Sf9 insect cells

HY-P76746

	BCCIP Protein, Human (sf9) BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; TOK1	Human	Sf9 insect cells
	BCCIP proteins contribute to interphase microtubule organization and anchoring as well as spindle pole organization and stability during mitosis. BCCIP protein may induce cell cycle arrest by enhancing CDK2 inhibition and participate in DNA damage repair through homologous recombination with BRCA2. BCCIP Protein, Human (sf9) is the recombinant human-derived BCCIP protein, expressed by Sf9 insect cells , with tag free.

HY-P76747

	BCCIP Protein, Human (sf9, His-GST) BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; TOK1	Human	Sf9 insect cells
	BCCIP proteins contribute to interphase microtubule organization and anchoring as well as spindle pole organization and stability during mitosis. BCCIP protein may induce cell cycle arrest by enhancing CDK2 inhibition and participate in DNA damage repair through homologous recombination with BRCA2. BCCIP Protein, Human (sf9, His-GST) is the recombinant human-derived BCCIP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P700575

	PAK4 Protein, Human (His-SUMO) P21-activated kinase 4 ; PAK-4	Human	E. coli
	PAK4 is an important serine/threonine kinase that affects cytoskeletal regulation, cell migration, growth, and survival through multiple pathways. Activation triggered by various effectors induces autophosphorylation, targeting proteins such as SSH1 and LIMK1 to regulate cofilin activity and stabilize actin filaments. PAK4 Protein, Human (His-SUMO) is the recombinant human-derived PAK4 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of PAK4 Protein, Human (His-SUMO) is 426 a.a., with molecular weight of 63.9 kDa.

HY-P701732

	PAK6 Protein, Human PAK6; Serine/threonine-protein kinase PAK 6; PAK-5; P21-activated kinase 6; PAK-6	Human	E. coli
	PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human is the recombinant human-derived PAK6 protein, expressed by E. coli , with tag free. The total length of PAK6 Protein, Human is 292 a.a., .

HY-P701733

	PAK6 Protein, Human (His) PAK6; Serine/threonine-protein kinase PAK 6; PAK-5; P21-activated kinase 6; PAK-6	Human	E. coli
	PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human (His) is the recombinant human-derived PAK6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PAK6 Protein, Human (His) is 292 a.a., .

HY-P74608

	RAC1 Protein, Human (sf9, GST) Ras-related C3 botulinum toxin substrate 1; P21-Rac1; RAC1; TC25; MIG5	Human	Sf9 insect cells
	The RAC1 protein is a plasma membrane-associated small GTPase that dynamically regulates multiple cellular responses by cycling between an active GTP-bound state and an inactive GDP-bound state. In its active form, RAC1 regulates processes such as secretory function, phagocytosis, cell polarization, neuronal activity, and growth factor-induced membrane ruffle formation. RAC1 Protein, Human (sf9, GST) is the recombinant human-derived RAC1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of RAC1 Protein, Human (sf9, GST) is 189 a.a., with molecular weight of ~44 kDa.

HY-P71530

	PAK1 Protein, Human (His-SUMO) Serine/threonine-protein kinase PAK 1; Alpha-PAK; P21-activated kinase 1 ; p65-PAK; PAK1	Human	E. coli
	PAK1 is a dynamic protein kinase that plays an important role in multiple intracellular signaling pathways, affecting cytoskeletal dynamics, adhesion, migration, proliferation, apoptosis, mitosis, and vesicle trafficking. Multifunctional PAK1 directly phosphorylates BAD to provide antiapoptotic cell protection. PAK1 Protein, Human (His-SUMO) is the recombinant human-derived PAK1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-15027S

5-Aminosalicylic Acid-d3 hydrochloride
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-15027S1

5-Aminosalicylic acid-d3
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

HY-15027S2

5-Aminosalicylic acid-13C6
5-Aminosalicylic acid- ¹³C₆ is the ¹³C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].

HY-15027S3

5-Aminosalicylic acid-d3 disodium
5-Aminosalicylic acid-d₃ disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-N1952S

Isoeugenol-d3
Isoeugenol-d₃ is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-15027S4

5-Aminosalicylic acid-d7
5-Aminosalicylic acid-d₇ (5-ASA-d₇; Mesalamie-d₇; Mesalazie-d₇) is deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN) .

HY-W012998S2

2,3-Pentanedione-d3
2,3-Pentanedione-d₃ is deuterated labeled Eugenol acetate (HY-W014612). Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HY-143704S

5-Aminosalicylic acid-13C6 hydrochloride
5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80774

	p21 Antibody CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; P21	WB, ICC/IF	Human, Mouse, Rat
	p21 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 18 kDa, targeting to p21. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80773

	p21 Antibody (YA254) CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; P21	WB	Human, Mouse
	p21 Antibody (YA254) is a non-conjugated and Rabbit origined monoclonal antibody about 18 kDa, targeting to p21. It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P81618

	PAK1 Antibody (YA1363) PAK1; Serine/threonine-protein kinase PAK 1; Alpha-PAK; P21-activated kinase 1; PAK-1; p65-PAK	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	PAK1 Antibody (YA1363) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1363), targeting PAK1, with a predicted molecular weight of 61 kDa (observed band size: 66 kDa). PAK1 Antibody (YA1363) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P80778

	PAK2 Antibody (YA695) PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; P21-activated kinase 2; PAK-2; p58	WB, IHC-F, IHC-P, ICC/IF	Human, Monkey
	PAK2 Antibody (YA695) is a non-conjugated and Mouse origined monoclonal antibody about 58 kDa, targeting to PAK2 (7H3). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Monkey.

HY-P81785

	Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (YA1530) PAK3; OPHN3; Serine/threonine-protein kinase PAK 3; Beta-PAK; Oligophrenin-3; P21-activated kinase 3; PAK-3	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (YA1530) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1530), targeting Phospho-PAK1/2/3 (Ser144/Ser141/Ser154), with a predicted molecular weight of 62 kDa (observed band size: 62 kDa). Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (YA1530) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P83545

	Rac Antibody (YA3290) Cell migration-inducing gene 5 protein; EN-7; GX; P21-Rac1; P21-Rac2; P21-Rac3; RAC1; RAC2; RAC3; TC25	WB	Human, Mouse, Rat
	Rac Antibody (YA3290) is a biotin-conjugated non-conjugated IgG antibody, targeting Rac, with a predicted molecular weight of 21 kDa. Rac Antibody (YA3290) can be used for WB experiment in human, mouse, rat background.

HY-P81622

	PAK3 Antibody (YA1367) PAK3; OPHN3; Serine/threonine-protein kinase PAK 3; Beta-PAK; Oligophrenin-3; P21-activated kinase 3; PAK-3	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	PAK3 Antibody (YA1367) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1367), targeting PAK3, with a predicted molecular weight of 62 kDa (observed band size: 62 kDa). PAK3 Antibody (YA1367) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-115715A

EN219-alkyne		Alkynes
EN219-alkyne is an alkyne-functionalized EN219 probe. EN219 (HY-P0287A) is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination . EN219-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-132607A

MTL-CEBPA sodium CEBPA-51 sodium		saRNAs
MTL-CEBPA (sodium) is the sodium form of MTL-CEBPA (HY-132607). MTL-CEBPA (sodium) is a small activating RNA targeting for upregulation of C/EBPα. MTL-CEBPA (sodium) has anti-inflammatory and anti-cancer activity .

HY-132607

MTL-CEBPA CEBPA-51		saRNAs
MTL-CEPBA is a small activating RNA targeting for upregulation of C/EBPα. MTL-CEPBA has anti-inflammatory and anti-cancer activity .

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P21

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