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Results for "

serotonin reuptake

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (44) Serotonin Transporter (123) Adrenergic Receptor (22) Akt (1) Apoptosis (3) Autophagy (15) Calcium Channel (2) Cytochrome P450 (2) Dopamine Receptor (7) Dopamine Transporter (13) Drug Metabolite (11) Endogenous Metabolite (1) GlyT (1) Histamine Receptor (8) Histone Methyltransferase (2) iGluR (4) Isotope-Labeled Compounds (20) mAChR (5) Monoamine Oxidase (1) Monoamine Transporter (1) mTOR (1) P2X Receptor (2) PI3K (1) Sodium Channel (8) Trk Receptor (5)
By Research Areas:	Cancer (42) Cardiovascular Disease (3) Endocrinology (2) Inflammation/Immunology (2) Metabolic Disease (8) Neurological Disease (156)

By Targets:

5-HT Receptor (44)

Serotonin Transporter (123)

Adrenergic Receptor (22)

Akt (1)

Apoptosis (3)

Autophagy (15)

Calcium Channel (2)

Cytochrome P450 (2)

Dopamine Receptor (7)

Dopamine Transporter (13)

Drug Metabolite (11)

Endogenous Metabolite (1)

GlyT (1)

Histamine Receptor (8)

Histone Methyltransferase (2)

iGluR (4)

Isotope-Labeled Compounds (20)

mAChR (5)

Monoamine Oxidase (1)

Monoamine Transporter (1)

mTOR (1)

P2X Receptor (2)

PI3K (1)

Sodium Channel (8)

Trk Receptor (5)

By Research Areas:

Cancer (42)

Cardiovascular Disease (3)

Endocrinology (2)

Inflammation/Immunology (2)

Metabolic Disease (8)

Neurological Disease (156)

174

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Serotonin Transporter 5-HT Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0196

Venlafaxine 2 Publications Verification Wy 45030	Serotonin Transporter	Neurological Disease Cancer
Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B0196A

Venlafaxine hydrochloride 2 Publications Verification Wy 45030 hydrochloride	Serotonin Transporter	Neurological Disease Cancer
Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-122272

Paroxetine 5+ Cited Publications BRL29060	Serotonin Transporter Adrenergic Receptor P2X Receptor Apoptosis	Neurological Disease Cancer
Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-B0773

Paroxetine mesylate BRL29060 mesylate	Serotonin Transporter Adrenergic Receptor	Neurological Disease
Paroxetine mesylate, a phenylpiperidine derivative, is a potent and selective *serotonin* reuptake inhibitor (SSRI). Paroxetine mesylate is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .

HY-106397

Delucemine NPS-1506	Serotonin Transporter iGluR	Neurological Disease
Delucemine is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. Delucemine can be used as an antidepressant .

HY-129985

Clovoxamine DU23811	Serotonin Transporter 5-HT Receptor	Neurological Disease
Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (K_i: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant .

HY-124320

Desmethylene paroxetine hydrochloride	Drug Metabolite	Neurological Disease
Desmethylene paroxetine hydrochloride is a major urinary metabolite of Paroxetine. Paroxetine is a potent serotonin reuptake inhibitor .

HY-106194

SLV310	Dopamine Receptor Serotonin Transporter	Neurological Disease
SLV310 is an orally active dopamine D2 receptor antagonist (K_i: 5 nM) and serotonin reuptake receptor inhibitor. SLV310 antagonizes Apomorphine (HY-12723) induced climbing behaviour and 5-HTP (HY-N0122) induced serotonin syndrome like behaviour in mice (ED₅₀: 5.6 and 5.9 mg/kg, p.o.). SLV310 is an antipsychotic compound and can be used for schizophrenia research .

HY-106397A

Delucemine hydrochloride NPS-1506 hydrochloride	Serotonin Transporter iGluR	Neurological Disease
Delucemine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. Delucemine hydrochloride can be used as an antidepressant .

HY-133171A

(S)-Norfluoxetine	Serotonin Transporter	Neurological Disease
(S)-Norfluoxetine, a S enantiomer of Norfluoxetine (HY-135556), is a selective **serotonin reuptake** inhibitor. (S)-Norfluoxetine can increase allopregnanolone levels and reduce aggression in socially isolated mice .

HY-B1287

Citalopram hydrobromide 5+ Cited Publications (±)-Citalopram hydrobromide; Lu 10-171	Serotonin Transporter Autophagy	Neurological Disease Cancer
Citalopram hydrobromide is a *selective serotonin* reuptake inhibitor (SSRI)*. Citalopram hydrobromide inhibits 5-HT uptake* into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

HY-121203

Citalopram 5+ Cited Publications	Serotonin Transporter	Neurological Disease Cancer
Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active *selective serotonin* reuptake inhibitor (SSRI)**. Citalopram is an antidepressant and enhances serotoninergic neurotransmission .

HY-B0304A

Dapoxetine hydrochloride 1 Publications Verification LY-210448 hydrochloride	Serotonin Transporter	Neurological Disease
Dapoxetine (LY-210448) hydrochloride is an orally active and selective **serotonin reuptake inhibitor (SSRI**). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE) .

HY-B0304

Dapoxetine (S)-(+)-Dapoxetine; LY-210448	Serotonin Transporter	Neurological Disease
Dapoxetine (LY-210448) is an orally active and selective **serotonin reuptake inhibitor (SSRI**). Dapoxetine can be used for the research of premature ejaculation (PE) .

HY-14472

Tesofensine NS-2330	Dopamine Transporter Serotonin Transporter	Metabolic Disease
Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC₅₀=6.5 nM), norepinephrine (NE;IC₅₀=1.7 nM), and serotonin (5-HT;IC₅₀=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .

HY-121203S4

Citalopram-d3 hydrochloride	Serotonin Transporter Isotope-Labeled Compounds	Neurological Disease Cancer
Citalopram-d₃ hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active *selective serotonin* reuptake inhibitor (SSRI)**. Citalopram is an antidepressant and enhances serotoninergic neurotransmission .

HY-121203R

Citalopram (Standard)	Serotonin Transporter	Neurological Disease Cancer
Citalopram (Standard) is the analytical standard of Citalopram. This product is intended for research and analytical applications. Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission .

HY-B0304AR

Dapoxetine (hydrochloride) (Standard)	Serotonin Transporter	Neurological Disease
Dapoxetine (hydrochloride) (Standard) is the analytical standard of Dapoxetine (hydrochloride). This product is intended for research and analytical applications. Dapoxetine (LY-210448) hydrochloride is an orally active and selective **serotonin reuptake inhibitor (SSRI**). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE) .

HY-B0304R

Dapoxetine (Standard)	Serotonin Transporter	Neurological Disease
Dapoxetine (Standard) is the analytical standard of Dapoxetine. This product is intended for research and analytical applications. Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE) .

HY-110019

Indatraline hydrochloride Lu 19-005	Serotonin Transporter Dopamine Transporter	Neurological Disease
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, *serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy* while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis .

HY-W011235

Norfluoxetine hydrochloride	5-HT Receptor Calcium Channel Drug Metabolite	Cardiovascular Disease Neurological Disease
Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity .

HY-A0022

Azaphen Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride	Serotonin Transporter	Neurological Disease
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.

HY-A0022A

Azaphen dihydrochloride monohydrate 1 Publications Verification Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Pipofezine dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate	Serotonin Transporter	Neurological Disease
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.

HY-B0168A

Milnacipran hydrochloride 2 Publications Verification	Serotonin Transporter	Neurological Disease
Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for fibromyalgia.

HY-B0102A

Fluoxetine hydrochloride Maximum Cited Publications 30 Publications Verification LY 110140	Serotonin Transporter Autophagy	Neurological Disease Cancer
Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective **serotonin reuptake** inhibitor.

HY-B0102B

(S)-Fluoxetine hydrochloride	Serotonin Transporter	Neurological Disease
(S)-Fluoxetine hydrochloride, an antidepressant, is **serotonin reuptake** inhibitor (SSRI) .

HY-101612

SPD-473 citrate	Serotonin Transporter Dopamine Transporter	Neurological Disease
SPD-473 citrate is a *serotonin/dopamine/norepinephrine* reuptake inhibitior.

HY-U00096

Ansofaxine hydrochloride LY03005; LPM570065	5-HT Receptor Dopamine Receptor	Neurological Disease Inflammation/Immunology
Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits *serotonin, dopamine* and norepinephrine reuptake with IC₅₀ values of 723, 491 and 763 nM, respectively.

HY-B0168

Milnacipran	Serotonin Transporter	Neurological Disease
Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.

HY-U00096A

Ansofaxine Toludesvenlafaxine; LY03005 free base; LPM570065 free base	Serotonin Transporter	Neurological Disease
Ansofaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for the research of depression .

HY-106956

Lubazodone	Serotonin Transporter	Neurological Disease
Lubazodone is a selective serotonin reuptake inhibitor and can be used for study of depression .

HY-G0005

Duloxetine metabolite Para-Naphthol Duloxetine Para-Naphthol duloxetine	Drug Metabolite	Neurological Disease
Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI).

HY-B0102D

Fluoxetine oxalate LY-110140 oxalate	Serotonin Transporter Autophagy	Neurological Disease
Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-18332A

Amitifadine hydrochloride DOV-21947 hydrochloride; EB-1010 hydrochloride	Serotonin Transporter Dopamine Transporter	Neurological Disease
Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC₅₀s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

HY-101684

Nitroxazepine CIBA 2330Go	Serotonin Transporter	Neurological Disease
Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.

HY-B0103A

Fluvoxamine maleate 5+ Cited Publications DU-23000 maleate	Serotonin Transporter	Neurological Disease Cancer
Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-B0103

Fluvoxamine 5+ Cited Publications DU-23000	Serotonin Transporter	Neurological Disease
Fluvoxamine (DU-23000) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-101684A

Nitroxazepine hydrochloride CIBA 2330Go hydrochloride	Serotonin Transporter	Neurological Disease
Nitroxazepine hydrochloride is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.

HY-123322

PF-184298	Adrenergic Receptor	Cardiovascular Disease
PF-184298 is a dual serotonin/noradrenaline reuptake inhibitor with IC₅₀ of 6 nM and 21 nM, respectively .

HY-12389

8-Hydroxyamoxapine 8-OHAMX	GlyT	Neurological Disease
8-Hydroxyamoxapine is an orally active antidepressant, which inhibits the reuptake of norepinephrine and serotonin at synapses .

HY-B0168B

Milnacipran ((1S-cis) hydrochloride) Levomilnacipran hydrochloride; F-2695 hydrochloride	Serotonin Transporter	Neurological Disease
Milnacipran (1S-cis) hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI), used in the clinical treatment of fibromyalgia.

HY-18332

Amitifadine DOV-21947; EB-1010	Serotonin Transporter Dopamine Transporter Dopamine Receptor	Neurological Disease
Amitifadine (DOV-21947) is an antidepressant drug candidate that functions as a triple reuptake inhibitor, targeting the reuptake of serotonin, norepinephrine, and dopamine, and has been shown to decrease binge drinking and alleviate negative emotions in animal models.

HY-12850

Dasotraline SEP 225289	Dopamine Transporter Serotonin Transporter	Neurological Disease
Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and *serotonin* transporters with IC₅₀ values of 4, 6, and 11 nM, respectively.

HY-B0102

Fluoxetine Maximum Cited Publications 30 Publications Verification LY-110140 free base	Serotonin Transporter Autophagy	Neurological Disease
Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

HY-20696

Tetrahydro-β-carboline Tryptoline	5-HT Receptor	Metabolic Disease
Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive **serotonin reuptake inhibitor with an K_i** value of 6.1 µM .

HY-B0492A

Paroxetine hydrochloride hemihydrate 5+ Cited Publications BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate	Serotonin Transporter Autophagy	Neurological Disease
Paroxetine hydrochloride hemihydrate is a potent selective *serotonin-reuptake* inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC₅₀ of 14 μM.

HY-B0304AS

Dapoxetine-d7 hydrochloride LY-210448-d₇ hydrochloride	Serotonin Transporter	Neurological Disease
Dapoxetine-d₇ (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)[1].

HY-158264

SNRI-IN-1	Serotonin Transporter	Endocrinology
SNRI-IN-1 (Compound 7a) is a dual serotonin and noradrenaline monoamine reuptake inhibitor, P-glycoprotein Efflux Ratio is 20 .

HY-B0176A

Sertraline hydrochloride 10+ Cited Publications	Serotonin Transporter	Neurological Disease Cancer
Sertraline hydrochloride is an antidepressant of the selective **serotonin reuptake** inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive .

HY-B0161

Duloxetine LY248686	Serotonin Transporter	Neurological Disease Cancer
Duloxetine is a **serotonin-norepinephrine reuptake inhibitor with a K_i** of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14258

Escitalopram 5 Publications Verification (S)-Citalopram; (S)-(+)-Citalopram	Natural Products Source classification Endogenous metabolite	Serotonin Transporter
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective **serotonin reuptake inhibitor (SSRI) with a K_i** of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-A0022

Azaphen Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride	Natural Products Animals Source classification	Serotonin Transporter
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.

HY-N0913R

Manninotriose (Standard)	Structural Classification Polysaccharides Microorganisms other families Source classification Plants Saccharides	Endogenous Metabolite
Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.

Cat. No.	Product Name	Chemical Structure

HY-B0304AS

Dapoxetine-d7 hydrochloride
Dapoxetine-d₇ (hydrochloride) is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)[1].

HY-121203S

Citalopram-d4 hydrobromide
Citalopram-d₄ (hydrobromide) is the deuterium labeled Citalopram hydrobromide. Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI)[1].

HY-14261S

Vilazodone-d8
Vilazodone-d₈ is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist.

HY-B0196S

Venlafaxine-d6
Venlafaxine-d₆ is the deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].

HY-B0196AS1

Venlafaxine-d6 hydrochloride
Venlafaxine-d₆ (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].

HY-121203S4

Citalopram-d3 hydrochloride
Citalopram-d₃ hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active *selective serotonin* reuptake inhibitor (SSRI)**. Citalopram is an antidepressant and enhances serotoninergic neurotransmission .

HY-B0103AS1

Fluvoxamine-d4 maleate
Fluvoxamine-d₄ (maleate) is the deuterium labeled Fluvoxamine maleate. Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-B0168S

Milnacipran-d10 hydrochloride
Milnacipran-d₁₀ (hydrochloride) is the deuterium labeled Milnacipran hydrochloride. Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia[1][2].

HY-B0304AS1

Dapoxetine-d6 hydrochloride
Dapoxetine-d6 (LY-210448-d6) hydrochloride is the deuterium labeled Dapoxetine hydrochloride. Dapoxetine hydrochloride is a short-acting selective serotonin reuptake inhibitor (SSRI)

HY-B0103AS2

Fluvoxamine-13C, d3 maleate
Fluvoxamine- ¹³C, d₃ maleate is ¹³C and deuterated labeled Fluvoxamine maleate (HY-B0103A). Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.

HY-B0176AS1

(±)-cis-Sertraline-d3 hydrochloride
(±)-cis-Sertraline-d₃ (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].

HY-B0196AS

Venlafaxine-d10 hydrochloride
Venlafaxine-d₁₀ (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine (Wy 45030) hydrochloride is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1][2].

HY-B0176AS

rel-Sertraline-d3 hydrochloride
rel-Sertraline-d₃ (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].

HY-B0161AS

Duloxetine D3 hydrochloride
Duloxetine-d₃ (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-B0196S1

Venlafaxine-d6-1
Venlafaxine-d₆-1 is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].

HY-B0527AS

Amitriptyline-d6 hydrochloride

Amitriptyline-d₆ (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

HY-B0161ES

(±)-Duloxetine-d3 hydrochloride
(±)-Duloxetine-d₃ (hydrochloride) is deuterium labeled (±)-Duloxetine (hydrochloride). (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research[1].

HY-B0304S

Dapoxetine-d6
Dapoxetine-d₆ is the deuterium labeled Dapoxetine[1]. Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[2].

HY-B0161S

Duloxetine-d7
Duloxetine-d₇ ((S)-Duloxetine-d₇) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-B0196S2

Venlafaxine-d4
Venlafaxine-d₄ (Wy 45030-d₄) is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .

HY-B0492S1

Paroxetine-d4 hydrochloride
Paroxetine-d₄ (hydrochloride) is deuterium labeled Paroxetine (hydrochloride). Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14 μM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3].

HY-122272S2

Paroxetine-d6-1
Paroxetine-d6-1 is a deuterated labeled Paroxetine . Paroxetine, a phenylpiperidine derivative, is a potent and selective *serotonin* reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .

HY-B0602S

(R)-(-)-O-Desmethyl Venlafaxine-d6
(R)-(-)-O-Desmethyl Venlafaxine-d₆ is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].

HY-B0602S1

(S)-(+)-O-Desmethyl Venlafaxine-d6
(S)-(+)-O-Desmethyl Venlafaxine-d₆ is the deuterium labeled (S)-(+)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].

HY-B0161AS1

Duloxetine-d7 hydrochloride
Duloxetine-d7 hydrochloride ((S)-Duloxetine-d7 hydrochloride) is the deuterium labeled Duloxetine hydrochloride (HY-B0161A). Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a **serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i** of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-151216S

rel-Paroxetine-d4 hydrochloride
rel-Paroxetine-d₄ (hydrochloride) is an isotope-labeled Paroxetine hydrochloride (HY-B0492). Paroxetine hydrochloride is an orally active and selective serotonin-reuptake inhibitor, commonly prescribed as an GRK2 inhibitor with IC50 of 14 μM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3][4].

HY-122272S

Paroxetine-d4

Paroxetine-d₄ (BRL29060-d₄) is deuterium labeled Paroxetine. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-B1287S

Citalopram-d3 hydrobromide

Citalopram-d₃ ((±)-Citalopram-d₃) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].

HY-14262S1

Vilazodone-d8 hydrochloride
Vilazodone-d₈ hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT₁A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .

HY-14258AS

Escitalopram-d6 oxalate

Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

HY-14258AS1

Escitalopram-d4 oxalate

Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

HY-14794AS

Levomilnacipran-d10 hydrochloride
Levomilnacipran-d₁₀ ((1S,2R)-Milnacipran-d₁₀) hydrochloride is deuterium labeled Levomilnacipran. Levomilnacipran (F2696; (1R,2S)-milnacipran), an enantiomer of milnacipran, is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. Levomilnacipran also is a human alpha-adrenergic receptor antagonist, with an IC₅₀ of 3.4 μM. (patent WO2013014263A1) .

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