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Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM) .
Endoproteinase GluC (V8 protease) is a serine proteinase. Endoproteinase GluC is able to hydrolyze some serpins and all classes of mammalian immunoglobulins .
ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM .
Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research .
Serpin B5/Maspin Protein is a tumor suppressor and a unique member of the serpin family. Maspin inhibits cancer cell invasion, attachment to the extracellular matrix, increases sensitivity to apoptosis, and inhibits angiogenesis. Maspin interacting with diverse group of intercellular and extracellular proteins, regulating cell adhesion, motility, apoptosis, and critically involved in mammary gland development. Maspin acts as an endogenous inhibitor of histone deacetylase (HDAC1). Serpin B5/Maspin Protein, Human (His) is the recombinant human-derived Serpin B5/Maspin protein, expressed by E. coli, with His labeled tag. The total length of Serpin B5/Maspin Protein, Human (His) is 375 a.a., with molecular weight of approximately 40-45 kDa.
Serpin A11 protein is a member of the serpin family and is an important serine protease inhibitor that regulates proteolytic activity. Its study deepens our understanding of cellular processes related to proteolysis and has potential applications in therapy. Serpin A11 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A11 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A11 Protein, Mouse (HEK293, His) is 403 a.a., with molecular weight of 50-70 kDa.
Serpin B5/Maspin Protein, Human (375 a.a) could inhibit invasion and motility of mammary tumors. Maspin Protein, Human is also found to be a potent angiogenesis inhibitor.
Serpin A8 (or angiotensinogen) is a key regulator of the renin-angiotensin system, affecting blood pressure, fluid and electrolyte balance.As a vasoconstrictor, it directly affects vascular smooth muscle and affects myocardial contractility and heart rate through the sympathetic nervous system.Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag.
Serpin A8 (or angiotensinogen) is an important regulator in the renin-angiotensin system, fine-tuning blood pressure and electrolyte balance. This multifunctional protein acts as a potent vasoconstrictor, affecting vascular smooth muscle and affecting cardiac function via the sympathetic nervous system. Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) is 453 a.a., with molecular weight of ~58 kDa.
Serpin A8/angiotensinogen protein is an important component of the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and electrolyte homeostasis. Serpin A8/Angiotensinogen Protein, Human (HEK293, His) is the recombinant human-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Human (HEK293, His) is 452 a.a., with molecular weight of 52-64 kDa.
Serpin A8/angiotensinogen protein is an important component of the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and electrolyte homeostasis. Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) is the recombinant human-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) is 452 a.a., with molecular weight of 55.0-72.27 kDa.
The serpin A1 protein is a vigilant guardian in cell regulation, effectively inhibiting elastase and providing a strong barrier to its enzymatic activity.Serpin A1 has moderate affinity for plasmin and thrombin and exhibits versatility in binding a range of serine proteases.Serpin A1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin A1 protein, expressed by HEK293 , with C-His labeled tag.
Serpin B12 Protein inhibits trypsin and plasmin, excluding thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. It may have a role in cell differentiation, interacting with SLFN12 in a pathway regulating differentiation, and potentially interacting with USP14. Serpin B12 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B12 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B12 Protein, Human (HEK293, His) is 425 a.a., with molecular weight of ~55.0 kDa.
Serpin F1 is a neurotrophin that significantly induces extensive neuronal differentiation of retinoblastoma cells and exhibits potent anti-angiogenic effects.Its unique conformation lacks the S (stress) to R (relaxation) transition typical of active serpins, resulting in a lack of serpin activity.Serpin F1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin F1 protein, expressed by HEK293 , with C-His labeled tag.
Serpin A3 protein is a serine protease inhibitor on chromosome 14 that affects protease targeting through tissue-specific polymorphisms. Sequence variants are associated with Alzheimer's disease, while deficiencies are associated with liver disease. Serpin A3 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A3 Protein, Human (HEK293, His) is 398 a.a., with molecular weight of ~50-70 kDa.
Serpin F1 Protein, part of the secreted frizzled-related protein (sFRP) family, modulates Wnt signaling pathways. As a member, Serpin F1 likely interacts with Wnt ligands and frizzled receptors, regulating crucial cellular processes. The unique structural characteristics of Serpin F1 within the sFRP family, marked by the absence of conserved residue(s) for feature annotation propagation, underscore its distinctive role in Wnt signaling modulation. Despite lacking certain conserved elements, Serpin F1's specific attributes may contribute to its distinct influence on cellular activities, such as proliferation, differentiation, or tissue development. Serpin F1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin F1 protein, expressed by HEK293, with C-His labeled tag. The total length of Serpin F1 Protein, Rat (HEK293, His) is 399 a.a., with molecular weight of ~45.9 kDa.
Serpin B12 inhibits trypsin and plasmin but not thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Additionally, it interacts with SLFN12, contributing to cellular differentiation pathways, showcasing its multifunctional nature beyond classical protease inhibition. Serpin B12 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B12 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Serpin B12 Protein, Mouse (sf9, His) is 423 a.a., with molecular weight of ~58 kDa.
Serpin A7, or thyroxine-binding globulin (TBG), acts as a glycoprotein carrier for thyroid hormones, specifically binding and transporting thyroxine (T4) and triiodothyronine (T3). TBG regulates the availability and distribution of thyroid hormones critical for physiological processes like metabolism and growth. Mutations in the SERPINA7 gene can affect TBG function, influencing thyroid hormone levels. Serpin A7 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A7 Protein, Human (HEK293, His) is 395 a.a., with molecular weight of 55-65 kDa.
Serpin A7 protein binds hormones and inhibits serine-type endopeptidase activity. It is involved in negative regulation of endopeptidase activity, response to vitamin A, and thyroid hormone transport. It is located in the extracellular region and is active in the extracellular space. Serpin A7 is orthologous to human SERPINA7 and is expressed primarily in liver E18, liver E14.5, and two other tissues. Serpin A7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A7 protein, expressed by HEK293 , with C-His labeled tag.
Serpin B4 is a protease inhibitor that may modulate the host immune response against tumor cells, suggesting a crucial role in fine-tuning immune balance. Its ability to inhibit proteases emphasizes its importance in influencing key regulatory pathways, enhancing the immune system's effectiveness against cancer cells. Serpin B4 Protein, Human (sf9, His) is the recombinant human-derived Serpin B4 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Serpin B4 Protein, Human (sf9, His) is 390 a.a., with molecular weight of ~45 kDa.
Serpin E1 is a serine protease inhibitor that regulates TMPRSS7 and inhibits tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).It can significantly downregulate fibrinolysis and control thrombus degradation.Serpin E1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-hFc labeled tag.
Serpin E1 Protein, Rat (HEK293, His) is one important member of the serine proteinase inhibitor E superfamily that plays a crucial role in the fibrinolytic system. The Serpin E1 protein is a single-chain glycoprotein composed of 379 amino acids. The active site of the protein is Arg346-Met347. SERPINE1 encodes plasminogen activator inhibitor type 1 (PAI-1), which serves as the primary inhibitor of urokinase plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). The Serpin E1 protein can quickly inhibit the formation of plasmin. Serpin E1 can be transcribed through several signaling cascades, including pro-fibrogenic and pro-inflammatory pathways. Serpin E1 is a serine proteinase inhibitor, serves as an important regulator of extracellular matrix remodeling. Serpin E1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of Serpin E1 Protein, Rat (HEK293, His) is 379 a.a., with molecular weight of 48-60 kDa.
Serpin F1 is a neurotrophin that significantly induces extensive neuronal differentiation of retinoblastoma cells and exhibits potent anti-angiogenic effects.Its unique conformation lacks the S (stress) to R (relaxation) transition typical of active serpins, resulting in a lack of serpin activity.Serpin F1 Protein, Mouse is the recombinant mouse-derived Serpin F1 protein, expressed by E.coli , with tag free.
Serpin A10 protein inhibits coagulation proteases, such as factor Xa, in the presence of PROZ, calcium, and phospholipids. It can also inhibit factor XIa without cofactors. Serpin A10 interacts with PROZ to exert its inhibitory effects on these coagulation factors. Serpin A10 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A10 protein, expressed by HEK293 , with C-6*His labeled tag.
The serpin A3N protein is ubiquitously found in a variety of tissues, showing elevated expression in the brain, heart, liver, lung, spleen, testis, and thymus, implying a variety of physiological functions.In contrast, it shows lower expression in bone marrow, kidney, and skeletal muscle, suggesting a tissue-specific pattern of regulation.Serpin A3N Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A3N protein, expressed by HEK293 , with C-6*His labeled tag.
The serpin A3N protein is ubiquitously found in a variety of tissues, showing elevated expression in the brain, heart, liver, lung, spleen, testis, and thymus, implying a variety of physiological functions.In contrast, it shows lower expression in bone marrow, kidney, and skeletal muscle, suggesting a tissue-specific pattern of regulation.Serpin A3N Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Serpin A3N protein, expressed by P.pastoris , with N-6*His labeled tag.
Serpin G1, also known as C1 inhibitor, controls C1 complex activation by forming a proteolytically inactive complex with C1r or C1s proteases. Their interactions regulate physiological pathways such as complement activation, coagulation, fibrinolysis, and kinin production. Serpin G1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin G1 protein, expressed by HEK293 , with C-10*His labeled tag.
Serpin G1 protein binds complement and inhibits serine-type endopeptidases. It is located in the extracellular space and is involved in aging. Serpin G1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin G1 protein, expressed by HEK293 , with C-His labeled tag.
The Serpin A3N Protein, belonging to the serpin family, is predominantly expressed in the liver, where it regulates protease activity.As a serine protease inhibitor, Serpin A3N plays a crucial role in modulating enzymatic processes within the liver, highlighting its significance in hepatic functions and maintaining the balance of proteolytic activities in this vital organ.Serpin A3N Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin A3N protein, expressed by HEK293 , with C-His labeled tag.
Serpin A10 Protein, an inhibitor, regulates by inhibiting the activity of coagulation protease factor Xa in the presence of PROZ, calcium, and phospholipids. It also shows inhibitory effects on factor XIa even without cofactors, highlighting its versatility in modulating key components of the coagulation cascade. Serpin A10 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A10 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A10 Protein, Mouse (HEK293, His) is 427 a.a., with molecular weight of 60-80 kDa.
Alpha-1 protease inhibitor 1 Protein, Mouse (HEK293, His) is a mouse recombinant Serpin A1a with a His tag at the C-terminus. Alpha-1 protease inhibitor 1 Protein, Mouse (HEK293, His) is produced by Mammalian expression system.
Serpin D1 is a thrombin inhibitor that is activated by glycosaminoglycans such as heparin or dermatan sulfate. In the presence of dermatan sulfate, HC-II surpasses antithrombin III (AT) as the primary thrombin inhibitor. Serpin D1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin D1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin D1 Protein, Mouse (HEK293, His) is 455 a.a., with molecular weight of 70-90 kDa.
The Serpin B9 Protein, a member of the serpin family, crucially regulates immune responses by specifically inhibiting granzyme B, a protease involved in immune cell-mediated apoptosis. Acting as a potent inhibitor, Serpin B9 modulates granzyme B's cytotoxic activity, fine-tuning immune responses and preventing unwarranted cell death, emphasizing its significance in maintaining immune balance. Serpin B9 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B9 Protein, Human (HEK293, His) is 376 a.a., with molecular weight of 35-40 kDa.
Serpin E1 protein is a serine protease inhibitor that regulates TMPRSS7 and is a major inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).It can significantly downregulate fibrinolysis and control thrombus degradation.Serpin E1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag.
Serpin A4 Protein inhibits tissue kallikrein's amidolytic and kininogenase activities by forming a heat- and SDS-stable equimolar complex with the enzyme. Tissue kallikrein concurrently cleaves the reactive site of Serpin A4, producing a small C-terminal fragment. The protein, existing as a monomer and occasionally forming homodimers, demonstrates its regulatory role in modulating tissue kallikrein-mediated enzymatic activities. Serpin A4 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A4 Protein, Human (HEK293, His) is 407 a.a., with molecular weight of 60-80 kDa.
Serpin F1 protein, a neurotrophic factor, crucially promotes extensive neuronal differentiation in retinoblastoma cells and serves as a potent inhibitor of angiogenesis. Unlike active serpins, Serpin F1 does not undergo the typical S (stressed) to R (relaxed) conformational transition, lacking serine protease inhibitory activity. It also interacts with PNPLA2, enhancing the phospholipase A2 activity of PNPLA2. Serpin F1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin F1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin F1 Protein, Human (HEK293, His) is 399 a.a., with molecular weight of ~50.0 kDa.
Serpin A3 Proteinas, with unclear physiological function, inhibits neutrophil cathepsin G and mast cell chymase, involved in angiotensin-1 to angiotensin-2 conversion. Serpin A3 also interacts with DNAJC1. Serpin A3 Protein, Human (K267R, HEK293, His) is the recombinant human-derived Serpin A3 protein, expressed by HEK293 , with C-6*His labeled tag and K267R mutation. The total length of Serpin A3 Protein, Human (K267R, HEK293, His) is 400 a.a., with molecular weight of 56-80 kDa.
Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (Trx-His) is the recombinant human-derived Serpin B6 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of Serpin B6 Protein, Human (Trx-His) is 376 a.a., with molecular weight of 58-60 kDa.
Serpin E1 is a serine protease inhibitor that regulates various cellular processes by inhibiting TMPRSS7, tissue-type plasminogen activator (PLAT), and urokinase-type plasminogen activator (PLAU). During fibrinolysis, it downregulates PLAT to control thrombus degradation and acts as a PLAU inhibitor to regulate cell adhesion. Serpin E1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag.
Serpin F1 protein, a neurotrophic factor, crucially promotes extensive neuronal differentiation in retinoblastoma cells and serves as a potent inhibitor of angiogenesis. Unlike active serpins, Serpin F1 does not undergo the typical S (stressed) to R (relaxed) conformational transition, lacking serine protease inhibitory activity. It also interacts with PNPLA2, enhancing the phospholipase A2 activity of PNPLA2. Serpin F1 Protein, Human (HEK293, N-His) is the recombinant human-derived Serpin F1 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of Serpin F1 Protein, Human (HEK293, N-His) is 399 a.a., with molecular weight of ~49.37 kDa.
Serpin A5 protein is a heparin-dependent serine protease inhibitor that controls proteolytic activity in body fluids. It binds irreversibly to the serine activation site, inactivating serine proteases and regulating intravascular and extravascular proteolysis. Serpin A5 Protein, Mouse (Baculovirus, His) is the recombinant mouse-derived Serpin A5 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of Serpin A5 Protein, Mouse (Baculovirus, His) is 381 a.a., with molecular weight of ~45.3 kDa.
Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (sf9, His) is the recombinant human-derived Serpin B6 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Serpin B6 Protein, Human (sf9, His) is 375 a.a., with molecular weight of ~43 kDa.
Serpin G1 protein, also known as C1 inhibitor, regulates complement activation, coagulation, fibrinolysis, and kinin production. It forms an inactive complex with C1r or C1s protease and controls C1 complex activation. Serpin G1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin G1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin G1 Protein, Mouse (HEK293, His) is 485 a.a., with molecular weight of 92-95 kDa.
Serpin A6 Protein serves as the primary transport protein for glucocorticoids and progestins in the blood of nearly all vertebrate species. Serpin A6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A6 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A6 Protein, Mouse (HEK293, His) is 375 a.a., with molecular weight of 50-60 kDa.
Serpin A6 Protein functions as a vital transport protein, facilitating the transport of glucocorticoids and progestins in the bloodstream across various vertebrate species. Serpin A6 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A6 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A6 Protein, Human (HEK293, His) is 383 a.a., with molecular weight of 55-60 kDa.
Serpin A1 Protein, Human (HEK293, His) produced in HEK293 cells is a mouse recombinant Serpin A1a with a His tag at the C-terminus. Alpha-1 Antitrypsin Exerts a hepatoprotective effect on immune-mediated hepatitis and acetaminophen-induced liver injury.
Serpin I2 Protein, is a member of the serpin (serine protease inhibitor) superfamily. Serpin I2 (pancpin) is an inhibitory serpin targeting pancreatic elastase and chymotrypsin. Serpin I2 is downregulated in pancreatic and breast cancer, and associated with acinar cell apoptosis and pancreatic insufficiency when absent in mice. Serpin I2 is associated with refractive error and has the potential for further investigations of the genetic susceptibility to myopia research. Serpin I2 Protein, Human (HEK293, His) is the recombinant human-derived Serpin I2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin I2 Protein, Human (HEK293, His) is 387 a.a., with molecular weight of 44-60 kDa.
The Serpin B3 protein exhibits versatility in cellular regulation and may act as a papain-like cysteine protease inhibitor to modulate immune responses against tumor cells. Its dual role extends to inhibiting UV-induced apoptosis by inhibiting c-Jun NH(2)-terminal kinase (JNK1) activity, suggesting that Serpin B3 is involved in the stress response. Serpin B3 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B3 Protein, Human (HEK293, His) is 390 a.a., with molecular weight of 41-50 kDa.
Serpin A6 Protein functions as a vital transport protein, facilitating the transport of glucocorticoids and progestins in the bloodstream across various vertebrate species. Serpin A6 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Serpin A6 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Serpin A6 Protein, Human (Biotinylated, HEK293, His-Avi) is 383 a.a., with molecular weight of ~45.9 kDa.
Plasma serine protease inhibitor (SERPINA5) is a glycoproteins that inhibit serine proteases. SERPINA5 is involved in the regulation of intravascular and extravascular proteolytic activities, controls the sperm motility and fertilization and protect components of the genital tract. SERPINA5 also inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. Serpin A5 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A5 Protein, Human (HEK293, His) is 387 a.a., with molecular weight of 44-55 kDa.
Serpin E2 is a serine protease inhibitor that inhibits thrombin, trypsin, and urokinase. Its unique role in promoting neurite extension involves specific inhibition of thrombin activity. Serpin E2 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin E2 Protein, Human (HEK293, His) is 378 a.a., with molecular weight of ~50.0 kDa.
SERPINB10 is an important protease inhibitor that may regulate protease activity in hematopoiesis and TNF-induced apoptosis. SERPINB10 acts in both the cytoplasm and the nucleus, demonstrating versatility in influencing key cellular processes. SERPINB10 Protein, Mouse (sf9, His) is the recombinant mouse-derived SERPINB10 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of SERPINB10 Protein, Mouse (sf9, His) is 397 a.a., with molecular weight of ~44 kDa.
Serpin A3C Protein, with its reactive center loop (RCL), guides interactions with target proteases.Binding leads to protease cleavage at the RCL, forming a stable serpin-protease complex, inactivating the protease.Variability in Serpin A3C's RCL sequences among Serpina3 paralogs may influence the specificity of target protease interactions, showcasing the protein's adaptability.Serpin A3C Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A3C protein, expressed by HEK293 , with C-His labeled tag.
Serpin B6b protein is an important member of the serine protease inhibitor family and plays a crucial role as a serine protease inhibitor, regulating proteolytic activity.His research enhances the understanding of cellular processes related to proteolysis and its therapeutic applications.Serpin B6b Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B6b protein, expressed by Sf9 insect cells , with C-His labeled tag.
Serpin E2, a serine protease inhibitor, inhibits thrombin, trypsin, and urokinase, with a notable role in promoting neurite extension by specifically inhibiting thrombin.Its ability to bind heparin underscores interactions with glycosaminoglycans.The multifaceted inhibitory functions of Serpin E2 highlight its significance in regulating serine protease activities and potential impact on cellular processes, particularly in neurodevelopment.Serpin E2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin E2 protein, expressed by HEK293 , with C-10*His labeled tag.
Serpin D1 protein is a thrombin inhibitor activated by glycosaminoglycans such as heparin or dermatan sulfate. It replaces antithrombin III and becomes the main thrombin inhibitor in the presence of dermatan sulfate. In addition to thrombin inhibition, serpin D1 also has glycosaminoglycan-independent chymotrypsin inhibitory activity. Serpin D1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin D1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin D1 Protein, Human (HEK293, His) is 480 a.a., with molecular weight of ~75-80 kDa.
Serpin E2, a serine protease inhibitor, inhibits thrombin, trypsin, and urokinase, with a notable role in promoting neurite extension by specifically inhibiting thrombin.Its ability to bind heparin underscores interactions with glycosaminoglycans.The multifaceted inhibitory functions of Serpin E2 highlight its significance in regulating serine protease activities and potential impact on cellular processes, particularly in neurodevelopment.Serpin E2 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived Serpin E2 protein, expressed by HEK293 , with C-10*His labeled tag.
Serpin H1 protein exhibits a specific affinity for collagen, indicating its role as a chaperone in the biosynthetic pathway of collagen. This suggests its potential contribution to collagen synthesis, emphasizing its importance in maintaining tissue integrity and modulating cellular responses related to collagen metabolism. Serpin H1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin H1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin H1 Protein, Human (HEK293, His) is 400 a.a., with molecular weight of ~51.0 kDa.
The Serpin B8 protein plays a critical role in promoting epithelial desmosome-mediated intercellular adhesion, underscoring its importance in maintaining cell adhesion within epithelial tissues.The protein's involvement suggests an important contribution to the structural integrity and stability of desmosomes, key cellular structures that mediate adhesion between adjacent cells.Serpin B8 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B8 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Serpin A1b Protein, a vigilant guardian in cellular regulation, adeptly inhibits elastase, providing formidable defense against its enzymatic activity.Beyond this specialization, Serpin A1b shows moderate affinity for plasmin and thrombin, highlighting its versatility in interacting with various serine proteases.As a multifaceted sentinel, Serpin A1b contributes to the nuanced orchestration of proteolytic processes within cellular landscapes.Serpin A1b Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Serpin A1b protein, expressed by HEK293 , with C-hFc labeled tag.
Serpin B1 protein is an important neutrophil serine protease inhibitor that regulates innate immune responses by protecting cells from cytoplasmic proteases during stress. It inhibits various neutrophil proteases, including elastase and chymotrypsin, and blocks GZMH activity intracellularly. Serpin B1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B1 Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~44.0 kDa.
The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with tag free.
The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with C-hFc labeled tag.
The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with C-His labeled tag.
The Serpin A1c protein is a skilled guardian of cellular regulation, specifically acting as an inhibitor of serine proteases, specifically trypsin and chymotrypsin. Its efficacy in blocking enzymatic activity contrasts with its relative ineffectiveness against elastase. Serpin A1c Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A1c protein, expressed by HEK293 , with C-6*His labeled tag.
Antithrombin III, also known as Serpin C1, forms a protease inhibitory heterodimer with TMPRSS7. This interaction exemplifies the regulatory role of antithrombin III as a serine protease inhibitor, highlighting its ability to modulate TMPRSS7 activity. Antithrombin III/Serpin C1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Antithrombin III/Serpin C1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Antithrombin III/Serpin C1 Protein, Cynomolgus (HEK293, His) is 430 a.a., with molecular weight of ~55-75 kDa.
Vaspin is an adipokine that regulates adipogenesis, metabolism, and inflammation by binding to the chemokine receptors CMKLR1 and CMKLR2. It mainly regulates adipocyte differentiation and affects lipid and glucose metabolism genes. Vaspin Protein, Human (GST) is the recombinant human-derived Vaspin protein, expressed by E. coli , with N-GST labeled tag. The total length of Vaspin Protein, Human (GST) is 394 a.a., with molecular weight of ~72.0 kDa.
Antithrombin III/Serpin C1 protein, the main plasma serine protease inhibitor, regulates the blood coagulation cascade. It inhibits thrombin, matriptase-3/TMPRSS7, and factors IXa, Xa, and XIa, with enhanced potency in the presence of heparin. Furthermore, it forms a protease-inhibiting heterodimer with TMPRSS7. Antithrombin III/Serpin C1 Protein, Human (432a.a, HEK293, His) is the recombinant human-derived Antithrombin III/Serpin C1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Antithrombin III/Serpin C1 Protein, Human (432a.a, HEK293, His) is 432 a.a., with molecular weight of 55-60 kDa.
Vaspin is an adipokine that regulates adipogenesis, metabolism, and inflammation by binding to the chemokine receptors CMKLR1 and CMKLR2. It mainly regulates adipocyte differentiation and affects lipid and glucose metabolism genes. Vaspin Protein, Human (HEK293, His) is the recombinant human-derived Vaspin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Vaspin Protein, Human (HEK293, His) is 394 a.a., with molecular weight of 50-60 kDa.
Alpha-2-antiplasmin/serpin F2 protein is a member of the serine protease inhibitor family and can significantly inhibit plasmin to regulate thrombolysis. Synthesized in the liver and circulating in the blood, it prevents excessive fibrinolysis and ensures clot stabilization. Alpha-2-Antiplasmin/Serpin F2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Alpha-2-Antiplasmin/Serpin F2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Alpha-2-Antiplasmin/Serpin F2 Protein, Cynomolgus (HEK293, His) is 464 a.a., with molecular weight of 60-70 kDa.
Neuroserpin Protein, Human (CHO) is a member of the serpin family of serine protease inhibitors, playing an important role in synaptic plasticity and memory formation in the hippocampus.
Alpha-2-Antiplasmin/Serpin F2 Protein, a serine protease inhibitor, targets plasmin and trypsin, also inhibiting matriptase-3/TMPRSS7 and chymotrypsin.It forms a heterodimer with TMPRSS7, enhancing its protease inhibiting activity.Alpha-2-Antiplasmin/Serpin F2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Alpha-2-Antiplasmin/Serpin F2 protein, expressed by HEK293 , with C-6*His labeled tag.
Neuroserpin is a serine protease inhibitor that significantly inhibits plasminogen activator and plasmin without affecting thrombin.In addition to their role in protease inhibition, neuroserine proteases contribute to synaptic plasticity, affecting synaptic connections in the adult nervous system.Neuroserpin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Neuroserpin protein, expressed by HEK293 , with C-His labeled tag.
The leukocyte elastase inhibitor/SERPINB1 protein is an important neutrophil serine protease inhibitor that regulates innate immune responses by protecting cells from cytoplasmic proteases during stress. It inhibits various neutrophil proteases, including elastase and chymotrypsin, and blocks GZMH activity intracellularly. Leukocyte elastase inhibitor/SERPINB1 Protein, Pig (His, myc) is the recombinant pig-derived Leukocyte elastase inhibitor/SERPINB1 protein, expressed by E. coli , with N-His, C-Myc labeled tag. The total length of Leukocyte elastase inhibitor/SERPINB1 Protein, Pig (His, myc) is 378 a.a., with molecular weight of ~50.0 kDa.
Alpha-2-Antiplasmin/Serpin F2 Protein, a serine protease inhibitor, primarily targets plasmin and trypsin, also inactivating matriptase-3/TMPRSS7 and chymotrypsin. It can form a heterodimer with TMPRSS7, enhancing its protease inhibitory activity. Alpha-2-Antiplasmin/Serpin F2 Protein, Human (HEK293, His) is the recombinant human-derived Alpha-2-Antiplasmin/Serpin F2 protein, expressed by HEK293 , with C-His labeled tag.
Alpha-2-antiplasmin/serpin F2 protein is an important member of the serine protease inhibitor family and plays a key role as a serine protease inhibitor, regulating proteolytic activity. His research enhances the understanding of cellular processes related to proteolysis and its therapeutic applications. Alpha-2-Antiplasmin/Serpin F2 Protein, Rat (HEK293, His) is the recombinant rat-derived Alpha-2-Antiplasmin/Serpin F2 protein, expressed by HEK293 , with C-His labeled tag.
PAI1 Antibody (YA1524) is a biotin-conjugated non-conjugated IgG antibody, targeting PAI1, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). PAI1 Antibody (YA1524) can be used for WB experiment in human, mouse background.
SERPING1 Antibody (YA1980) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1980), targeting SERPING1, with a predicted molecular weight of 55 kDa (observed band size: 100 kDa). SERPING1 Antibody (YA1980) can be used for WB, IP experiment in human, mouse, rat background.
Antithrombin; Antithrombin III; AT 3; AT III; AT3; AT3D; ATIII; Heparin cofactor I; serpin C1; serpin family C member 1; serpinC1; THPH7
WB, ICC/IF
Human
Antithrombin III Antibody (YA3352) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3352), targeting Antithrombin III, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). Antithrombin III Antibody (YA3352) can be used for WB, ICC/IF experiment in human background.
Angiotensinogen Antibody (YA2097) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2097), targeting Angiotensinogen, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). Angiotensinogen Antibody (YA2097) can be used for WB, IHC-P, IP experiment in mouse background.
AACT Antibody (YA1103) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1103), targeting AACT. AACT Antibody (YA1103) can be used for IHC-P experiment in human background.
alpha 1-Antitrypsin Antibody (YA1122) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1122), targeting alpha 1-Antitrypsin. alpha 1-Antitrypsin Antibody (YA1122) can be used for IHC-P experiment in human background.
PEDF Antibody (YA1687) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1687), targeting PEDF, with a predicted molecular weight of 46 kDa (observed band size: 46 kDa). PEDF Antibody (YA1687) can be used for WB, FC experiment in human background.
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