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Results for "

TNF Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (40) ADC Cytotoxin (1) Adenosine Receptor (3) Adrenergic Receptor (7) AMPK (1) Amyloid-β (1) Antibody-Drug Conjugates (ADCs) (2) AP-1 (1) Apoptosis (4) Autophagy (3) Bacterial (2) c-Fms (1) Calcium Channel (2) Cannabinoid Receptor (2) CaSR (1) CCR (1) CD28 (1) CDK (1) Complement System (1) COX (2) CXCR (1) Dopamine Receptor (2) Drug-Linker Conjugates for ADC (3) Endogenous Metabolite (1) ERK (1) Estrogen Receptor/ERR (1) Formyl Peptide Receptor (FPR) (1) FXR (1) G protein-coupled Bile Acid Receptor 1 (1) G Protein-coupled Receptor Kinase (GRK) (1) Glucocorticoid Receptor (9) GLUT (1) HCV (2) Histamine Receptor (3) IFNAR (1) Interleukin Related (13) IRAK (2) Isotope-Labeled Compounds (1) JAK (1) Leukotriene Receptor (2) Melanocortin Receptor (1) mGluR (1) MyD88 (1) NF-κB (8) NO Synthase (1) NOD-like Receptor (NLR) (2) Opioid Receptor (1) Orexin Receptor (OX Receptor) (1) p38 MAPK (2) PGE synthase (1) PKC (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) RIP kinase (2) STAT (1) STING (1) Toll-like Receptor (TLR) (17) Trace Amine-associated Receptor (TAAR) (1) VEGFR (5) Wnt (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (9) Endocrinology (2) Infection (3) Inflammation/Immunology (68) Metabolic Disease (5) Neurological Disease (12)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Recombinant Proteins

Isotope-Labeled Compounds

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Click Chemistry

Sinensetin 5+ Cited Publications Pedalitin permethyl ether	PGE synthase TNF Receptor	Others
Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties.

SPD304 5 Publications Verification	TNF Receptor	Cancer
SPD304 is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

SPD304 dihydrochloride 5 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
SPD304 dihydrochloride is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

WP9QY TFA	TNF Receptor	Others Cancer
WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

WP9QY	TNF Receptor	Others
WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

Etanercept 5+ Cited Publications	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Etanercept, a dimeric fusion protein that binds TNF, acts as a *TNF* inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

Infliximab (Anti-TNF-α) Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .

R-7050 15+ Cited Publications TNF-α Antagonist III	TNF Receptor	Cancer
R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

Infliximab 10+ Cited Publications Avakine; CT-P13	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .

Tanfanercept HL036337; HBM9036	TNF Receptor	Inflammation/Immunology
Tanfanercept (HL036337) is an **TNF-α receptor** fusion protein that targets TNF-α. Tanfanercept is effective in ameliorating corneal erosions in a dry eye (DE) mouse model .

*Glucocorticoid receptor* agonist-4**	Glucocorticoid Receptor ADC Cytotoxin	Inflammation/Immunology
Glucocorticoid receptor agonist-4 (Compound Preparation 5) is a glucocorticoid receptor agonist that can be conjugated to TNF-α antibodies for the study of autoimmune and inflammatory diseases .

Tulinercept OPRX-106; PRX-106; TNFR-Fc	TNF Receptor	Cancer
Tulinercept (OPRX-106) is a recombinant TNF receptor fusion protein fused to an IgG1 Fc domain .

LTβR-IN-1	NF-κB	Metabolic Disease
LTβR-IN-1 is a potent, selective *lymphotoxin β receptor* (LTβR)** inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner .

*Glucocorticoid receptor* activator 1**	Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoid receptor activator 1 (compound A) is a phenyl aziridine precursor and an activator of the glucocorticoid receptor (GR). Glucocorticoid receptor activator 1 down-modulates TNF-induced pro-inflammatory gene expression by activating GR and can be utilized in inflammation research .

Tavolixizumab MEDI 0562; Tavolimab	TNF Receptor	Cancer
Tavolixizumab (MEDI 0562; Tavolimab) is a human monoclonal antibody to TNFRSF4 (TNF receptor superfamily member 4) for use in cancer immunology research .

Anti-inflammatory agent 61	TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent. Anti-inflammatory agent 61 reduces TNF-α expression in LPS-induced inflammation in RAW 264.7 cells. Anti-inflammatory agent 61 alleviates APAP-induced inflammation in HepG2 cells .

Lenercept p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1	TNF Receptor	Inflammation/Immunology
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble *TNF-receptor* (p55) linked to the Fc portion of human IgG1 .

Ataquimast	COX Leukotriene Receptor TNF Receptor c-Fms	Inflammation/Immunology
Ataquimast is a COX-2 inhibitor that inhibits the release of leukotrienes, TNF-α and GM-CSF. Ataquimast can be used in the study of advanced receptor-positive breast cancer .

*Glucocorticoid receptor* agonist-4 Ala-Ala-Mal**	TNF Receptor Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Inflammation/Immunology
Glucocorticoid receptor agonist-4 Ala-Ala-Mal (Compound Preparation 9) is an anti-human TNFα antibody-glucocorticoid receptor agonist (GC) conjugate. Glucocorticoid receptor agonist-4 Ala-Ala-Mal can be used in the study of autoimmune and inflammatory diseases .

*Glucocorticoid receptor* agonist-3 Ala-Ala-Mal**	TNF Receptor Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Inflammation/Immunology
Glucocorticoid receptor agonist-3 Ala-Ala-Mal (Compound Preparation 8) is an anti-human TNFα antibody-glucocorticoid receptor agonist (GC) conjugate. Glucocorticoid receptor agonist-3 Ala-Ala-Mal can be used in the study of autoimmune and inflammatory diseases .

Resiquimod 75+ Cited Publications R848; S28463	Toll-like Receptor (TLR) HCV	Inflammation/Immunology Cancer
Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.

Ruplizumab BG 9588; Anti-Human CD40L Recombinant Antibody	TNF Receptor	Inflammation/Immunology
Ruplizumab (BG 9588) is a humanized monoclonal anti-CD40L (TNF Receptor) IgG1κ antibody. Ruplizumab has the potential for systemic lupus erythematosus disease research .

Ataquimast free base	COX	Inflammation/Immunology
Ataquimast free base is a COX-2 inhibitor that inhibits the release of leukotrienes, TNF-α and GM-CSF. Ataquimast free base can be used in the study of advanced receptor-positive breast cancer .

Ferolin	FXR	Inflammation/Immunology
Ferolin is the agonist for farnesoid X receptor (FXR) with an EC₅₀ of 0.56 µM. Ferolin inhibits the expression of inflammatory genes (such as iNOS, IL-1β and TNFα) upon the FXR activation .

*Glucocorticoid receptor* modulator 4**	Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Inflammation/Immunology
Glucocorticoid receptor modulator 4 (Compound DL5) is a conjugate of a linker and a glucocorticoid receptor modulator. Glucocorticoid receptor modulator 4 exhibits GRE Reporter activity in mTNF expressing K562 cell with an EC₅₀ of 40 μM. Glucocorticoid receptor modulator 4 binds with an anti-tumor necrosis factor (TNF) antibody, and exhibits anti-inflammtory activity against arthritis in mouse models .

4-Methoxylonchocarpin	NF-κB Interleukin Related Toll-like Receptor (TLR)	Inflammation/Immunology
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to *Toll-like Receptor* (TLR) TLR4 to inhibit NF-κB** activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model .

N-Formyl-Met-Leu-Phe 10+ Cited Publications fMLP; N-Formyl-MLF	TNF Receptor	Inflammation/Immunology
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit *TNF-alpha* secretion.

*CB2 receptor* agonist 9**	Cannabinoid Receptor	Inflammation/Immunology
CB2 receptor agonist 9 (Compound 33) is an orally active agonist for *cannabinoid receptor* 2** (CB2 receptor) with an EC₅₀ of 16.2 nM. CB2 receptor agonist 9 inhibits the expression of TNF-α, IL-1β and IL-6, exhibits anti-inflammatory efficacy in DDS (HY-116282)-induced mouse acute colitis model .

KAG-308 2 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a K_i and an EC₅₀ of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor .

Revdofilimab ABBV-368	Orexin Receptor (OX Receptor)	Inflammation/Immunology Cancer
Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells .

*Glucocorticoid receptor* modulator 1**	Glucocorticoid Receptor NF-κB AP-1	Inflammation/Immunology
Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC₅₀ value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice .

*Glucocorticoid receptor/NF-κB modulator-1*	Glucocorticoid Receptor NF-κB	Inflammation/Immunology
Glucocorticoid receptor/NF-κB modulator-1 (Compound 20) is a derivative of ocotillol. Glucocorticoid receptor/NF-κB modulator-1 suppresses the degradation of glucocorticoid receptor (GR) mRNA and GR protein, inhibits the activation of NF-κB signaling pathway. Glucocorticoid receptor/NF-κB modulator-1 downregulates levels of NO, interleukin-6 and tumor necrosis factor-alpha (TNF-α). Glucocorticoid receptor/NF-κB modulator-1 ameliorates sepsis in mouse model .

Epobis	TNF Receptor	Neurological Disease Inflammation/Immunology
Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties .

17-Epiestriol	Estrogen Receptor/ERR	Endocrinology
17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

ABBV-3373	Antibody-Drug Conjugates (ADCs) TNF Receptor Glucocorticoid Receptor	Inflammation/Immunology
ABBV-3373 is an anti-TNF antibody drug conjugate (ADC). ABBV-3373 is composed of the humanized antibody Adalimumab (HY-P9908) conjugated with a glucocorticoid receptor modulator (HY-148436). ABBV-3373 can be used in the study of rheumatoid arthritis .

CTX-471	Interleukin Related	Inflammation/Immunology Cancer
CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K_d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer .

Mizolastine dihydrochloride	Histamine Receptor	Inflammation/Immunology
Mizolastine dihydrochloride is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine dihydrochloride effectively inhibits mRNA expression of VEGF165, VEGF120, *TNF-α* and KC. Mizolastine dihydrochloride can be used in studies of allergic rhinitis and chronic idiopathic urticarial .

Mizolastine	Histamine Receptor	Inflammation/Immunology
Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, *TNF-α* and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial .

ABBV-154	Antibody-Drug Conjugates (ADCs) TNF Receptor Glucocorticoid Receptor	Inflammation/Immunology
ABBV-154 is an anti-TNF antibody-drug conjugate (ADC). ABBV-154 is composed of the humanized antibody Adalimumab (HY-P9908) conjugated with a glucocorticoid receptor modulator (HY-137883). ABBV-154 can be used in studies of rheumatoid arthritis, Crohn's disease and polymyalgia rheumatica .

DOR agonist 2	Opioid Receptor TNF Receptor NF-κB ERK	Neurological Disease Inflammation/Immunology
DOR agonist 2 (Compound 3) is a Delta Opioid Receptor agonist. DOR agonist 2 can inhibit the expression of *TNF-α, prevent NF-κB* transport to the nucleus, and activate the G protein-mediated ERK1/2 pathway. DOR agonist 2 can be used in the study of neurodegenerative diseases .

Clenbuterol NAB-365	Adrenergic Receptor	Inflammation/Immunology
Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC₅₀ of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

N'-Nitro-D-arginine	NO Synthase	Others
N'-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) .

Atibuclimab 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Atibuclimab, is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis . Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist .

PK68	RIP kinase	Inflammation/Immunology Cancer
PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC₅₀ of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis .

J-113863 3 Publications Verification	CCR	Inflammation/Immunology
J-113863 is a potent and selective CCR1 antagonist with IC₅₀ values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC₅₀ of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC₅₀ of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect .

Cat. No.	Product Name

HY-L156

Autoimmune Disease Compound Library

611 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 611 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

HY-L161

Cytokine Inhibitors Library

981 compounds

Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases.

MCE designs a unique collection of 981 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.

HY-L150

Membrane Receptor-targeted Compound Library

5,648 compounds

Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules.

There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery.

MCE provides a unique collection of 5,648 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

Cat. No.	Product Name	Type

HY-134816

D-Glucan

Carbohydrates

D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism) .

Cat. No.	Product Name	Target	Research Area

HY-P2612A

WP9QY TFA	TNF Receptor	Others Cancer
WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

HY-P2612

WP9QY	TNF Receptor	Others
WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

HY-P0224

N-Formyl-Met-Leu-Phe 10+ Cited Publications fMLP; N-Formyl-MLF	TNF Receptor	Inflammation/Immunology
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit *TNF-alpha* secretion.

HY-P3585

Epobis	TNF Receptor	Neurological Disease Inflammation/Immunology
Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties .

HY-12557

γ-Glutamylvaline	CaSR Wnt TNF Receptor	Inflammation/Immunology
γ-Glutamylvaline is an activator of CaSR with anti-inflammatory activity. γ-Glutamylvaline inhibits *TNF-α*-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation .

HY-W014049

N'-Nitro-D-arginine	NO Synthase	Others
N'-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) .

Cat. No.	Product Name	Target	Research Area

HY-108847

Etanercept 5+ Cited Publications	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Etanercept, a dimeric fusion protein that binds TNF, acts as a *TNF* inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

HY-P9970A

Infliximab (Anti-TNF-α) Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .

HY-P9970

Infliximab Maximum Cited Publications 12 Publications Verification Avakine; CT-P13	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to *TNF-α. Infliximab prevents the interaction of TNF-α* with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .

HY-P99393

Tavolixizumab MEDI 0562; Tavolimab	TNF Receptor	Cancer
Tavolixizumab (MEDI 0562; Tavolimab) is a human monoclonal antibody to TNFRSF4 (TNF receptor superfamily member 4) for use in cancer immunology research .

HY-P99315

Ruplizumab BG 9588; Anti-Human CD40L Recombinant Antibody	TNF Receptor	Inflammation/Immunology
Ruplizumab (BG 9588) is a humanized monoclonal anti-CD40L (TNF Receptor) IgG1κ antibody. Ruplizumab has the potential for systemic lupus erythematosus disease research .

HY-P99945

Revdofilimab ABBV-368	Orexin Receptor (OX Receptor)	Inflammation/Immunology Cancer
Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells .

HY-P99178

CTX-471	Interleukin Related	Inflammation/Immunology Cancer
CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K_d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer .

HY-P99578

Tanfanercept HL036337; HBM9036	TNF Receptor	Inflammation/Immunology
Tanfanercept (HL036337) is an **TNF-α receptor** fusion protein that targets TNF-α. Tanfanercept is effective in ameliorating corneal erosions in a dry eye (DE) mouse model .

HY-P99543

Tulinercept OPRX-106; PRX-106; TNFR-Fc	TNF Receptor	Cancer
Tulinercept (OPRX-106) is a recombinant TNF receptor fusion protein fused to an IgG1 Fc domain .

HY-P99692

Lenercept p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1	TNF Receptor	Inflammation/Immunology
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble *TNF-receptor* (p55) linked to the Fc portion of human IgG1 .

HY-P99008

Atibuclimab 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Atibuclimab, is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis . Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

Species:	Human (16) Rhesus Macaque (2) Mouse (9) Rat (4) Cynomolgus (1)
Tag:	His (19) Tag Free (1) Avi (2) GST (1) Fc (11) Flag (1)
Source:	HEK293 (27) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P71126

	TNFRII Protein, Human (174a.a, HEK293, His) Tumor necrosis factor Receptor superfamily member 1B; Tumor necrosis factor Receptor 2; TNF-R2; Tumor necrosis factor Receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha Receptor; TNFRII; TNF RII	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (174a.a, HEK293, His) is expressed by HEK293 and has a transmembrane region (K288-S461) with 6*His tag at the C-terminus.

HY-P70536

	TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) TNF-RII; TNFRII; TNF RII; Tumor necrosis factor Receptor superfamily member 1B; TNFRSF1B; Tumor necrosis factor Receptor 2; TNF-R2; Tumor necrosis factor Receptor type II; p75; p80 TNF-alpha Receptor; CD120b	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) is expressed by HEK293 and has a transmembrane region (P24-T206) with mFc tag at the C-terminus.

HY-P72025

	TNFRII Protein, Human (HEK293, hFc) Tumor necrosis factor Receptor 2; TNF-R2; Tumor necrosis factor Receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha Receptor; CD120b; Etanercept; TBP-2; TBPII	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (HEK293, hFc) is expressed by HEK293 and has a transmembrane region (L23-D257) with hFc tag at the C-terminus.

HY-P70516

	TNF RII/TNFRSF1B Protein, Mouse (HEK293, His) Tumor necrosis factor Receptor superfamily member 1b; TNFrsf1b; TNF-RII; TNFRII; TNF RII	Mouse	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Mouse (HEK293, His) is expressed by HEK293 and has a transmembrane region with 6*His tag at the C-terminus.

HY-P70801

	TNFRSF1A Protein, Human (His) Tumor necrosis factor Receptor superfamily member 1A; Tumor necrosis factor Receptor 1; TNF-R1; Tumor necrosis factor Receptor type I; TNF-RI; TNFR-I; TNFAR; TNFR1	Human	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Human (His) is expressed by E. coli and has a transmembrane region (I22-T211) with a 6*His tag at the N-terminus.

HY-P72443

	TNF RI/TNFRSF1A Protein, Mouse Tumor necrosis factor Receptor superfamily member 1A; TNF-R1; CD120a; TNFrsf1a	Mouse	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse is expressed by E. coli and has a transmembrane region (I22-A212).

HY-P73449

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) Tumor necrosis factor Receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region with a Fc tag at the C-terminus.

HY-P72444

	TNF RII/TNFRSF1B Protein, Rhesus Macaque (HEK293, His) TNF-R2; CD120b; Tumor necrosis factor Receptor superfamily member 1b; p75; TNFr2	Rhesus Macaque	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Rhesus Macaque (HEK293, His) is expressed by HEK293 and has a transmembrane region (L23-D257) with 6*His tag at the C-terminus.

HY-P73450

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) Tumor necrosis factor Receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region with a His tag at the C-terminus.

HY-P76108

	TNF RII/TNFRSF1B Protein, Mouse (HEK293, Fc) TNF-R2; CD120b; Tumor necrosis factor Receptor superfamily member 1b; p75; TNFr2	Mouse	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Mouse (HEK293, Fc) is expressed by HEK293 and has a transmembrane region with Fc tag at the C-terminus.

HY-P77498

	TNF RII/TNFRSF1B Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) TNF-R2; CD120b; Tumor necrosis factor Receptor superfamily member 1b; p75; TNFr2	Rhesus Macaque	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is expressed by HEK293 and has a transmembrane region (M1-D257) with hFc tag at the C-terminus.

HY-P70815

	TNFRSF10C Protein, Human (HEK293, His) Tumor Necrosis Factor Receptor Superfamily Member 10C; Antagonist Decoy Receptor for TRAIL/Apo-2L; Decoy TRAIL Receptor Without Death Domain; Decoy Receptor 1; DcR1; Lymphocyte Inhibitor of TRAIL; TNF-Related Apoptosis-Inducing Ligand Receptor 3; TRAIL Receptor	Human	HEK293
	The TNFRSF10C protein is a receptor for TRAIL and lacks a cytoplasmic death domain, making it unable to induce apoptosis. Instead, it protects cells by competing for ligand binding with TRAIL-R1 and R2, acting as a decoy receptor and mitigating TRAIL-mediated apoptosis. TNFRSF10C Protein, Human (HEK293, His) is the recombinant human-derived TNFRSF10C protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TNFRSF10C Protein, Human (HEK293, His) is 196 a.a., with molecular weight of 50-60 kDa.

HY-P77500

	TNFRH3/TNFRSF26 Protein, Mouse (HEK293, Fc) Tumor necrosis factor Receptor superfamily member 26; TNF Receptor homolog 3; TNFrh3	Mouse	HEK293
	TNFRH3/TNFRSF26 protein is significantly expressed in the thymus and spleen, indicating that it plays a crucial role in regulating immune system function. Its presence in the thymus, a key organ for T-cell development, underscores its important role in overseeing fundamental cellular processes required for immune maturation. TNFRH3/TNFRSF26 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TNFRH3/TNFRSF26 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TNFRH3/TNFRSF26 Protein, Mouse (HEK293, Fc) is 143 a.a., with molecular weight of ~42.8 KDa.

HY-P70806

	TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) Tumor Necrosis Factor Receptor Superfamily Member 10B; Death Receptor 5; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9	Human	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is 127 a.a., with molecular weight of ~18.0 kDa.

HY-P72420

	TNF RII/TNFRSF1B Protein, Mouse (HEK293, His-Avi) Tumor necrosis factor Receptor superfamily member 1b; TNFrsf1b	Mouse	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Mouse (HEK293, His-Avi) is expressed by HEK293 and has a transmembrane region (V23-G258) with Avi and 6*His tag at the C-terminus.

HY-P75917

	TNFRSF3/LTBR Protein, Rat (HEK293, Fc) Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3	Rat	HEK293
	TNFRSF3/LTBR Protein, Rat (HEK293, Fc) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Rat (HEK293, Fc) is expressed by HEK293 cells with a His tag at the C-terminus.

HY-P75918

	TNFRSF3/LTBR Protein, Rat (HEK293, His) Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3	Rat	HEK293
	TNFRSF3/LTBR Protein, Rat (HEK293, His) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Rat (HEK293, His) is expressed by HEK293 cells and is a transmembrane protein (M222-W245) with a His tag at the C-terminus.

HY-P77445

	TNFRSF3/LTBR Protein, Cynomolgus (HEK293, Fc) Tumor Necrosis Factor Receptor Superfamily Member 3; TNF-RIII; TNFCR; TNFR3	Cynomolgus	HEK293
	TNFRSF3/LTBR Protein,Cynomolgus (HEK293, Fc) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Cynomolgus (HEK293, Fc) is expressed by HEK293 cells and is a transmembrane protein (M225-W248) with a His tag at the C-terminus.

HY-P72806

	TNFRSF3/LTBR Protein, Human (HEK293, Fc) Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3	Human	HEK293
	TNFRSF3/LTBR Protein, Human (HEK293, Fc) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Human (HEK293, Fc) is expressed by HEK293 cells and is a transmembrane protein (L228-W248) with a Fc tag at the C-terminus.

HY-P70345

	TNFRSF3/LTBR Protein, Human (HEK293, His) rHuTumor necrosis factor Receptor superfamily member 3/TNFRSF3, His; Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3	Human	HEK293
	TNFRSF3/LTBR Protein, Human (HEK293, His) is a cell surface receptor for apoptotic and cytokine-released lymphotoxins involved in activation of gene transcription programs and cell death, and is important in immune development and host defense. TNFRSF3/LTBR Protein, Human (HEK293, His) is expressed by HEK293 cells and is a transmembrane protein (L228-W248) with a His tag at the C-terminus.

HY-P74504

	TNFRSF1A Protein, Rat (HEK293, His) Tumor necrosis factor Receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, His) is expressed by HEK293 and has a transmembrane region (M1-A211) with a His tag at the C-terminus.

HY-P74505

	TNFRSF1A Protein, Rat (HEK293, Fc) Tumor necrosis factor Receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, Fc) is expressed by HEK293 and has a transmembrane region with a Fc tag at the C-terminus.

HY-P76683

	TNFRII Protein, Human (257a.a, HEK293, His) TNF-R2; CD120b; Tumor necrosis factor Receptor superfamily member 1b; p75; TNFr2	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (257a.a, HEK293, His) is expressed by HEK293 and has a transmembrane region (M1-D257) with His tag at the C-terminus.

HY-P700263

	TNFR-1/CD120a Protein, Human (HEK293, His) Tumor necrosis factor Receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Human	HEK293
	The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, His) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-8*His labeled tag. The total length of TNFR-1/CD120a Protein, Human (HEK293, His) is 182 a.a., with molecular weight of 28-38 kDa.

HY-P700264

	TNFR-1/CD120a Protein, Human (HEK293, Fc) Tumor necrosis factor Receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Human	HEK293
	The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, Fc) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TNFR-1/CD120a Protein, Human (HEK293, Fc) is 182 a.a., with molecular weight of 55-70 kDa.

HY-P700147AF

	Animal-Free RANK L/TNFSF11 Protein, Human (His) soluble Receptor Activator of NF-kB Ligand; TNFSF11; TRANCE (TNF-Related Activation-induced Cytokine); OPGL; ODF (Osteoclast Differentiation Factor); CD254; sRNAK Ligand	Human	E. coli
	RANK L/TNFSF11 protein is a cytokine that binds to TNFRSF11B/OPG and TNFRSF11A/RANK and serves as a key regulator of osteoclast differentiation and activation. In addition, it is a factor that enhances the ability of dendritic cells to stimulate naive T cell proliferation, indicating its importance in regulating the interaction between T cells and dendritic cells, as well as its potential role in T cell-dependent immune responses. Animal-Free RANK L/TNFSF11 Protein, Human (His) is the recombinant human-derived animal-FreeRANK L/TNFSF11 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free RANK L/TNFSF11 Protein, Human (His) is 175 a.a., with molecular weight of ~20.67 kDa.This product is for cell culture use only.

HY-P700226AF

	Animal-Free RANK L/TNFSF11 Protein, Mouse (His) soluble Receptor Activator of NF-kB Ligand; TNFSF11; TRANCE (TNF-Related Activation-induced Cytokine); OPGL; ODF (Osteoclast Differentiation Factor); CD254; sRNAK Ligand	Mouse	E. coli
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). Animal-Free RANK L/TNFSF11 Protein, Mouse (His) is a recombinant mouse RANKL (P143-D316) with C-terminal His tag, which is produced in E.coli.This product is for cell culture use only.

HY-P7425C

	RANKL/TNFSF11 Protein, Mouse (HEK293, His, Flag) soluble Receptor Activator of NF-kB Ligand; TNFSF11; TRANCE (TNF-Related Activation-induced Cytokine); OPGL; ODF (Osteoclast Differentiation Factor); CD254; sRNAK Ligand	Mouse	HEK293
	RANKL/TNFSF11 Protein, Mouse (HEK293, His, Flag) is the recombinant mouse-derived RANKL/TNFSF11, expressed by HEK293 , with C-Flag, C-6*His labeled tag. ,

HY-P78091

	CD40 Protein, Human (Biotinylated, HEK293, His-Avi) CD40; CD40L Receptor; TNFRSF5; B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF Receptor superfamily member 5; CD40 type II isoform; CDw40; MGC9013; nerve growth factor Receptor-relat	Human	HEK293
	CD40 protein is a TNFSF5/CD40LG receptor that transduces signals through TRAF6 and MAP3K8-mediated pathways, activates ERK in macrophages and B cells, and induces immunoglobulin secretion. CD40 exists as monomers and homodimers and interacts with TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6). CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD40 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is 173 a.a., with molecular weight of 35-40 kDa.

HY-P71537

	TRAP1 Protein, Human (GST) Heat shock protein 75kDa; Heat shock protein 75kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF Receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 Receptor-associated protein	Human	E. coli
	As a chaperone with ATPase activity, TRAP1 protein plays a crucial role in protecting mitochondrial function and polarization, especially downstream of PINK1 and mitochondrial complex I. TRAP1 acts as a negative regulator of mitochondrial respiration, affecting the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1 Protein, Human (GST) is the recombinant human-derived TRAP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRAP1 Protein, Human (GST) is 249 a.a., with molecular weight of ~54.5 kDa.

HY-P70011A

	Cyclophilin B/PPIB Protein, Human (HEK293, His) Ephrin-A1; EPH-Related Receptor Tyrosine Kinase Ligand 1; LERK-1; Immediate Early Response Protein B61; Tumor Necrosis Factor Alpha-Induced Protein 4; TNF Alpha-Induced Protein 4; EFNA1; EPLG1; LERK1; TNFAIP4	Human	HEK293
	Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, His) is 179 a.a., with molecular weight of ~19 kDa.

HY-P70164

	Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) rHuEphrin-A1, His; Ephrin-A1; EPH-Related Receptor Tyrosine Kinase Ligand 1; LERK-1; Immediate Early Response Protein B61; Tumor Necrosis Factor Alpha-Induced Protein 4; TNF Alpha-Induced Protein 4; EFNA1; EPLG1; LERK1; TNFAIP4	Human	HEK293
	Ephrin-A1/EFNA1 Protein is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family (EphA2). EFNA1 exerts its function largely through interactions with EphA2. EFNA1 exists in a soluble form as well as a glycophosphatidylinositol (GPI) membrane attached form. EFNA1 acts as a membrane-bound, GPI-anchored protein capable of mediating juxtacrine signalling and requiring membrane attachment or clustering/oligomerization. EFNA1 is a novel TNF-inducible protein. EFNA1 efficiently binds to the EphA8 receptor expressed in NIH3T3 fibroblasts. EFNA1 stimulates PI3K activity via direct interaction of EphA2 with the p85 subunit of PI3K. EFNA1 can both inhibit and stimulate oncogenesis, depending on the cellular context. Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) is the recombinant human-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) is 164 a.a., with molecular weight of 25-30 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-13740S

Resiquimod-d5 1 Publications Verification
Resiquimod-d₅ is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80915

	TNF Receptor 2 Antibody CD120b; p75 TNF Receptor; p80 TNF alpha Receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R75; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII; TNFrsf1b	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	TNF Receptor 2 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 48 kDa, targeting to TNF Receptor 2. It can be used for WB,IHC-F,IHC-P,ICC/IF,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82843

	DcR2 Antibody (YA2588) TNFRSF10D; DCR2; TRAILR4; TRUNDD; Tumor necrosis factor Receptor superfamily member 10D; Decoy Receptor 2; DcR2; TNF-related apoptosis-inducing ligand Receptor 4; TRAIL Receptor 4; TRAIL-R4; TRAIL Receptor with a truncated death domain; CD	WB, IHC-P, ICC/IF	Human
	DcR2 Antibody (YA2588) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2588), targeting DcR2, with a predicted molecular weight of 42 kDa (observed band size: 36 kDa). DcR2 Antibody (YA2588) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P80919

	TRAF6 Antibody TRAF6; RNF85; TNF Receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85	WB	Human, Rat
	TRAF6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to TRAF6. It can be used for WB assays with tag free, in the background of Human, Rat.

HY-P81124

	RANKL/CD254 Antibody OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.	WB, IHC-P, ELISA	Human, Mouse, Rat
	RANKL/CD254 Antibody is an unconjugated, approximately 35 kDa, rabbit-derived, anti-RANKL/CD254 polyclonal antibody. RANKL/CD254 Antibody can be used for: WB, IHC-P, ELISA expriments in human, mouse, rat background without labeling.

HY-P81123

	OPG Antibody MGC29565 antibody; OCIF antibody; OPG antibody; Osteoclastogenesis inhibitory factor antibody; Osteoprotegerin antibody; PDB5 antibody; TNF Receptor superfamily member 11b antibody; TNFRSF 11B antibody; TNFRSF11B antibody; TR 1 antibody; TR1 antibody; TR11B_HUMAN antibody; Tumor necrosis factor Receptor superfamily member 11B antibody;	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	OPG Antibody is an unconjugated, approximately 46 kDa,mouse-derived, anti-OPG monoclonal antibody. OPG Antibody can be used for: WB, IF-Cell, IHC-P expriments in human, mouse, rat background without labeling.

HY-P83063

	TRAF4 Antibody (YA2808) TRAF4; CART1; MLN62; RNF83; TNF Receptor-associated factor 4; Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83	WB, ICC/IF, FC	Human, Mouse
	TRAF4 Antibody (YA2808) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2808), targeting TRAF4, with a predicted molecular weight of 54 kDa (observed band size: 54 kDa). TRAF4 Antibody (YA2808) can be used for WB, ICC/IF, FC experiment in human, mouse background.