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CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier .
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .
Ki11502 is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGF β/α receptors with IC50 values less than 10 nM. Ki11502 selectively inhibits PDGF β receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Ki11502 can induce Apoptosis) and exhibits profound antiproliferative effects on select subsets of leukemia, including those with Imatinib (HY-15463) resistant mutations. Ki11502 is highly suitable for studying the role of PDGF in vascular diseases, particularly the role of proteoglycans in atherosclerosis .
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .
Copper tripeptide (GHK-Cu) acetate is a tripeptide. During wound healing, Copper tripeptide acetate may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide acetate has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide acetate is a natural modulator of multiple cllular pathways in skin regeneration .
Ledelabricin alfa is a human proteoglycan 4 (PRG4) isoform A variant. PRG4 is a joint/boundary lubricant. Ledelabricin Alfa can be used for the research arthropathy .
Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Chondroitinase ABC facilitates reinnervation by degrading CS-GAGs around motoneurons. Chondroitinase ABC has the potential for the research of spinal injury .
NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM). NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation .
Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair .
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .
PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS) .
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .
CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier .
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .
PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS) .
Ledelabricin alfa is a human proteoglycan 4 (PRG4) isoform A variant. PRG4 is a joint/boundary lubricant. Ledelabricin Alfa can be used for the research arthropathy .
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity .
DSPG3/Epiphycan Protein plays a crucial role in bone formation and the establishment of ordered cartilage structure by contributing to matrix organization. Its multifaceted function in skeletal development influences dynamic processes related to bone formation and cartilage structural integrity. The protein's dual impact underscores its significance in maintaining the integrity and organization of the extracellular matrix in skeletal tissues. DSPG3/Epiphycan Protein, Human (HEK293, His) is the recombinant human-derived DSPG3/Epiphycan protein, expressed by HEK293 , with C-His labeled tag. The total length of DSPG3/Epiphycan Protein, Human (HEK293, His) is 303 a.a., with molecular weight of ~43-52 KDa.
Versican Isoform V3 Protein, involved in intercellular signaling, connects cells to the extracellular matrix, regulating cell motility, growth, and differentiation. It binds hyaluronic acid and interacts with FBLN1. Versican Isoform V0 Protein, Human (His, B2M, Myc) is the recombinant human-derived Versican Isoform V0, expressed by E. coli.
Agrin is critical for neuromuscular junction development and was discovered in mouse knockout studies. It contains laminin G, Kazal-type serpin, and epidermal growth factor domains. Agrin Protein, Human (CHO, His) is the recombinant human-derived Agrin protein, expressed by CHO , with N-6*His labeled tag.
Serine (SRGN) is essential for the formation of mast cell secretory granules and the storage of various compounds. It plays a crucial role in the storage of proteases in mast cells, including granzyme B in T lymphocytes, and contributes to the localization of neutrophil elastase. Serglycin/SRGN Protein, Human (HEK293, His-Myc) is the recombinant human-derived Serglycin/SRGN protein, expressed by HEK293 , with C-His, C-Myc labeled tag.
The PTPRZ1 protein is an important tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. It plays a crucial role in guiding the normal differentiation of precursor cells into mature oligodendrocytes and may act as an anti-apoptotic factor. PTPRZ1 Protein, Human (P.pastoris, His) is the recombinant human-derived PTPRZ1 protein, expressed by P. pastoris , with N-His labeled tag.
Glypican-5 (GPC5) protein is a cell surface proteoglycan characterized by specific binding to heparan sulfate. As a proteoglycan, GPC5 consists of a core protein covalently linked to heparan sulfate chains. Glypican-5/GPC5 Protein, Human (sf9, His) is the recombinant human-derived Glypican-5/GPC5 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Syntaxin-3 protein plays a potentially critical role in docking synaptic vesicles at the presynaptic zone, suggesting a role in regulating neurotransmitter release. Furthermore, it is also implicated as an apical receptor in apical vesicle membrane fusion, suggesting a broader involvement in intracellular trafficking. Syntaxin-3 Protein, Human (His) is the recombinant human-derived Syntaxin-3 protein, expressed by E. coli , with N-His labeled tag. The total length of Syntaxin-3 Protein, Human (His) is 289 a.a., with molecular weight of ~37 kDa.
Syndecan-3 Protein, Human (HEK293, His) is a Dendritic cells (DCs)-specific heparan sulfate (HS) proteoglycan that captures HIV-1 through interaction with the HIV-1 envelope glycoprotein gp120. SDC3 is involved in the regulation of growth factor signalling, Notch and BMP signalling, adhesion and migration, proliferation and differentiation. Syndecan-3 is associated with the control of feeding behaviour and the generation of cerebellar fibrillar plaques in Alzheimer鈥檚 disease. Syndecan-3 Protein, Human (HEK293, His) is the recombinant human-derived Syndecan-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Syndecan-3 Protein, Human (HEK293, His) is 311 a.a., with molecular weight of 45-100 kDa.
The CSPG5 protein is a potential growth and differentiation factor that is actively involved in and critical for neural development. It may induce ERBB3 activation, a key pathway for cell growth and differentiation. CSPG5 Protein, Human (HEK293, His) is the recombinant human-derived CSPG5 protein, expressed by HEK293 , with C-His labeled tag.
CSPG5 protein plays a key role as a growth and differentiation factor in neuritogenesis and may induce ERBB3 activation and participate in signaling pathways related to cell growth and differentiation. Its ability to bind to TNR and possibly TNC suggests interactions with key molecules in cellular processes. CSPG5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CSPG5 protein, expressed by HEK293 , with C-His labeled tag.
Agrin, especially the neuron-specific (z+) isoform, plays a crucial role in neuromuscular junction (NMJ) formation and postsynaptic differentiation. It activates the AGRN-LRP4 receptor complex, leading to NMJ formation through phosphorylation of MUSK. Agrin Protein, Rat (HEK293, His) is the recombinant rat-derived Agrin protein, expressed by HEK293 , with N-6*His labeled tag and P1788-S1798 del.
PRG3 Protein is a stress-resistant extracellular matrix structural component. PRG3 Protein can stimulate granulocyte activation, histamine synthesis and regulation of gene expression. PRG3 Protein, Human (HEK293, His) is the recombinant human-derived PRG3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PRG3 Protein, Human (HEK293, His) is 208 a.a., with molecular weight of ~27.0 kDa.
Agrin is a heparan sulfate basal glycoprotein that is critical for the formation and maintenance of the neuromuscular junction (NMJ). It forms the AGRN-LRP4 receptor complex, activates MUSK and regulates gene transcription and AChR clusters in the postsynaptic membrane to form the NMJ. Agrin Protein, Human (1073a.a, CHO, His) is the recombinant human-derived Agrin protein, expressed by CHO , with C-6*His labeled tag.
OGN/Osteoglycin protein collaborates with TGF-beta-1 or TGF-beta-2 to regulate bone formation. It interacts synergistically with specific isoforms of TGF-beta, modulating bone development and remodeling. This highlights OGN's significance in bone homeostasis and its potential as a therapeutic target for bone-related conditions. OGN/Osteoglycin Protein, Mouse (HEK293, His) is the recombinant mouse-derived OGN/Osteoglycin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of OGN/Osteoglycin Protein, Mouse (HEK293, His) is 279 a.a..
Osteomodulin is a potential contributor to the biomineralization process, exerting its functional role through α(V)β(3)-integrin binding to osteoblasts. This interaction highlights its importance in bone-related cellular activities, affecting osteoblast function and potentially bone formation and remodeling. Osteomodulin Protein, Human (HEK293, His) is the recombinant human-derived Osteomodulin protein, expressed by HEK293 , with C-His labeled tag. The total length of Osteomodulin Protein, Human (HEK293, His) is 401 a.a., with molecular weight of 50-70 KDa.
Osteomodulin protein likely contributes to biomineralization processes, influencing the formation and regulation of mineralized tissues.It binds to osteoblasts via the alpha(V)beta(3)-integrin, indicating involvement in cell adhesion and interactions with the extracellular matrix.The specific binding to the alpha(V)beta(3)-integrin suggests its potential role in mediating cellular processes associated with integrin signaling.Osteomodulin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Osteomodulin protein, expressed by HEK293 , with C-His labeled tag.
Lumican/LUM protein binds specifically to laminin.Lumican/LUM Protein, Mouse (HEK293, His) is the recombinant mouse-derived Lumican/LUM protein, expressed by HEK293 , with C-6*His labeled tag.
Decorin/PGS2 protein is involved in regulating extracellular matrix dynamics, affecting the rate of fibril formation and participating in rat cervical dilation. It has versatile binding properties, interacting with type I and type II collagen, fibronectin, and TGF-β, suggesting involvement in a variety of cellular processes. Decorin/PGS2 Protein, Rat (HEK293, His) is the recombinant rat-derived Decorin/PGS2 protein, expressed by HEK293 , with C-His labeled tag.
Decorin/PGS2 protein, influencing fibril formation rate, binds strongly to type I and type II collagen, fibronectin, and TGF-beta. It participates in extracellular matrix organization by forming a ternary complex with MFAP2 and ELN, and interacts with DPT, potentially modulating matrix assembly and structure. Decorin/PGS2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Decorin/PGS2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Decorin/PGS2 Protein, Mouse (HEK293, His) is 338 a.a., with molecular weight of 41-50 kDa.
Lumican, also known as LUM protein, is a protein with the ability to bind to laminin. Laminin is a key component of the extracellular matrix, a complex network of molecules that provides structural support to tissues. Lumican/LUM Protein, Human (HEK293, His) is the recombinant human-derived Lumican/LUM protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Lumican/LUM Protein, Human (HEK293, His) is 320 a.a., with molecular weight of 40-60 kDa.
HAPLN1 protein is vital in stabilizing proteoglycan monomer aggregates in cartilage's extracellular matrix. Through interaction with hyaluronic acid, it ensures structural integrity and stability, facilitating proteoglycan binding and organization. HAPLN1's role is crucial for maintaining the extracellular environment, providing proper support and resilience in cartilage tissues. HAPLN1 Protein, Human (HEK293, His) is the recombinant human-derived HAPLN1 protein, expressed by HEK293 , with C-His labeled tag. The total length of HAPLN1 Protein, Human (HEK293, His) is 339 a.a., with molecular weight of ~52 KDa.
Syndecan-2 Protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. Syndecan-2 functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-2 is necessary for tumor angiogenesis that facilitates tumor growth and metastasis. Syndecan-2 Protein, Human (HEK293, His) is the recombinant human-derived Syndecan-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Syndecan-2 Protein, Human (HEK293, His) is 126 a.a., with molecular weight of 25-40 kDa.
Decorin/PGS2 Protein, Human (HEK 293, His) expresses in HEK293 with a His tag at the N-terminus. Decorin, an extracellular matrix (ECM) protein, belongs to the small leucine-rich proteoglycan family. Decorin acts as a ligand of various cytokines and growth factors by directly or indirectly interacting with the corresponding signalling molecules involved in cell growth, differentiation, proliferation, adhesion and metastasis.
The EXTL2 protein is a key glycosyltransferase in heparan sulfate biosynthesis, responsible for overseeing the conversion of β-1-4-linked glucuronic acid (GlcA) and α-1-4-linked N-acetylglucosamine (GlcNAc) units Alternating sulfate chains are added to the nascent heparan. The function of this enzyme is critical for the complex and precise construction of heparan sulfate, a key component of various biological processes. EXTL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EXTL2 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of EXTL2 Protein, Mouse (HEK293, His) is 288 a.a., with molecular weight of ~35.0 kDa.
CD44 Protein is a type of cell surface receptor protein. CD44 Protein mediates various signaling pathways, including protein kinases, changes in the cytoskeleton, intracellular pathways, proteases, and transcription factors, which promote cancer cell division, proliferation, invasion, angiogenesis, and metabolic changes. The expression level of CD44 Protein is positively correlated with the malignancy and invasiveness of glioblastoma. CD44 Protein, Human (HEK293, His) is a recombinant CD44 protein tagged with a C-6*His label, expressed by HEK293. CD44 Protein, Human (HEK293, His) consists of 200 amino acids and has a molecular weight of 38-50 kDa.
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (Biotinylated, HEK293) is the recombinant human-derived CD44 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of CD44 Protein, Human (Biotinylated, HEK293) is 200 a.a., with molecular weight of 51 kDa.
The CD44 protein is characterized by a lack of conserved residues critical for annotation of propagation signatures. This defective residue in CD44 prevents the propagation of specific functional features associated with this protein. CD44 Protein, Macaca fascicularis (HEK293, His) is the recombinant cynomolgus-derived CD44 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CD44 Protein, Macaca fascicularis (HEK293, His) is 630 a.a., with molecular weight of 71.6 kDa.
ASPN protein acts as a negative regulator in periodontal ligament (PDL) differentiation and mineralization, preventing ossification and maintaining homeostasis of the tooth support system. It inhibits BMP2-induced cell differentiation by blocking the binding of BMP2 to BMPR1B, thereby preventing BMP-dependent activation of SMAD proteins. ASPN Protein, Human (His-SUMO) is the recombinant human-derived ASPN protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of ASPN Protein, Human (His-SUMO) is 348 a.a., with molecular weight of 55-60 kDa.
ACAN Antibody is an unconjugated, rabbit-derived, anti-ACAN monoclonal antibody. ACAN Antibody can be used for:IHC-P expriments in human background without labeling.
CD44 Antibody (YA801) is a non-conjugated and Mouse origined monoclonal antibody about 82 kDa, targeting to CD44 (2H12). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.
CD44 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 82 kDa, targeting to CD44. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Mouse.
Neurocan Antibody (YA2846) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2846), targeting Neurocan, with a predicted molecular weight of 143 kDa (observed band size: 130/270 kDa). Neurocan Antibody (YA2846) can be used for WB, IHC-P, IP experiment in human background.
Hyaluronan and proteoglycan link protein 1; Cartilage-linking protein 1; Cartilage-link protein; proteoglycan link protein; HAPLN1; CRTL1
WB, IHC-P, ICC/IF
Human, Mouse, Rat
HAPLN1 Antibody (YA2805) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2805), targeting HAPLN1, with a predicted molecular weight of 40 kDa (observed band size: 48 kDa). HAPLN1 Antibody (YA2805) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.
CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
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