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Results for "

apoptosis-inducing

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (129) 5-HT Receptor (2) ADC Cytotoxin (1) Akt (3) Aminopeptidase (1) Antibiotic (8) ATP Synthase (1) Autophagy (12) Bacterial (10) Bcl-2 Family (4) c-Myc (3) Calcium Channel (5) Caspase (13) Complement System (2) COX (1) Cytochrome P450 (1) DNA Methyltransferase (1) DNA/RNA Synthesis (3) E1/E2/E3 Enzyme (2) EGFR (3) Endogenous Metabolite (8) Epigenetic Reader Domain (2) ERK (2) Ferroptosis (1) Fungal (4) GABA Receptor (1) Galectin (1) Glucocorticoid Receptor (2) GLUT (1) GSK-3 (1) HDAC (2) Histamine Receptor (2) Histone Methyltransferase (1) HIV (2) HSP (1) HSV (2) Influenza Virus (1) Isotope-Labeled Compounds (3) JAK (1) Keap1-Nrf2 (2) MDM-2/p53 (3) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) Mitophagy (2) MMP (1) Na+/Ca2+ Exchanger (2) Necroptosis (1) NF-κB (2) NO Synthase (2) Orthopoxvirus (3) p38 MAPK (2) Parasite (2) PDI (1) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (5) Pim (1) PKA (1) PKC (1) Potassium Channel (2) PPAR (2) Proteasome (2) Raf (1) Ras (1) Reactive Oxygen Species (11) RIP kinase (1) SARS-CoV (2) STAT (1) Tau Protein (1) TGF-beta/Smad (5) TGF-β Receptor (1) TNF Receptor (2) Topoisomerase (2) VEGFR (2) β-catenin (2)
By Research Areas:	Cancer (123) Cardiovascular Disease (8) Endocrinology (6) Infection (19) Inflammation/Immunology (21) Metabolic Disease (7) Neurological Disease (8)

By Targets:

Apoptosis (129)

5-HT Receptor (2)

ADC Cytotoxin (1)

Akt (3)

Aminopeptidase (1)

Antibiotic (8)

ATP Synthase (1)

Autophagy (12)

Bacterial (10)

Bcl-2 Family (4)

c-Myc (3)

Calcium Channel (5)

Caspase (13)

Complement System (2)

COX (1)

Cytochrome P450 (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (3)

E1/E2/E3 Enzyme (2)

EGFR (3)

Endogenous Metabolite (8)

Epigenetic Reader Domain (2)

ERK (2)

Ferroptosis (1)

Fungal (4)

GABA Receptor (1)

Galectin (1)

Glucocorticoid Receptor (2)

GLUT (1)

GSK-3 (1)

HDAC (2)

Histamine Receptor (2)

Histone Methyltransferase (1)

HIV (2)

HSP (1)

HSV (2)

Influenza Virus (1)

Isotope-Labeled Compounds (3)

JAK (1)

Keap1-Nrf2 (2)

MDM-2/p53 (3)

Microtubule/Tubulin (4)

Mitochondrial Metabolism (1)

Mitophagy (2)

MMP (1)

Na+/Ca2+ Exchanger (2)

Necroptosis (1)

NF-κB (2)

NO Synthase (2)

Orthopoxvirus (3)

p38 MAPK (2)

Parasite (2)

PDI (1)

Phosphodiesterase (PDE) (2)

Phospholipase (1)

PI3K (5)

Pim (1)

PKA (1)

PKC (1)

Potassium Channel (2)

PPAR (2)

Proteasome (2)

Raf (1)

Ras (1)

Reactive Oxygen Species (11)

RIP kinase (1)

SARS-CoV (2)

STAT (1)

Tau Protein (1)

TGF-beta/Smad (5)

TGF-β Receptor (1)

TNF Receptor (2)

Topoisomerase (2)

VEGFR (2)

β-catenin (2)

By Research Areas:

Cancer (123)

Cardiovascular Disease (8)

Endocrinology (6)

Infection (19)

Inflammation/Immunology (21)

Metabolic Disease (7)

Neurological Disease (8)

145

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

DB1976 dihydrochloride 4 Publications Verification	Apoptosis	Cancer
DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC₅₀ of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, K_D of 12 nM) in vitro. DB1976 dihydrochloride has *apoptosis*-inducing effect .

YH239-EE 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.

Pinoresinol (+)-Pinoresinol	Apoptosis	Cancer
Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

Ginsenoside Rg6	NF-κB Apoptosis	Inflammation/Immunology Cancer
Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits *apoptosis*-inducing effect.

DB1976	Apoptosis	Cancer
DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC₅₀ of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, K_D of 12 nM) in vitro. DB1976 has *apoptosis*-inducing effect .

Eriosematin	Apoptosis	Metabolic Disease
Eriosematin is a compound from the roots of Flemingia philippinensis with antiproliferative activity and *apoptosis*-inducing property .

Apoptosis inducer 28	Apoptosis	Cancer
Apoptosis Inducer 28 (Compound X1) is an apoptosis-inducing agent with anticancer activity in vitro. Apoptosis Inducer 28 can arrest the cell cycle at the G1 phase, promote cell death, and induce *apoptosis* by disrupting mitochondrial membrane potential .

Apoptosis inducer 8	Galectin Apoptosis	Cancer
Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated *apoptosis*-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent .

Desacetylxanthanol	Others	Others
Desacetylxanthanol (Compound 4) is a sesquiterpenoid derived from Xanthium strumarium. Desacetylxanthanol has anti-tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) activity .

Diselaginellin B	Apoptosis	Cancer
Diselaginellin B (compound 2) is a natural product isolated from Selaginella Pulvinata, which exhibits anti-proliferative, *apoptosis*-inducing and antimetastatic activities against human carcinoma hepatocellular cells .

iMAC2 hydrochloride	Apoptosis	Inflammation/Immunology Cancer
iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC₅₀ of 28 nM and a LD₅₀ of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release .

Caspase-3/7 activator 1	Apoptosis Caspase	Cancer
Caspase-3/7 activator 1 is an effective activator of Caspase-3/7. Caspase-3/7 activator 1 has tumor selectivity, anti-proliferative activity and high *Apoptosis*-inducing ability .

Caspase-3/7 activator 2	Apoptosis Caspase	Cancer
Caspase-3/7 activator 2 is an effective activator of Caspase-3/7. Caspase-3/7 activator 2 has tumor selectivity, anti-proliferative activity and high *Apoptosis*-inducing ability .

Caspase-3/7 activator 3	Apoptosis Caspase	Cancer
Caspase-3/7 activator 3 is an effective activator of Caspase-3/7. Caspase-3/7 activator 3 has tumor selectivity, anti-proliferative activity and high *Apoptosis*-inducing ability .

Chlorquinaldol 4 Publications Verification Chloquinan	Antibiotic Bacterial Fungal β-catenin Apoptosis	Infection Cancer
Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and *apoptosis*-inducing activity in cancer cells .

Harmalol	Apoptosis	Cancer
Harmalol is a β-carbazine alkaloid with anticancer activity. Harmalol binds and interacts with several natural and synthetic nucleic acids of different motifs, including DNA and RNA. In addition, harmalol has an *apoptosis*-inducing effect on human hepatoma cells in vitro .

Kuguaglycoside C	Apoptosis	Neurological Disease Cancer
Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF) .

Pinoresinol (Standard)	Apoptosis	Cancer
Pinoresinol (Standard) is the analytical standard of Pinoresinol. This product is intended for research and analytical applications. Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

Anticancer agent 136	Apoptosis	Cancer
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC₅₀ of 3.38 μM for HDF and a K_d of 3.86 μM for Hsp90. Anticancer agent 136 is an *apoptosis*-inducing agent .

BRAFV600E-IN-1	Raf	Cancer
BRAFV600E-IN-1 (compound 9S) is a BRAF inhibitor. BRAFV600E-IN-1 has a significant apoptosis-inducing effect in cell lines expressing mutant KRAS and cancer cells expressing BRAFV600E .

CCF642	Apoptosis PDI	Cancer
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

Azadirone	TNF Receptor Bcl-2 Family Parasite	Infection Cancer
Azadirone sensitized cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 expression, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins (Bid). Azadirone has antiplasmodial activity .

Humulone α-Lupulic acid	COX GABA Receptor Apoptosis	Cardiovascular Disease
Humulone (α-Lupulic acid), a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone acts as a positive modulator of GABA_A receptor at low micromolar concentrations. Humulone is an inhibitor of bone resorption. Humulone possesses antioxidant, anti-angiogenic and *apoptosis*-inducing properties .

4-Methyldaphnetin	Apoptosis	Cancer
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation .

Dehydrobruceine B	Bcl-2 Family Keap1-Nrf2 Apoptosis	Cancer
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce *apoptosis* via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2 .

Eftozanermin alfa ABBV-621	Apoptosis	Cancer
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces *apoptosis* in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone	Apoptosis	Neurological Disease Cancer
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers *apoptosis* and has anti-tumor effects .

Chlorquinaldol (Standard)	Antibiotic Bacterial Fungal β-catenin Apoptosis	Infection Cancer
Chlorquinaldol (Standard) is the analytical standard of Chlorquinaldol. This product is intended for research and analytical applications. Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and *apoptosis*-inducing activity in cancer cells .

MTBT	p38 MAPK	Cancer
MTBT is an anticancer agent and p38 activator with antiproliferative and apoptosis-inducing (apoptosis) activities. MTBT increases the phosphorylation of histone H3 serine in cancer cells, thereby arresting the cell cycle in the M phase. SB203580 (HY-10256), a specific inhibitor of p38 MAPK, abolished MTBT-induced cell cycle arrest .

IV-275	Epigenetic Reader Domain	Cancer
IV-275 is an inhibitor of both BRG1 and BRM bromodomains. IV-275 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-275 inhibits the invasiveness of GBM cells. IV-275 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide .

IV-255	Epigenetic Reader Domain	Cancer
IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain. IV-255 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-255 inhibits the invasiveness of GBM cells. IV-255 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide .

(S)-10-Hydroxycamptothecin 10-HCPT; 10-Hydroxycamptothecin	Topoisomerase Apoptosis	Cancer
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable *apoptosis*-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment .

API-1	Akt Apoptosis	Cancer
API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC₅₀ of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces *apoptosis* by synergizing with TNF-related apoptosis-inducing ligand (TRAIL) .

Myristicin Myristicine	5-HT Receptor EGFR ERK Apoptosis Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and *apoptosis*-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

Fasentin 4 Publications Verification	GLUT TNF Receptor Apoptosis	Cardiovascular Disease Cancer
Fasentin, a potent glucose uptake inhibitor, inhibits GLUT-1/GLUT-4 transporters. Fasentin preferentially inhibits GLUT4 (IC₅₀=68 μM) over GLUT1. Fasentin is a death receptor stimuli (FAS) sensitizer and sensitizes cells to FAS-induced cell death. Fasentin is also a tumor necrosis factor (TNF) apoptosis-inducing ligand sensitizer. Fasentin blocks glucose uptake in cancer cell lines and has anti-angiogenic activity .

Myristicin (Standard)	5-HT Receptor EGFR ERK Apoptosis Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Myristicin (Standard) is the analytical standard of Myristicin. This product is intended for research and analytical applications. Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

(S)-10-Hydroxycamptothecin (Standard)	Topoisomerase Apoptosis	Cancer
(S)-10-Hydroxycamptothecin (Standard) is the analytical standard of (S)-10-Hydroxycamptothecin. This product is intended for research and analytical applications. (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment .

Apoptosis inducer 10	Apoptosis	Cancer
Apoptosis inducer 10 is a potent *apoptosis* inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces *apoptosis* in HeLa cancer cells via a mitochondria-dependent endogenous pathway .

Apoptosis inducer 3	Apoptosis	Cancer
Apoptosis inducer 3 (Compound 3) is an *apoptosis* inducer that selectively triggers apoptosis and late-apoptosis. Apoptosis inducer 3 shows cytotoxicity against cancer cells .

Apoptosis inducer 12	Apoptosis	Cancer
Apoptosis inducer 12 (Compound 3z) is an *apoptosis* inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer .

Apoptosis inducer 4	Apoptosis	Cancer
Apoptosis inducer 4 (Compound 12b) is an *apoptosis* inducer with anticancer activities .

Apoptosis inducer 23	Apoptosis	Cancer
Apoptosis inducer 23 (compound 6e) is an *apoptosis* inducer with antitumor activity. Apoptosis inducer 23 plays an important role in lung cancer research by inducing *apoptosis* through mitochondrial damage .

Apoptosis inducer 19	Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species	Cancer
Apoptosis inducer 19 (Compound 7g) is an *Apoptosis* inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and caspase-3) and downregulates anti-apoptotic protein (Bcl-2). Apoptosis inducer 19 upregulates cellular reactive oxygen species (ROS) levels and disrupts mitochondrial membrane potential (MMP). Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research .

Apoptosis inducer 22	Apoptosis	Cancer
Apoptosis inducer 22 (QR-5) is an *apoptosis* inducer with IC₅₀ values of 63.1 and 46.5 μM for colon cancer cell lines SW480 and HT29, respectively. Apoptosis inducer 22 induces *apoptosis* by inhibiting the Wnt/β-catenin axis in colon cancer cells. Apoptosis inducer 22 can be used in anti-colon cancer research.

Apoptosis inducer 7	Apoptosis	Cancer
Apoptosis inducer 7 (Compound 5I) induces *apoptosis* in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .

Apoptosis inducer 16	Apoptosis	Cancer
Apoptosis inducer 16 (Compound 3) is a bivalent Smac mimic that can effectively bind to BIR2 and BIR3, and exhibits cancer cell (apoptosis) inducing activity .

Cat. No.	Product Name	Target	Research Area

HY-P0118B

Disitertide diammonium Maximum Cited Publications 13 Publications Verification P144 diammonium	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) diammonium is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide diammonium is also a PI3K inhibitor and an *apoptosis* inducer .

HY-P0034A

Ac-DEVD-CMK TFA 2 Publications Verification Caspase-3 Inhibitor III TFA	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK TFA significantly inhibits *apoptosis* induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis .

HY-P0118

Disitertide P144	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor and an *apoptosis* inducer .

HY-P0118A

Disitertide TFA P144 TFA	TGF-beta/Smad PI3K Apoptosis	Cancer
Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide TFA is also a PI3K inhibitor and an *apoptosis* inducer .

HY-P0034

Ac-DEVD-CMK Caspase-3 Inhibitor III	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits *apoptosis* induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis .

Cat. No.	Product Name	Target	Research Area

HY-P99265

Mapatumumab HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody	Inhibitory Antibodies	Cancer
Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer .

HY-P99934

Eftozanermin alfa ABBV-621	Apoptosis	Cancer
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces *apoptosis* in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

Species:	Human (4) Rhesus Macaque (1) Mouse (1)
Tag:	His (4) Tag Free (2)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P7089AF

	Animal-Free TRAIL/TNFSF10 Protein, Mouse (His) rMuTRAIL/TNFSF10; TNF-related apoptosis-inducing ligand; Tumor necrosis factor ligand superfamily member 10	Mouse	E. coli
	TRAIL/TNFSF10 protein binds to TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, and possibly TNFRSF11B, inducing apoptosis.It can be modulated by decoy receptors TNFRSF10C, TNFRSF10D, and TNFRSF11B, which do not induce apoptosis.TRAIL/TNFSF10 exists as a homotrimer, interacting with its receptor monomers.This complex molecular interaction governs apoptotic signaling pathways.Animal-Free TRAIL/TNFSF10 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeTRAIL/TNFSF10 protein, expressed by E.coli , with C-His labeled tag.

HY-P7856

	PDCD8/AIFM1 Protein, Human (His) rHuapoptosis-inducing factor 1, mitochondrial/AIFM1, His; apoptosis-inducing Factor 1 Mitochondrial; Programmed Cell Death Protein 8; AIFM1; AIF; PDCD8	Human	E. coli
	PDCD8/AIFM1 protein has the dual functions of NADH oxidoreductase and apoptosis regulator, and translocates from the mitochondrial intermembrane space to the cytoplasm and nucleus in response to apoptotic stimuli. It acts through a caspase-independent pathway, inducing “parthanatos” characterized by fragmentation of chromosomal DNA. PDCD8/AIFM1 Protein, Human (His) is the recombinant human-derived PDCD8/AIFM1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PDCD8/AIFM1 Protein, Human (His) is 493 a.a., with molecular weight of ~68.0 kDa.

HY-P77256

	TRAIL/TNFSF10 Protein, Rhesus Macaque Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related apoptosis-inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL	Rhesus Macaque	E. coli
	TRAIL Protein (TNFSF10), a member of the TNF superfamily, is a type II transmembrane protein. TRAIL Protein mainly interacts with TRAIL-R1 and TRAIL-R2, and induces apoptosis in tumor or infected cells. TRAIL Protein also binds with DR4, DR5, and OPG. TRAIL Protein can recruit FADD and further recruit and activates caspase-8 after binding to DR4 or DR5. Besides, TRAIL may also trigger nonapoptotic signaling through activating pro-inflammatory pathways. TRAIL protein is mainly expressed on surface of immune cells, such as cytotoxic T cells and natural killer (NK) cell. TRAIL/TNFSF10 Protein, Rhesus Macaque is a recombinant Rhesus Macaque TRAIL (V114-G281) without any tag, which is expressed in E. coli.

HY-P70815

	TNFRSF10C Protein, Human (HEK293, His) Tumor Necrosis Factor Receptor Superfamily Member 10C; Antagonist Decoy Receptor for TRAIL/Apo-2L; Decoy TRAIL Receptor Without Death Domain; Decoy Receptor 1; DcR1; Lymphocyte Inhibitor of TRAIL; TNF-Related apoptosis-inducing Ligand Receptor 3; TRAIL Receptor	Human	HEK293
	The TNFRSF10C protein is a receptor for TRAIL and lacks a cytoplasmic death domain, making it unable to induce apoptosis. Instead, it protects cells by competing for ligand binding with TRAIL-R1 and R2, acting as a decoy receptor and mitigating TRAIL-mediated apoptosis. TNFRSF10C Protein, Human (HEK293, His) is the recombinant human-derived TNFRSF10C protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TNFRSF10C Protein, Human (HEK293, His) is 196 a.a., with molecular weight of 50-60 kDa.

HY-P70806

	TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) Tumor Necrosis Factor Receptor Superfamily Member 10B; Death Receptor 5; TNF-Related apoptosis-inducing Ligand Receptor 2; TRAIL Receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9	Human	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is 127 a.a., with molecular weight of ~18.0 kDa.

HY-P702659

	STK17A Protein, Human (sf9) STK17A; serine/threonine kinase 17a; serine/threonine kinase 17a (apoptosis inducing); serine/threonine-protein kinase 17A; death associated protein kinase related 1; DRAK1; death-associated protein kinase-related 1; serine/threonine kinase 17a (apoptosis-inducing); DAP kinase-related apoptosis-inducing protein kinase 1	Human	Sf9 insect cells
	STK17A Protein, Human (sf9) is the recombinant human-derived STK17A, expressed by Sf9 insect cells , with tag Free labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

HY-B0347S3

Lacidipine-13C4

Lacidipine- ¹³C₄ is ¹³C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80679

	AMID/FSP1 Antibody AIFM2; AMID; PRG3; apoptosis-inducing factor 2; apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; p53-responsive gene 3 protein	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey
	FSP1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 41 kDa, targeting to FSP1. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Monkey.

HY-P80534

	AIF Antibody (YA835) AIFM1; AIF; PDCD8; apoptosis-inducing factor 1; mitochondrial; Programmed cell death protein 8	WB, ICC/IF	Human
	AIF Antibody (YA835) is a non-conjugated and Mouse origined monoclonal antibody about 67 kDa, targeting to AIF (8H1). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P82843

	DcR2 Antibody (YA2588) TNFRSF10D; DCR2; TRAILR4; TRUNDD; Tumor necrosis factor receptor superfamily member 10D; Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD	WB, IHC-P, ICC/IF	Human
	DcR2 Antibody (YA2588) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2588), targeting DcR2, with a predicted molecular weight of 42 kDa (observed band size: 36 kDa). DcR2 Antibody (YA2588) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P80916

	TNFRSF10B Antibody (YA660) Fas like protein; apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L; D	WB, ICC/IF	Human, Mouse
	TNFRSF10B Antibody (YA660) is a non-conjugated and Mouse origined monoclonal antibody about 48 kDa, targeting to TNFRSF10B (7F4). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse.